-
1
-
-
0034124565
-
Effects of cigarette smoking and carbon monoxide on nicotine and cotinine metabolism
-
Benowitz NL and Jacob P III (2000) Effects of cigarette smoking and carbon monoxide on nicotine and cotinine metabolism. Clin Pharmacol Ther 67:653-659.
-
(2000)
Clin Pharmacol Ther
, vol.67
, pp. 653-659
-
-
Benowitz, N.L.1
Jacob P. III2
-
2
-
-
0027958225
-
Nicotine metabolic profile in man: Comparison of cigarette smoking and transdermal nicotine
-
Benowitz NL, Jacob P III, Fong I, and Gupta S (1994) Nicotine metabolic profile in man: Comparison of cigarette smoking and transdermal nicotine. J Pharmacol Exp Ther 268:296-303.
-
(1994)
J Pharmacol Exp Ther
, vol.268
, pp. 296-303
-
-
Benowitz, N.L.1
Jacob P. III2
Fong, I.3
Gupta, S.4
-
3
-
-
0032705773
-
Ethnic differences in N-glucuronidation of nicotine and cotinine
-
Benowitz NL, Perez-Stable EJ, Fong I, Modin G, Herrera B, and Jacob P 3rd (1999) Ethnic differences in N-glucuronidation of nicotine and cotinine. J Pharmacol Exp Ther 291:1196-1203.
-
(1999)
J Pharmacol Exp Ther
, vol.291
, pp. 1196-1203
-
-
Benowitz, N.L.1
Perez-Stable, E.J.2
Fong, I.3
Modin, G.4
Herrera, B.5
Jacob P. III6
-
4
-
-
0026586611
-
Evidence for urinary excretion of glucuronide conjugates of nicotine, cotinine and trans-3′-hydroxycotinine in smokers
-
Byrd GD, Chang K-M, Greene JM, and deBethizy JD (1992) Evidence for urinary excretion of glucuronide conjugates of nicotine, cotinine and trans-3′-hydroxycotinine in smokers. Drug Metab Dispos 20:192-197.
-
(1992)
Drug Metab Dispos
, vol.20
, pp. 192-197
-
-
Byrd, G.D.1
Chang, K.-M.2
Greene, J.M.3
DeBethizy, J.D.4
-
5
-
-
0026525695
-
Characterization of the glucuronide conjugate of cotinine: A previously unidentified major metabolite of nicotine in smokers' urine
-
Caldwell WS, Greene JM, Byrd GD, Chang KM, Uhrig MS, deBethizy JD, Crooks PA, Bhatti BS, and Riggs RM (1992) Characterization of the glucuronide conjugate of cotinine: A previously unidentified major metabolite of nicotine in smokers' urine. Chem Res Toxicol 5:280-285.
-
(1992)
Chem Res Toxicol
, vol.5
, pp. 280-285
-
-
Caldwell, W.S.1
Greene, J.M.2
Byrd, G.D.3
Chang, K.M.4
Uhrig, M.S.5
DeBethizy, J.D.6
Crooks, P.A.7
Bhatti, B.S.8
Riggs, R.M.9
-
6
-
-
0031704509
-
Species differences in N-glucuronidation
-
Chiu S-HL and Huskey S-EW (1998) Species differences in N-glucuronidation. Drug Metab Dispos 26:838-847.
-
(1998)
Drug Metab Dispos
, vol.26
, pp. 838-847
-
-
Chiu, S.-H.L.1
Huskey, S.-E.W.2
-
7
-
-
0035197725
-
Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms
-
Court MH, Duan SX, von Moltke LL, Greenblatt DJ, Patten CJ, Miners JO, and Mackenzie PI (2001) Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther 299:998-1006.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 998-1006
-
-
Court, M.H.1
Duan, S.X.2
Von Moltke, L.L.3
Greenblatt, D.J.4
Patten, C.J.5
Miners, J.O.6
Mackenzie, P.I.7
-
8
-
-
0035209568
-
The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism
-
Fisher MB, Paine MF, Strelevitz TJ, and Wrighton SA (2001) The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism. Drug Metab Rev 33:273-297.
