-
1
-
-
33747403154
-
Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia
-
Ottmann OG, Wassmann B. Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. Hematology Am Soc Hematol Educ Program 2005;118-122.
-
(2005)
Hematology Am Soc Hematol Educ Program
, pp. 118-122
-
-
Ottmann, O.G.1
Wassmann, B.2
-
2
-
-
0035093711
-
Philadelphia chromosome-positive acute lymphocytic leukemia
-
Radich JP. Philadelphia chromosome-positive acute lymphocytic leukemia. Hematol Oncol Clin North Am 2001;15: 21-36.
-
(2001)
Hematol Oncol Clin North Am
, vol.15
, pp. 21-36
-
-
Radich, J.P.1
-
3
-
-
33745964354
-
Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: Results from the international ALL trial MRC UKALL XII/ECOG E2993
-
Lazarus HM, Richards SM, Chopra R, et al. Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993. Blood 2006;108:465-472.
-
(2006)
Blood
, vol.108
, pp. 465-472
-
-
Lazarus, H.M.1
Richards, S.M.2
Chopra, R.3
-
4
-
-
10744223495
-
Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate
-
Pfeifer H, Wassmann B, Hofmann WK, et al. Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate. Clin Cancer Res 2003;9:4674-4681.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 4674-4681
-
-
Pfeifer, H.1
Wassmann, B.2
Hofmann, W.K.3
-
5
-
-
0038702520
-
Bone marrow transplant in Ph+ ALL patients
-
Avivi I, Goldstone AH. Bone marrow transplant in Ph+ ALL patients. Bone Marrow Transplant 2003;31:623-632.
-
(2003)
Bone Marrow Transplant
, vol.31
, pp. 623-632
-
-
Avivi, I.1
Goldstone, A.H.2
-
6
-
-
33846916856
-
Imatinib combined with induction or consolidation chemotherapy in patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: Results of the GRAAPH-2003 study
-
for Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL)
-
de Labarthe A, Rousselot P, Huguet-Rigal F, et al. for Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL). Imatinib combined with induction or consolidation chemotherapy in patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: results of the GRAAPH-2003 study. Blood 2007;109:1408-1413.
-
(2007)
Blood
, vol.109
, pp. 1408-1413
-
-
De Labarthe, A.1
Rousselot, P.2
Huguet-Rigal, F.3
-
7
-
-
26944439774
-
Clinical effect of imatinib added to intensive combination chemotherapy for newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia
-
Lee KH, Lee JH, Choi SJ, et al. Clinical effect of imatinib added to intensive combination chemotherapy for newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Leukemia 2005;19:1509-1516.
-
(2005)
Leukemia
, vol.19
, pp. 1509-1516
-
-
Lee, K.H.1
Lee, J.H.2
Choi, S.J.3
-
8
-
-
18244407767
-
The effect of first-line imatinib interim therapy on the outcome of allogeneic stem cell transplantation in adults with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia
-
Lee S, Kim YJ, Min CK, et al. The effect of first-line imatinib interim therapy on the outcome of allogeneic stem cell transplantation in adults with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 2005;105:3449-3457.
-
(2005)
Blood
, vol.105
, pp. 3449-3457
-
-
Lee, S.1
Kim, Y.J.2
Min, C.K.3
-
9
-
-
33748132456
-
Imatinib given concurrently with induction chemotherapy is superior to imatinib subsequent to induction and consolidation in newly diagnosed Philadelphia-positive acute lymphoblastic leukemia (PH+ALL) [abstract]
-
Abstract 685
-
Ottmann OG, Wassmann B, Pfeifer H, et al. Imatinib given concurrently with induction chemotherapy is superior to imatinib subsequent to induction and consolidation in newly diagnosed Philadelphia-positive acute lymphoblastic leukemia (PH+ALL) [abstract]. Blood 2004;104(Suppl.):(Abstract 685).
-
(2004)
Blood
, vol.104
, Issue.SUPPL.
-
-
Ottmann, O.G.1
Wassmann, B.2
Pfeifer, H.3
-
10
-
-
34249748062
-
Outcome with the hyper-CVAD and imatinib mesylate regimen in Philadelphia (Ph) positive acute lymphocytic leukemia (ALL) [abstract]
-
Abstract 1830
-
Thomas DA, Faderl S, Cortes J, et al. Outcome with the hyper-CVAD and imatinib mesylate regimen in Philadelphia (Ph) positive acute lymphocytic leukemia (ALL) [abstract]. Blood 2005;106(Suppl.):(Abstract 1830).
-
(2005)
Blood
, vol.106
, Issue.SUPPL.
-
-
Thomas, D.A.1
Faderl, S.2
Cortes, J.3
-
11
-
-
33644845774
-
High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABLpositive acute lymphoblastic leukemia: A phase II study by the Japan Adult Leukemia Study Group
-
Yanada M, Takeuchi J, Sugiura I, et al. High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABLpositive acute lymphoblastic leukemia: a phase II study by the Japan Adult Leukemia Study Group. J Clin Oncol 2006;24: 460-466.
-
(2006)
J Clin Oncol
, vol.24
, pp. 460-466
-
-
Yanada, M.1
Takeuchi, J.2
Sugiura, I.3
-
12
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker BJ, Sawyers CL, Kantarjian H, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001;344:1038-1042.
-
(2001)
N Engl J Med
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
-
13
-
-
0037105560
-
A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias
-
Ottmann OG, Druker BJ, Sawyers CL, et al. A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias. Blood 2002;100:1965-1971.
-
(2002)
Blood
, vol.100
, pp. 1965-1971
-
-
Ottmann, O.G.1
Druker, B.J.2
Sawyers, C.L.3
-
14
-
-
33947716671
-
Emerging therapeutic options for Philadelphia-positive acute lymphocytic leukemia
-
Alvarado Y, Apostolidou E, Swords R, Giles F. Emerging therapeutic options for Philadelphia-positive acute lymphocytic leukemia. Expert Opin Emerg Drugs 2007;1:165-179.
