Survivors of childhood acute lymphoblastic leukaemia, with radiation-induced GH deficiency, exhibit hyperleptinaemia and impaired insulin sensitivity, unaffected by 12 months of GH treatment

Clinical Endocrinology

Volumn 61, Issue 6, 2004, Pages 683-691

  Bülow, Birgitta ^a   Link, Katarina ^a   Ahrén, Bo ^a   Nilsson, Ann Sofie ^a   Erfurth, Eva Marie ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; INSULIN; LEPTIN; SOMATOMEDIN C;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ARTICLE; BODY COMPOSITION; BODY MASS; CANCER RADIOTHERAPY; CANCER SURVIVAL; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FEMALE; GROWTH HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MALE; OBESITY; PRIORITY JOURNAL;

ADULT; BLOOD GLUCOSE; BODY COMPOSITION; BODY MASS INDEX; CASE-CONTROL STUDIES; FATTY ACIDS, NONESTERIFIED; FEMALE; GLUCOSE; GROWTH HORMONE; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; MALE; SURVIVORS;

EID: 10944220736     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2004.02149.x     Document Type: Article

References (52)

1. Al-Shoumer, K.A.S., Gray, R., Anyaoku, V., Hughes, C., Beshyah, S., Richmond, W. & Johnston, D.G. (1998) Effects of four years' treatment with biosynthetic human growth hormone (GH) on glucose homeostasis, insulin secretion and lipid metabolism in GH-deficient adults. Clinical Endocrinology, 48, 795-802.
2. Andrews, R.C. & Walker, B.R. (1999) Glucocorticoids and insulin resistance: old hormones, new targets. Clinical Science, 96, 513-523.
3. Ashworth, L., Gibb, I. & Alberti, K.G.M.M. (1992) HemoCue: evaluation of a portable photometric system for determining glucose in whole blood. Clinical Chemistry, 38, 1479-1482.
4. Barinaga, M., Yomonoto, G., Rivier, C., Vale, W., Evans, R. & Rosenfeld, M.G. (1983) Transcriptional regulation of growth hormone gene expression by growth hormone-releasing factor. Nature, 306, 84-85.
5. Bengtsson, B.-Å., Edén, S., Lönn, L., Kvist, H., Stokland, A., Lindstedt, G., Bosaeus, I., Tölli, J., Sjöström, L. & Isaksson, O.G. (1993) Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. Journal of Clinical Endocrinology and Metabolism, 76, 309-317.
6. Beshyah, S.A., Henderson, A., Niththyananthan, R., Skinner, E., Anyaoku, V., Richmond, W., Sharp, P. & Johnston, D.G. (1995) The effects of short and long term growth hormone replacement therapy in hypopituitary adults on lipid metabolism and carbohydrate tolerance. Journal of Clinical Endocrinology and Metabolism, 80, 356-363.
7. Bianda, T.L., Glatz, Y., Boeni-Sehnetzler, M., Froesch, E.R. & Schmid, C. (1997) Effects of growth hormone (GH) and insulin-like growth factor-I on serum leptin in GH-deficient adults. Diabetologia, 40, 363-364.
8. Birkebaek, N.H., Fisker, S., Clausen, N., Tuovinen, V., Sindet-Pedersen, S. & Christiansen, J.S. (1998) Growth and endocrinological disorders up to 21 years after treatment of acute lymphoblastic leukemia in childhood. Medical and Pediatric Oncology, 30, 351-356.
9. Boeni-Schnetzler, M., Gosteli-Peter, M.A., Moritz, W., Froeseh, E.R. & Zapf, J. (1996) Reduced ob mRNA in hypophysectomised rats is not restored by growth hormone (GH), but further suppressed by exogenously administered insulin-like growth factor (IGF) I. Biochemical and Biophysical Research Communications, 225, 296-301.
