메뉴 건너뛰기




Volumn 59, Issue 3, 2010, Pages 350-358

Comparison of glucose and lipid metabolism and bone mineralization in patients with growth hormone deficiency with and without long-term growth hormone replacement

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; C PEPTIDE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; HYDROCORTISONE; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN; METFORMIN; RECOMBINANT GROWTH HORMONE; SOMATOMEDIN C; TRIACYLGLYCEROL;

EID: 76249093601     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.08.002     Document Type: Article
Times cited : (13)

References (57)
  • 1
    • 0019970112 scopus 로고
    • Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization
    • Rizza R.A., Mandarino L.J., and Gerich J.E. Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization. Diabetes 31 8 Pt 1 (1982) 663-669
    • (1982) Diabetes , vol.31 , Issue.8 PART 1 , pp. 663-669
    • Rizza, R.A.1    Mandarino, L.J.2    Gerich, J.E.3
  • 3
    • 0038526307 scopus 로고    scopus 로고
    • Growth hormone replacement therapy induces insulin resistance by activating the glucose-fatty acid cycle
    • Bramnert M., Segerlantz M., Laurila E., Daugaard J.R., Manhem P., and Groop L. Growth hormone replacement therapy induces insulin resistance by activating the glucose-fatty acid cycle. J Clin Endocrinol Metab 88 (2003) 1455-1463
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1455-1463
    • Bramnert, M.1    Segerlantz, M.2    Laurila, E.3    Daugaard, J.R.4    Manhem, P.5    Groop, L.6
  • 4
    • 0031057076 scopus 로고    scopus 로고
    • Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure
    • Johannsson G., Marin P., Lonn L., Ottosson M., Stenlof K., Bjorntorp P., et al. Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. J Clin Endocrinol Metab 82 (1997) 727-734
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 727-734
    • Johannsson, G.1    Marin, P.2    Lonn, L.3    Ottosson, M.4    Stenlof, K.5    Bjorntorp, P.6
  • 5
    • 0021813187 scopus 로고
    • Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 6
    • 10944220736 scopus 로고    scopus 로고
    • Survivors of childhood acute lymphoblastic leukaemia, with radiation-induced GH deficiency, exhibit hyperleptinaemia and impaired insulin sensitivity, unaffected by 12 months of GH treatment
    • Bulow B., Link K., Ahren B., Nilsson A.S., and Erfurth E.M. Survivors of childhood acute lymphoblastic leukaemia, with radiation-induced GH deficiency, exhibit hyperleptinaemia and impaired insulin sensitivity, unaffected by 12 months of GH treatment. Clin Endocrinol (Oxf) 61 (2004) 683-691
    • (2004) Clin Endocrinol (Oxf) , vol.61 , pp. 683-691
    • Bulow, B.1    Link, K.2    Ahren, B.3    Nilsson, A.S.4    Erfurth, E.M.5
  • 7
    • 0032602201 scopus 로고    scopus 로고
    • Insulin sensitivity in growth hormone (GH)-deficient adults and effect of GH replacement therapy
    • Alford F.P., Hew F.L., Christopher M.C., and Rantzau C. Insulin sensitivity in growth hormone (GH)-deficient adults and effect of GH replacement therapy. J Endocrinol Invest 22 5 Suppl (1999) 28-32
    • (1999) J Endocrinol Invest , vol.22 , Issue.5 SUPPL , pp. 28-32
    • Alford, F.P.1    Hew, F.L.2    Christopher, M.C.3    Rantzau, C.4
  • 8
    • 0035726804 scopus 로고    scopus 로고
    • Commencing growth hormone replacement in adults with a fixed low dose. Effects on serum lipoproteins, glucose metabolism, body composition, and cardiovascular function
