Order out of complexity - Protein structures that interact with heparin

Current Opinion in Structural Biology

Volumn 11, Issue 5, 2001, Pages 623-628

  Mulloy, Barbara ^a   Linhardt, Robert J ^b  

^a NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^b E11 SSH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; FIBROBLAST GROWTH FACTOR; HEPARIN; LIPOCORTIN 5; OLIGOSACCHARIDE; VIRUS PROTEIN;

COMPLEX FORMATION; CRYSTAL STRUCTURE; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; STRUCTURE ANALYSIS;

EID: 0035443891     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(00)00257-8     Document Type: Review

References (45)

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18. Characterrization of the stromal cell-derived factor-1α/heparin complex
19. The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity
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22. The region of antithrombin interacting with full-length heparin chains outside the high-affinity pentasaccharide sequence extends to Lys136 but not to Lys139
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27. Site-directed mutagenesis and molecular modeling identify a crucial amino acid in specifying the heparin affinity of FGF-1
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33. A dimeric ternary complex of FGFR [correction of FGFR1], heparin and FGF-1 leads to an 'electrostatic sandwich' model for heparin binding
34. Oligomerization reduces heparin affinity but enhances receptor binding of fibroblast growth factor 2
35. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin
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37. Structural interactions of fibroblast growth factor receptor with its ligands
38. Structural basis for FGF receptor dimerization and activation
39. Heparan sulfate oligosaccharides require 6-O-sulfation for promotion of basic fibroblast growth factor mitogenic activity
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44. Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor
45. Identification and dynamics of a heparin-binding site in hepatocyte growth factor