10. Brennan, B.M.D., Rahim, A., Blum, W.F., Adams, J.A., Eden, O.B. & Shalet, S.M. (1999) Hyperleptinaemia in young adults following cranial irradiation in childhood: growth hormone deficiency or leptin insensitivity? Clinical Endocrinology, 50, 163-169.
11. Brennan, B.M.D., Rahim, A., Mackie, E.M., Eden, O.B. & Shalet, S.M. (1998) Growth hormone status in adults treated for acute lymphoblastic leukaemia in childhood. Clinical Endocrinology, 48, 777-783.
12. Bülow, B. & Erfurth, E.M. (1999) A low individualized GH dose in young patients with childhood onset GH deficiency normalized serum IGF-I without significant deterioration in glucose tolerance. Clinical Endocrinology, 50, 45-55.
13. Chessells, J.M., Bailey, C. & Richards, S.M. (1995) Intensification of treatment and survival in all children with lymphoblastic leukaemia: results of UK Medical Research Council trial UKALL X. Lancet, 345, 143-148.
14. Chrisoulidou, A., Beshyah, S.A., Rutherford, O., Spinks, T.J., Mayet, J., Kyd, P., Anyaoku, V., Haida, A., Ariff, B., Murphy, M., Thomas, E., Robinson, S., Foale, R. & Johnston, D.G. (2000) Effects of 7 years of growth hormone replacement therapy in hypopituitary adults. Journal of Clinical Endocrinology and Metabolism, 85, 3762-3769.
15. Christopher, M., Hew, F.L., Oakley, M., Rantzau, C. & Alford, F. (1998) Defects of insulin action and skeletal muscle glucose metabolism in growth hormone-deficient adults persist after 24 months of recombinant human growth hormone therapy. Journal of Clinical Endocrinology and Metabolism, 83, 1668-1681.
16. Constine, L.S., Woolf, P.D., Cann, D., Mick, G., McCormick, K., Raubertas, R.F. & Rubin, P. (1993) Hypothalmic-pituitary dysfunction after radiation for brain tumors. New England Journal of Medicine, 328, 87-94.
17. Cordido, F., Dieguez, C. & Casanueva, F.F. (1990) Effect of central cholinergic neurotransmission enhancement by pyridostigmine on the growth hormone secretion elicited by clonidine, arginine, or hypoglycemia in normal and obese subjects. Journal of Clinical Endocrinology and Metabolism, 70, 1361-1370.
18. Cryer, P. & Gerich, J. (1985) Glucose counterregulation, hypoglycemia, and intensive insulin therapy in diabetes mellitus. New England Journal of Medicine, 313, 232-241.
19. Darzy, K.H., Aimaretti, G., Wieringa, G., Rao Gattamaneni, H., Ghigo, E. & Shalet, S.M. (2003) The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time interval. Journal of Clinical Endocrinology and Metabolism, 88, 95-102.
20. DeFronzo, R.A., Tobin, J.D. & Andres, R. (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. American Journal of Physiology, 237, E214-E223.
21. Diamond, M.P., Grant, D.B. & Defronzo, R.A. (1989) Menstrual cyclicity has a profound effect on glucose homeostasis. Fertility and Sterility, 52, 204-208.
22. Elimam, A., Lindgren, A.C., Norgren, S., Kamel, A., Skwirut, C., Bang, P. & Marcus, C. (1999) Growth hormone treatment downregulates serum leptin levels in children independent of changes in body mass index. Hormone Research, 52, 66-72.
23. Foss, M.C., Paula, F.J., Paccola, G.M. & Piccinato, C.E. (1995) Peripheral glucose metabolism in human hyperprolactinaemia. Clinical Endocrinology, 43, 721-726.
24. Fowelin, J., Attvall, S., Lager, I. & Bengtsson, B.-Å. (1993) Effects of treatment with recombinant human growth hormone on insulin sensitivity and glucose metabolism in adults with growth hormone deficiency. Metabolism, 42, 1443-1447.
