Galacto-oligosaccharide production using microbial β-galactosidase: Current state and perspectives

Applied Microbiology and Biotechnology

Volumn 85, Issue 5, 2010, Pages 1279-1286

  Park, Ah Reum ^a   Oh, Deok Kun ^a  

^a Konkuk University   (South Korea)

Author keywords

Galactosidase; Characterization; Galacto oligosaccharides; Product inhibition; Transgalactosylation

Indexed keywords

FERMENTED MILK; FUNCTIONAL FOODS; GALACTO-OLIGOSACCHARIDES; GALACTOSIDASES; HEALTH BENEFITS; PRODUCT INHIBITION; STRUCTURE MODIFICATION;

BEVERAGES; DAIRY PRODUCTS; ENZYME IMMOBILIZATION; ENZYME INHIBITION;

OLIGOSACCHARIDES;

BETA GALACTOSIDASE; GALACTOSE OLIGOSACCHARIDE; LACTOSE;

ENZYME ACTIVITY; FERMENTATION; FOOD PROCESSING; IMMOBILIZATION; INDUSTRIAL PRODUCTION; MICROBIAL ACTIVITY; POLYSACCHARIDE;

ALICYCLOBACILLUS ACIDOCALDARIUS; ARTHROBACTER; ASPERGILLUS; ASPERGILLUS ORYZAE; BACILLUS CIRCULANS; BACILLUS MEGATERIUM; BIFIDOBACTERIUM ADOLESCENTIS; BIFIDOBACTERIUM BIFIDUM; BIFIDOBACTERIUM LONGUM INFANTIS; CARBOHYDRATE SYNTHESIS; CRYPTOCOCCUS LAURENTII; ENZYME ACTIVITY; ENZYME INHIBITION; FERMENTED PRODUCT; FUNCTIONAL FOOD; GEOBACILLUS STEAROTHERMOPHILUS; GEOBACILLUS THERMOLEOVORANS; IMMOBILIZATION; KLUYVEROMYCES; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS REUTERI; NEGATIVE FEEDBACK; NONHUMAN; PANTOEA AGGLOMERANS; SACCHAROPOLYSPORA RECTIVIRGULA; SHORT SURVEY; STREPTOCOCCUS PNEUMONIA; THERMOTOGA MARITIMA; THERMUS AQUATICUS;

BACTERIA; BETA-GALACTOSIDASE; CATALYSIS; ENZYME INHIBITORS; FUNGI; GALACTOSE; GLUCOSE; GLYCOSYLATION; KINETICS; LACTOSE; OLIGOSACCHARIDES; TEMPERATURE;

EID: 76649107887     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-2356-2     Document Type: Short Survey

References (63)