-
(2007)
Expert Opin Emerg Drugs
, vol.1
, pp. 165-179
-
-
Alvarado, Y.1
Apostolidou, E.2
Swords, R.3
Giles, F.4
-
15
-
-
0036786909
-
Outcome of treatment in adults with Philadelphia chromosomepositive acute lymphoblastic leukemia - Results of the prospective multicenter LALA-94 trial
-
Dombret H, Gabert J, Boiron JM, et al. Outcome of treatment in adults with Philadelphia chromosomepositive acute lymphoblastic leukemia - results of the prospective multicenter LALA-94 trial. Blood 2002;100: 2357-2366.
-
(2002)
Blood
, vol.100
, pp. 2357-2366
-
-
Dombret, H.1
Gabert, J.2
Boiron, J.M.3
-
16
-
-
0036493694
-
Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: A prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis
-
Gleissner B, Gokbuget N, Bartram CR, et al. Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: a prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis. Blood 2002;99:1536-1543.
-
(2002)
Blood
, vol.99
, pp. 1536-1543
-
-
Gleissner, B.1
Gokbuget, N.2
Bartram, C.R.3
-
17
-
-
0343714608
-
Recent approaches in acute lymphoblastic leukemia in adults
-
Hoelzer D, Gokbuget N. Recent approaches in acute lymphoblastic leukemia in adults. Crit Rev Oncol Hematol 2000;36:49-58.
-
(2000)
Crit Rev Oncol Hematol
, vol.36
, pp. 49-58
-
-
Hoelzer, D.1
Gokbuget, N.2
-
18
-
-
33646168391
-
Treatment of elderly patients with acute lymphoblastic leukemia [abstract]
-
Perry MC editor. Baltimore MD: Lippincott Williams and Wilkins
-
Hoelzer D, Gokbuget N. Treatment of elderly patients with acute lymphoblastic leukemia [abstract]. In: Perry MC, editor. American Society of Clinical Oncology Educational Book. Baltimore, MD: Lippincott Williams and Wilkins; 2002. pp 533-539.
-
(2002)
American Society of Clinical Oncology Educational Book
, pp. 533-539
-
-
Hoelzer, D.1
Gokbuget, N.2
-
19
-
-
0033964380
-
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia
-
Kantarjian HM, O'Brien S, Smith TL, et al. Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. J Clin Oncol 2000;18: 547-561.
-
(2000)
J Clin Oncol
, vol.18
, pp. 547-561
-
-
Kantarjian, H.M.1
O'Brien, S.2
Smith, T.L.3
-
20
-
-
0034986409
-
Preliminary experience with a new chemotherapy regimen for adults with acute lymphoblastic leukemia
-
Cataland SR, Daugherty CK, Weseman EC, Larson RA. Preliminary experience with a new chemotherapy regimen for adults with acute lymphoblastic leukemia. Leuk Lymphoma 2001;41:297-307.
-
(2001)
Leuk Lymphoma
, vol.41
, pp. 297-307
-
-
Cataland, S.R.1
Daugherty, C.K.2
Weseman, E.C.3
Larson, R.A.4
-
21
-
-
0033636586
-
Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87
-
x
-
Thiebaut A, Vernant JP, Degos L, et al. Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87. Hematol Oncol Clin North Am 2000;14:1353-1366, x.
-
(2000)
Hematol Oncol Clin North Am
, vol.14
, pp. 1353-1366
-
-
Thiebaut, A.1
Vernant, J.P.2
Degos, L.3
-
22
-
-
66549084080
-
Prospective outcome data on 267 unselected adult patients with Philadelphia-chromosome positive acute lymphoblastic leukaemia confirms the superiority of allogeneic transplant over chemotherapy in the pre-imatinib era: Results from the international ALL trial MRC UKALLXII/ECOG2993
-
Fielding AK, Rowe JM, Richards SM, et al. Prospective outcome data on 267 unselected adult patients with Philadelphia-chromosome positive acute lymphoblastic leukaemia confirms the superiority of allogeneic transplant over chemotherapy in the pre-imatinib era: results from the international ALL trial MRC UKALLXII/ECOG2993. Blood 2009;113:4489-4496.
-
(2009)
Blood
, vol.113
, pp. 4489-4496
-
-
Fielding, A.K.1
Rowe, J.M.2
Richards, S.M.3
-
23
-
-
0026636931
-
Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia
-
Barrett AJ, Horowitz MM, Ash RC, et al. Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 1992;79:3067-3070.
-
(1992)
Blood
, vol.79
, pp. 3067-3070
-
-
Barrett, A.J.1
Horowitz, M.M.2
Ash, R.C.3
-
24
-
-
0030749222
-
Marrow transplants from unrelated donors for treatment of Philadelphia chromosomepositive acute lymphoblastic leukemia
-
Sierra J, Radich J, Hansen JA, et al. Marrow transplants from unrelated donors for treatment of Philadelphia chromosomepositive acute lymphoblastic leukemia. Blood 1997;90:1410-1414.
-
(1997)
Blood
, vol.90
, pp. 1410-1414
-
-
Sierra, J.1
Radich, J.2
Hansen, J.A.3
-
25
-
-
0032756124
-
Longterm follow-up of 23 patients with Philadelphia chromosomepositive acute lymphoblastic leukemia treated with allogeneic bone marrow transplant in first complete remission
-
Snyder DS, Nademanee AP, O'Donnell MR, et al. Longterm follow-up of 23 patients with Philadelphia chromosomepositive acute lymphoblastic leukemia treated with allogeneic bone marrow transplant in first complete remission. Leukemia 1999;13:2053-2058.
-
(1999)
Leukemia
, vol.13
, pp. 2053-2058
-
-
Snyder, D.S.1
Nademanee, A.P.2
O'Donnell, M.R.3
-
26
-
-
7044263031
-
Outcome of treatment in adults with acute lymphoblastic leukemia: Analysis of the LALA-94 Trial
-
DOI 10.1200/JCO.2004.10.050
-
Thomas X, Boiron JM, Huguet F, et al. Outcome of treatment in adults with acute lymphoblastic leukemia: analysis of the LALA-94 trial. J Clin Oncol 2004;22:4075-4086. (Pubitemid 41185176)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.20
, pp. 4075-4086
-
-
Thomas, X.1
Boiron, J.-M.2
Huguet, F.3
Dombret, H.4
Bradstock, K.5
Vey, N.6
Kovacsovics, T.7
Delannoy, A.8
Fegueux, N.9
Fenaux, P.10
Stamatoullas, A.11
Vernant, J.-P.12
Tournilhac, O.13
Buzyn, A.14
Reman, O.15
Charrin, C.16
Boucheix, C.17
Gabert, J.18
Lheritier, V.19
Fiere, D.20
more..