    • Gillberg P., Bramnert M., Thoren M., Werner S., and Johannsson G. Commencing growth hormone replacement in adults with a fixed low dose. Effects on serum lipoproteins, glucose metabolism, body composition, and cardiovascular function. Growth Horm IGF Res 11 5 (2001) 273-281
    • (2001) Growth Horm IGF Res , vol.11 , Issue.5 , pp. 273-281
    • Gillberg, P.1    Bramnert, M.2    Thoren, M.3    Werner, S.4    Johannsson, G.5
  • 10
  • 12
    • 1842734397 scopus 로고    scopus 로고
    • The effects of GH replacement in adult GH-deficient patients: changes in body composition without concomitant changes in the adipokines and insulin resistance
    • Hana V., Silha J.V., Justova V., Lacinova Z., Stepan J.J., and Murphy L.J. The effects of GH replacement in adult GH-deficient patients: changes in body composition without concomitant changes in the adipokines and insulin resistance. Clin Endocrinol (Oxf) 60 (2004) 442-450
    • (2004) Clin Endocrinol (Oxf) , vol.60 , pp. 442-450
    • Hana, V.1    Silha, J.V.2    Justova, V.3    Lacinova, Z.4    Stepan, J.J.5    Murphy, L.J.6
  • 13
    • 9844221403 scopus 로고    scopus 로고
    • Growth hormone (GH) replacement reduces total body fat and normalizes insulin sensitivity in GH-deficient adults: a report of one-year clinical experience
    • Hwu C.M., Kwok C.F., Lai T.Y., Shih K.C., Lee T.S., Hsiao L.C., et al. Growth hormone (GH) replacement reduces total body fat and normalizes insulin sensitivity in GH-deficient adults: a report of one-year clinical experience. J Clin Endocrinol Metab 82 (1997) 3285-3292
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3285-3292
    • Hwu, C.M.1    Kwok, C.F.2    Lai, T.Y.3    Shih, K.C.4    Lee, T.S.5    Hsiao, L.C.6
  • 14
    • 0036096692 scopus 로고    scopus 로고
    • Effects of seven years of GH-replacement therapy on insulin sensitivity in GH-deficient adults
    • Svensson J., Fowelin J., Landin K., Bengtsson B.A., and Johansson J.O. Effects of seven years of GH-replacement therapy on insulin sensitivity in GH-deficient adults. J Clin Endocrinol Metab 87 (2002) 2121-2127
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2121-2127
    • Svensson, J.1    Fowelin, J.2    Landin, K.3    Bengtsson, B.A.4    Johansson, J.O.5
  • 15
    • 33745215422 scopus 로고    scopus 로고
    • Impact of treatment with recombinant human GH and IGF-I on visceral adipose tissue and glucose homeostasis in adults
    • Yuen K.C., and Dunger D.B. Impact of treatment with recombinant human GH and IGF-I on visceral adipose tissue and glucose homeostasis in adults. Growth Horm IGF Res 16 Suppl A (2006) S55-S61
    • (2006) Growth Horm IGF Res , vol.16 , Issue.SUPPL. A
    • Yuen, K.C.1    Dunger, D.B.2
  • 16
    • 0034685191 scopus 로고    scopus 로고
    • Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment
    • Cutfield W.S., Wilton P., Bennmarker H., Albertsson-Wikland K., Chatelain P., Ranke M.B., et al. Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment. Lancet 355 (2000) 610-613
    • (2000) Lancet , vol.355 , pp. 610-613
    • Cutfield, W.S.1    Wilton, P.2    Bennmarker, H.3    Albertsson-Wikland, K.4    Chatelain, P.5    Ranke, M.B.6
  • 17
    • 13244275093 scopus 로고    scopus 로고
    • One year of GH replacement therapy with a fixed low-dose regimen improves body composition, bone mineral density and lipid profile of GH-deficient adults
    • Boguszewski C.L., Meister L.H., Zaninelli D.C., and Radominski R.B. One year of GH replacement therapy with a fixed low-dose regimen improves body composition, bone mineral density and lipid profile of GH-deficient adults. Eur J Endocrinol 152 (2005) 67-75
    • (2005) Eur J Endocrinol , vol.152 , pp. 67-75
