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Volumn , Issue 40, 1996, Pages 299-317

Nitrone-based free radical traps as neuroprotective agents in cerebral ischaemia and other pathologies

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; NEUROPROTECTIVE AGENT; NITROGEN OXIDE; NITRONES;

EID: 33845218951     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0074-7742(08)60725-4     Document Type: Article
Times cited : (87)

References (106)
  • 2
    • 0028132265 scopus 로고
    • Involvement of tyrosine kinase in the induction of cyclo-oxygenase and nitric oxide by endotoxin in cultured cells
    • Akarasereenant, P., Mitchell, J.A., Appleton, I., Thiemermann, C. & Vane, J.R. (1994) Involvement of tyrosine kinase in the induction of cyclo-oxygenase and nitric oxide by endotoxin in cultured cells. Br. J. Pharmacol. 113, 1522-1528.
    • (1994) Br. J. Pharmacol. , vol.113 , pp. 1522-1528
    • Akarasereenant, P.1    Mitchell, J.A.2    Appleton, I.3    Thiemermann, C.4    Vane, J.R.5
  • 3
    • 0026753708 scopus 로고
    • Mechanism of c-fos induction by active oxygen
    • Amstad, P.A., Krupitza, G. & Cerutti, P.A. (1992) Mechanism of c-fos induction by active oxygen. Cancer Res. 52, 3952-3960.
    • (1992) Cancer Res. , vol.52 , pp. 3952-3960
    • Amstad, P.A.1    Krupitza, G.2    Cerutti, P.A.3
  • 4
    • 0027172051 scopus 로고
    • Nitrone spin-traps block calcium channels and induce pulmonary artery relaxation independent of free radicals
    • Anderson, D.E., Yuan, X.J., Tseng, C.M., Rubin, L.J., Rosen, G.M. &Tod, M.L. (1993)Nitrone spin-traps block calcium channels and induce pulmonary artery relaxation independent of free radicals. Biochem. Biophjs. Res. Commun. 193, 878-885.
    • (1993) Biochem. Biophjs. Res. Commun. , vol.193 , pp. 878-885
    • Anderson, D.E.1    Yuan, X.J.2    Tseng, C.M.3    Rubin, L.J.4    Rosen, G.M.5    Tod, M.L.6
  • 5
    • 0025865317 scopus 로고
    • An inducible transcription activator NF-kappa B: Regulation by distinct protein subunits
    • Baeuerle, P.A. (1991) An inducible transcription activator NF-kappa B: Regulation by distinct protein subunits. Biochim. Biophys. Acta 1072, 63-80.
    • (1991) Biochim. Biophys. Acta , vol.1072 , pp. 63-80
    • Baeuerle, P.A.1
  • 6
    • 0028233494 scopus 로고
    • Hydrogen peroxide mediates amyloid βpeptide toxicity
    • Behl, C., Davis, J.B., Lesley, R. & Schubert, D. (1994) Hydrogen peroxide mediates amyloid βpeptide toxicity.Cell 77, 817-827.
    • (1994) Cell , vol.77 , pp. 817-827
    • Behl, C.1    Davis, J.B.2    Lesley, R.3    Schubert, D.4
  • 7
    • 0020647482 scopus 로고
    • Reduction of long-term potentiation in the dentate gyrus of the rat following selective depletion of monoamines
    • Bliss, T.VR, Goddard, G.V. & Riives, M. (1983) Reduction of long-term potentiation in the dentate gyrus of the rat following selective depletion of monoamines. J. Physiol. 334, 475-491.
    • (1983) J. Physiol. , vol.334 , pp. 475-491
    • Bliss, T.V.R.1    Goddard, G.V.2    Riives, M.3
  • 8
    • 0024502081 scopus 로고
    • Vasopressin neuromodulation in the hippocampus
    • Brinton, R.E. & McEwen, B.S. (1989) Vasopressin neuromodulation in the hippocampus. J. Aeurosci. 9, 752-759.
    • (1989) J. Neurosci. , vol.9 , pp. 752-759
    • Brinton, R.E.1    McEwen, B.S.2
  • 9
    • 0029417023 scopus 로고
    • Appoptosis and increased generation of reactive oxygen species in Down's syndrome neurones
    • Busciglio, J. & Yankner, B.A. (1995) Appoptosis and increased generation of reactive oxygen species in Down's syndrome neurones in vilro. Nature 378, 776-779.
    • (1995) Vitro. Nature , vol.378 , pp. 776-779
    • Busciglio, J.1    Yankner, B.A.2
  • 10
    • 0028181531 scopus 로고
    • Phenyl-tert-butyl-nitrone reduces cortical infarct and oedema in rats subject to focal ischaemia
    • Cao, X. & Phillis, J.W. (1994) a-Phenyl-tert-butyl-nitrone reduces cortical infarct and oedema in rats subject to focal ischaemia. Brain Res. 644, 267-272
    • (1994) Brain Res. , vol.644 , pp. 267-272
    • Cao, X.1    Phillis, J.W.2
  • 11
    • 0025932511 scopus 로고
    • Protection against oxidative damage to CNS by a-phenyltert-butyl-nitronc (PEN) and other spin-trapping agents: A novel series of nonlipid free radical scavengers
    • Carney, J.M. & Floyd, R.A. (1991) Protection against oxidative damage to CNS by a-phenyltert-butyl-nitronc (PEN) and other spin-trapping agents: A novel series of nonlipid free radical scavengers. J. Mol. Neurosci. 3, 47-57.
    • (1991) J. Mol. Neurosci. , vol.3 , pp. 47-57
    • Carney, J.M.1    Floyd, R.A.2
  • 12
    • 0013654323 scopus 로고
    • Gene expression and functional changes after acute ischaemia: Age-related differences in outcome and mechanisms
    • (eds Hartmann, A., Yatsu, F. & Kuschinsky, W)
    • CarneyJ.M., Kindy, M.S., Smith, C.D., Wood, K., Tatsuno, T., Wu, J.F., Landrum, W.R. & Floyd, R.A. (1994) Gene expression and functional changes after acute ischaemia: age-related differences in outcome and mechanisms. In Cerebral Ischaemia and Basic Mechanisms (eds Hartmann, A., Yatsu, F. & Kuschinsky, W), pp. 301-311. Springer-Verlag, Berlin, Heidelberg.