-
27
-
-
0035869381
-
Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia: Strong graft-versus-leukemia effect and risk factors determining outcome
-
Cornelissen JJ, Carston M, Kollman C, et al. Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia: strong graft-versus-leukemia effect and risk factors determining outcome. Blood 2001;97: 1572-1577.
-
(2001)
Blood
, vol.97
, pp. 1572-1577
-
-
Cornelissen, J.J.1
Carston, M.2
Kollman, C.3
-
28
-
-
33749022243
-
Alternative donor transplants for adult acute lymphoblastic leukaemia: A comparison of the three major options
-
Marks DI, Aversa F, Lazarus HM. Alternative donor transplants for adult acute lymphoblastic leukaemia: a comparison of the three major options. Bone Marrow Transplant 2006;38:467-475.
-
(2006)
Bone Marrow Transplant
, vol.38
, pp. 467-475
-
-
Marks, D.I.1
Aversa, F.2
Lazarus, H.M.3
-
29
-
-
0001290589
-
Autologous BMT/PBSCT in 40 patients with bcr-abl positive acute lymphoblastic leukemia: Long-term follow-up of a GMALL study [abstract]
-
Abstract 187
-
Martin H, Atta J, Klein SA, et al. Autologous BMT/PBSCT in 40 patients with bcr-abl positive acute lymphoblastic leukemia: long-term follow-up of a GMALL study [abstract]. Hematol J 2001;I:Abstract 187.
-
(2001)
Hematol J
, vol.1
-
-
Martin, H.1
Atta, J.2
Klein, S.A.3
-
30
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001;344:1031-1037.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
31
-
-
2942567555
-
Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate
-
DOI 10.1182/blood-2003-08-2958
-
Thomas DA, Faderl S, Cortes J, et al. Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate. Blood 2004;103:4396-4407. (Pubitemid 38745962)
-
(2004)
Blood
, vol.103
, Issue.12
, pp. 4396-4407
-
-
Thomas, D.A.1
Faderl, S.2
Cortes, J.3
O'Brien, S.4
Giles, F.J.5
Kornblau, S.M.6
Garcia-Manero, G.7
Keating, M.J.8
Andreeff, M.9
Jeha, S.10
Beran, M.11
Verstovsek, S.12
Pierce, S.13
Letvak, L.14
Salvado, A.15
Champlin, R.16
Talpaz, M.17
Kantarjian, H.18
-
32
-
-
34948829146
-
Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: Interim results of a phase 2 study
-
Ottmann O, Dombret H, Martinelli G, et al. Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study. Blood 2007;110: 2309-2315.
-
(2007)
Blood
, vol.110
, pp. 2309-2315
-
-
Ottmann, O.1
Dombret, H.2
Martinelli, G.3
-
33
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
-
DOI 10.1056/NEJMoa055229
-
Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006;354:2531-2541. (Pubitemid 43882349)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.24
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
Donato, N.4
Nicoll, J.5
Paquette, R.6
Cortes, J.7
O'Brien, S.8
Nicaise, C.9
Bleickardt, E.10
Blackwood-Chirchir, M.A.11
Iyer, V.12
Chen, T.-T.13
Huang, F.14
Decillis, A.P.15
Sawyers, C.L.16
-
34
-
-
36048948259
-
A phase II study of nilotinib administered to imatinib resistant or intolerant patients with chronic myelogenous leukemia (CML) in blast crisis (BC) or relapsed/refractory Ph+ acute lymphoblastic leukemia (ALL) [abstract]
-
Abstract 7040
-
Larson R, Ottmann O, Kantarjian H, et al. A phase II study of nilotinib administered to imatinib resistant or intolerant patients with chronic myelogenous leukemia (CML) in blast crisis (BC) or relapsed/refractory Ph+ acute lymphoblastic leukemia (ALL) [abstract]. J Clin Oncol 2007;25(Suppl. 8): (Abstract 7040).
-
(2007)
J Clin Oncol
, vol.25
, Issue.SUPPL. 8
-
-
Larson, R.1
Ottmann, O.2
Kantarjian, H.3
-
35
-
-
33747598699
-
Imatinib and methylprednisolone alternated with chemotherapy improve the outcome of elderly patients with Philadelphia-positive acute lymphoblastic leukemia: Results of the GRAALL AFR09 study
-
Delannoy A, Delabesse E, Lheritier V, et al. Imatinib and methylprednisolone alternated with chemotherapy improve the outcome of elderly patients with Philadelphia-positive acute lymphoblastic leukemia: results of the GRAALL AFR09 study. Leukemia 2006;20:1526-1532.
-
(2006)
Leukemia
, vol.20
, pp. 1526-1532
-
-
Delannoy, A.1
Delabesse, E.2
Lheritier, V.3
-
36
-
-
34248575091
-
Imatinib compared with chemotherapy as front-line treatment of elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
-
Ottmann O, Wassmann B, Pfeifer H, et al. Imatinib compared with chemotherapy as front-line treatment of elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Cancer 2007;109:2068-2076.
-
(2007)
Cancer
, vol.109
, pp. 2068-2076
-
-
Ottmann, O.1
Wassmann, B.2
Pfeifer, H.3
-
37
-
-
23844446650
-
Dramatic improvement in CR rate and CR duration with imatinib in adult and elderly Ph+ ALL patients: Results of the GIMEMA prospective study LAL0201 [abstract]
-
Abstract 2739
-
Vignetti M, Fazi P, Meloni G, et al. Dramatic improvement in CR rate and CR duration with imatinib in adult and elderly Ph+ ALL patients: results of the GIMEMA prospective study LAL0201 [abstract]. Blood 2004;104 (Suppl.):(Abstract 2739).
