Effects of four years' treatment with biosynthetic human growth hormone (GH) on glucose homeostasis, insulin secretion and lipid metabolism in GH- deficient adults

Clinical Endocrinology

Volumn 48, Issue 6, 1998, Pages 795-802

  Al Shoumer, Kamal A S ^a,b   Gray, Robert ^a   Anyaoku, Victor ^a   Hughes, Carol ^a   Beshyah, Salem ^a   Richmond, William ^a   Johnston, Desmond G ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

^b KUWAIT UNIVERSITY   (Kuwait)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; CARBOHYDRATE TOLERANCE; CLINICAL ARTICLE; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GROWTH HORMONE DEFICIENCY; HUMAN; HYPOPITUITARISM; INSULIN BLOOD LEVEL; INSULIN RELEASE; LIPID METABOLISM; MALE; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

ADULT; AGED; AREA UNDER CURVE; BLOOD GLUCOSE; CHOLESTEROL; CHOLESTEROL, LDL; FEMALE; FOLLOW-UP STUDIES; GLUCOSE TOLERANCE TEST; GROWTH HORMONE; HUMAN GROWTH HORMONE; HUMANS; HYPOPITUITARISM; INSULIN; LIPID METABOLISM; MALE; MIDDLE AGED;

EID: 0031863120     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1998.00460.x     Document Type: Article

References (47)