    • (1994) Cerebral Ischaemia and Basic Mechanisms , pp. 301-311
    • Carney, J.M.1    Kindy, M.S.2    Smith, C.D.3    Wood, K.4    Tatsuno, T.5    Wu, J.F.6    Landrum, W.R.7    Floyd, R.A.8
  • 13
    • 0027241010 scopus 로고
    • Nitric oxide formation during light-induced decomposition of a-phenyl-A-tert-butylnitrone
    • Chamulitrat, W.Jordan, S.J., Mason, R.P.,' Sàito, K. & Cutler, R.G. (1993) Nitric oxide formation during light-induced decomposition of a-phenyl-A-tert-butylnitrone, J. Biol. Chem. 268, 11520-11527.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11520-11527
    • Chamulitrat, W.1    Jordan, S.J.2    Mason, R.P.3    Sàito, K.4    Cutler, R.G.5
  • 14
    • 0025173450 scopus 로고
    • Excretion, metabolism, and tissue distribution of a spin trapping agent, a-phenyl-tertbutyl nitrone (PBN) in rats
    • Chen, G., Bray, T.M.Janzen, E.G. & McCay, P.B. (1990) Excretion, metabolism, and tissue distribution of a spin trapping agent, a-phenyl-tertbutyl nitrone (PBN) in rats. Free Rod. Rts. Commun. 9, 317-323.
    • (1990) Free Rad. Commun. , vol.9 , pp. 317-323
    • Chen, G.1    Bray, T.M.2    Janzen, E.G.3    McCay, P.B.4
  • 15
    • 0028345161 scopus 로고
    • Senescence-like growth arrest by hydrogen peroxide in human fibroblast F65 cells
    • USA
    • Chen, Q. & Ames, B.N. (1994) Senescence-like growth arrest by hydrogen peroxide in human fibroblast F65 cells. Proc. Natl Acad. Sci. USA 91, 4130-4134.
    • (1994) Proc. Natl Acad. Sci. , vol.91 , pp. 4130-4134
    • Chen, Q.1    Ames, B.N.2
  • 16
    • 0029051426 scopus 로고
    • Oxidative DNA damage and senescence of human diploid fibroblast cells
    • USA
    • Chen, Q, Fisher, A., ReaganJ.D., Van, LJ. & Ames, B.N. (1995) Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc. Natl Acad. Sei. USA 92, 4337-4341.
    • (1995) Proc. Natl Acad. Sci. , vol.92 , pp. 4337-4341
    • Chen, Q.1    Fisher, A.2    Reagan, J.D.3    Van, L.J.4    Ames, B.N.5
  • 17
    • 0027400449 scopus 로고
    • Distribution of spin-trapping compounds in rat blood and brain: In vk'o microdialysis determination
    • Cheng, H.Y., Liu, T., Feuerstein, G. & Barone, F.C. (1993) Distribution of spin-trapping compounds in rat blood and brain: In vk'o microdialysis determination. Free Rod. Biol. Med. 14, 243-250.
    • (1993) Free Rad. Biol. Med. , vol.14 , pp. 243-250
    • Cheng, H.Y.1    Liu, T.2    Feuerstein, G.3    Barone, F.C.4
  • 18
    • 28044464985 scopus 로고
    • Reversible inhibition of cytochrome C oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases
    • Cleeter, M.WJ., Cooper, J.M., Darley-Usmar, VM., Moncada, S. & Schapira, A.H.V (1994) Reversible inhibition of cytochrome C oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett. 345, 50-54.
    • (1994) FEBS Lett. , vol.345 , pp. 50-54
    • Cleeter, M.W.J.1    Cooper, J.M.2    Darley-Usmar, V.M.3    Moncada, S.4    Schapira, A.H.V.5
  • 19
    • 0026409177 scopus 로고
    • The free radical trapping agent JV-tert-butyl-alphaphenylnitone (PBN) attenuates cerebral ischaemic injury in gerbils
    • Clough-Helfman, C. & Phillis, J.W. (1991) The free radical trapping agent JV-tert-butyl-alphaphenylnitone (PBN) attenuates cerebral ischaemic injury in gerbils. Free Rod. Res. Commun. 15, 177-186.
    • (1991) Free Rad. Res. Commun. , vol.15 , pp. 177-186
    • Clough-Helfman, C.1    Phillis, J.W.2
  • 20
    • 0027049804 scopus 로고
    • The mammalian ultraviolet response is triggered by activation of Src tyrosine kinase
    • Devary, Y., Gottlieb, R.A., Smeal, T. & Karin, M. (1992) The mammalian ultraviolet response is triggered by activation of Src tyrosine kinase. Cell 71, 1081-1091.
    • (1992) Cell , vol.71 , pp. 1081-1091
    • Devary, Y.1    Gottlieb, R.A.2    Smeal, T.3    Karin, M.4
  • 21
    • 0027363407 scopus 로고
    • NF-KB activation by ultraviolet light is not dependent on a nuclear signal
    • Devary, Y, Rosette, C., DidonatoJ.A. & Karin, M. (1993) NF-KB activation by ultraviolet light is not dependent on a nuclear signal. Science 261, 1442-1445.
    • (1993) Science , vol.261 , pp. 1442-1445
    • Devary, Y.1    Rosette, C.2    Didonato, J.A.3    Karin, M.4
  • 22
    • 0026341905 scopus 로고
    • Rapid and preferential activation of the c-jun gene during the mammalian UV response
    • Devary, Y, Gottlieb, R.A., Lau, L.F. & Karin, M. (1991) Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol. Cell Biol. 11, 2804-2811.
    • (1991) Mol. Cell Biol. , vol.11 , pp. 2804-2811
    • Devary, Y.1    Gottlieb, R.A.2    Lau, L.F.3    Karin, M.4
  • 23
    • 0023940538 scopus 로고
    • Differentiation of murine macrophages to express nonspecific cytotoxicity for tumour cells results in L-arginine-dependent inhibition of mitochondria iron-sulfur enzymes in the macrophage effector cells
    • Drapier, J.C. & Hibbs, J.B. Jr. (1988) Differentiation of murine macrophages to express nonspecific cytotoxicity for tumour cells results in L-arginine-dependent inhibition of mitochondria] iron-sulfur enzymes in the macrophage effector cells. J. Immunol. 140, 2829-2838.
    • (1988) J. Immunol. , vol.140 , pp. 2829-2838
    • Drapier, J.C.1    Hibbs Jr., J.B.2
  • 24
    • 0025788509 scopus 로고
    • Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages
    • Drapier, J.C., Pellat, C. & Henry, Y (1991) Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages. J. Biol. Chem. 266, 10162-10167.
    • (1991) J. Biol. Chem. , vol.266 , pp. 10162-10167
    • Drapier, J.C.1    Pellat, C.2    Henry, Y.3
  • 25
    • 0029058728 scopus 로고
    • The spin-trap.A-tert-a-phenyl-nitrone prolongs the life span of the senescence accelerated mouse
    • Edamatsu, R., Mori, A. & Packer, L. (1995) The spin-trap.A-tert-a-phenyl-nitrone prolongs the life span of the senescence accelerated mouse. Biochem. Biophjs. Res. Commun. 211, 847-849.