-
(2004)
Blood
, vol.104
, Issue.SUPPL.
-
-
Vignetti, M.1
Fazi, P.2
Meloni, G.3
-
38
-
-
76349125190
-
Does imatinib change the outcome in Philadelphia chromosomepositive acute lymphoblastic leukaemia in adults? Data from the UKALLXII/ECOG2993 study [abstract]
-
Abstract 8
-
Fielding AK, Richards SM, Lazarus HM, et al. Does imatinib change the outcome in Philadelphia chromosomepositive acute lymphoblastic leukaemia in adults? Data from the UKALLXII/ECOG2993 study [abstract]. Blood 2007; 110(Suppl.):(Abstract 8).
-
(2007)
Blood
, vol.110
, Issue.SUPPL.
-
-
Fielding, A.K.1
Richards, S.M.2
Lazarus, H.M.3
-
39
-
-
68049088345
-
Outcome after frontline therapy with the hyper-CVAD and imatinib mesylate regimen for adults with de novo or minimally treated Philadelphia chromosome (Ph) positive acute lymphocytic leukemia (ALL) [abstract]
-
Abstract 2931
-
Thomas DA, Kantarjian HM, Cortes J, et al. Outcome after frontline therapy with the hyper-CVAD and imatinib mesylate regimen for adults with de novo or minimally treated Philadelphia chromosome (Ph) positive acute lymphocytic leukemia (ALL) [abstract]. Blood 2008;112(Suppl.): (Abstract 2931).
-
(2008)
Blood
, vol.112
, Issue.SUPPL.
-
-
Thomas, D.A.1
Kantarjian, H.M.2
Cortes, J.3
-
40
-
-
52949099951
-
Improved early event free survival (EFS) in children with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) with intensive imatinib in combination with high dose chemotherapy: Children's Oncology Group (COG) Study AALL0031 [abstract]
-
Abstract 4
-
Schultz KR, Bowman P, Slayton W, et al. Improved early event free survival (EFS) in children with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) with intensive imatinib in combination with high dose chemotherapy: Children's Oncology Group (COG) Study AALL0031 [abstract]. Blood 2007;110(Suppl.):(Abstract 4).
-
(2007)
Blood
, vol.110
, Issue.SUPPL.
-
-
Schultz, K.R.1
Bowman, P.2
Slayton, W.3
-
41
-
-
0035205062
-
Prospective BCR-ABL analysis by polymerase chain reaction (RT-PCR) in adult acute B-lineage lymphoblastic leukemia: Reliability of RTnested- PCR and comparison to cytogenetic data
-
Gleissner B, Rieder H, Thiel E, et al. Prospective BCR-ABL analysis by polymerase chain reaction (RT-PCR) in adult acute B-lineage lymphoblastic leukemia: reliability of RTnested- PCR and comparison to cytogenetic data. Leukemia 2001;15:1834-1840.
-
(2001)
Leukemia
, vol.15
, pp. 1834-1840
-
-
Gleissner, B.1
Rieder, H.2
Thiel, E.3
-
42
-
-
0037217606
-
Risk factors for adults with Philadelphia-chromosome-positive acute lymphoblastic leukaemia in remission treated with allogeneic bone marrow transplantation: The potential of real-time quantitative reverse-transcription polymerase chain reaction
-
Lee S, Kim DW, Cho B, et al. Risk factors for adults with Philadelphia-chromosome-positive acute lymphoblastic leukaemia in remission treated with allogeneic bone marrow transplantation: the potential of real-time quantitative re- verse-transcription polymerase chain reaction. Br J Haematol 2003;120:145-153.
-
(2003)
Br J Haematol
, vol.120
, pp. 145-153
-
-
Lee, S.1
Kim, D.W.2
Cho, B.3
-
43
-
-
0032865769
-
Quantification of minimal residual disease in patients with BCR-ABL-positive acute lymphoblastic leukaemia using quantitative competitive polymerase chain reaction
-
Mitterbauer G, Nemeth P, Wacha S, et al. Quantification of minimal residual disease in patients with BCR-ABL-positive acute lymphoblastic leukaemia using quantitative competitive polymerase chain reaction. Br J Haematol 1999;106:634-643.
-
(1999)
Br J Haematol
, vol.106
, pp. 634-643
-
-
Mitterbauer, G.1
Nemeth, P.2
Wacha, S.3
-
44
-
-
0031002040
-
Detection of bcr-abl transcripts in philadelphia chromosome-positive acute lymphoblastic leukemia after marrow transplantation
-
Radich J, Gehly G, Lee A, et al. Detection of bcr-abl transcripts in Philadelphia chromosome-positive acute lymphoblastic leukemia after marrow transplantation. Blood 1997;89:2602-2609. (Pubitemid 27143311)
-
(1997)
Blood
, vol.89
, Issue.7
, pp. 2602-2609
-
-
Radich, J.1
Gehly, G.2
Lee, A.3
Avery, R.4
Bryant, E.5
Edmands, S.6
Gooley, T.7
Kessler, P.8
Kirk, J.9
Ladne, P.10
Thomas, E.D.11
Appelbaum, F.R.12
-
45
-
-
0242367154
-
Predictors of relapse and overall survival in Philadelphia chromosomepositive acute lymphoblastic leukemia after transplantation
-
Stirewalt DL, Guthrie KA, Beppu L, et al. Predictors of relapse and overall survival in Philadelphia chromosomepositive acute lymphoblastic leukemia after transplantation. Biol Blood Marrow Transplant 2003;9:206-212.
-
(2003)
Biol Blood Marrow Transplant
, vol.9
, pp. 206-212
-
-
Stirewalt, D.L.1
Guthrie, K.A.2
Beppu, L.3
-
46
-
-
22144460555
-
Early molecular response to post-transplantation imatinib determines outcome in MRD+ Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)
-
Wassmann B, Pfeifer H, Stadler M, et al. Early molecular response to post-transplantation imatinib determines outcome in MRD+ Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Blood 2005;106:458-463.