1. K Akiyama M Takase K Horikoshi S Okonogi 2001 Production of galactooligosaccharides from lactose using a β-glucosidase from Thermus sp. Z-1 Biosci Biotechnol Biochem 65 438 441 10.1271/bbb.65.438 1:CAS:528:DC%2BD3MXhslKgurw%3D (Pubitemid 33626261)
2. N Albayrak ST Yang 2002 Production of galacto-oligosaccharides from lactose by Aspergillus oryzae β-galactosidase immobilized on cotton cloth Biotechnol Bioeng 77 8 19 10.1002/bit.1195 1:CAS:528:DC%2BD38XktlaksQ%3D%3D
3. JL Berger BH Lee C Lacroix 1997 Purification, properties and characterization of a high molecular-mass β-galactosidase isoenzyme from Thermus aquaticus Biotechnol Appl Biochem 25 29 41 1:CAS:528:DyaK2sXhtVaqsrc%3D
4. ME Bruins M Strubel JFT van Lieshout AEM Janssen RM Boom 2003 Oligosaccharide synthesis by the hyperthermostable β-glucosidase from Pyrococcus furiosus: kinetics and modelling Enzyme Microb Technol 33 3 11 10.1016/S0141-0229(03)00096-6 1:CAS:528:DC%2BD3sXkvVKjur0%3D (Pubitemid 36733569)
5. L Cao 2005 Immobilised enzymes: science or art? Cur Opin Chem Biol 9 217 226 10.1016/j.cbpa.2005.02.014 1:CAS:528:DC%2BD2MXivFSls7Y%3D (Pubitemid 40462493)
6. W Chen H Chen Y Xia J Zhao F Tian H Zhang 2008 Production, purification, and characterization of a potential thermostable galactosidase for milk lactose hydrolysis from Bacillus stearothermophilus J Dairy Sci 91 1751 1758 10.3168/jds.2007-617 1:CAS:528:DC%2BD1cXltlWmt7Y%3D (Pubitemid 351730878)
7. YJ Cho HJ Shin C Bucke 2003 Purification and biochemical properties of a galactooligosaccharide producing β-galactosidase from Bullera singularis Biotechnol Lett 25 2107 2111 10.1023/B:BILE.0000007077.58019.bb 1:CAS:528:DC%2BD3sXpsFOnsbg%3D (Pubitemid 38097781)
8. S Chockchaisawasdee VI Athanasopoulos K Niranjan RA Rastall 2004 Synthesis of galacto-oligosaccharide from lactose using β-galactosidase from Kluyveromyces lactis: Studies on batch and continuous UF membrane-fitted bioreactors Biotechnol Bioeng 89 434 443 10.1002/bit.20357
9. JA Coker PP Sheridan J Loveland-Curtze KR Gutshall AJ Auman JE Brenchley 2003 Biochemical characterization of a β-galactosidase with a low temperature optimum obtained from an Antarctic Arthrobacter isolate J Bacteriol 185 5473 5482 10.1128/JB.185.18.5473-5482.2003 1:CAS:528:DC%2BD3sXnt1Wktr4%3D (Pubitemid 37082404)
10. RG Crittenden MJ Playne 1996 Production, properties and applications of food-grade oligosaccharides Trends Food Sci Technol 7 353 361 10.1016/S0924-2244(96)10038-8 1:CAS:528:DyaK28XnsF2ksbw%3D (Pubitemid 27079410)
11. R Cruz V D'Arcadia Cruz JG Belote M de Oliveira Khenayfes C Dorta LH dos Santos Oliveira E Ardiles A Galli 1999 Production of transgalactosylated oligosaccharides (TOS) by galactosyltransferase activity from Penicillium simplicissimum Biores Technol 70 165 171 10.1016/S0960-8524(99)00033-4 1:CAS:528:DyaK1MXjvFWju74%3D (Pubitemid 29253529)
12. B Di Lauro A Strazzulli G Perugino F La Cara E Bedini MM Corsaro M Rossi M Moracci 2008 Isolation and characterization of a new family 42 β-galactosidase from the thermoacidophilic bacterium Alicyclobacillus acidocaldarius: identification of the active site residues Biochim Biophys Acta 1784 292 301
13. V Dumortier C Brassart S Bouquelet 1994 Purification and properties of a β-D-galactosidase from Bifidobacterium bifidum exhibiting a transgalactosylation reaction Biotechnol Appl Biochem 19 341 354 1:CAS:528:DyaK2MXhvVWktQ%3D%3D