    • (1995) Biochem. Biophjs. Res. Commun. , vol.211 , pp. 847-849
    • Edamatsu, R.1    Mori, A.2    Packer, L.3
  • 26
    • 0027946686 scopus 로고
    • Altered gene expression in neurones during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
    • Estus, S., Zaks, WJ., Freeman, R.S., Gruda, M., Bravo, R. &Johnson, M. (1994) Altered gene expression in neurones during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis. J. Cell Biol. 127, 1717-1727.
    • (1994) J. Cell Biol. , vol.127 , pp. 1717-1727
    • Estus, S.1    Zaks, W.J.2    Freeman, R.S.3    Gruda, M.4    Bravo, R.5    Johnson, M.6
  • 27
    • 0001933792 scopus 로고
    • Spin trapping
    • Evans, C.A. (1979) Spin trapping. Aldrichim. Acta. 12, 23-29.
    • (1979) Aldrichim. Acta. , vol.12 , pp. 23-29
    • Evans, C.A.1
  • 28
    • 0025314685 scopus 로고
    • Role of oxygen free radicals in carcinogenesis and brain ischaemia
    • Floyd, R.A. (1990) Role of oxygen free radicals in carcinogenesis and brain ischaemia. FASEB J. 4, 2587-2597.
    • (1990) FASEB J. , vol.4 , pp. 2587-2597
    • Floyd, R.A.1
  • 29
    • 0025778702 scopus 로고
    • Age influence on oxidative events during brain ischaemia/reperfusion
    • Floyd, R.A. & Carney, J.M. (1991) Age influence on oxidative events during brain ischaemia/reperfusion. Arch. Gerontol. Geriatr. 12, 155-177.
    • (1991) Arch. Gerontol. Geriatr. , vol.12 , pp. 155-177
    • Floyd, R.A.1    Carney, J.M.2
  • 30
    • 0007356905 scopus 로고    scopus 로고
    • The protective action of nitrone-based free radical traps in neurodegenerative diseases
    • ed. G. Fiskum, Plenum Press, New York.
    • Floyd, R.A. (1996) The protective action of nitrone-based free radical traps in neurodegenerative diseases. In Neurodegenerative Diseases (ed. G. Fiskum), pp. 235-245. Plenum Press, New York.
    • (1996) Neurodegenerative Diseases , pp. 235-245
    • Floyd, R.A.1
  • 31
    • 0029067088 scopus 로고
    • A-tert-butyl-a-phenylnitrone improves recovery of brain energy state in rats following transient focal ischaemia
    • USA
    • Folbergrova, J., Zhao, Q., Katsura, K.I. & Seisjö, B.K. (1995).A-tert-butyl-a-phenylnitrone improves recovery of brain energy state in rats following transient focal ischaemia. Proc. Jlatl Acad. Sa. USA 91, 5057-5061.
    • (1995) Proc. Natl. Acad. Sci. , vol.91 , pp. 5057-5061
    • Folbergrova, J.1    Zhao, Q.2    Katsura, K.I.3    Seisjö, B.K.4
  • 32
    • 0028099839 scopus 로고
    • Protective effects of a cyclic nitrone antioxidant in animal models of endotoxic shock and chronic bacteremia
    • French, J.F., Thomas, C.E., Downs, T.R., Ohlweiler, D.F., Carr, A.A. & Dagc, R.C. (1994) Protective effects of a cyclic nitrone antioxidant in animal models of endotoxic shock and chronic bacteremia. Circ. Shock13, 130-136.
    • (1994) Circ. Shock , vol.13 , pp. 130-136
    • French, J.F.1    Thomas, C.E.2    Downs, T.R.3    Ohlweiler, D.F.4    Carr, A.A.5    Dagc, R.C.6
  • 33
    • 0028987869 scopus 로고
    • Inhibition of constitutive and inducible nitric oxide synthase: Potential inhibition
    • Fukuto,J.M. & Chaudhuri, G. (1995) Inhibition of constitutive and inducible nitric oxide synthase: Potential inhibition. Annu. Rev. Pharmacol. Toxicol. 35, 165-194.
    • (1995) Annu. Rev. Pharmacol. Toxicol , vol.35 , pp. 165-194
    • Fukuto, J.M.1    Chaudhuri, G.2
  • 34
    • 0027650908 scopus 로고
    • The activity of a 70 kilodalton IK-B molecule identical to the carboxyl terminus of the P105 NF-KB precursor is modulated by protein kinase A
    • Gerondakis, S., Morrice, N., Richardson, I.E., Wettenhall, R., Fecondo, J. & Grumont, RJ. (1993) The activity of a 70 kilodalton IK-B molecule identical to the carboxyl terminus of the P105 NF-KB precursor is modulated by protein kinase A. Cell Growth Differ. 4, 617-627.
    • (1993) Cell Growth Differ. , vol.4 , pp. 617-627
    • Gerondakis, S.1    Morrice, N.2    Richardson, I.E.3    Wettenhall, R.4    Fecondo, J.5    Grumont, R.J.6
  • 35
    • 0028070396 scopus 로고
    • The effects of chronic treatment with jV-tert-butyl-a-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats
    • Gould, TJ. & Bickford, P.C. (1994) The effects of chronic treatment with jV-tert-butyl-a-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats. Brain Res. 660, 333-336.
    • (1994) Brain Res. , vol.660 , pp. 333-336
    • Gould, T.J.1    Bickford, P.C.2
  • 36
    • 0023228677 scopus 로고
    • Noradrenaline and β-adrenoceptor agonists increase activity of voltage-dependent calcium channels in hippocampal neurones
    • Gray, R. &Johnston, D. ( 1987) Noradrenaline and β-adrenoceptor agonists increase activity of voltage-dependent calcium channels in hippocampal neurones. Nature 327, 620-628.
    • (1987) Nature , vol.327 , pp. 620-628
    • Gray, R.1    Johnston, D.2
  • 38
    • 0024792041 scopus 로고
    • Endotoxin-induced mortality in rats is reduced by nitrones
    • Hamburger, S.A. & McCay, P.B. (1989) Endotoxin-induced mortality in rats is reduced by nitrones. Circ. Shock 29, 329-334.