    • Boguszewski, C.L.1    Meister, L.H.2    Zaninelli, D.C.3    Radominski, R.B.4
  • 18
    • 0344826523 scopus 로고    scopus 로고
    • Effects of growth hormone (GH) on ghrelin, leptin, and adiponectin in GH-deficient patients
    • Eden Engstrom B., Burman P., Holdstock C., and Karlsson F.A. Effects of growth hormone (GH) on ghrelin, leptin, and adiponectin in GH-deficient patients. J Clin Endocrinol Metab 88 (2003) 5193-5198
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5193-5198
    • Eden Engstrom, B.1    Burman, P.2    Holdstock, C.3    Karlsson, F.A.4
  • 20
    • 37049010929 scopus 로고    scopus 로고
    • Impact of 5 years of growth hormone replacement therapy on cardiovascular risk factors in growth hormone-deficient adults
    • Cenci M.C., Conceicao F.L., Soares D.V., Spina L.D., Brasil R.R., Lobo P.M., et al. Impact of 5 years of growth hormone replacement therapy on cardiovascular risk factors in growth hormone-deficient adults. Metabolism 57 (2008) 121-129
    • (2008) Metabolism , vol.57 , pp. 121-129
    • Cenci, M.C.1    Conceicao, F.L.2    Soares, D.V.3    Spina, L.D.4    Brasil, R.R.5    Lobo, P.M.6
  • 22
    • 0034749231 scopus 로고    scopus 로고
    • A prospective study of 5 years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass, and metabolic indices
    • Gotherstrom G., Svensson J., Koranyi J., Alpsten M., Bosaeus I., Bengtsson B., et al. A prospective study of 5 years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass, and metabolic indices. J Clin Endocrinol Metab 86 (2001) 4657-4665
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4657-4665
    • Gotherstrom, G.1    Svensson, J.2    Koranyi, J.3    Alpsten, M.4    Bosaeus, I.5    Bengtsson, B.6
  • 23
    • 0033306143 scopus 로고    scopus 로고
    • Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency
    • ter Maaten J.C., de Boer H., Kamp O., Stuurman L., and van der Veen E.A. Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency. J Clin Endocrinol Metab 84 (1999) 2373-2380
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2373-2380
    • ter Maaten, J.C.1    de Boer, H.2    Kamp, O.3    Stuurman, L.4    van der Veen, E.A.5
  • 24
    • 76249132136 scopus 로고    scopus 로고
    • A densitometric and morphometric analysis of the skeleton in adults with varying degrees of GH deficiency
    • Murray R.D., Adams J.E., and Shalet S.M. A densitometric and morphometric analysis of the skeleton in adults with varying degrees of GH deficiency. J Clin Endocrinol Metab (2005)
    • (2005) J Clin Endocrinol Metab
    • Murray, R.D.1    Adams, J.E.2    Shalet, S.M.3
  • 25
    • 0035726384 scopus 로고    scopus 로고
    • Effects of 6 years of growth hormone (GH) treatment on bone mineral density in GH-deficient adults
    • Clanget C., Seck T., Hinke V., Wuster C., Ziegler R., and Pfeilschifter J. Effects of 6 years of growth hormone (GH) treatment on bone mineral density in GH-deficient adults. Clin Endocrinol (Oxf) 55 (2001) 93-99
    • (2001) Clin Endocrinol (Oxf) , vol.55 , pp. 93-99
    • Clanget, C.1    Seck, T.2    Hinke, V.3    Wuster, C.4    Ziegler, R.5    Pfeilschifter, J.6
  • 26
    • 34147153476 scopus 로고    scopus 로고
    • Ten-year GH replacement increases bone mineral density in hypopituitary patients with adult onset GH deficiency
    • Gotherstrom G., Bengtsson B.A., Bosaeus I., Johannsson G., and Svensson J. Ten-year GH replacement increases bone mineral density in hypopituitary patients with adult onset GH deficiency. Eur J Endocrinol 156 (2007) 55-64
    • (2007) Eur J Endocrinol , vol.156 , pp. 55-64