-
(2005)
Blood
, vol.106
, pp. 458-463
-
-
Wassmann, B.1
Pfeifer, H.2
Stadler, M.3
-
47
-
-
54849426674
-
Prospective monitoring of BCR-ABL1 transcript levels in patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia undergoing imatinib-combined chemotherapy
-
Yanada M, Sugiura I, Takeuchi J, et al. Prospective monitoring of BCR-ABL1 transcript levels in patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia undergoing imatinib-combined chemotherapy. Br J Haematol 2008;143:503-510.
-
(2008)
Br J Haematol
, vol.143
, pp. 503-510
-
-
Yanada, M.1
Sugiura, I.2
Takeuchi, J.3
-
48
-
-
33745603988
-
Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: Review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results
-
Hughes T, Deininger M, Hochhaus A, et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 2006;108:28-37.
-
(2006)
Blood
, vol.108
, pp. 28-37
-
-
Hughes, T.1
Deininger, M.2
Hochhaus, A.3
-
49
-
-
15944404601
-
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
-
Deininger M, Buchdunger E, Druker BJ. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005;105:2640-2653.
-
(2005)
Blood
, vol.105
, pp. 2640-2653
-
-
Deininger, M.1
Buchdunger, E.2
Druker, B.J.3
-
50
-
-
1342330094
-
Mechanisms of resistance to STI571 (Imatinib) in Philadelphia-chromosome positive acute lymphoblastic leukemia
-
Hofmann WK, Komor M, Hoelzer D, Ottmann OG. Mechanisms of resistance to STI571 (Imatinib) in Philadelphia- chromosome positive acute lymphoblastic leukemia. Leuk Lymphoma 2004;45:655-660.
-
(2004)
Leuk Lymphoma
, vol.45
, pp. 655-660
-
-
Hofmann, W.K.1
Komor, M.2
Hoelzer, D.3
Ottmann, O.G.4
-
51
-
-
33846228789
-
Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia-positive patients: By the GIMEMA working party on chronic myeloid leukemia
-
on behalf of GIMEMA Working Party on Chronic Myeloid Leukemia
-
Soverini S, Colarossi S, Gnani A, et al. on behalf of GIMEMA Working Party on Chronic Myeloid Leukemia. Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia-positive patients: by the GIMEMA working party on chronic myeloid leukemia. Clin Cancer Res 2006;12:7374-7379.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 7374-7379
-
-
Soverini, S.1
Colarossi, S.2
Gnani, A.3
-
52
-
-
10744232328
-
Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
-
Branford S, Rudzki Z, Walsh S, et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 2003;102:276-283.
-
(2003)
Blood
, vol.102
, pp. 276-283
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
-
53
-
-
23044458596
-
ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: A study by the GIMEMA Working Party on Chronic Myeloid Leukemia
-
Soverini S, Martinelli G, Rosti G, et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 2005;23:4100-4109.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4100-4109
-
-
Soverini, S.1
Martinelli, G.2
Rosti, G.3
-
54
-
-
34547221085
-
Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)
-
Pfeifer H, Wassmann B, Pavlova A, et al. Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Blood 2007;110:727-734.
-
(2007)
Blood
, vol.110
, pp. 727-734
-
-
Pfeifer, H.1
Wassmann, B.2
Pavlova, A.3
-
55
-
-
1542713480
-
P-glycoproteinmediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate
-
Illmer T, Schaich M, Platzbecker U, et al. P-glycoproteinmediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate. Leukemia 2004;18:401-408.
-
(2004)
Leukemia
, vol.18
, pp. 401-408
-
-
Illmer, T.1
Schaich, M.2
Platzbecker, U.3
-
56
-
-
0034254368
-
Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: Diverse mechanisms of resistance
-
Mahon FX, Deininger MW, Schultheis B, et al. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance. Blood 2000;96:1070-1079.
-
(2000)
Blood
, vol.96
, pp. 1070-1079
-
-
Mahon, F.X.1
Deininger, M.W.2
Schultheis, B.3
-
57
-
-
9444282642
-
Active transport of imatinib into and out of cells: Implications for drug resistance
-
Thomas J, Wang L, Clark RE, Pirmohamed M. Active transport of imatinib into and out of cells: implications for drug resistance. Blood 2004;104:3739-3745.
-
(2004)
Blood
, vol.104
, pp. 3739-3745
-
-
Thomas, J.1
Wang, L.2
Clark, R.E.3
Pirmohamed, M.4
-
58
-
-
33745085275
-
OCT-1 mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107); Reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib
-
White DL, Saunders VA, Dang P, et al. OCT-1 mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107); reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. Blood 2006;108:697-704.
-
(2006)
Blood
, vol.108
, pp. 697-704
-
-
White, D.L.1
Saunders, V.A.2
Dang, P.3
-
59
-
-
4344672552
-
Imatinib therapy in chronic myelogenous leukemia: Strategies to avoid and overcome resistance
-
Hochhaus A, La Rosee P. Imatinib therapy in chronic myelogenous leukemia: strategies to avoid and overcome resistance. Leukemia 2004;18:1321-1331.
-
(2004)
Leukemia
, vol.18
, pp. 1321-1331
-
-
Hochhaus, A.1
La Rosee, P.2
-
60
-
-
4544343214
-
A Bcr/Ablindependent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2
-
Dai Y, Rahmani M, Corey SJ, Dent P, Grant S. A Bcr/Ablindependent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2. J Biol Chem 2004;279:34227-34239.
-
(2004)
J Biol Chem
, vol.279
, pp. 34227-34239
-
-
Dai, Y.1
Rahmani, M.2
Corey, S.J.3
Dent, P.4
Grant, S.5
-
61
-
-
0037438640
-
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
-
Donato NJ, Wu JY, Stapley J, et al. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 2003; 101:690-698.
-
(2003)
Blood
, vol.101
, pp. 690-698
-
-
Donato, N.J.1
Wu, J.Y.2
Stapley, J.3
-
62
-
-
33750937577
-
Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
-
Hu Y, Swerdlow S, Duffy TM, Weinmann R, Lee FY, Li S. Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice. Proc Natl Acad Sci USA 2006;103:16870-16875.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 16870-16875
-
-
Hu, Y.1
Swerdlow, S.2
Duffy, T.M.3
Weinmann, R.4
Lee, F.Y.5
Li, S.6
-
63
-
-
0036847027
-
The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells
-
Klejman A, Schreiner SJ, Nieborowska-Skorska M, et al. The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells. EMBO J 2006;21: 5766-5774.