    • (1989) Circ. Shock , vol.29 , pp. 329-334
    • Hamburger, S.A.1    McCay, P.B.2
  • 40
    • 0344645402 scopus 로고    scopus 로고
    • Prevention of hyperoxia-induced alterations in synaptosomal membrane-associated proteins by.A-fer/-butyl-a-phenylnitrone and 4-hydroxy-2,2,6,6-tetramethyl-I-oxyl (tempol)
    • Howard, B J., Yatin, S., Hensley, K., Allen, K.L., KellyJ.P., CarneyJ. & Butterfield, D.A. (1996) Prevention of hyperoxia-induced alterations in synaptosomal membrane-associated proteins by.A-fer/-butyl-a-phenylnitrone and 4-hydroxy-2,2,6,6-tetramethyl-I-oxyl (tempol). J. Neurochem. 678, 1-6.
    • (1996) J. Neurochem. , vol.678 , pp. 1-6
    • Howard, B.J.1    Yatin, S.2    Hensley, K.3    Allen, K.L.4    Kelly, J.P.5    Carney, J.6    Butterfield, D.A.7
  • 41
    • 0028891572 scopus 로고
    • Inhibition of inducible nitric oxide synthase ameliorates cerebral ischaemic damage
    • ladecola, C., Zhang, F. & Xu, X. (1995a) Inhibition of inducible nitric oxide synthase ameliorates cerebral ischaemic damage. Am. J. Physiol. 268, R286-R292.
    • (1995) Am. J. Physiol. , vol.268
    • Iadecola, C.1    Zhang, F.2    Xu, X.3
  • 42
    • 0029294575 scopus 로고
    • Inducible nitric oxide synthase gene expression in brain following cerebral ischaemia
    • ladecola, C., Zhang, F., Xu, S., Casey, R. & Ross, M.E. (1995b) Inducible nitric oxide synthase gene expression in brain following cerebral ischaemia. J. Cereb. Blood Flow. Metab. 15, 378-384
    • (1995) J. Cereb. Blood Flow. Metab. , vol.15 , pp. 378-384
    • Iadecola, C.1    Zhang, F.2    Xu, S.3    Casey, R.4    Ross, M.E.5
  • 43
    • 0029012070 scopus 로고
    • Phenyl.A-tert-butyl-nitrone (PBN) increases the cortical cerebral blood flow by inhibiting the breakdown of nitric oxide in anesthetized rats
    • Inanami, O. & Kuwabara, M. (1995) a-Phenyl.A-tert-butyl-nitrone (PBN) increases the cortical cerebral blood flow by inhibiting the breakdown of nitric oxide in anesthetized rats. Free Rad. Res. 23, 33-39.
    • (1995) Free Rad. Res. , vol.23 , pp. 33-39
    • Inanami, O.1    Kuwabara, M.2
  • 44
    • 0346114246 scopus 로고
    • Detection and identification of short-lived free radicals by an electron spin resonance trapping technique
    • Janzen, E.G. & Blackburn, BJ. (1968) Detection and identification of short-lived free radicals by an electron spin resonance trapping technique. J. Am. Chem. Soc. 90, 5909.
    • (1968) J. Am. Chem. Soc. , vol.90 , pp. 5909
    • Janzen, E.G.1    Blackburn, B.J.2
  • 45
    • 0026530490 scopus 로고
    • Stabilities of hydroxyl radical spin adducts of PBN-type spin traps
    • Janzen, E.G., Kotake, Y. & Hinton, R.D. (1992) Stabilities of hydroxyl radical spin adducts of PBN-type spin traps. Free Rod. Biol. Med. 12, 169-173.
    • (1992) Free Rod. Biol. Med. , vol.12 , pp. 169-173
    • Janzen, E.G.1    Kotake, Y.2    Hinton, R.D.3
  • 46
    • 0002510591 scopus 로고
    • Comparison of antioxidant activity of PBN with hindered phenols in initiated rat liver microsomal peroxidation
    • (eds Asada, K. & Yoshikawa, T.), Elsevier Science, Amsterdam.
    • Janzen, E.G., West, M.S. & Poyer.J.L. (1994) Comparison of antioxidant activity of PBN with hindered phenols in initiated rat liver microsomal peroxidation. In Frontiers of Reactive Oxygen Species in Biology and Medicine (eds Asada, K. & Yoshikawa, T.), pp. 431-134. Elsevier Science, Amsterdam.
    • (1994) Frontiers of Reactive Oxygen Species in Biology and Medicine , pp. 431-1134
    • Janzen, E.G.1    West, M.S.2    Poyer, J.L.3
  • 47
    • 0028926437 scopus 로고
    • Vivo or in vitro administration of the nitrone spintrapping compound,.A-tert-butyl-a-phenylnitrone (PBN), reduces age-related deficits in stri-atal muscarinic receptor sensitivity
    • Joseph,J.A., Cao, G. & Cutler, R.C. (1995) In vivo or in vitro administration of the nitrone spintrapping compound,.A-tert-butyl-a-phenylnitrone (PBN), reduces age-related deficits in stri-atal muscarinic receptor sensitivity. Brain Res. 6761, 73-77.
    • (1995) Brain Res. , vol.6761 , pp. 73-77
    • Joseph, J.A.1    Cao, G.2    Cutler, R.C.3
  • 48
    • 0024435285 scopus 로고
    • Regulation of neuronal function by calcium
    • Kennedy, M.B. ( 1989) Regulation of neuronal function by calcium. Trends Neurosci. 12,417-420.
    • (1989) Trends Neurosci. , vol.12 , pp. 417-420
    • Kennedy, M.B.1
  • 49
    • 0027473299 scopus 로고
    • Vasodilatory and toxic effects of spin traps on aerobic cardiac function
    • Konorev, E.A., Baker,J.E.,Joseph,J. & Kalyanaraman, B. (1993) Vasodilatory and toxic effects of spin traps on aerobic cardiac function. Free Rad. Biol. Med. 14, 127-137.
    • (1993) Free Rad. Biol. Med. , vol.14 , pp. 127-137
    • Konorev, E.A.1    Baker, J.E.2    Joseph, J.3    Kalyanaraman, B.4
  • 50
    • 0001125283 scopus 로고
    • Decay and fate of the hydroxyl radical adduct of a-phenyKAtert-butylnitrone in aqueous media
    • Kotake, Y. & Janzen, E.G. (1991) Decay and fate of the hydroxyl radical adduct of a-phenyKAtert-butylnitrone in aqueous media. J. Am. Chem. Soc. 113, 948-951.
    • (1991) J. Am. Chem. Soc. , vol.113 , pp. 948-951
    • Kotake, Y.1    Janzen, E.G.2
  • 51
    • 0027221998 scopus 로고
    • NMDA-dependent Superoxide production and neurotoxicity
    • Lafon-Cazal, M., Pietri, S., Culcasi, M. & Bockaert, J. (1993) NMDA-dependent Superoxide production and neurotoxicity. Nature 364, 535-537.