    • Gotherstrom, G.1    Bengtsson, B.A.2    Bosaeus, I.3    Johannsson, G.4    Svensson, J.5
  • 27
    • 20244383254 scopus 로고    scopus 로고
    • Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3)
    • Elmlinger M.W., Kuhnel W., Weber M.M., and Ranke M.B. Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3). Clin Chem Lab Med 42 (2004) 654-664
    • (2004) Clin Chem Lab Med , vol.42 , pp. 654-664
    • Elmlinger, M.W.1    Kuhnel, W.2    Weber, M.M.3    Ranke, M.B.4
  • 28
    • 0025264982 scopus 로고
    • The international reference reagent for insulin-like growth factor-I
    • Bristow A.F., Gooding R.P., and Das R.E. The international reference reagent for insulin-like growth factor-I. J Endocrinol 125 (1990) 191-197
    • (1990) J Endocrinol , vol.125 , pp. 191-197
    • Bristow, A.F.1    Gooding, R.P.2    Das, R.E.3
  • 29
    • 0036075860 scopus 로고    scopus 로고
    • Quantification of the soluble leptin receptor in human blood by ligand-mediated immunofunctional assay
    • Wu Z., Bidlingmaier M., Liu C., De Souza E.B., Tschop M., Morrison K.M., et al. Quantification of the soluble leptin receptor in human blood by ligand-mediated immunofunctional assay. J Clin Endocrinol Metab 87 (2002) 2931-2939
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2931-2939
    • Wu, Z.1    Bidlingmaier, M.2    Liu, C.3    De Souza, E.B.4    Tschop, M.5    Morrison, K.M.6
  • 30
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp
    • Matsuda M., and DeFronzo R.A. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22 (1999) 1462-1470
    • (1999) Diabetes Care , vol.22 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 31
    • 0031863120 scopus 로고    scopus 로고
    • Effects of four years' treatment with biosynthetic human growth hormone (GH) on glucose homeostasis, insulin secretion and lipid metabolism in GH-deficient adults
    • al-Shoumer K.A., Gray R., Anyaoku V., Hughes C., Beshyah S., Richmond W., et al. Effects of four years' treatment with biosynthetic human growth hormone (GH) on glucose homeostasis, insulin secretion and lipid metabolism in GH-deficient adults. Clin Endocrinol (Oxf) 48 (1998) 795-802
    • (1998) Clin Endocrinol (Oxf) , vol.48 , pp. 795-802
    • al-Shoumer, K.A.1    Gray, R.2    Anyaoku, V.3    Hughes, C.4    Beshyah, S.5    Richmond, W.6
  • 32
    • 0027429860 scopus 로고
    • Effects of treatment with recombinant human growth hormone on insulin sensitivity and glucose metabolism in adults with growth hormone deficiency
    • Fowelin J., Attvall S., Lager I., and Bengtsson B.A. Effects of treatment with recombinant human growth hormone on insulin sensitivity and glucose metabolism in adults with growth hormone deficiency. Metabolism 42 (1993) 1443-1447
    • (1993) Metabolism , vol.42 , pp. 1443-1447
    • Fowelin, J.1    Attvall, S.2    Lager, I.3    Bengtsson, B.A.4
  • 33
    • 3042854517 scopus 로고    scopus 로고
    • Long-term monitoring of insulin sensitivity in growth hormone-deficient adults on substitutive recombinant human growth hormone therapy
    • Giavoli C., Porretti S., Ronchi C.L., Cappiello V., Ferrante E., Orsi E., et al. Long-term monitoring of insulin sensitivity in growth hormone-deficient adults on substitutive recombinant human growth hormone therapy. Metabolism 53 (2004) 740-743
    • (2004) Metabolism , vol.53 , pp. 740-743
    • Giavoli, C.1    Porretti, S.2    Ronchi, C.L.3    Cappiello, V.4    Ferrante, E.5    Orsi, E.6
  • 34
    • 33646004291 scopus 로고    scopus 로고
    • Persisting effects on fasting glucose levels and insulin sensitivity after 6 months of discontinuation of a very low-dose GH therapy in adults with severe GH deficiency