-
(2001)
Drug Metab Rev
, vol.33
, pp. 273-297
-
-
Fisher, M.B.1
Paine, M.F.2
Strelevitz, T.J.3
Wrighton, S.A.4
-
9
-
-
0032937925
-
Glucuronidation of drugs by hepatic microsomes derived from healthy and cirrhotic human livers
-
Furlan V, Demirdjian S, Bourdon O, Magdalou J, and Taburet A-M (1999) Glucuronidation of drugs by hepatic microsomes derived from healthy and cirrhotic human livers. J Pharmacol Exp Ther 289:1169-1175.
-
(1999)
J Pharmacol Exp Ther
, vol.289
, pp. 1169-1175
-
-
Furlan, V.1
Demirdjian, S.2
Bourdon, O.3
Magdalou, J.4
Taburet, A.-M.5
-
10
-
-
0036707617
-
N-Glucuronidation of nicotine and cotinine in human: Formation of cotinine glucuronide in liver microsomes and lack of catalysis by ten examined UDP-glucuronosyltransferases
-
Ghosheh O and Hawes EM (2002) N-Glucuronidation of nicotine and cotinine in human: Formation of cotinine glucuronide in liver microsomes and lack of catalysis by ten examined UDP-glucuronosyltransferases. Drug Metab Dispos 30:991-996.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 991-996
-
-
Ghosheh, O.1
Hawes, E.M.2
-
11
-
-
0035193376
-
Formation of the quaternary ammoniumlinked glucuronide of nicotine in human liver microsomes: Identification and stereoselectivity in the kinetics
-
Ghosheh O, Vashishtha SC, and Hawes EM (2001) Formation of the quaternary ammoniumlinked glucuronide of nicotine in human liver microsomes: Identification and stereoselectivity in the kinetics. Drug Metab Dispos 29:1525-1528.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 1525-1528
-
-
Ghosheh, O.1
Vashishtha, S.C.2
Hawes, E.M.3
-
12
-
-
0028948889
-
Expressed human UGT1.4 protein catalyzes the formation of quaternary ammonium-linked glucuronides
-
Green MD, Bishop WP, and Tephly TR (1995) Expressed human UGT1.4 protein catalyzes the formation of quaternary ammonium-linked glucuronides. Drug Metab Dispos 23:299-302.
-
(1995)
Drug Metab Dispos
, vol.23
, pp. 299-302
-
-
Green, M.D.1
Bishop, W.P.2
Tephly, T.R.3
-
13
-
-
0031765698
-
Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3
-
Green MD, King CD, Mojarrabi B, Mackenzie PI, and Tephly TR (1998) Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. Drug Metab Dispos 26:507-512.
-
(1998)
Drug Metab Dispos
, vol.26
, pp. 507-512
-
-
Green, M.D.1
King, C.D.2
Mojarrabi, B.3
Mackenzie, P.I.4
Tephly, T.R.5
-
14
-
-
0029962074
-
Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein
-
Green MD and Tephly TR (1996) Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein. Drug Metab Dispos 24:356-363.
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 356-363
-
-
Green, M.D.1
Tephly, T.R.2
-
15
-
-
0018232839
-
Physiological disposition and metabolism of cyclobenzaprine in the rat, dog, rhesus monkey, and man
-
Hucker HB, Stauffer SC, Balletto AJ, White SD, Zacchei AG, and Arison BH (1978) Physiological disposition and metabolism of cyclobenzaprine in the rat, dog, rhesus monkey, and man. Drug Metab Dispos 6:659-672.
-
(1978)
Drug Metab Dispos
, vol.6
, pp. 659-672
-
-
Hucker, H.B.1
Stauffer, S.C.2
Balletto, A.J.3
White, S.D.4
Zacchei, A.G.5
Arison, B.H.6
-
16
-
-
0033388771
-
CYP2A6 genetic polymorphisms and liver microsomal coumarin and nicotine oxidation activities in Japanese and Caucasians
-
Inoue K, Yamazaki H, and Shimada T (2000) CYP2A6 genetic polymorphisms and liver microsomal coumarin and nicotine oxidation activities in Japanese and Caucasians. Arch Toxicol 73:532-539.
