New heteroaryl nitrones with spin trap properties: Identification of a 4-furoxanyl derivative with excellent properties to be used in biological systems

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 2, 2010, Pages 795-802

  Barriga, Germán ^a   Olea Azar, Claudio ^a   Norambuena, Ester ^b   Castro, Ana ^c   Porcal, Williams ^d   Gerpe, Alejandra ^d   González, Mercedes ^d   Cerecetto, Hugo ^d  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN   (Chile)

^c INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^d UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

Biological system; Furoxanyl nitrone; Heteroaryl nitrones; Spin trap

Indexed keywords

4 FUROXANYL NITRONE; ALPHA( 3 METHYLFUROXAN 4 YL) N TERT BUTYLNITRONE; ALPHA( 3 PHENYL 1,2,4 THIADIAZOL 5 YL) N TERT BUTYLNITRONE; ALPHA( 4 METHYL 1,2,3 THIADIAZOL 5 YL) N TERT BUTYLNITRONE; ALPHA( 4 PHENYLFUROXAN 3 YL) N TERT BUTYLNITRONE; ALPHA( 5 ETHOXYCARBONYL 1,2,3 THIADIAZOL 4 YL) N TERT BUTYLNITRONE; ALPHA( 5 PHENYL 1,2,4 THIADIAZOL 3 YL) N TERT BUTYLNITRONE; ALPHA(BENZOFUROXAN 5 ( 6 )YL) N TERT BUTYLNITRONE; CARBON; FREE RADICAL; FURAN; FURAN DERIVATIVE; HYDROXYL GROUP; NITROGEN; NITRONE DERIVATIVE; OXYGEN; SULFUR; SUPEROXIDE; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIPROTOZOAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; ARTIFACT; CYCLOADDITION; DRUG HALF LIFE; ELECTRON SPIN RESONANCE; EQUILIBRIUM CONSTANT; IN VIVO STUDY; KINETICS; NONHUMAN; PH; PHYSICAL CHEMISTRY; PROTEIN STABILITY; RADICAL REACTION; SCAVENGING SYSTEM; SOLUBILITY; SPIN TRAPPING; TRYPANOSOMA CRUZI;

ELECTRON SPIN RESONANCE SPECTROSCOPY; HETEROCYCLIC COMPOUNDS; HYDROGEN-ION CONCENTRATION; KINETICS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NITROGEN OXIDES; SOLUBILITY; STEREOISOMERISM; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI; TRYPANOSOMATIDAE;

EID: 76449083534     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.11.053     Document Type: Article

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