1. Al-Shoumer, K.A.S., Page, B., Thomas, E., Murphy, M., Beshyah, S.A. & Johnston, D.G. (1996a) Effects of four years' treatment with biosynthetic human growth hormone (GH) on body composition in GH-deficient hypopituitary adults. European Journal of Endocrinology, 135, 559-567.
2. Al-Shoumer, K.A.S., Ali, K., Anyaoku, V., Niththyananthan, R. & Johnston, D.G. (1996b) Overnight metabolic fuel deficiency in patients treated conventionally for hypopituitarism. Clinical Endocrinology, 45, 171-178.
3. Al-Shoumer, K.A.S., Cox, K., Hughes, C., Richmond, W. & Johnston, D.G. (1997) Fasting and post-prandial lipid abnormalities in hypopituitary women on conventional replacement therapy. Journal of Clinical Endocrinology and Metabolism, 82, 2653-2659.
4. Bates, A.S., Hoff, W.V., Jones, P.J. & Clayton, R.N. (1996) The effects of hypopituitarism on life expectancy. Journal of Clinical Endocrinology and Metabolism, 81, 1169-1172.
5. Bengtsson, B.-Å., Eden, S., Lönn, L., Kvist, H., Stokland, A., Lindstedt, G., Bosaeus, I., Tölli, J., Sjöström, L. & Isaksson, O.G.P. (1993) Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. Journal of Clinical Endocrinology and Metabolism, 76, 309-317.
6. Beshyah, S.A., Henderson, A., Niththyananthan, R., Sharp, P., Richmond, W. & Johnston, D.G. (1994) Metabolic abnormalities in growth hormone deficient adults II: carbohydrate tolerance and lipid metabolism. Endocrinology and Metabolism, 1, 173-180.
7. Beshyah, S.A., Henderson, A., Niththyananthan, R., Skinner, E., Anyaoku, V., Richmond, W., Sharp, P. & Johnston, D.G. (1995) The effects of short and long term growth hormone therapy in hypopituitary adults on lipid metabolism and carbohydrate tolerance. Journal of Clinical Endocrinological and Metabolism, 80, 356-363.
8. Binnerts, A., Swart, G.R., Wilson, J.H.P., Hoogerbrugge, N., Pols, H.A.P., Birkenhäger, J.C. & Lamberts, S.W.J. (1992) The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clinical Endocrinology, 37, 79-87.
9. Blackett, P.R., Weech, P.K., McConathy, W.J. & Fesmire, J.D. (1982) Growth hormone in the regulation of hyperlipidemia. Metabolism, 31, 117-120.
10. Cuneo, R.C., Salomon, F., Watts, G.F., Hesp, R. & Sönksen, P.H. (1993) Growth hormone treatment improves serum lipid and lipoproteins in adults with growth hormone deficiency. Metabolism, 42, 1519-1523.
11. Davidson, M.B. (1987) Effect of growth hormone on carbohydrate and lipid metabolism. Endocrine Reviews, 8, 115-131.
12. DeBoer, H., Blok, G.J., Voerman, H.J., Philips, M. & Schouten, J.A. (1994) Serum lipid in growth hormone deficient men. Metabolism, 43, 199-203.
13. Eden, S., Wiklund, O., Oscarsson, J., Rosen, T. & Bengtsson, B.-Å. (1993) Growth hormone treatment of growth hormone deficient adults results in a marked increase in Lp(a) and HDL cholesterol concentrations. Arteriosclerosis Thrombosis, 13, 296-301.
14. Elkeles, R.S., Wright, A.D., Lowy, C. & Fraser, T.R. (1969) Serum insulin in acromegaly. Lancet, 2, 615-618.
15. Erfurth, E.M., Bülow, B., Mikozy, Z., Nordström, C.-H. & Hagmar, L. (1996) Increased cardiovascular mortality in patients with hypopituitarism. Endocrinology and Metabolism, 3 (suppl. A), 121.
16. Fineberg, S.E., Merimee, T.J., Rabinomitz, D. & Edgar, P.J. (1970) Insulin secretion in acromegaly. Journal of Clinical Endocrinology and Metabolism, 30, 288-292.
17. Garry, P., Collins, P. & Devlin, J.G. (1996) An open 36-month study of lipid changes with growth hormone in adults: lipid changes following replacement of growth hormone in adult acquired growth hormone deficiency. European Journal of Endocrinology, 134, 61-66.
18. Hampton, S.M., Morgan, L.M., Tredger, J.A., Cramb, R. & Marks, V. (1986) Insulin and C-peptide levels after oral and intravenous glucose. Diabetes, 35, 612-616.
19. Härle, U., Wüster, C.H.R., Rehn, U., Butz, S., Erdmann, J. & Ziegler, R. (1995) Effects of 18 months of recombinant human growth hormone treatment on lipid metabolism in pituitary-insufficient patients. Endocrinology and Metabolism, 2 (suppl. B), 143.
20. Jadresic, A., Banks, L.M., Child, D.F., Diamant, L., Doyle, F.H., Fraser, T.R. & Joplin, G.F. (1982) The acromegaly syndrome. Relation between clinical features, growth hormone values and radiological characteristics of the pituitary tumours. Quaternary Journal of Medicine, 202, 189-204.
21. Johansson, J.-O., Oscarsson, J., Bjarnason, R. & Bengtsson, B-Å. (1996) Two weeks of daily injections and continuous infusion of recombinant human growth hormone (GH) in GH-deficient adults. I. Effects on insulin-like growth factor-I (IGF-I), GH and IGF binding proteins, and glucose homeostasis. Metabolism, 45, 362-369.
22. Jørgensen, J.O.L., Pedersen, S.A., Thuesen, L., Jørgensen, J., Ingemann-Hansen, T., Skakkeback, N.E. & Christiansen, J.S. (1989) Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet, 1, 1221-1225.
23. Libber, S.M., Plotnick, L.P., Johanson, A.J., Blizzard, R.M., Kwiterovich, P.O. & Migeon, C.J. (1990) Long-term follow-up of hypopituitary patients treated with human growth hormone. Medicine (Baltimore), 69, 46-55.