    • (1993) Nature , vol.364 , pp. 535-537
    • Lafon-Cazal, M.1    Pietri, S.2    Culcasi, M.3    Bockaert, J.4
  • 52
    • 0028982274 scopus 로고
    • ras as a common signaling target of reactive free radicals and cellular redox stress
    • ras as a common signaling target of reactive free radicals and cellular redox stress. J. Biol. Chem. 270, 21 195-21 198.
    • (1995) J. Biol. Chem. , vol.270 , pp. 21195-21198
    • Lander, H.M.1    Ogiste, J.S.2    Teng, K.K.3    Novogrodsky, A.4
  • 53
    • 0002776853 scopus 로고
    • A continuous in riro model of ischaemia/reperfusion induced free radical production in the CSF of pig using spin-trapping agents and EPR techniques
    • Lange, D.G., Kirsch, J.R., Helfaer, M.A. & Traystman, RJ. (1990) A continuous in riro model of ischaemia/reperfusion induced free radical production in the CSF of pig using spin-trapping agents and EPR techniques. Free Rad. Biol. Med. 9 (Supp. 1), 97.
    • (1990) Free Rad. Biol. Med. , vol.9 , Issue.1 SUPPL. , pp. 97
    • Lange, D.G.1    Kirsch, J.R.2    Helfaer, M.A.3    Traystman, R.J.4
  • 55
    • 0029038416 scopus 로고
    • Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat
    • Li, Y, Sharov, VJiang, N., Zaloga, C., Sabbah, H.N. & Chopp, M. (1995) Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat. Am. J. Palhol 146, 1045-1051.
    • (1995) Am. J. Pathol , vol.146 , pp. 1045-1051
    • Sharov, L.Y.1    Vjiang, N.2    Zaloga, C.3    Sabbah, H.N.4    Chopp, M.5
  • 57
    • 0027956162 scopus 로고
    • Apoptosis in substantia nigra following developmental striatal excitotoxic injury
    • USA
    • Macaya, A., Munell, F., Cubits, R.M. & Burke, R.E. (1994) Apoptosis in substantia nigra following developmental striatal excitotoxic injury. Proc. Natl Acad. Sei. USA 91, 87 117-8121.
    • (1994) Proc. NatlAcad. Sci. , vol.91 , pp. 87117-88121
    • Macaya, A.1    Munell, F.2    Cubits, R.M.3    Burke, R.E.4
  • 59
    • 0028981159 scopus 로고
    • Amyloid -peptide impairs ion-motive ATPase activities: Evidence for a role in loss of neuronal Ca2homeostasis and cell death
    • Mark, R.J., Hensley, K., Butterfield, D.A. & Mattson, M.P. (1995) Amyloid -peptide impairs ion-motive ATPase activities: Evidence for a role in loss of neuronal Ca2homeostasis and cell death. J. Neurosti. 15, 6239-6249.
    • (1995) J. Neurosci. , vol.15 , pp. 6239-6249
    • Mark, R.J.1    Hensley, K.2    Butterfield, D.A.3    Mattson, M.P.4
  • 60
    • 0026341653 scopus 로고
    • Induction of the protooncogene c-fos and recovery of cytosolic adenosine triphosphate in reperfused liver after transient warm ischaemia: Effect of nitrone free-radical spintrap reagents
    • Marterre, W.F.Jr., Kindy, M.S., CarneyJ.M., Landrum, R.W. & Strodel, W.E. (1991) Induction of the protooncogene c-fos and recovery of cytosolic adenosine triphosphate in reperfused liver after transient warm ischaemia: Effect of nitrone free-radical spintrap reagents. Surgery 110, 184-193.
    • (1991) Surgery , vol.110 , pp. 184-193
    • Marterre, W.F.J.1    Kindy, M.S.2    Carney, J.M.3    Landrum, R.W.4    Strodel, W.E.5
  • 61
    • 0027365599 scopus 로고
    • Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells
    • Marui, N., Oflermann, M.K., Swerlick, R., Kunsch, C., Rosen, C.A., Ahmad, M., Alexander, R.W. & Medford, R.M. (1993) Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J. Clin. Invest. 92,1866-1874.
    • (1993) J. Clin. Invest. , vol.92 , pp. 1866-1874
    • Marui, N.1    Oflermann, M.K.2    Swerlick, R.3    Kunsch, C.4    Rosen, C.A.5    Ahmad, M.6    Alexander, R.W.7    Medford, R.M.8
  • 62
    • 0024589688 scopus 로고
    • Involvement of hormonal and neuromodulatory systems in the regulation of memory storage
    • McGaugh, J.L. (1989) Involvement of hormonal and neuromodulatory systems in the regulation of memory storage. Annu. Rev. Neurosci. 12, 255-287.
    • (1989) Annu. Rev. Neurosci. , vol.12 , pp. 255-287
    • McGaugh, J.L.1
  • 63
    • 0022445713 scopus 로고
    • Modification by oxygen free radical scavengers of the metabolic and cardiovascular effects of endotoxin infusion in conscious rats
    • McKechnie, K., Furman, B.L. & Parratt,J.R. (1986) Modification by oxygen free radical scavengers of the metabolic and cardiovascular effects of endotoxin infusion in conscious rats. Circ. Shock. 19,429-439.
    • (1986) Circ. Shock. , vol.19 , pp. 429-439
    • McKechnie, K.1    Furman, B.L.2    Parratt, J.R.3
  • 64
    • 0028064368 scopus 로고
    • Regulation of tyrosine hydroxylase in olfactory bulb cultures: Selective inhibition of depolarization-induced increase by endogenous opioids
    • McMillian, M.K., Mullis, S.B., Wu, G.G., Hudson, P.M., Pennypacker, K.R. & Hong, J.S. (1994) Regulation of tyrosine hydroxylase in olfactory bulb cultures: Selective inhibition of depolarization-induced increase by endogenous opioids. Brain Res. 658, 105-111.
    • (1994) Brain Res. , vol.658 , pp. 105-111
    • McMillian, M.K.1    Mullis, S.B.2    Wu, G.G.3    Hudson, P.M.4    Pennypacker, K.R.5    Hong, J.S.6
  • 65
    • 0027269781 scopus 로고
    • H2O and antioxidants have opposite effects on activation of NF-KB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
    • Meyer, M., Schreck, R. & Baeuerle, P.A. (1993) H2O and antioxidants have opposite effects on activation of NF-KB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J. 12, 2005-2015.
    • (1993) EMBO J. , vol.12 , pp. 2005-2015
    • Meyer, M.1    Schreck, R.2    Baeuerle, P.A.3
  • 66
    • 0028889292 scopus 로고
    • Spin trapping agent, phenyl-JV-tert-butyl nitrone, inhibits induction of nitric oxide synthase in endotoxin-induced shock in mice
    • Miyajima, T. & Kotake, Y. (1995) Spin trapping agent, phenyl-JV-tert-butyl nitrone, inhibits induction of nitric oxide synthase in endotoxin-induced shock in mice. Biochem. Biophys. Res. Commun. 215, 114-121.