14. H Fujimoto M Miyasato Y Ito T Sasaki K Ajisaka 1998 Purification and properties of recombinant β-galactosidase from Bacillus circulans Glycoconj J 15 155 160 10.1023/A:1006916222187 1:CAS:528:DyaK1cXhvVWmt7s%3D (Pubitemid 28260919)
15. V Gekas M Lopez-Leiva 1985 Hydrolysis of lactose: a literature review Process Biochem 20 2 12 1:CAS:528:DyaL2MXhs1Ghurg%3D
16. GD Haki SK Rakshit 2003 Developments in industrially important thermostable enzymes: a review Biores Technol 89 17 34 10.1016/S0960-8524(03) 00033-6 1:CAS:528:DC%2BD3sXis1aqu7s%3D (Pubitemid 36379207)
17. M Hidaka S Fushinobu N Ohtsu H Motoshima H Matsuzawa H Shoun T Wakagi 2002 Trimeric crystal structure of the glycoside hydrolase family 42 β-galactosidase from Thermus thermophilus A4 and the structure of its complex with galactose J Mol Biol 322 79 91 10.1016/S0022-2836(02)00746-5 1:CAS:528:DC%2BD38Xms1Wktb8%3D (Pubitemid 36132672)
18. SWA Hinz LAM van den Brock G Beldman JP Vincken AGJ Voragen 2004 β-Galactosidase from Bifidobacterium adolescentis DSM20083 prefers β(1, 4)-galactosides over lactose Appl Microbiol Biotechnol 66 276 284 10.1007/s00253-004-1745-9 1:CAS:528:DC%2BD2cXhtVShsL3N (Pubitemid 40064357)
19. CA Hsu SL Lee CC Chou 2007 Enzymatic production of galactooligosaccharides by β-galactosidase from Bifidobacterium longum BCRC 15708 J Agric Food Chem 55 2225 2230 10.1021/jf063126+ 1:CAS:528: DC%2BD2sXhvF2ru78%3D (Pubitemid 46556209)
20. MN Hung BH Lee 2002 Purification and characterization of a recombinant β-galactosidase with transgalactosylation activity from Bifidobacterium infantis HL96 Appl Microbiol Biotechnol 58 439 445 10.1007/s00253-001-0911-6 1:CAS:528:DC%2BD38XivFGls7k%3D (Pubitemid 34230703)
21. MJ In HJ Chae 1998 Characterization of β-galactosidase with high transgalactosylation activity produced by Penicillium sp. KFCC 10888 Korean J Appl Microbiol Biothechnol 26 40 44 1:CAS:528:DyaK1cXisFajsr0%3D
22. E Ishikawa T Sakai H Ikemura K Matsumoto H Abe 2005 Identification, cloning, and characterization of a Sporobolomyces singularis β-galactosidase-like enzyme involved in galacto-oligosaccharide production J Biosci Bioeng 99 331 339 10.1263/jbb.99.331 1:CAS:528:DC%2BD2MXlsFCns7w%3D (Pubitemid 40740582)
23. K Iwasaki M Nakajima S Nakao 1996 Galacto-oligosaccharide production from lactose by an enzymic batch reaction using β-galactosidase Process Biochem 31 69 76 10.1016/0032-9592(94)00067-0 1:CAS:528:DyaK2MXovV2rs7Y%3D
24. JK Jeong O Kwon YM Lee DB Oh JM Lee S Kim EH Kim TN Le DK Rhee HA Kang 2009 Characterization of the Streptococcus pneumoniae BgaC protein as a novel surface β-galactosidase with specific hydrolysis activity for the Galβ1-3GlcNAc moiety of oligosaccharides J Bacteriol 191 3011 3023 10.1128/JB.01601-08 1:CAS:528:DC%2BD1MXlsFCht7o%3D
25. ES Ji NH Park DK Oh 2005 Galacto-oligosaccharide production by a thermostable recombinant β-galactosidase from Thermotoga maritima World J Microbiol Biotechnol 21 759 764 10.1007/s11274-004-5487-8 1:CAS:528: DC%2BD2MXmsFWlur8%3D (Pubitemid 41073920)
26. CS Kim ES Ji DK Oh 2003 Expression and characterization of Kluyveromyces lactis β-galactosidase in Escherichia coli Biotechnol Lett 25 1769 1774 10.1023/A:1026092029785 1:CAS:528:DC%2BD3sXnslaqsLo%3D (Pubitemid 37325539)