    • Yuen K.C., and Dunger D.B. Persisting effects on fasting glucose levels and insulin sensitivity after 6 months of discontinuation of a very low-dose GH therapy in adults with severe GH deficiency. Clin Endocrinol (Oxf) 64 (2006) 549-555
    • (2006) Clin Endocrinol (Oxf) , vol.64 , pp. 549-555
    • Yuen, K.C.1    Dunger, D.B.2
  • 35
    • 26644463217 scopus 로고    scopus 로고
    • Improvement in insulin sensitivity without concomitant changes in body composition and cardiovascular risk markers following fixed administration of a very low growth hormone (GH) dose in adults with severe GH deficiency
    • Yuen K.C., Frystyk J., White D.K., Twickler T.B., Koppeschaar H.P., Harris P.E., et al. Improvement in insulin sensitivity without concomitant changes in body composition and cardiovascular risk markers following fixed administration of a very low growth hormone (GH) dose in adults with severe GH deficiency. Clin Endocrinol (Oxf) 63 (2005) 428-436
    • (2005) Clin Endocrinol (Oxf) , vol.63 , pp. 428-436
    • Yuen, K.C.1    Frystyk, J.2    White, D.K.3    Twickler, T.B.4    Koppeschaar, H.P.5    Harris, P.E.6
  • 36
    • 0036042655 scopus 로고    scopus 로고
    • The metabolic effects of short-term administration of physiological versus high doses of GH therapy in GH deficient adults
    • Yuen K., Cook D., Ong K., Chatelain P., Fryklund L., Gluckman P., et al. The metabolic effects of short-term administration of physiological versus high doses of GH therapy in GH deficient adults. Clin Endocrinol (Oxf) 57 (2002) 333-341
    • (2002) Clin Endocrinol (Oxf) , vol.57 , pp. 333-341
    • Yuen, K.1    Cook, D.2    Ong, K.3    Chatelain, P.4    Fryklund, L.5    Gluckman, P.6
  • 38
    • 0038644496 scopus 로고    scopus 로고
    • Fat-free body mass is the most important body composition determinant of 10-yr longitudinal development of lumbar bone in adult men and women
    • Bakker I., Twisk J.W., Van Mechelen W., and Kemper H.C. Fat-free body mass is the most important body composition determinant of 10-yr longitudinal development of lumbar bone in adult men and women. J Clin Endocrinol Metab 88 (2003) 2607-2613
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2607-2613
    • Bakker, I.1    Twisk, J.W.2    Van Mechelen, W.3    Kemper, H.C.4
  • 40
    • 33745192515 scopus 로고    scopus 로고
    • Visceral obesity, impaired glucose tolerance, metabolic syndrome, and growth hormone therapy
    • Attallah H., Friedlander A.L., and Hoffman A.R. Visceral obesity, impaired glucose tolerance, metabolic syndrome, and growth hormone therapy. Growth Horm IGF Res 16 Suppl A (2006) S62-S67
    • (2006) Growth Horm IGF Res , vol.16 , Issue.SUPPL. A
    • Attallah, H.1    Friedlander, A.L.2    Hoffman, A.R.3
  • 41
    • 34250733933 scopus 로고    scopus 로고
    • Superiority of skinfold measurements and waist over waist-to-hip ratio for determination of body fat distribution in a population-based cohort of Caucasian Dutch adults
    • Ketel I.J., Volman M.N., Seidell J.C., Stehouwer C.D., Twisk J.W., and Lambalk C.B. Superiority of skinfold measurements and waist over waist-to-hip ratio for determination of body fat distribution in a population-based cohort of Caucasian Dutch adults. Eur J Endocrinol 156 (2007) 655-661
    • (2007) Eur J Endocrinol , vol.156 , pp. 655-661
    • Ketel, I.J.1    Volman, M.N.2    Seidell, J.C.3    Stehouwer, C.D.4    Twisk, J.W.5    Lambalk, C.B.6
  • 42
    • 0029920648 scopus 로고    scopus 로고
    • Sex differences in measures of body fat and body distribution in the elderly