    • (1995) Biochem. Biophys. Res. Commun. , vol.215 , pp. 114-121
    • Miyajima, T.1    Kotake, Y.2
  • 67
    • 0027287397 scopus 로고
    • Role of protein kinase A in LPS-induced activation of NF-KB proteins of a mouse macrophage-like cell line, J774
    • Moroi, M. & Suzuki, T. (1993) Role of protein kinase A in LPS-induced activation of NF-KB proteins of a mouse macrophage-like cell line, J774. Cell Signal. 5, 289-298.
    • (1993) Cell Signal. , vol.5 , pp. 289-298
    • Moroi, M.1    Suzuki, T.2
  • 68
    • 0028247859 scopus 로고
    • Temporal profiles of Ca2Vcalmodulin-dependent and -independent nitric oxide synthase in the rat brain microvessels following cerebral ischaemia
    • Nagafuji, T., Sugiyama, M. & Matsui, T. (1994) Temporal profiles of Ca2Vcalmodulin-dependent and -independent nitric oxide synthase in the rat brain microvessels following cerebral ischaemia. Acta. Neurochir., Supp. 60, 285-288.
    • (1994) Acta. Neurochir., Supp. , vol.60 , pp. 285-288
    • Nagafuji, T.1    Sugiyama, M.2    Matsui, T.3
  • 69
    • 0029103090 scopus 로고
    • The neuroprotective effect of a potent and selective inhibitor of type i NOS (L-MIN) in a rat model of focal cerebral ischaemia
    • Nagafuji, T., Sugiyama, M., Muto, A., Makino, T., Miyauchi, T. & Nabata, H. (1995) The neuroprotective effect of a potent and selective inhibitor of type I NOS (L-MIN) in a rat model of focal cerebral ischaemia. NeuroReport 6, 1541-1545.
    • (1995) NeuroReport , vol.6 , pp. 1541-1545
    • Nagafuji, T.1    Sugiyama, M.2    Muto, A.3    Makino, T.4    Miyauchi, T.5    Nabata, H.6
  • 71
    • 0025165279 scopus 로고    scopus 로고
    • Spin-trappers and vitamin e prolong endurance to muscle fatigue in mice
    • Novelli, G.P., Bracciotti, G. & Falsini, S. (l 990) Spin-trappers and vitamin E prolong endurance to muscle fatigue in mice. Free Rad. Biol. Med. 8, 9-13.
    • Free Rad. Biol. Med. , vol.8 , pp. 9-13
    • Novelli, G.P.1    Bracciotti, G.2
  • 72
    • 0025309904 scopus 로고
    • Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischaemia/reperfusion - Induced injury to gerbil brain
    • USA
    • Oliver, C.N., Starke-Reed, P.E., Stadtman, E.R., Liu, GJ., CarneyJ.M. & Floyd, R.A. (1990) Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischaemia/reperfusion - induced injury to gerbil brain. Proc. Natl Acad Sci.7.5487,5144-5147.
    • (1990) Proc. Natl Acad. Sci. , vol.87 , pp. 5144-5147
    • Oliver, C.N.1    Starke-Reed, P.E.2    Stadtman, E.R.3    Liu, G.J.4    Carney, J.M.5    Floyd, R.A.6
  • 74
    • 0028306269 scopus 로고
    • Peroxynitrite causes calcium efflux from mitochondria which is prevented by cyclosporin A
    • Packer, M.A. & Murphy, M.P. (1994) Peroxynitrite causes calcium efflux from mitochondria which is prevented by cyclosporin A. FEBS Lett. 345, 237-240.
    • (1994) FEBS Lett. , vol.345 , pp. 237-240
    • Packer, M.A.1    Murphy, M.P.2
  • 75
    • 0027181961 scopus 로고
    • Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumour necrosis factor-a production and protect mice against endotoxin challenge
    • Parmely, MJ., Zhou, W.W., Edwards, C.K., Borcherding, D.R., Silverstein, R. & Morrison, D.G. (1993) Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumour necrosis factor-a production and protect mice against endotoxin challenge. J. Immunol. 151, 389-396.
    • (1993) J. Immunol. , vol.151 , pp. 389-396
    • Parmely, M.J.1    Zhou, W.W.2    Edwards, C.K.3    Borcherding, D.R.4    Silverstein, R.5    Morrison, D.G.6
  • 76
    • 0025088070 scopus 로고
    • Protection from cerebral ischaemic injury in gerbils with the spin trap.A-tert-butyl-a-phenylnitrone (PBN) Neurosà
    • Phillis,J.W. & Clough-Helfman, C. (1990) Protection from cerebral ischaemic injury in gerbils with the spin trap.A-tert-butyl-a-phenylnitrone (PBN) Neurosà. Lett. 116, 315-319.
    • (1990) Lett. , vol.116 , pp. 315-319
    • Phillis, J.W.1    Clough-Helfman, C.2
  • 77
    • 0029058120 scopus 로고
    • Pharmacological action of a new spin 'trapping compound, 2-phenyl-DMPO, in the adriamycin-induced cardiotoxicity
    • Piccinini, E, Bradamante, S., Moni, E., Zhang, Y.K. &Janzen, E.G. (1995) Pharmacological action of a new spin 'trapping compound, 2-phenyl-DMPO, in the adriamycin-induced cardiotoxicity. Free Rad. Res. 23, 81-87.
    • (1995) Free Rad. Res. , vol.23 , pp. 81-87
    • Piccinini, E.1    Bradamante, S.2    Moni, E.3    Zhang, Y.K.4    Janzen, E.G.5
  • 78
    • 0026742656 scopus 로고
    • Spin trap salvage from endotoxemia: The role of cytokine down-regulation
    • Pogrebniak, H.W., Merino, MJ., Hahn, S.M., Mitchell, J.B. & Pass, H.I. (1992) Spin trap salvage from endotoxemia: The role of cytokine down-regulation. Surgery 112, 130-139.
    • (1992) Surgery , vol.112 , pp. 130-139
    • Pogrebniak, H.W.1    Merino, M.J.2    Hahn, S.M.3    Mitchell, J.B.4    Pass, H.I.5
  • 80
    • 0003144259 scopus 로고
    • Effects of antioxidants on IL-6 secretion induced by IL-1 in human cultured lung fibroblasts. Involvement of NFicB
    • (ed. Pasquier, C.), pp. Birkhauser Verlag, Basel.