27. CS Kim ES Ji DK Oh 2004 Characterization of a thermostable recombinant β-galactosidase from Thermotoga maritima J Appl Microbiol 97 1006 1014 10.1111/j.1365-2672.2004.02377.x 1:CAS:528:DC%2BD2cXhtVahtL3N (Pubitemid 39390228)
28. CS Kim ES Ji DK Oh 2004 A new kinetic model of recombinant β-galactosidase from Kluyveromyces lactis for both hydrolysis and transgalactosylation reactions Biochem Biophys Res Commun 316 738 743 10.1016/j.bbrc.2004.02.118 1:CAS:528:DC%2BD2cXitFKgsLg%3D (Pubitemid 38368014)
29. M Ladero A Santos JL Garcia AV Carrascosa BCC Pessela F Garcia-Ochoa 2002 Studies on the activity and the stability of β-galactosidases from Thermus sp. strain T2 and from Klyveromyces fragilis Enzyme Microb Technol 30 392 405 10.1016/S0141-0229(01)00506-3 1:CAS:528:DC%2BD38XhslWgsr4%3D (Pubitemid 34203852)
30. M Ladero MT Perez A Santos F Garcia-Ochoa 2003 Hydrolysis of lactose by free and immobilized β-galactosidase from Thermus sp. strain T2 Biotechnol Bioeng 81 241 252 10.1002/bit.10466 1:CAS:528:DC%2BD3sXht1Wkuw%3D%3D (Pubitemid 36077300)
31. Y Li H Wang L Lu Z Li X Xu M Xiao 2009 Purification and characterization of a novel β-galactosidase with transglycosylation activity from Bacillus megaterium 2-37-4-1 Appl Biochem Biotechnol 158 192 199 10.1007/s12010-008-8310- 4 1:CAS:528:DC%2BD1MXptVynsLc%3D
32. L Lu M Xiao X Xu Z Li Y Li 2007 A novel β-galactosidase capable of glycosyl transfer from Enterobacter agglomerans B1 Biochem Biophys Res Commun 356 78 84 10.1016/j.bbrc.2007.02.106 1:CAS:528:DC%2BD2sXjt1Smsro%3D (Pubitemid 46413131)
33. GT Macfarlane H Steed S Macfarlane 2008 Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics J Appl Microbiol 104 305 344 1:STN:280:DC%2BD1c%2FmtlehsQ%3D%3D
34. C Mateo R Monti BCC Pessela M Fuentes R Torres JM Guisan R Fernandez-Lafuente 2004 Immobilization of lactase from Kluyveromyces lactis greatly reduces the inhibition promoted by glucose. Full hydrolysis of lactose in milk Biotechnol Prog 20 1259 1262 10.1021/bp049957m 1:CAS:528: DC%2BD2cXis1CjtLw%3D (Pubitemid 39059641)
35. Z Mozaffar K Nakanishi R Matsuno 1985 Formation of oligosaccharides during hydrolysis of lactose in milk using β-galactosidase from Bacillus circulans J Food Sci 50 1602 1606 10.1111/j.1365-2621.1985.tb10543.x 1:CAS:528:DyaL28Xjtlahtg%3D%3D
36. Z Mozaffar K Nakanishi R Matsuno 1986 Mechanism for reversible inactivation of immobilized β-galactosidase from Bacillus circulans during continuous production of galacto-oligosaccharides Appl Microbiol Biotechnol 25 229 231 1:CAS:528:DyaL2sXotVylsg%3D%3D (Pubitemid 17012915)
37. T Nakagawa R Ikehata M Uchino T Miyaji K Takano N Tomizuka 2006 Cold-active acid beta-galactosidase activity of isolated psychrophilic- basidiomycetous yeast Guehomyces pullulans Microbiol Res 161 75 79 10.1016/j.micres.2005.07.003 1:CAS:528:DC%2BD28XhslOit70%3D (Pubitemid 41773117)
38. T Nakagawa R Ikehata T Myoda T Miyaji N Tomizuka 2007 Overexpression and functional analysis of cold-active β-galactosidase from Arthrobacter psychrolactophilus strain F2 Protein Exp Purif 54 295 299 10.1016/j.pep.2007.03. 010 1:CAS:528:DC%2BD2sXlvVOqsb4%3D (Pubitemid 46783595)