    • Goodman-Gruen D., and Barrett-Connor E. Sex differences in measures of body fat and body distribution in the elderly. Am J Epidemiol 143 (1996) 898-906
    • (1996) Am J Epidemiol , vol.143 , pp. 898-906
    • Goodman-Gruen, D.1    Barrett-Connor, E.2
  • 43
    • 0034682622 scopus 로고    scopus 로고
    • Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial
    • Sesmilo G., Biller B.M., Llevadot J., Hayden D., Hanson G., Rifai N., et al. Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial. Ann Intern Med. 133 (2000) 111-122
    • (2000) Ann Intern Med. , vol.133 , pp. 111-122
    • Sesmilo, G.1    Biller, B.M.2    Llevadot, J.3    Hayden, D.4    Hanson, G.5    Rifai, N.6
  • 44
    • 0033345441 scopus 로고    scopus 로고
    • The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients
    • Gibney J., Wallace J.D., Spinks T., Schnorr L., Ranicar A., Cuneo R.C., et al. The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients. J Clin Endocrinol Metab 84 (1999) 2596-2602
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2596-2602
    • Gibney, J.1    Wallace, J.D.2    Spinks, T.3    Schnorr, L.4    Ranicar, A.5    Cuneo, R.C.6
  • 45
    • 18444413530 scopus 로고    scopus 로고
    • Human growth hormone replacement in adult hypopituitary patients: long-term effects on body composition and lipid status-3-year results from the HypoCCS Database
    • Attanasio A.F., Bates P.C., Ho K.K., Webb S.M., Ross R.J., Strasburger C.J., et al. Human growth hormone replacement in adult hypopituitary patients: long-term effects on body composition and lipid status-3-year results from the HypoCCS Database. J Clin Endocrinol Metab 87 (2002) 1600-1606
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1600-1606
    • Attanasio, A.F.1    Bates, P.C.2    Ho, K.K.3    Webb, S.M.4    Ross, R.J.5    Strasburger, C.J.6
  • 47
    • 33744466066 scopus 로고    scopus 로고
    • Serum ghrelin and leptin levels in adult growth hormone deficiency syndrome
    • Jung C.H., Lee W.Y., Rhee E.J., Kim S.Y., Oh K.W., Yun E.J., et al. Serum ghrelin and leptin levels in adult growth hormone deficiency syndrome. Arch Med Res 37 (2006) 612-618
    • (2006) Arch Med Res , vol.37 , pp. 612-618
    • Jung, C.H.1    Lee, W.Y.2    Rhee, E.J.3    Kim, S.Y.4    Oh, K.W.5    Yun, E.J.6
  • 48
    • 0031796402 scopus 로고    scopus 로고
    • Effect of growth hormone (GH) on serum concentrations of leptin: study in patients with acromegaly and GH deficiency
    • Miyakawa M., Tsushima T., Murakami H., Isozaki O., Demura H., and Tanaka T. Effect of growth hormone (GH) on serum concentrations of leptin: study in patients with acromegaly and GH deficiency. J Clin Endocrinol Metab 83 (1998) 3476-3479
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3476-3479
    • Miyakawa, M.1    Tsushima, T.2    Murakami, H.3    Isozaki, O.4    Demura, H.5    Tanaka, T.6
  • 49
    • 0029821102 scopus 로고    scopus 로고
    • Effects of 12 months of growth hormone (GH) treatment on calciotropic hormones, calcium homeostasis, and bone metabolism in adults with acquired GH deficiency: a double blind, randomized, placebo-controlled study
    • Hansen T.B., Brixen K., Vahl N., Jorgensen J.O., Christiansen J.S., Mosekilde L., et al. Effects of 12 months of growth hormone (GH) treatment on calciotropic hormones, calcium homeostasis, and bone metabolism in adults with acquired GH deficiency: a double blind, randomized, placebo-controlled study. J Clin Endocrinol Metab 81 (1996) 3352-3359
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3352-3359