    • Raes, M., Renard, P., Bosmans, E., Delaive, E. & Remacle,J. (1994) Effects of antioxidants on IL-6 secretion induced by IL-1 in human cultured lung fibroblasts. Involvement of NFicB. In Oxidative Stress, Cell Activation and lrml Infection (ed. Pasquier, C.), pp. 7 7-90. Birkhauser Verlag, Basel.
    • (1994) Oxidative Stress, Cell Activation and Lrml Infection , vol.7 , pp. 7-90
    • Raes, M.1    Renard, P.2    Bosmans, E.3    Delaive, E.4    Remacle, J.5
  • 81
    • 0028894557 scopus 로고
    • Low levels of reactive oxygen species as modulators of cell function
    • Remacle,J., Raes, M., Toussaint, O., Renard, P. & Rao, G. (1995) Low levels of reactive oxygen species as modulators of cell function. Mutation Res. 316, 103-122.
    • (1995) Mutation Res. , vol.316 , pp. 103-122
    • Remacle, J.1    Raes, M.2    Toussaint, O.3    Renard, P.4    Rao, G.5
  • 83
    • 0027152090 scopus 로고
    • EPR spin-trapping study of nitric oxide formation during bilateral carotid occlusion in the rat
    • Sato, S., Tominaga, T., Ohnishi, T. & Ohnishi, S.T. (1993) EPR spin-trapping study of nitric oxide formation during bilateral carotid occlusion in the rat. Biochem. Biophys. Acta 1181, 195-197.
    • (1993) Biochem. Biophys. Acta , vol.1181 , pp. 195-197
    • Sato, S.1    Tominaga, T.2    Ohnishi, T.3    Ohnishi, S.T.4
  • 84
    • 0028238555 scopus 로고
    • Electron paramagnetic resonance study on nitric oxide production during brain focal ischaemia and reperfusion in the rat
    • Sato, S., Tominaga, T., Ohnishi, T. & Ohnishi, S.T. (1994) Electron paramagnetic resonance study on nitric oxide production during brain focal ischaemia and reperfusion in the rat. Br. Res. 647,91-96.
    • (1994) Br. Res. , vol.647 , pp. 91-96
    • Sato, S.1    Tominaga, T.2    Ohnishi, T.3    Ohnishi, S.T.4
  • 85
    • 0025820624 scopus 로고
    • A role for oxygen radicals as second messengers
    • Schreck, R. & Baeuerle, P. (1991) A role for oxygen radicals as second messengers. Trends Cell Biol. 1, 39-2.
    • (1991) Trends Cell Biol. , vol.1 , pp. 39-42
    • Schreck, R.1    Baeuerle, P.2
  • 86
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of NF-KB transcription factor and HIV-1
    • Schreck, R., Rieber, P. & Baeuerle, P.A. (1991) Reactive oxygen intermediates as apparently widely used messengers in the activation of NF-KB transcription factor and HIV-1. EUT. Mol. Biol. Organ. J. 10, 2247-2258.
    • (1991) Eur. Mol. Biol. Organ. J. , vol.10 , pp. 2247-2258
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.A.3
  • 87
    • 0028978106 scopus 로고
    • Coenzymne Q.10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity
    • SchulzJ.B., Henshaw, D.R., Mathews, R.T. & Beal, M.F. (1995) Coenzymne Q.10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity. Exp. Neural. 132, 279-283
    • (1995) Exp. Neurol. , vol.132 , pp. 279-283
    • Schulz, J.B.1    Henshaw, D.R.2    Mathews, R.T.3    Beal, M.F.4
  • 88
    • 0029055280 scopus 로고
    • Can spin trap-ping compounds like PBN protect against self-inflicted damage in polymorphonuclear leukocytes?
    • Seawright, L., Tanigawa, M., Tanigawa, T., Kotake, Y. &Janzen, E.G. (1995) Can spin trap-ping compounds like PBN protect against self-inflicted damage in polymorphonuclear leukocytes? Free Rad. Res. 23, 73-80.
    • (1995) Free Rad. Res. , vol.23 , pp. 73-80
    • Seawright, L.1    Tanigawa, M.2    Tanigawa, T.3    Kotake, Y.4    Janzen, E.G.5
  • 89
    • 0027433560 scopus 로고
    • Ct-Phenyl-tert-butyl-nitrone (PBN) attenuates hydroxyl radical production during ischaemia-reperfusion injury of rat brain: An EPR study
    • Sen, S. & PhillisJ.W. (1993) ct-Phenyl-tert-butyl-nitrone (PBN) attenuates hydroxyl radical production during ischaemia-reperfusion injury of rat brain: An EPR study. Free Rad. Res. Commun. 19, 255-265.
    • (1993) Free Rad. Res. Commun. , vol.19 , pp. 255-265
    • Sen, S.1    Phillis, J.W.2
  • 90
    • 0028298805 scopus 로고
    • A-Phenyl-tert-butylnitrone inhibits free radical release in brain concussion
    • Sen, S.H., Goldman, H., Morehead, M., Murphy, S. & Phillis.J.W. (1994) a-Phenyl-tert-butylnitrone inhibits free radical release in brain concussion. Free Rad. Biol. Med. 16, 685-691.
    • (1994) Free Rad. Biol. Med. , vol.16 , pp. 685-691
    • Sen, S.H.1    Goldman, H.2    Morehead, M.3    Murphy, S.4    Phillis, J.W.5
  • 91
    • 0027204183 scopus 로고
    • P>Trolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages
    • Sherman, M.P., Aeberhard, E.E., Wong, V.Z., Griscavargen, J.M. & Ignarro, LJ. (1993) P>Trolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Biochem. Biophys. Res. Commun. 191, 1301-1308.
    • (1993) Biochem. Biophys. Res. Commun. , vol.191 , pp. 1301-1308
    • Sherman, M.P.1    Aeberhard, E.E.2    Wong, V.Z.3    Griscavargen, J.M.4    Ignarro, L.J.5
  • 93
    • 0028967848 scopus 로고
    • Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis
    • Slater, A.F.G., Nobel, O.S., Maellaro, E., Bustamante.J., Kimland, M. & Orrhenius, S. (1995b) Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. Biochem. J. 306, 771-779.
    • (1995) Biochem. J. , vol.306 , pp. 771-779
    • Slater, A.F.G.1    Nobel, O.S.2    Maellaro, E.3    Bustamante, J.4    Kimland, M.5    Orrhenius, S.6
  • 95
    • 0028875182 scopus 로고
    • Oxygen-dependent regulation of mitochondrial energy metabolism by nitric oxide
    • Takehara, Y, Kanno, T., Yoshioka, T., Inoue, M. & Utsumi, K. (1995) Oxygen-dependent regulation of mitochondrial energy metabolism by nitric oxide. Arch. Biochem. Biophjs. 323, 27-32.