-
(2006)
EMBO J
, vol.21
, pp. 5766-5774
-
-
Klejman, A.1
Schreiner, S.J.2
Nieborowska-Skorska, M.3
-
64
-
-
33750083890
-
Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity
-
Meyn MA, III, Wilson MB, Abdi FA, et al. Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity. J Biol Chem 2006;281:30907-30916.
-
(2006)
J Biol Chem
, vol.281
, pp. 30907-30916
-
-
Meyn III, M.A.1
Wilson, M.B.2
Abdi, F.A.3
-
65
-
-
0036715514
-
Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells
-
Ptasznik A, Urbanowska E, Chinta S, et al. Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells. J Exp Med 2002;196:667-678.
-
(2002)
J Exp Med
, vol.196
, pp. 667-678
-
-
Ptasznik, A.1
Urbanowska, E.2
Chinta, S.3
-
66
-
-
9144223047
-
Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCRABL1(+) leukemia cells
-
Ptasznik A, Nakata Y, Kalota A, Emerson SG, Gewirtz AM. Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCRABL1(+) leukemia cells. Nat Med 2004;10:1187-1189.
-
(2004)
Nat Med
, vol.10
, pp. 1187-1189
-
-
Ptasznik, A.1
Nakata, Y.2
Kalota, A.3
Emerson, S.G.4
Gewirtz, A.M.5
-
67
-
-
0037508877
-
Two distinct phosphorylation pathways have additive effects on Abl family kinase activation
-
Tanis KQ, Veach D, Duewel HS, Bornmann WG, Koleske AJ. Two distinct phosphorylation pathways have additive effects on Abl family kinase activation. Mol Cell Biol 2003; 23:3884-3896.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 3884-3896
-
-
Tanis, K.Q.1
Veach, D.2
Duewel, H.S.3
Bornmann, W.G.4
Koleske, A.J.5
-
68
-
-
4043063997
-
Efficacy of dualspecific Bcr-Abl and Src-family kinase inhibitors in cells sensitive and resistant to imatinib mesylate
-
Tipping AJ, Baluch S, Barnes DJ, et al. Efficacy of dualspecific Bcr-Abl and Src-family kinase inhibitors in cells sensitive and resistant to imatinib mesylate. Leukemia 2004; 18:1352-1356.
-
(2004)
Leukemia
, vol.18
, pp. 1352-1356
-
-
Tipping, A.J.1
Baluch, S.2
Barnes, D.J.3
-
69
-
-
0025353718
-
Bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation
-
Engelman A, Rosenberg N. Bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation. Mol Cell Biol 1990;10:4365-4369.
-
(1990)
Mol Cell Biol
, vol.10
, pp. 4365-4369
-
-
Engelman, A.1
Rosenberg, N.2
-
70
-
-
2442465000
-
Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
-
Hu Y, Liu Y, Pelletier S, et al. Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet 2004; 36:453-461.
-
(2004)
Nat Genet
, vol.36
, pp. 453-461
-
-
Hu, Y.1
Liu, Y.2
Pelletier, S.3
-
71
-
-
18144426133
-
Src kinases as targets for B cell acute lymphoblastic leukaemia therapy
-
Li S. Src kinases as targets for B cell acute lymphoblastic leukaemia therapy. Expert Opin Ther Targets 2005;9:329-341.
-
(2005)
Expert Opin Ther Targets
, vol.9
, pp. 329-341
-
-
Li, S.1
-
72
-
-
0037153476
-
Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis
-
Wilson MB, Schreiner SJ, Choi HJ, Kamens J, Smithgall TE. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene 2002;21:8075-8088.
-
(2002)
Oncogene
, vol.21
, pp. 8075-8088
-
-
Wilson, M.B.1
Schreiner, S.J.2
Choi, H.J.3
Kamens, J.4
Smithgall, T.E.5
-
73
-
-
21144451094
-
In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
-
O'Hare T, Walters DK, Stoffregen EP, et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 2005;65:4500-4505.
-
(2005)
Cancer Res
, vol.65
, pp. 4500-4505
-
-
O'Hare, T.1
Walters, D.K.2
Stoffregen, E.P.3
-
74
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004;305:399-401.
-
(2004)
Science
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
Chen, P.4
Norris, D.5
Sawyers, C.L.6
-
75
-
-
33745283618
-
The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinibresistant ABL mutants
-
Tokarski JS, Newitt JA, Chang CY, et al. The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinibresistant ABL mutants. Cancer Res 2006;66:5790-5797.
-
(2006)
Cancer Res
, vol.66
, pp. 5790-5797
-
-
Tokarski, J.S.1
Newitt, J.A.2
Chang, C.Y.3
-
76
-
-
33745164854
-
Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance
-
Azam M, Nardi V, Shakespeare WC, et al. Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proc Natl Acad Sci USA 2006; 103:9244-9249.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9244-9249
-
-
Azam, M.1
Nardi, V.2
Shakespeare, W.C.3
-
77
-
-
14744274624
-
Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance
-
Burgess MR, Skaggs BJ, Shah NP, Lee FY, Sawyers CL. Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance. Proc Natl Acad Sci USA 2005;102: 3395-3400.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 3395-3400
-
-
Burgess, M.R.1
Skaggs, B.J.2
Shah, N.P.3
Lee, F.Y.4
Sawyers, C.L.5
-
78
-
-
34247644944
-
Resistance to dasatinib in Philadelphia-positive leukemia patients and the presence or the selection of mutations at residues 315 and 317 in the BCR-ABL kinase domain
-
Soverini S, Colarossi S, Gnani A, et al. Resistance to dasatinib in Philadelphia-positive leukemia patients and the presence or the selection of mutations at residues 315 and 317 in the BCR-ABL kinase domain. Haematologica 2007; 92:401-404.