-
(2000)
Arch Toxicol
, vol.73
, pp. 532-539
-
-
Inoue, K.1
Yamazaki, H.2
Shimada, T.3
-
18
-
-
0020541055
-
Quaternary ammonium-linked glucuronides of amitriptyline, imipramine, and chlorpromazine
-
Lehman JP, Fenselau C, and dePaulo JR (1983) Quaternary ammonium-linked glucuronides of amitriptyline, imipramine, and chlorpromazine. Drug Metab Dispos 11:221-225.
-
(1983)
Drug Metab Dispos
, vol.11
, pp. 221-225
-
-
Lehman, J.P.1
Fenselau, C.2
DePaulo, J.R.3
-
19
-
-
0035112167
-
Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: Leading to structural optimization
-
Li C, Chauret N, Trimble LA, Nicoll-Griffith DA, Silva JM, MacDonald D, Perrier H, Yergey JA, Parton T, Alexander RP, and Warrellow GJ (2001) Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: Leading to structural optimization. Drug Metab Dispos 29:232-241.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 232-241
-
-
Li, C.1
Chauret, N.2
Trimble, L.A.3
Nicoll-Griffith, D.A.4
Silva, J.M.5
MacDonald, D.6
Perrier, H.7
Yergey, J.A.8
Parton, T.9
Alexander, R.P.10
Warrellow, G.J.11
-
22
-
-
0032055273
-
Drug glucuronidation by human renal UDP-glucuronosyltransferases
-
McGurk KA, Brierley CH, and Burchell B (1998) Drug glucuronidation by human renal UDP-glucuronosyltransferases. Biochem Pharmacol 55:1005-1012.
-
(1998)
Biochem Pharmacol
, vol.55
, pp. 1005-1012
-
-
McGurk, K.A.1
Brierley, C.H.2
Burchell, B.3
-
23
-
-
0035138840
-
Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans
-
Nakajima M, Kwon J-T, Tanaka N, Zenta T, Yamamoto Y, Yamamoto H, Yamazaki H, Yamamoto T, Kuroiwa Y, and Yokoi T (2001) Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans. Clin Pharmacol Ther 69:72-78.
-
(2001)
Clin Pharmacol Ther
, vol.69
, pp. 72-78
-
-
Nakajima, M.1
Kwon, J.-T.2
Tanaka, N.3
Zenta, T.4
Yamamoto, Y.5
Yamamoto, H.6
Yamazaki, H.7
Yamamoto, T.8
Kuroiwa, Y.9
Yokoi, T.10
-
24
-
-
0035154274
-
Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: Implications for interindividual differences in nicotine metabolism
-
Oscarson M (2001) Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: Implications for interindividual differences in nicotine metabolism. Drug Metab Dispos 29:91-95.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 91-95
-
-
Oscarson, M.1
-
26
-
-
0025893724
-
A quaternary ammonium glucuronide is the major metabolite of lamotrigine in guinea pigs, in vitro and in vivo studies
-
Remmel RP and Sinz MW (1991) A quaternary ammonium glucuronide is the major metabolite of lamotrigine in guinea pigs, in vitro and in vivo studies. Drug Metab Dispos 19:630-636.
-
(1991)
Drug Metab Dispos
, vol.19
, pp. 630-636
-
-
Remmel, R.P.1
Sinz, M.W.2
-
27
-
-
0027378475
-
Rates of excretion of cotinine, nicotine glucuronide, and 3-hydroxycotinine glucuronide in rat bile
-
Seaton MJ, Kyerematen GA, and Vesell ES (1993b) Rates of excretion of cotinine, nicotine glucuronide, and 3-hydroxycotinine glucuronide in rat bile. Drug Metab Dispos 21:927-932.
-
(1993)
Drug Metab Dispos
, vol.21
, pp. 927-932
-
-
Seaton, M.J.1
Kyerematen, G.A.2
Vesell, E.S.3
-
28
-
-
0027525449
-
Identification of radiolabeled metabolites of nicotine in rat bile, synthesis of S-(-)-nicotine N-glucuronide, and direct separation of nicotine-derived conjugates using high-performance liquid chromatography
-
Seaton MJ, Vesell ES, Luo H, and Hawes EM (1993a) Identification of radiolabeled metabolites of nicotine in rat bile, synthesis of S-(-)-nicotine N-glucuronide, and direct separation of nicotine-derived conjugates using high-performance liquid chromatography. J Chromatogr 621:49-53.
