Role of c-jun n-terminal kinase in the regulation of vascular tone

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 15, Issue 1, 2010, Pages 78-83

  Zhou, Ming Sheng ^a,b   Schulman, Ivonne Hernandez ^a,b   Chadipiralla, Kiranmai ^a,b   Raij, Leopoldo ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensin II; Endothelium; Hypertension

Indexed keywords

ANGIOTENSIN II; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ENDOTHELIN 1; NORADRENALIN; POTASSIUM CHLORIDE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; IN VIVO STUDY; INHIBITION KINETICS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; STEREOISOMERISM; SYSTOLIC BLOOD PRESSURE; VASCULAR RING; VASOCONSTRICTION;

ANALYSIS OF VARIANCE; ANGIOTENSIN II; ANIMALS; AORTA; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; NOREPINEPHRINE; POTASSIUM CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 76649097620     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248409354603     Document Type: Article

References (28)

1. Bogoyevitch MA, Arthur PG. Inhibitors of c-Jun N-terminal kinases: JuNK no more ? Biochim Biophys Acta. 2008 ; 1784 (1). 76-93.
2. Bogoyevitch MA The isoform-specific functions of the c-Jun N-terminal Kinases (JNKs): differences revealed by gene targeting. Bioessays. 2006 ; 28 (9). 923-934.
3. Muslin AJ MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets. Clin Sci (Lond). 2008 ; 115 (7). 203-218.
4. Milano G., Morel S., Bonny C., et al. A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo. Am J Physiol Heart Circ Physiol. 2007 ; 292 (4). H1828 - H1835.
5. Kaneto H., Nakatani Y., Miyatsuka T., et al. Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat Med. 2004 ; 10 (10). 1128-1132.
6. Hirosumi J., Tuncman G., Chang L., et al. A central role for JNK in obesity and insulin resistance. Nature. 2002 ; 420 (6913). 333-336.
7. Kyaw M., Yoshizumi M., Tsuchiya K., Kirima K., Tamaki T. Antioxidants inhibit JNK and p38 MAPK activation but not ERK 1/2 activation by angiotensin II in rat aortic smooth muscle cells. Hypertens Res. 2001 ; 24 (3). 251-261.
8. Xu Q., Liu Y., Gorospe M., Udelsman R., Holbrook NJ Acute hypertension activates mitogen-activated protein kinases in arterial wall. J Clin Invest. 1996 ; 97 (2). 508-514.
9. Touyz RM, Yao G. Up-regulation of vascular and renal mitogen-activated protein kinases in hypertensive rats is normalized by inhibitors of the Na+/Mg2+ exchanger. Clin Sci (Lond). 2003 ; 105 (2). 235-242.
10. Izumi Y., Kim S., Zhan Y., Namba M., Yasumoto H., Iwao H. Important role of angiotensin II-mediated c-Jun NH(2)-terminal kinase activation in cardiac hypertrophy in hypertensive rats. Hypertension. 2000 ; 36 (4). 511-516.
11. Lee YR, Lee CK, Park HJ, et al. C-Jun N-terminal kinase contributes to norepinephrine-induced contraction through phosphorylation of caldesmon in rat aortic smooth muscle. J Pharmacol Sci. 2006 ; 100 (2). 119-125.
12. Adam LP, Haeberle JR, Hathaway DR Phosphorylation of caldesmon in arterial smooth muscle. J Biol Chem. 1989 ; 264 (13). 7698-7703.
13. Kim S., Murakami T., Izumi Y., et al. Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activities are continuously and differentially increased in aorta of hypertensive rats. Biochem Biophys Res Commun. 1997 ; 236 (1). 199-204.
14. Yano M., Kim S., Izumi Y., Yamanaka S., Iwao H. Differential activation of cardiac c-jun amino-terminal kinase and extracellular signal-regulated kinase in angiotensin II-mediated hypertension. Circ Res. 1998 ; 83 (7). 752-760.
15. Ohtsu H., Mifune M., Frank GD, et al. Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II. Arterioscler Thromb Vasc Biol. 2005 ; 25 (9). 1831-1836.
16. Ding G., Zhang A., Huang S., et al. ANG II induces c-Jun NH2-terminal kinase activation and proliferation of human mesangial cells via redox-sensitive transactivation of the EGFR. Am J Physiol Renal Physiol. 2007 ; 293 (6). F1889 - F1897.
17. Sugita M., Sugita H., Kaneki M. Increased insulin receptor substrate 1 serine phosphorylation and stress-activated protein kinase/c-Jun N-terminal kinase activation associated with vascular insulin resistance in spontaneously hypertensive rats. Hypertension. 2004 ; 44 (4). 484-489.
18. Bennett BL, Sasaki DT, Murray BW, et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A. 2001 ; 98 (24). 13681-13686.
19. Bachar O., Adner M., Uddman R., Cardell LO. Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-kappa B signaling pathways. Eur J Immunol. 2004 ; 34 (4). 1196-1207.
20. Zhang C., Hein TW, Wang W., Ren Y., Shipley RD, Kuo L. Activation of JNK and xanthine oxidase by TNF-alpha impairs nitric oxide-mediated dilation of coronary arterioles. J Mol Cell Car-diol. 2006 ; 40 (2). 247-257. (Pubitemid 43153793)
21. Rahaman SO, Lennon DJ, Febbraio M., Podrez EA, Hazen SL, Silverstein RL A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. Cell Metab. 2006 ; 4 (3). 211-221.
22. Ricci R., Sumara G., Sumara I., et al. Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science. 2004 ; 306 (5701). 1558-1561.
23. Osto E., Matter CM, Kouroedov A., et al. c-Jun N-terminal kinase 2 deficiency protects against hypercholesterolemia-induced endothelial dysfunction and oxidative stress. Circulation. 2008 ; 118 (20). 2073-2080.
24. Laukeviciene A., Brecht S., Kevelaitis E., Herdegen T. Enhanced contractility of small blood vessels in JNK knockout mice. Eur J Pharm Sci. 2006 ; 29 (5). 335-339.
25. Mehta PK, Griendling KK Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol. 2007 ; 292 (1). C82 - C97.
26. Kim J., Lee YR, Lee CH, et al. Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats. Eur J Pharmacol. 2005 ; 514 (2-3). 209-215.
27. Zhou MS, Schulman IH, Raij L. Role of angiotensin II and oxidative stress in vascular insulin resistance linked to hypertension. Am J Physiol Heart Circ Physiol. 2009 ; 296 (3). H833 - H839.
28. Sobue K., Kanda K., Tanaka T., Ueki N. Caldesmon: a common actin-linked regulatory protein in the smooth muscle and nonmuscle contractile system. J Cell Biochem. 1988 ; 37 (3). 317-325.