-
(2007)
Haematologica
, vol.92
, pp. 401-404
-
-
Soverini, S.1
Colarossi, S.2
Gnani, A.3
-
79
-
-
76349096345
-
Dasatinib 140 mg once daily (QD) has equivalent efficacy and improved safety compared with 70 mg twice daily (BID) in patients with imatinib-resistant or-intolerant Philadelphia chromosomepositive acute lymphoblastic leukemia (Ph+ ALL): 2-year data from CA180-035 [abstract]
-
Abstract 2926
-
Larson RA, Ottmann OG, Shah NP, et al. Dasatinib 140 mg once daily (QD) has equivalent efficacy and improved safety compared with 70 mg twice daily (BID) in patients with imatinib-resistant or -intolerant Philadelphia chromosomepositive acute lymphoblastic leukemia (Ph+ ALL): 2-year data from CA180-035 [abstract]. Blood 2008;112(Suppl.): (Abstract 2926).
-
(2008)
Blood
, vol.112
, Issue.SUPPL.
-
-
Larson, R.A.1
Ottmann, O.G.2
Shah, N.P.3
-
80
-
-
76349101502
-
Dasatinib is an effective treatment of central nervous system Ph-positive leukemia [abstract]
-
Abstract 0315
-
Koskenvesa P, Rimpilainen J, Lundan T, et al. Dasatinib is an effective treatment of central nervous system Ph-positive leukemia [abstract]. Haematologica 2007;92(Suppl. 2): (Abstract 0315).
-
(2007)
Haematologica
, vol.92
, Issue.SUPPL. 2
-
-
Koskenvesa, P.1
Rimpilainen, J.2
Lundan, T.3
-
81
-
-
33745203000
-
BMS-354825, a dual SRC/ABL kinase inhibitor, displays potent anti-tumor activity in a model of intracranial CML growth [abstract]
-
Abstract 1988
-
Wild R, Castaneda S, Flefleh C, et al. BMS-354825, a dual SRC/ABL kinase inhibitor, displays potent anti-tumor activity in a model of intracranial CML growth [abstract]. Blood 2004;104(Suppl.):(Abstract 1988).
-
(2004)
Blood
, vol.104
, Issue.SUPPL.
-
-
Wild, R.1
Castaneda, S.2
Flefleh, C.3
-
82
-
-
0344520475
-
Distribution of STI-571 to the brain is limited by Pglycoprotein-mediated efflux
-
Dai H, Marbach P, Lemaire M, Hayes M, Elmquist WF. Distribution of STI-571 to the brain is limited by Pglycoprotein- mediated efflux. J Pharmacol Exp Ther 2003; 304:1085-1092.
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 1085-1092
-
-
Dai, H.1
Marbach, P.2
Lemaire, M.3
Hayes, M.4
Elmquist, W.F.5
-
83
-
-
70349648230
-
Line treatment of adult Ph+ acute lymphoblastic leukemia (ALL) patients. Final results of the GIMEMA LAL1205 study [abstract]
-
Abstract 305
-
Foa R, Vitale A, Guarini A, et al. Line treatment of adult Ph+ acute lymphoblastic leukemia (ALL) patients. Final results of the GIMEMA LAL1205 study [abstract]. Blood 2008;112(Suppl.):(Abstract 305).
-
(2008)
Blood
, vol.112
, Issue.SUPPL.
-
-
Foa, R.1
Vitale, A.2
Guarini, A.3
-
84
-
-
68049097700
-
Phase II study of combination of hyperCVAD with dasatinib in frontline therapy of patients with Philadelphia chromosome (Ph) positive acute lymphoblastic leukemia (ALL) [abstract]
-
Abstract 2921
-
Ravandi F, Thomas D, Kantarjian H, et al. Phase II study of combination of hyperCVAD with dasatinib in frontline therapy of patients with Philadelphia chromosome (Ph) positive acute lymphoblastic leukemia (ALL) [abstract]. Blood 2008;112(Suppl.):(Abstract 2921).
-
(2008)
Blood
, vol.112
, Issue.SUPPL.
-
-
Ravandi, F.1
Thomas, D.2
Kantarjian, H.3
-
85
-
-
76349100350
-
Dasatinib (Sprycel1) and chemotherapy for first-line treatment in elderly patients with de novo Philadelphia positive ALL: Results of the first 22 patients included in the EWALL-Ph-01 trial
-
(on behalf of the European Working Group on Adult ALL [EWALL]) [abstract] (Abstract 2920)
-
Rousselot P, Cayuela J-M, Recher C, et al. Dasatinib (Sprycel1) and chemotherapy for first-line treatment in elderly patients with de novo Philadelphia positive ALL: results of the first 22 patients included in the EWALL-Ph-01 trial (on behalf of the European Working Group on Adult ALL [EWALL]) [abstract]. Blood 2008;112(Suppl.): (Abstract 2920).
-
(2008)
Blood
, vol.112
, Issue.SUPPL.
-
-
Rousselot, P.1
Cayuela, J.-M.2
Recher, C.3
-
86
-
-
67650230452
-
Combination of the hyperCVAD regimen with dasatinib is effective in patients with relapsed Philadelphia chromosome (Ph) positive acute lymphoblastic leukemia (ALL) and lymphoid blast phase chronic myeloid leukemia (CML-LB) [abstract]
-
Abstract 2919
-
Jabbour E, O'Brien S, Thomas DA, et al. Combination of the hyperCVAD regimen with dasatinib is effective in patients with relapsed Philadelphia chromosome (Ph) positive acute lymphoblastic leukemia (ALL) and lymphoid blast phase chronic myeloid leukemia (CML-LB) [abstract]. Blood 2008;112(Suppl.): (Abstract 2919).
-
(2008)
Blood
, vol.112
, Issue.SUPPL.
-
-
Jabbour, E.1
O'Brien, S.2
Thomas, D.A.3
-
87
-
-
33750089322
-
AMN107: Efficacy of the selective Bcr-Abl tyrosine kinase inhibitor in a murine model of chronic myelogenous leukemia [abstract]
-
Abstract 261
-
Jensen MR, Bruggen J, Dilea C, Mestan J, Manley PW. AMN107: efficacy of the selective Bcr-Abl tyrosine kinase inhibitor in a murine model of chronic myelogenous leukemia [abstract]. Proc Am Assoc Cancer Res 2006;47: (Abstract 261).
