The central tolerance response to male antigen in normal mice is deletion and not receptor editing

Journal of Immunology

Volumn 171, Issue 8, 2003, Pages 4048-4053

  Holman, Philmore O ^a   Walsh, Elizabeth R ^a   Hogquist, Kristin A ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; AUTOANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; FEMALE; GENE LOCUS; GENETIC RECOMBINATION; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; T LYMPHOCYTE; THYMUS; TRANSGENIC MOUSE;

EID: 0141958201     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.8.4048     Document Type: Article

References (35)

1. Hesslein, D. G., and D. G. Schatz. 2001. Factors and forces controlling V(D)J recombination. Adv. Immunol. 78:169.
2. Starr, T. K., S. C. Jameson, and K. A. Hogquist. 2003. Positive and negative selection of T cells. Annu. Rev. Immunol. 21:139.
3. Guy-Grand, D., C. Vanden Broecke, C. Briottet, M. Malassis-Seris, F. Selz, and P. Vassalli. 1992. Different expression of the recombination activity gene RAG-1 in various populations of thymocytes, peripheral T cells and gut thymus-independent intraepithelial lymphocytes suggests two pathways of T cell receptor rearrangement. Eur. J. Immunol. 22:505.
4. Wilson, A., W. Held, and H. R. MacDonald. 1994. Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 179:1355.
5. Khor, B., and B. P. Sleckman. 2002. Allelic exclusion at the TCRβ locus. Curr. Opin. Immunol. 14:230.
6. Hoffman, E. S., L. Passoni, T. Crompton, T. M. Leu, D. G. Schatz, A. Koff, M. J. Owen, and A. C. Hayday. 1996. Productive T-cell receptor β-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev. 10:948.
7. Petrie, H. T., F. Livak, D. G. Schatz, A. Strasser, I. N. Crispe, and K. Shortman. 1993. Multiple rearrangements in T cell receptor α chain genes maximize the production of useful thymocytes. J. Exp. Med. 178:615.
8. Pasqual, N., M. Gallagher, C. Aude-Garcia, M. Loiodice, F. Thuderoz, J. Demongeot, R. Ceredig, P. N. Marche, and E. Jouvin-Marche. 2002. Quantitative and qualitative changes in V-Jα rearrangements during mouse thymocytes differentiation: implication for a limited T cell receptor α chain repertoire. J. Exp. Med. 196:1163.
9. Bosc, N., and M. P. Lefranc. 2003. The mouse (Mus musculus) T cell receptor α (TRA) and δ (TRD) variable genes. Dev. Comp. Immunol. 27:465.
10. Petrie, H. T., F. Livak, D. Burtrum, and S. Mazel. 1995. T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production. J. Exp. Med. 182:121.
11. Davodeau, F., M. Difilippantonio, E. Roldan, M. Malissen, J. L. Casanova, C. Couedel, J. F. Morcet, M. Merkenschlager, A. Nussenzweig, M. Bonneville, et al. 2001. The tight interallelic positional coincidence that distinguishes T-cell receptor Jα usage does not result from homologous chromosomal pairing during VαJα rearrangement. EMBO J. 20:4717.
12. + thymocytes. Nat. Immunol. 3:469.
13. Heath, W. R., F. R. Carbone, P. Bertolino, J. Kelly, S. Cose, and J. F. Miller. 1995. Expression of two T cell receptor α chains on the surface of normal murine T cells. Eur. J. Immunol. 25:1617.
14. Alam, S. M., I. N. Crispe, and N. R. Gascoigne. 1995. Allelic exclusion of mouse T cell receptor α chains occurs at the time of thymocyte TCR up-regulation. Immunity 3:449.
15. Nemazee, D., and K. A. Hogquist. 2003. Antigen receptor selection by editing or downregulation of V(D)J recombination. Curr. Opin. Immunol. 15:182.
16. Borgulya, P., H. Kishi, Y. Uematsu, and H. von Boehmer. 1992. Exclusion and inclusion of α and β T cell receptor alleles. Cell 69:529.
17. Wang, F., C. Y. Huang, and O. Kanagawa. 1998. Rapid deletion of rearranged T cell antigen receptor (TCR) Vα-Jα segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR α chain gene and positive selection in the T cell repertoire formation. Proc. Natl. Acad. Sci. USA 95:11834.
18. + T cells. Immunity 3:79.
19. McGargill, M. A., J. M. Derbinski, and K. A. Hogquist. 2000. Receptor editing in developing T cells. Nat. Immunol. 1:336.
20. Buch, T., F. Rieux-Laucat, I. Forster, and K. Rajewsky. 2002. Failure of HY-specific thymocytes to escape negative selection by receptor editing. Immunity 16:707.
21. Lacorazza, H. D., C. Tucek-Szabo, L. V. Vasovic, K. Remus, and J. Nikolich-Zugich. 2001. Premature TCR αβ expression and signaling in early thymocytes impair thymocyte expansion and partially block their development. J. Immunol. 166:3184.
22. Trop, S., M. Rhodes, D. L. Wiest, P. Hugo, and J. C. Zuniga-Pflucker. 2000. Competitive displacement of pTα by TCR-α during TCR assembly prevents surface coexpression of pre-TCR and αβ TCR. J. Immunol. 165:5566.
23. Erman, B., L. Feigenbaum, J. E. Coligan, and A. Singer. 2002. Early TCRα expression generates TCRαγ complexes that signal the DN-to-DP transition and impair development. Nat. Immunol. 3:564.
24. Brabb, T., E. S. Huseby, T. M. Morgan, D. B. Sant'Angelo, J. Kirchner, A. G. Farr, and J. Goverman. 1997. Thymic stromal organization is regulated by the specificity of T cell receptor/major histocompatibility complex interactions. Eur. J. Immunol. 27:136.
25. Terrence, K., C. P. Pavlovich, E. O. Matechak, and B. J. Fowlkes. 2000. Premature expression of T cell receptor (TCR)αβ suppresses TCRγδ gene rearrangement but permits development of γδ lineage T cells. J. Exp. Med. 192:537.
26. + cells. Science 258:653.
27. Uematsu, Y., S. Ryser, Z. Dembic, P. Borgulya, P. Krimpenfort, A. Berns, H. von Boehmer, and M. Steinmetz. 1988. In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes. Cell 52:831.
28. Sleckman, B. P., C. G. Bardon, R. Ferrini, L. Davidson, and F. W. Alt. 1997. Function of the TCR α enhancer in αβ and γδ T cells. Immunity 7:505.
29. Bouneaud, C., P. Kourilsky, and P. Bousso. 2000. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 13:829.
30. + thymocytes. Int. Immunol. 5:801.
31. Griem, P., H. J. Wallny, K. Falk, O. Rotzschke, B. Arnold, G. Schonrich, G. Hammerling, and H. G. Rammensee. 1991. Uneven tissue distribution of minor histocompatibility proteins versus peptides is caused by MHC expression. Cell 65:633.
32. Livak, F., and D. G. Schatz. 1996. T-cell receptor α locus V(D)J recombination by-products are abundant in thymocytes and mature T cells. Mol. Cell. Biol. 16:609.
33. Martin, S., and M. J. Bevan. 1997. Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection. Eur. J. Immunol. 27:2726.
34. Zhan, Y., J. F. Purton, D. I. Godfrey, T. J. Cole, W. R. Heath, and A. M. Lew. 2003. Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation. Proc. Natl. Acad. Sci. USA 100:1197.
35. Brewer, J. A., O. Kanagawa, B. P. Sleckman, and L. J. Muglia. 2002. Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J. Immunol. 169:1837.