39. M Nakao M Hatada Y Kodama T Nakayama Y Shibano T Amachi 1994 Purification and characterization of a thermostable β-galactosidase with high transgalactosylation activity from Saccharopolyspora rectivirgula Appl Microbiol Biotechnol 40 657 663 10.1007/BF00173325 1:CAS:528:DyaK2cXlsFWrsbg%3D
40. P Nakkharat KD Kulbe M Yamabhai D Haltrich 2006 Formation of galacto-oligosaccharides during lactose hydrolysis by a novel β-galactosidase from the moderately thermophilic fungus Talaromyces thermophilus Biotechnol J 1 633 638 10.1002/biot.200600013 1:CAS:528: DC%2BD28Xht1WgsrjN
41. TH Nguyen B Splechtna M Steinbock W Kneifel HP Lettner KD Kulbe D Haltrich 2006 Purification and characterization of two novel β-galactosidases from Lactobacillus reuteri J Agric Food Chem 54 4989 4998 10.1021/jf053126u 1:CAS:528:DC%2BD28XlvFKgtbs%3D (Pubitemid 44140893)
42. TH Nguyen B Splechtna S Krasteva W Kneifel KD Kulbe C Divne D Haltrich 2007 Characterization and molecular cloning of a heterodimeric β-galactosidase from the probiotic strain Lactobacillus acidophilus R22 FEMS Microbiol Lett 269 136 144 10.1111/j.1574-6968.2006.00614.x 1:CAS:528:DC%2BD2sXjvVyntbs%3D (Pubitemid 46354144)
43. N Ohtsu H Motoshima K Goto F Tsukasaki H Matsuzawa 1998 Thermostable beta-galactosidase from an extreme thermophile, Thermus sp. A4: enzyme purification and characterization, and gene cloning and sequencing Biosci Biotechnol Biochem 62 1539 1545 10.1271/bbb.62.1539 1:CAS:528:DyaK1cXlvFemsLw%3D
44. K Ohtsuka A Tanoh O Ozawa T Kanematsu T Uchida R Shinke 1990 Purification and properties of a β-galactosidase with high galactosyl transfer activity from Cryptococcus laurentii OKN-4 J Ferment Bioeng 70 301 307 10.1016/0922-338X(90)90138-M 1:CAS:528:DyaK3MXjvVagug%3D%3D
45. N Onishi T Tanaka 1995 Purification and properties of a novel thermostable galacto-oligosaccharide-producing β-galactosidase from Sterigmatomyces elviae CBS8119 Appl Environ Microbiol 61 4026 4030 1:CAS:528:DyaK2MXptFGgtb8%3D
46. N Onishi K Yokozeki 1996 Gluco-oligosaccharide and galacto- oligosaccharide production by Rhodotorula minuta IFO879 J Ferment Bioeng 82 124 127 10.1016/0922-338X(96)85033-1 1:CAS:528:DyaK28Xls1elu7g%3D (Pubitemid 26327254)
47. N Onishi I Kira K Yokozeki 1996 Galacto-oligosaccharide production from lactose by Sirobasidium magnum CBS6803 Lett Appl Microbiol 23 253 256 10.1111/j.1472-765X.1996.tb00077.x 1:CAS:528:DyaK28XmvFyltro%3D
48. O Ozawa K Ohtsuka T Uchida 1989 Production of 4′-galactosyllactose by mixed cells of Cryptococcus laurentii and Baker's yeast Nippon Shokuhin Kogyo Gakkaishi 36 898 902 1:CAS:528:DyaK3cXhtlOnsr8%3D
49. PS Panesar R Panesar RS Singh JF Kennedy H Kumar 2006 Microbial production, immobilization and applications of β-D-galactosidase J Chem Technol Biotechnol 81 530 543 10.1002/jctb.1453 1:CAS:528:DC%2BD28XjvFyjs74%3D
50. AR Park DK Oh 2009 Effects of galactose and glucose on the hydrolysis reaction of a thermostable β-galactosidase from Caldicellulosiruptor saccharolyticus Appl Microbiol Biotechnol 10.1007/s00253-009-2165-7
51. HY Park HJ Kim JK Lee D Kim DK Oh 2008 Galactooligosaccharide production by a thermostable β-galactosidase from Sulfolobus solfataricus World J Microbiol Biotechnol 24 1553 1558 10.1007/s11274-007-9642-x 1:CAS:528: DC%2BD1cXnsVCqsbY%3D