-
(2006)
Proc Am Assoc Cancer Res
, vol.47
-
-
Jensen, M.R.1
Bruggen, J.2
Dilea, C.3
Mestan, J.4
Manley, P.W.5
-
88
-
-
13844251975
-
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
-
Weisberg E, Manley PW, Breitenstein W, et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 2005;7:129-141.
-
(2005)
Cancer Cell
, vol.7
, pp. 129-141
-
-
Weisberg, E.1
Manley, P.W.2
Breitenstein, W.3
-
89
-
-
33745086350
-
Nilotinib in imatinib-resistant CML and Philadelphia chromosomepositive ALL
-
Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosomepositive ALL. N Engl J Med 2006;354:2542-2551.
-
(2006)
N Engl J Med
, vol.354
, pp. 2542-2551
-
-
Kantarjian, H.1
Giles, F.2
Wunderle, L.3
-
90
-
-
0037439689
-
SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice
-
Golas JM, Arndt K, Etienne C, et al. SKI-606, a 4-anilino-3- quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res 2003;63:375-381.
-
(2003)
Cancer Res
, vol.63
, pp. 375-381
-
-
Golas, J.M.1
Arndt, K.2
Etienne, C.3
-
91
-
-
28444479480
-
NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia
-
Kimura S, Naito H, Segawa H, et al. NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia. Blood 2005; 3948-3954.
-
(2005)
Blood
, pp. 3948-3954
-
-
Kimura, S.1
Naito, H.2
Segawa, H.3
-
92
-
-
33748094100
-
In vivo antiproliferative effect of NS-187, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor, on leukemic cells harbouring Abl kinase domain mutations
-
Naito H, Kimura S, Nakaya Y, et al. In vivo antiproliferative effect of NS-187, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor, on leukemic cells harbouring Abl kinase domain mutations. Leuk Res 2006;30:1443-1446.
-
(2006)
Leuk Res
, vol.30
, pp. 1443-1446
-
-
Naito, H.1
Kimura, S.2
Nakaya, Y.3
-
93
-
-
68949109452
-
Bosutinib (SKI-606) demonstrates clinical activity and is well tolerated in patients with AP and BP CML and Ph+ ALL [abstract]
-
Abstract 1101
-
Gambacorti-Passarini C, Pogliani EM, Baccarani M, et al. Bosutinib (SKI-606) demonstrates clinical activity and is well tolerated in patients with AP and BP CML and Ph+ ALL [abstract]. Blood 2008;112(Suppl.):(Abstract 1101).
-
(2008)
Blood
, vol.112
, Issue.SUPPL.
-
-
Gambacorti-Passarini, C.1
Pogliani, E.M.2
Baccarani, M.3
-
94
-
-
23344440655
-
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
-
Carter TA, Wodicka LM, Shah NP, et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci USA 2005;102: 11011-11016.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 11011-11016
-
-
Carter, T.A.1
Wodicka, L.M.2
Shah, N.P.3
-
95
-
-
33846240316
-
MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation
-
Giles FJ, Cortes J, Jones D, Bergstrom D, Kantarjian H, Freedman SJ. MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. Blood 2007; 109:500-502.
-
(2007)
Blood
, vol.109
, pp. 500-502
-
-
Giles, F.J.1
Cortes, J.2
Jones, D.3
Bergstrom, D.4
Kantarjian, H.5
Freedman, S.J.6
-
96
-
-
2342639645
-
VX-680 a potent and selective small-molecule inhibitor of the Aurora kinases suppresses tumor growth in vivo
-
Harrington EA, Bebbington D, Moore J, et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo.Nat Med 2004;10: 262-267.
-
(2004)
Nat Med
, vol.10
, pp. 262-267
-
-
Harrington, E.A.1
Bebbington, D.2
Moore, J.3
-
97
-
-
31644438945
-
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680
-
Young MA, Shah NP, Chao LH, et al. Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res 2006;66:1007-1014.
-
(2006)
Cancer Res
, vol.66
, pp. 1007-1014
-
-
Young, M.A.1
Shah, N.P.2
Chao, L.H.3
-
98
-
-
34948830170
-
Interferon- {a} or homoharringtonine as salvage treatment for chronic myeloid leukemia patients who acquire the T315I BCR-ABL mutation
-
de Lavallade H, Khorashad JS, Davis HP, et al. Interferon- {a} or homoharringtonine as salvage treatment for chronic myeloid leukemia patients who acquire the T315I BCR-ABL mutation. Blood 2007;110:2779-2780.
-
(2007)
Blood
, vol.110
, pp. 2779-2780
-
-
De Lavallade, H.1
Khorashad, J.S.2
Davis, H.P.3
-
99
-
-
0043016178
-
Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or-refractory chronic myelogenous leukemia-blast crisis cells
-
Nimmanapalli R, Fuino L, Bali P, et al. Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells. Cancer Res 2003;63:5126-5135.
-
(2003)
Cancer Res
, vol.63
, pp. 5126-5135
-
-
Nimmanapalli, R.1
Fuino, L.2
Bali, P.3
-
100
-
-
43049139905
-
BCR-ABL1 lymphoblastic leukemia is characterized by the deletion of Ikaros
-
Mullighan CG, Millrt CB, Radtke I, et al. BCR-ABL1 lymphoblastic leukemia is characterized by the deletion of Ikaros. Nature 2008;453:110-115.
-
(2008)
Nature
, vol.453
, pp. 110-115
-
-
Mullighan, C.G.1
Millrt, C.B.2
Radtke, I.3
-
101
-
-
10744231268
-
Early prediction of response in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) treated with imatinib
-
Wassmann B, PfeiferH, Scheuring UJ, et al. Early prediction of response in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) treated with imatinib. Blood 2004;103:1495-1498.
-
(2004)
Blood
, vol.103
, pp. 1495-1498
-
-
Wassmann, B.1
Pfeifer, H.2
Scheuring, U.J.3
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