Nitrones, their value as therapeutics and probes to understand aging

Mechanisms of Ageing and Development

Volumn 123, Issue 8, 2002, Pages 1021-1031

  Floyd, Robert A ^a   Hensley, Kenneth ^a   Forster, Michael J ^b   Kelleher Andersson, Judith A ^c   Wood, Paul L ^c  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^c EVOTEC AG   (Germany)

Author keywords

Anti aging nitrones; Neuro inflammation; Oxygen free radicals; Reactive oxygen species; phenyl tert butylnitrone

Indexed keywords

CPI 1429; CYTOKINE; FREE RADICAL; MITOGEN ACTIVATED PROTEIN KINASE; N TERT BUTYL ALPHA PHENYLNITRONE; NITRIC OXIDE SYNTHASE; NITRONE DERIVATIVE; UNCLASSIFIED DRUG;

AGING; AMNESIA; BACTERIAL MENINGITIS; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ENZYME PHOSPHORYLATION; HEARING LOSS; HUMAN; LIFESPAN; LONG TERM CARE; LONGEVITY; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; REVIEW; SEIZURE; SIGNAL TRANSDUCTION; STROKE; SURVIVAL RATE;

AGING; ANIMALS; FREE RADICAL SCAVENGERS; HUMANS; NEUROPROTECTIVE AGENTS; NITROGEN OXIDES; SIGNAL TRANSDUCTION; SPIN LABELS; SPIN TRAPPING;

ANIMALIA;

EID: 0037198017     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(01)00385-2     Document Type: Review

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2. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor α gene expression in endotoxin-stimulated primary glial cultures
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6. Excretion, metabolism and tissue distribution of a spin trapping agent, α-phenyl-N-tert-butyl-nitrone (PBN) in rats
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14. The spin-trap N-tert-α-phenyl-butylnitrone prolongs the life span of the senescence accelerated mouse
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27. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation
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34. Spin trapping
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