25. Ghigo, E., Aimaretti, G., Arvat, E. & Camanni, F. (2001) Growth hormone-releasing hormone combined with arginine or growth hormone secretagogues for the diagnosis of growth hormone deficiency in adults. Endocrine, 15, 29-38.
26. Growth Hormone Research Society (GRS). (1998) Consensus guidelines for the Diagnosis and treatment of adults with growth hormone deficiency: summary statement of the growth hormone research society workshop on adult growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism, 83, 379-381.
27. Gustafsson, G., Garwicz, S., Hertz, H., Johanesson, G., Jonmundsson, G., Moe, P.J., Salmi, T., Seip, M., Siimes, M.A., Yssing, M. & Åhström, L. (1987) A population-based study of childhood acute lymphoblastic leukemia diagnosed from July 1981 through June 1985 in the five Nordic countries. Acta Paediatrica Scandinavica, 76, 781-788.
28. Gustafsson, G., Kreuger, A., Clausen, N., Garwicz, S., Kristinsson, J., Lie, S.O., Moe, P.J., Perkkiö, M., Yssing, M. & Saarinen-Pihkala, U.M. (1998) Intensified treatment of acute childhood lymphoblastic leukaemia has improved prognosis, especially in non-high risk patients: the Nordic experience of 2648 patients diagnosed between 1981 and 1996. Acta Paediatrica, 87, 1151-1161.
29. Gustafsson, G., Kreuger, A. & Dohlwitz, A. (1981) Acute lymphoblastic leukemia in Swedish children 1973-78. Acta Paediatrica Scandinavica, 70, 609-614.
30. Hew, F.L., Koschmann, M., Christopher, M., Rantzau, C., Vaag, A., Ward, G., Beck-Nielsen, H. & Alford, F. (1996) Insulin resistance in growth hormone-deficient adults: defects in glucose utilization and glycogen synthase activity. Journal of Clinical Endocrinology and Metabolism, 81, 555-564.
31. Hillebrand, J.J.G., de Wied, D. & Adan, R.A.H. (2002) Neuropeptides, food intake and body weight regulation: a hypothalamic focus. Peptides, 23, 2283-2306.
32. Hwu, C.-M., Kwok, C.F., Lai, T.-Y., Shih, K.-C., Lee, T.-S., Hsiao, L.-C., Lee, S.-H., Fang, V.S. & Ho, L.-T. (1997) Growth hormone (GH) replacement reduces total body fat and normalizes insulin sensitivity in GH-deficient adults: a report of one-year clinical experience. Journal of Clinical Endocrinology and Metabolism, 82, 3285-3292.
33. Johansson, J.-O., Fowelin, J., Landin, K., Lager, I. & Bengtsson, B.-Å. (1995) Growth hormone-deficient adults are insulin resistant. Metabolism, 44, 1126-1129.
34. Jørgensen, J.O.L., Pedersen, S.A., Thuesen, L., Jørgensen, J., Ingemann-Hansen, T., Skakkebaek, N.E. & Christiansen, J.S. (1989) Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet, i, 1221-1225.
35. Kelley, D.E., Williams, K.V., Price, J.C., McKolanis, T.M., Goodpaster, B.H. & Thaete, F.L. (2001) Plasma fatty acids, adiposity, and variance of skeletal muscle insulin resistance in type 2 diabetes mellitus. Journal of Clinical Endocrinology and Metabolism, 86, 5412-5419.
36. Khalfallah, Y., Sassolas, G., Borson-Chazot, F., Vega, N. & Vidal, H. (2001) Expression of insulin target genes in skeletal muscle and adipose tissue in adult patients with growth hormone deficiency: effect of one year recombinant human growth hormone therapy. Journal of Endocrinology, 171, 285-292.