52. BCC Pessela C Mateo M Fuentes A Vian JL Garcia AV Carrascosa JM Guisan R Fernandez-Lafuente 2003 The immobilization of a thermophilic β-galactosidase on sepabeads supports decrease product inhibition complete hydrolysis of lactose in dairy products Enzyme Microb Technol 33 199 205 10.1016/S0141-0229(03)00120-0 1:CAS:528:DC%2BD3sXlvVWju7c%3D (Pubitemid 37288905)
53. I Petzelbauer B Nidetzky D Haltrich KD Kulbe 1999 Development of an ultra-high-temperature process for the enzymatic hydrolysis of lactose. I. The properties of two thermostable β-glycosidases Biotechnol Bioeng 64 322 332 10.1002/(SICI)1097-0290(19990805)64:3<322::AID-BIT8>3.0.CO;2-9 1:CAS:528:DyaK1MXktVymsb8%3D (Pubitemid 29297385)
54. FM Pisani R Rella CA Raia C Rozzo R Nucci A Gambacorta M De Rosa M Rossi 1990 Thermostable β-galactosidase from the archaebacterium Sulfolobus solfataricus. Purification and properties Eur J Biochem 187 321 328 10.1111/j.1432-1033.1990.tb15308.x 1:CAS:528:DyaK3cXhtFClsLg%3D (Pubitemid 20040390)
55. G Placier H Watzlawick C Rabiller R Mattes 2009 Evolved β-galactosidases from Geobacillus stearothermophilus with improved transgalactosylation yield for galacto-oligosaccharides production Appl Environ Microbiol 10.1128/AEM.00714-09
56. T Sakai H Tsuji S Shibata K Hayakawa K Matsumoto 2008 Repeated-batch production of galactooligosaccharides from lactose at high concentration by using alginate-immobilized cells of Sporobolomyces singularis YIT 10047 J Gen Appl Microbiol 54 285 293 10.2323/jgam.54.285 1:CAS:528:DC%2BD1cXhtlyqtrrJ (Pubitemid 352770984)
57. T Sako K Matsumoto R Tanaka 1999 Recent progress on research and applications of non-digestible galacto-oligosaccharides Int Dairy J 9 69 80 10.1016/S0958-6946(99)00046-1 1:CAS:528:DyaK1MXltVKmt70%3D (Pubitemid 29342047)
58. HJ Shin JW Yang 1998 Enzymatic production of galactooligosaccharide by Bullera singularis β-galactosidase J Microbiol Biotechnol 8 484 489 1:CAS:528:DyaK1cXotVert7g%3D
59. B Splechtna TH Nguyen M Steinbock KD Kulbe W Lorenz D Haltrich 2006 Production of prebiotic galacto-oligosaccharides from lactose using β-galactosidases from Lactobacillus reuteri J Agric Food Chem 54 4999 5006 10.1021/jf053127m 1:CAS:528:DC%2BD28XlvFKgtbg%3D (Pubitemid 44140894)
60. D Todorova-Balvay I Stoilova S Gargova MA Vijayalakshmi 2006 An efficient two step purification and molecular characterization of β-galactosidases from Aspergillus oryzae J Mol Recognit 19 299 304 10.1002/jmr.788 1:CAS:528:DC%2BD28XovVWltb8%3D (Pubitemid 44238414)
61. G Tzortzis AK Goulas GR Gibson 2005 Synthesis of prebiotic galactooligosaccharides using whole cells of a novel strain, Bifidobacterium bifidum NCIMB 41171 Appl Microbiol Biotechnol 68 412 416 10.1007/s00253-005- 1919-0 1:CAS:528:DC%2BD2MXnsl2gsbw%3D (Pubitemid 41160015)
62. WHM van Casteren M Eimermann LAM van den Broek JP Vincken HA Schols AGJ Voragen 2000 Purification and characterisation of a β-galactosidase from Aspergillus aculeatus with activity towards (modified) exopolysaccharides from Lactococcus lactis subsp. cremoris B39 and B891 Carbohydr Res 329 75 85 10.1016/S0008-6215(00)00152-X (Pubitemid 30797972)
63. P Zheng H Yu Z Sun Y Ni W Zhang Y Fan Y Xu 2006 Production of galacto-oligosaccharides by immobilized recombinant β-galactosidase from Aspergillus candidus Biotechnol J 1 1464 1470 10.1002/biot.200600100 1:CAS:528:DC%2BD2sXisVyktb8%3D