Characterization of the radical trapping activity of a novel series of cyclic nitrone spin traps

Journal of Biological Chemistry

Volumn 271, Issue 6, 1996, Pages 3097-3104

  Thomas, Craig E ^a   Ohlweiler, David F ^a   Carr, Albert A ^a   Nieduzak, Thaddeus R ^a   Hay, David A ^a   Adams, Ginette ^a   Vaz, Roy ^a   Bernotas, Ronald C ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 DEOXYRIBOSE; 3,4 DIHYDRO 3,3 DIMETHYLISOQUINOLINE 2 OXIDE; ANILINE DERIVATIVE; FERROUS ION; HYDROXYL RADICAL; LIPOSOME; MDL 104342; N TERT BUTYL ALPHA PHENYLNITRONE; ORGANONITROGEN DERIVATIVE; SUPEROXIDE; TIRILAZAD; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CONVULSION; ELECTRON SPIN RESONANCE; INTRAPERITONEAL DRUG ADMINISTRATION; LIPID PEROXIDATION; LIPOPHILICITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARTITION COEFFICIENT; PRIORITY JOURNAL;

ANIMALS; CYCLIC N-OXIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; HYDROXYL RADICAL; IRON; ISOQUINOLINES; LIPID PEROXIDATION; LIPOSOMES; MICE; MODELS, MOLECULAR; MODELS, STRUCTURAL; NITROGEN OXIDES; OXIDATIVE STRESS; SPIN LABELS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDES; XANTHINE OXIDASE;

ANIMALIA;

EID: 0030063098     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.6.3097     Document Type: Article

References (38)

1. Kontos, H. A (1989) Chem Biol. Interact. 72, 229-255
2. Oliver, C N . Starke-Reed. P. E , Stadtman, E. R., Liu, G J., Carney. J. M., and Floyd, R. A. (1990) Proc Natl. Acad Sci U. S. A. 87, 5144-5147
3. Philhs, J. W., and Clough-Helfman, C (1990) Med. Sci Res. 18, 403-404
4. Yue, T -L , Gu, J.-L , Lysko, P. G., Cheng, H.-Y., Barone, F. C., and Feuerstein, G. (1992) Brain Res. 574, 193-197
5. Zhao, Q , Pahlmark, K., Smith, M.-L., and Siesjo. B. K. (1994) Acta Physiol. Scand. 152, 349-350
6. Cao, X., and Phillis, J W. (1994) Brain Res. 644, 267-272
7. Hamburger, S A., and McCay, P B. (1989) Circ. Shock 29, 329-334
8. Bolli, R., Patel, B. S., Jeroudi, M O . Li, X-Y. Triana, J. F., Lai, E. K, and McCay, P. B. (1990) Am. J Physiol. 259, H1901-H1911
9. Cova, D., DeAngelis, L., Monti, E., and Piccinini, F. (1992) Free Radical Res. Commun 15, 353-360
10. Kaduska, M. B , Hanna, P M , Jordan. S. J., and Mason, R. P (1993) Mol. Pharmacol. 44, 222-227
11. Knecht, K. T , and Mason, R P (1988) Drug Metab. Dispos. 16, 813-817
12. Tortolani, A. J , Powell, S R , Misik, V., Weglicki, W B., Pago, G. J., and Kramer, J H. (1993) Free Radical Biol. Med. 14, 421-426
13. Thomas, C. E., Ku, G., and Kalyanaraman, B. (1994) J. Lipid Res. 35, 610-619
14. Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Landum, R. W , Cheng, M. S., Wu, J. F , and Floyd, R A. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 3633-3636
15. Janzen, E. G., Hinton, R. D., and Kotake, Y. (1992) Tetrahedron Lett. 33, 1257-1260
16. Hinton, R. D., and Janzen, E G. (1992) J- Org. Chem. 57, 2646-2651
17. Thomas, C. E , Carney, J. M., Bernotas, R C , Hay, D. A., and Carr, A A. (1994) Ann. N. Y. Acad. Sci. 738, 243-249
18. French, J. F., Thomas, C. E., Downs, T R , Ohlweiler, D F., Carr, A. A., and Dage, R. C. (1994) Circ. Shock 43, 130-136
19. Downs, T. R., Dage, R. C , and French, J. F. (1995) Int. J. Immunopharmacol. 17, 571-380
20. Thomas, C. E., Ohlweiler, D F , and Kalyanaraman, B. (1994) J Biol. Chem. 269, 28055-28061
21. Carr, A. A., Thomas, C. E., Bernotas, R. C., and Ku, G. (March 8, 1994) U S. Patent 5,292,746
22. Larsen, R. D., Reamer, R. A, Corley, E. G., Davis, P., Grabowski, E. J. J., Reider, P. J., and Shinkai, I. (1991) J. Org. Chem. 56, 6034-6038
23. Murahashi, S., Shiota, T , and Imada, Y. (1991) Org. Synth. 70, 265-271
24. Tripos, Inc. (1993) SYBYL, Version 6.0, TRIPOS, Inc , St. Louis, MO
25. Clark, M., Cramer, R. D., III, and Van Opdenbosh, N. (1989) J. Comp. Chem. 10, 982-1012
26. QCPE (1989) MOPAC. Version 5.0. QCPE, Indiana University, Bloomington, IN
27. Wavefunction, Inc. (1993) Spartan, Version 3.0, Wavefunction, Inc., Irvine, CA
28. Leo, A. J. (1993) Chem. Rev. 93, 1281-1306
29. Daylight Chemical Informations Systems, Inc. (1994) PCMODELS, Version 4.34, Daylight Chemical Informations Systems, Inc., Irvine, CA
30. Thomas, C. E., McLean, L. R , Parker, R. A., and Ohlweiler, D. F. (1992) Lipids 27, 543-550
31. Bors, W., Michel, C., and Saran, M (1979) Eur. J. Biochem 95, 621-627
32. Abe., Y., Seno, S , Sakakibara, K., and Hirota, M. (1991) J Chem Soc., Perkin Trans 2, 897-903
33. Janzen, E., Zhang, Y., and Haire, D. L. (1994) J. Am. Chem Soc. 116, 3738-3743
34. Halliwell, B., Guttendge, J. M. C., and Aruoma, O I. (1987) Anal. Biochem. 165, 761-767
35. Ching T., Halnen, G. R. M. M., and Bast, A. (1993) Chem. Biol Interact. 86, 119-127
36. Minotti, G., and Aust, S. D. (1987) J. Biol Chem 262, 1098-1104
37. Kotake, Y., and Janzen, E. G. (1991) J. Am Chem. Soc. 113, 9503-9506
38. Buettner, G. R. (1987) Free Radical Biol. Med 3, 259-303