-
(1993)
J Chromatogr
, vol.621
, pp. 49-53
-
-
Seaton, M.J.1
Vesell, E.S.2
Luo, H.3
Hawes, E.M.4
-
29
-
-
0035079669
-
Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes
-
Shipkova M, Strassburg CP, Braun F, Streit F, Gröne H-J, Armstrong VW, Tukey RH, Oellerich M, and Wieland E (2001) Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes. Br J Clin Pharmacol 132:1027-1034.
-
(2001)
Br J Clin Pharmacol
, vol.132
, pp. 1027-1034
-
-
Shipkova, M.1
Strassburg, C.P.2
Braun, F.3
Streit, F.4
Gröne, H.-J.5
Armstrong, V.W.6
Tukey, R.H.7
Oellerich, M.8
Wieland, E.9
-
30
-
-
0035692560
-
Evaluation of the marmoset as a model species for drug glucuronidation
-
Soars MG, Riley RJ, and Burchell B (2001a) Evaluation of the marmoset as a model species for drug glucuronidation. Xenobiotica 31:849-860.
-
(2001)
Xenobiotica
, vol.31
, pp. 849-860
-
-
Soars, M.G.1
Riley, R.J.2
Burchell, B.3
-
31
-
-
0035154231
-
Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney
-
Soars MG, Riley RJ, Findlay KAB, Coffey MJ, and Burchell B (2001b) Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney. Drug Metab Dispos 29:121-126.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 121-126
-
-
Soars, M.G.1
Riley, R.J.2
Findlay, K.A.B.3
Coffey, M.J.4
Burchell, B.5
-
32
-
-
0034680792
-
Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine
-
Strassburg CP, Kneip S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, and Manns MP (2000) Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J Biol Chem 275:36164-36171.
-
(2000)
J Biol Chem
, vol.275
, pp. 36164-36171
-
-
Strassburg, C.P.1
Kneip, S.2
Topp, J.3
Obermayer-Straub, P.4
Barut, A.5
Tukey, R.H.6
Manns, M.P.7
-
34
-
-
0032701917
-
Evidence for the biosynthesis of a glucuronide conjugate of (S)-(-)-nicotine, but not (S)-(-)-cotinine or (±)-trans-3′-hydroxycotinine by marmoset hepatic microsomes
-
Tsai M-C and Gorrod JW (1999) Evidence for the biosynthesis of a glucuronide conjugate of (S)-(-)-nicotine, but not (S)-(-)-cotinine or (±)-trans-3′-hydroxycotinine by marmoset hepatic microsomes. Drug Metab Drug Interact 15:223-237.
-
(1999)
Drug Metab Drug Interact
, vol.15
, pp. 223-237
-
-
Tsai, M.-C.1
Gorrod, J.W.2
-
35
-
-
0034128936
-
Human UDP-glucuronosyltransferases: Metabolism, expression and disease
-
Tukey RH and Strassburg CP (2000) Human UDP-glucuronosyltransferases: Metabolism, expression and disease. Annu Rev Pharmacol Toxicol 40:581-616.
-
(2000)
Annu Rev Pharmacol Toxicol
, vol.40
, pp. 581-616
-
-
Tukey, R.H.1
Strassburg, C.P.2
-
36
-
-
0035115599
-
Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract
-
Tukey RH and Strassburg CP (2001) Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol 59:405-414.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 405-414
-
-
Tukey, R.H.1
Strassburg, C.P.2
-
37
-
-
0035064372
-
Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk
-
Tyndale RF and Sellers EM (2001) Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk. Drug Metab Dispos 29:548-552.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 548-552
-
-
Tyndale, R.F.1
Sellers, E.M.2
-
38
-
-
0036785444
-
Quaternary ammonium-linked glucuronidation of I-substituted imidazoles by liver microsomes: Interspecies differences and structure-metabolism relationships
-
Vashishtha SC, Hawes EM, McCann DJ, Ghosheh O, and Hogg L (2002) Quaternary ammonium-linked glucuronidation of I-substituted imidazoles by liver microsomes: Interspecies differences and structure-metabolism relationships. Drug Metab Dispos 30:1070-1076.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 1070-1076
-
-
Vashishtha, S.C.1
Hawes, E.M.2
McCann, D.J.3
Ghosheh, O.4
Hogg, L.5
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