    • (1995) Arch. Biochem. Biophys. , vol.323 , pp. 27-32
    • Takehara, Y.1    Kanno, T.2    Yoshioka, T.3    Inoue, M.4    Utsumi, K.5
  • 96
    • 0025850322 scopus 로고
    • Bacterial lipopolysaccharide-stimulated GTPase activity in RAW 264.7 macrophage membranes
    • Tanke, T., Van de Loo, J.W., Rhim, H., Leventhal, P.S., Proctor, R.A. & Bertics, PJ. (1991) Bacterial lipopolysaccharide-stimulated GTPase activity in RAW 264.7 macrophage membranes. Biochem. J. 277, 379-385.
    • (1991) Biochem. J. , vol.277 , pp. 379-385
    • Tanke, T.1    Van De Loo, J.W.2    Rhim, H.3    Leventhal, P.S.4    Proctor, R.A.5    Bertics, P.J.6
  • 97
    • 0027194051 scopus 로고
    • MRI study of the inhibitory effect of new sin traps on in livo CCl4-induced hepatotoxicity in rats
    • Towner, R.A.Janzen, E.G., Zhang, Y.K. & Yamashiro, S. (1993) MRI study of the inhibitory effect of new sin traps on in livo CCl4-induced hepatotoxicity in rats. Free Rod. Biol. Med. 14, 677-681.
    • (1993) Free Rad. Biol. Med. , vol.14 , pp. 677-681
    • Towner, R.A.1    Janzen, E.G.2    Zhang, Y.K.3    Yamashiro, S.4
  • 98
    • 0026612237 scopus 로고
    • G-nitro-L-arginine in focal stroke in the 7-dayold-rat
    • G-nitro-L-arginine in focal stroke in the 7-dayold-rat. Eur.J. Pharmacol. 218, 197-198.
    • (1992) Eur.J. Pharmacol. , vol.218 , pp. 197-198
    • Trifiletti, R.R.1
  • 99
    • 0027931558 scopus 로고
    • Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurones
    • Whittemore, E.R., Loo, D.T. & Cotman, C.W. (1994) Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurones. NeuroReport 5, 1485-1488.
    • (1994) NeuroReport , vol.5 , pp. 1485-1488
    • Whittemore, E.R.1    Loo, D.T.2    Cotman, C.W.3
  • 100
    • 0029152729 scopus 로고
    • Essential role of neocortical acetylcholine in spatial memory
    • Winkler, J., Suhr, S.T., Gage, EH., Thal, LJ. & Fisher, LJ. (1995) Essential role of neocortical acetylcholine in spatial memory. Nature 375, 484-187.
    • (1995) Nature , vol.375 , pp. 484-187
    • Winkler, J.1    Suhr, S.T.2    Gage, E.H.3    Thal, L.J.4    Fisher, L.J.5
  • 101
    • 0028911559 scopus 로고
    • Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotöxic shock
    • Wu, G., Chen, SJ., Szabo, C., Thiemermann, C. & Vane,J.R. (1995) Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotöxic shock. Dr. J. Pharmacol. 114, 1666-1672.
    • (1995) Dr. J. Pharmacol. , vol.114 , pp. 1666-1672
    • Wu, G.1    Chen, S.J.2    Szabo, C.3    Thiemermann, C.4    Vane, J.R.5
  • 102
    • 0029969392 scopus 로고    scopus 로고
    • Oxidative modification of a carboxyl-terminal vicinal methionine in calmodulin by hydrogen peroxide inhibits calmodulin-dependent activation of the plasma membrane calciumATPase
    • Yao, Y, Yin, D., Jas, G.S., Kuczera, K., Williams, T.D, Shoneich, C. & Squier, T.C. (1996) Oxidative modification of a carboxyl-terminal vicinal methionine in calmodulin by hydrogen peroxide inhibits calmodulin-dependent activation of the plasma membrane calciumATPase. Biochemistry 35, 2767-2787.
    • (1996) Biochemistry , vol.35 , pp. 2767-2787
    • Yao, Y.1    Yin, D.2    Jas, G.S.3    Kuczera, K.4    Williams, T.D.5    Shoneich, C.6    Squier, T.C.7
  • 103
    • 0026522028 scopus 로고
    • Neuroprotective efiects of phenyl-t-butyl-nitrone in gerbil global brain ischaemia and in cultured rat cerebellar neurones
    • Yue, TL., Gu, J.L., Lysko, EG., Cheng, H.Y., Barone, EC. & Feuerstein, G. (1992) Neuroprotective efiects of phenyl-t-butyl-nitrone in gerbil global brain ischaemia and in cultured rat cerebellar neurones. Brain Res. 574, 193-197.
    • (1992) Brain Res. , vol.574 , pp. 193-197
    • Yue, T.L.1    Gu, J.L.2    Lysko, E.G.3    Cheng, H.Y.4    Barone, E.C.5    Feuerstein, G.6
  • 104
    • 0028851010 scopus 로고
    • Nitric oxide changes in the rat brain after transient middle cerebral artery occlusion
    • Zhang, Z.G., Chopp, M., Bailey, F. & Malinsi, T. (1995) Nitric oxide changes in the rat brain after transient middle cerebral artery occlusion. J. Neural. Sci. 128, 22-27.
    • (1995) J. Neural. Sci. , vol.128 , pp. 22-27
    • Zhang, Z.G.1    Chopp, M.2    Bailey, F.3    Malinsi, T.4
  • 105
    • 0027937751 scopus 로고
    • Delayed treatment with the spin trap a-phenyl-jV-tert-butyl nitrone (PEN) reduces infarct size following transient middle cerebral artery occlusion in rats
    • Zhao, Q., Pahlmark, K., Smith, M.L. & Seisjö, B.K. (1994) Delayed treatment with the spin trap a-phenyl-jV-tert-butyl nitrone (PEN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol. Scand. 152, 349-350.
    • (1994) Acta Physiol. Scand. , vol.152 , pp. 349-350
    • Zhao, Q.1    Pahlmark, K.2    Smith, M.L.3    Seisjö, B.K.4
  • 106
    • 0026559421 scopus 로고
    • Detection of free radicals during brain ischaemia and reperfusion by spin trapping and microdialysis
    • Zini, I., Tomasi, A., Grimaldi, R., Vannini, V. & Agnati, L.F. (1992) Detection of free radicals during brain ischaemia and reperfusion by spin trapping and microdialysis. Neurosci. Lett. 138, 279-282.
    • (1992) Neurosci. Lett. , vol.138 , pp. 279-282
    • Zini, I.1    Tomasi, A.2    Grimaldi, R.3    Vannini, V.4    Agnati, L.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.