24. Luft, R., Cerasi, E. & Hamberger, C.A. (1967) Studies on the pathogenesis of diabetes in acromegaly. Acta Endocrinologica, 56, 593-607.
25. Merimee, T.J., Hollander, W. & Fineberg, S.E. (1972) Studies of hyperlipidemia in the HGH deficient state. Metabolism, 21, 1053-1061.
26. Merimee, T.J. & Pulkkenin, A. (1980) Familial combined hyperlipidemia: evidence for a role of growth hormone deficiency in affecting its manifestation. Journal of Clinical Investigation, 65, 829-835.
27. Nabarro, J.D.N. (1987) Acromegaly. Clinical Endocrinology, 26, 481-512.
28. O'Neal, D.N., Kalfas, A., Dunning, P.L., Christopher, M.J., Sawyer, S.D., Ward, G.M. & Alfred, F.P. (1994) The effect of 3 months of recombinant human growth hormone (GH) therapy on insulin and glucose-mediated glucose disposal and insulin secretion in GH-deficient adults: a minimal model analysis. Journal of Clinical Endocrinology and Metabolism, 79, 975-983.
29. O'Neal, D., Hew, F.L., Sikaris, K., Ward, G., Alford, F. & Best, J.D. (1996) Low density lipoprotein particle size in hypopituitary adults receiving conventional hormone replacement therapy. Journal of Clinical Endocrinology and Metabolism, 81, 2448-2454.
30. Oscarsson, J., Ottosson, M., Johansson, J.-O., Wiklund, O., Mårin, P., Björntorp, P. & Bengtsson, B.-Å. (1996) Two weeks of daily injections and continuous infusion of recombinant human growth hormone (GH) and GH-deficient adults. II. Effects on serum lipoproteins and lipoprotein and hepatic lipase activity. Metabolism, 45, 370-377.
31. Rosén, T. & Bengtsson, B.-Å. (1990) Premature cardiovascular mortality in hypopituitarism - a study of 333 consecutive patients. Lancet, 336, 285-288.
32. Rosén, T., Eden, S., Laron, G., Wilhemsen, L. & Bengtsson, B.-Å. (1993) Cardiovascular risk factors in growth hormone deficient adults. Acta Endocrinologica, 129, 195-200.
33. Rosén, T., Johannsson, G., Hallgren, P., Caidahl, K., Bosaeus, I. & Bengtsson, B.-Å. (1994) Beneficial effects of 12 months replacement with recombinant human growth hormone to growth hormone deficient adults. Endocrinology and Metabolism, 1, 55-66.
34. Russell-Jones, D.L., Watts, G.F., Weissberger, A., Naoumova, R., Thompson, G.R. & Sönksen, P.H. (1994) The effect of growth hormone replacement on serum lipids, lipoproteins, apolipoproteins and cholesterol precursors in adult growth hormone deficient patients. Clinical Endocrinology, 41, 345-350.
35. Salomon, F., Cuneo, R.C., Hesp, R. & Sönksen, P.H. (1989) The effects of treatment with recombinant human growth on body composition and metabolism in adults with growth hormone deficiency. New England Journal of Medicine, 321, 1797-1803.
36. Salomon, F., Cuneo, R.C., Umpleby, A.M. & Sönksen, P.H. (1994) Interactions of body fat and muscle mass with substrate concentrations and fasting insulin levels in adults with growth hormone deficiency. Clinical Science, 87, 201-206.
37. Schaefer, G.B., Greger, N.G., Fesmire, J.D., Blackett, P.R., Wilson, D.P. & Frindik, J.P. (1994) Lipids and apolipoproteins in growth hormone deficient children during treatment. Metabolism, 43, 1457-1461.
38. Sönksen, P.H., Greenwood, F.C., Ellis, J.P., Lowy, C., Rutherford, A. & Nabarro, J.D.N. (1967) Changes in carbohydrate tolerance in acromegaly with progress of disease, and response to treatment. Journal of Clinical Endocrinology and Metabolism, 27, 1418-1430.
39. Sönksen, P.H., Cuneo, R.C., Salomon, F., McGauley, G., Wiles, C.M., Wilmshurst, P., Byrne, C., Hesp, R., Lowy, C. & Weissberger, A. (1991) Growth hormone therapy in adults with growth hormone deficiency. Acta Paediatrica Scandinavia, 397 (suppl.), 139-146.
40. Summers, V.H., Hipkin, L.J. & Davis, J.C. (1967) Serum lipids in diseases of the pituitary. Metabolism, 12, 1106-1113.
41. Trimble, E.R., Atkinson, A.B., Buchanan, K.D. & Hadden, D.R. (1980) Plasma glucagon and insulin concentrations in acromegaly. Journal of Clinical Endocrinology and Metabolism, 51, 626-631.
42. +2 precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clinical Chemistry, 28, 1379-1388.
43. Wass, J.A.H., Cudworth, A.G., Bottazzo, G.F., Woodrow, J.C. & Besser, G.M. (1980) An assessment of glucose intolerance in acromegaly, and its response to medical treatment. Clinical Endocrinology, 12, 53-59.
44. Weaver, J.U., Manson, J.P., Noonan, K., John, W.G., Edwards, A., Evans, K.A. & Cunningham, J. (1995) The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults. Journal of Clinical Endocrinology and Metabolism, 80, 153-159.
45. Whitehead, H.M., Boreham, C., Mcllrath, E.M., Sheridan, B., Kennedy, L., Atkinson, A.B. & Hadden, D.R. (1992) Growth hormone treatment of adults with growth hormone deficiency: results of a 13-months placebo controlled cross over study. Clinical Endocrinology, 36, 45-52.
46. Winter, R.J., Thompson, R.G. & Green, O.C. (1979) Serum cholesterol and triglycerides in children with growth hormone deficiency. Metabolism, 28, 1244-1249.
47. Wüster, C., Slenczka, E. & Ziegler, R. (1991) Erhöhte Prävalenz von Osteoprose und Arteriosklerose bei konventionell substituierter hypophysenvorderlappen Insuffizienz: Bedraf einer zusätzlichen Wachstumshormonsubstitution? Klinische Wochenschrift, 68, 769-773.