    • Hansen, T.B.1    Brixen, K.2    Vahl, N.3    Jorgensen, J.O.4    Christiansen, J.S.5    Mosekilde, L.6
  • 50
    • 0029812889 scopus 로고    scopus 로고
    • Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency
    • Johannsson G., Rosen T., Bosaeus I., Sjostrom L., and Bengtsson B.A. Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency. J Clin Endocrinol Metab 81 (1996) 2865-2873
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2865-2873
    • Johannsson, G.1    Rosen, T.2    Bosaeus, I.3    Sjostrom, L.4    Bengtsson, B.A.5
  • 51
    • 0344011427 scopus 로고    scopus 로고
    • Growth hormone (GH) dose-response in young adults with childhood-onset GH deficiency: a two-year, multicenter, multiple-dose, placebo-controlled study
    • Underwood L.E., Attie K.M., and Baptista J. Growth hormone (GH) dose-response in young adults with childhood-onset GH deficiency: a two-year, multicenter, multiple-dose, placebo-controlled study. J Clin Endocrinol Metab 88 (2003) 5273-5280
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5273-5280
    • Underwood, L.E.1    Attie, K.M.2    Baptista, J.3
  • 52
    • 0034527637 scopus 로고    scopus 로고
    • Growth hormone replacement therapy improves body composition and increases bone metabolism in elderly patients with pituitary disease
    • Fernholm R., Bramnert M., Hagg E., Hilding A., Baylink D.J., Mohan S., et al. Growth hormone replacement therapy improves body composition and increases bone metabolism in elderly patients with pituitary disease. J Clin Endocrinol Metab 85 (2000) 4104-4112
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4104-4112
    • Fernholm, R.1    Bramnert, M.2    Hagg, E.3    Hilding, A.4    Baylink, D.J.5    Mohan, S.6
  • 53
    • 0033308714 scopus 로고    scopus 로고
    • Serum leptin response to the acute and chronic administration of growth hormone (GH) to elderly subjects with GH deficiency
    • Gill M.S., Toogood A.A., Jones J., Clayton P.E., and Shalet S.M. Serum leptin response to the acute and chronic administration of growth hormone (GH) to elderly subjects with GH deficiency. J Clin Endocrinol Metab 84 (1999) 1288-1295
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1288-1295
    • Gill, M.S.1    Toogood, A.A.2    Jones, J.3    Clayton, P.E.4    Shalet, S.M.5
  • 54
    • 0026590269 scopus 로고
    • Bone mineral status in growth hormone-deficient males with isolated and multiple pituitary deficiencies of childhood onset
    • Kaufman J.M., Taelman P., Vermeulen A., and Vandeweghe M. Bone mineral status in growth hormone-deficient males with isolated and multiple pituitary deficiencies of childhood onset. J Clin Endocrinol Metab 74 (1992) 118-123
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 118-123
    • Kaufman, J.M.1    Taelman, P.2    Vermeulen, A.3    Vandeweghe, M.4
  • 55
    • 0036315757 scopus 로고    scopus 로고
    • Body composition, IGF-I and IGFBP-3 concentrations as outcome measures in severely GH-deficient (GHD) patients after childhood GH treatment: a comparison with adult onset GHD patients
    • Attanasio A.F., Howell S., Bates P.C., Frewer P., Chipman J., Blum W.F., et al. Body composition, IGF-I and IGFBP-3 concentrations as outcome measures in severely GH-deficient (GHD) patients after childhood GH treatment: a comparison with adult onset GHD patients. J Clin Endocrinol Metab 87 (2002) 3368-3372
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3368-3372
    • Attanasio, A.F.1    Howell, S.2    Bates, P.C.3    Frewer, P.4    Chipman, J.5    Blum, W.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.