37. Link, K., Moëll, C., Garwicz, S., Cavallin-Ståhl, E., Björk, J., Thilén, U., Ahrén, B. & Erfurth, E.M. (2004) GH deficiency predicts cardiovascular risk in young adults treated for acute lymphoblastic leukaemia (ALL) in childhood. Journal of Clinical Endocrinology and Metabolism, 89, 5003-5012.
38. Livingstone, C. & Collison, M. (2002) Sex steroids and insulin resistance. Clinical Science, 102, 151-166.
39. Ma, Z.A., Gingerich, R.L., Santiago, J.V., Klein, S., Smith, C.H. & Landt, M. (1996) Radioimmunoassay of leptin in human plasma. Clinical Chemistry, 42, 942-946.
40. McConnell, E.M., Atkinson, A.B., Ennis, C., Hadden, D.R., McCance, D.R., Sheridan, B. & Bell, P.M. (2001) The effects on insulin action in adult hypopituitarism of recombinant human GH therapy individually titrated for six months. Journal of Clinical Endocrinology and Metabolism, 86, 5342-5347.
41. Moëll, C., Garwicz, S., Marky, I., Mellander, L. & Karlberg, J. (1988) Growth in children treated for acute lymphoblastic leukemia with and without prophylactic cranial irradiation. Acta Paediatrica Scandinavica, 77, 688-692.
42. Nysom, K., Holm, K., Michaelsen, K.F., Hertz, H., Müller, J. & Mølgaard, C. (1999) Degree of fatness after treatment for acute lymphoblastic leukemia in childhood. Journal of Clinical Endocrinology and Metabolism, 84, 4591-4596.
43. Oeffinger, K.C., Buchanan, G.R., Eshelman, D.A., Denke, M.A., Andrews, T.C., Germak, J.A., Tomlinson, G.E., Snell, M.E. & Foster, B.M. (2001) Cardiovascular risk factors in young adult survivors of childhood acute lymphoblastic leukemia. Journal of Pediatric Hematology/Oncology, 23, 424-430.
44. Pelkonen, R., Nikkilä, E.A. & Grahne, B. (1982) Serum lipids, post-heparin plasma lipase activities and glucose tolerance in patients with prolactonoma. Clinical Endocrinology, 16, 383-390.
45. Randle, P.J., Garland, P.B. & Hales, C.N. (1963) The glucose fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet, i, 785-789.
46. Reaven, G.M. (1988) Banting lecture. Role of insulin resistance in human disease. Diabetes, 37, 1595-1607.
47. Rosenfalck, A.M., Maghsoudi, S., Fisker, S., Jørgensen, J.O.L., Christiansen, J.S., Hilsted, J., Vølund, A.A. & Madsbad, S. (2000) The effect of 30 months of low-dose replacement therapy with recombinant human growth hormone (rhGH) on insulin and C-peptide kinetics, insulin secretion, insulin sensitivity, glucose effectiveness, and body composition in GH-deficient adults. Journal of Clinical Endocrinology and Metabolism, 85, 4173-4181.
48. Saunders, J., Hall, S.E. & Sönksen, P.H. (1980) Glucose and free fatty acid turnover in thyrotoxicosis and hypothyroidism, before and after treatment. Clinical Endocrinology, 13, 33-44.
49. Svensson, J., Fowelin, J., Landin, K., Bengtsson, B.-Å. & Johansson, J.O. (2002) Effects of seven years of GH-replacement therapy on insulin sensitivity in GH-deficient adults. Journal of Clinical Endocrinology and Metabolism, 87, 2121-2127.
50. Thorell, J.I. & Larson, S.M. (1978) Radioimmunoassay and Related Techniques, pp. 205-211. CV Mosby Co, St Louis.
51. Weaver, J.U., Monson, J.P., Noonan, K., John, W.G., Edwards, A., Evans, K.A. & Cunningham, J. (1995) The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults. Journal of Clinical Endocrinology and Metabolism, 80, 153-159.
52. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. & Friedman, J.M. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature, 1, 372.