Insulin sensitivity in growth hormone (GH)-deficient adults and effect of GH replacement therapy

Journal of Endocrinological Investigation

Volumn 22, Issue 5 SUPPL., 1999, Pages 28-32

  Alford, F P ^a   Hew, F L ^b   Christopher, M C ^b   Rantzau, C ^b  

^a ST VINCENT S HOSPITAL   (Australia)

^b NONE

Author keywords

Glycogen synthesis; Glycolytic flux; Growth hormone deficient adults; Insulin sensitivity

Indexed keywords

GLYCOGEN; HUMAN GROWTH HORMONE;

ADULT; ARTICLE; BIOSYNTHESIS; CASE CONTROL STUDY; DRUG EFFECT; GLUCOSE CLAMP TECHNIQUE; GLYCOGEN LIVER LEVEL; GLYCOLYSIS; HORMONE SUBSTITUTION; HUMAN; INSULIN RESISTANCE; LIVER; METABOLISM; MUSCLE;

ADULT; CASE-CONTROL STUDIES; GLUCOSE CLAMP TECHNIQUE; GLYCOGEN; GLYCOLYSIS; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; INSULIN RESISTANCE; LIVER; LIVER GLYCOGEN; MUSCLES;

EID: 0032602201     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Rosén T., Bosaeus I., Tölli J., Lindstedt G., Bengtsson B.-Å. Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency. Clin. Endocrinol. (Oxf.) 1993, 38: 63.
2. O'Neal D.N., Hew F.L., Sikaris K., Ward G., Alford F., Best J.D. Low density lipoprotein particle size in hypopituitary adults on conventional hormone replacement therapy. J. Clin. Endocrinol. Metab. 1996, 81: 2448
3. Johansson J.O., Landin K., Tengborn L., Rosén T., Bengtsson B.-Å. High fibrinogen and plasminogen activator inhibitor activity in growth hormone-deficient adults. Arterioscler. Thromb. 1994, 14: 434.
4. Beshyah S.A., Henderson A., Niththyananthan R., Sharp P., Richmond W., Johnston D.G. Metabolic abnormalities in growth hormone-deficient adults. II. Carbohydrate tolerance and lipid metabolism. Am. J. Physiol. 1994, 1: 173.
5. Hew F.L., O'Neal D.N., Kamarudin N., Alford F.P., Best J.D. Growth hormone deficiency and cardiovascular risk. In: Shalet S. (Ed.), Baillère's Clinical Endocrinology and metabolism. Ballière Tindall, Eastbourne, UK (in press).
6. Landon J., Greenwood F.C., Stamp T.C.B., Wynn V. The plasma sugar, free fatty acid, cortisol and growth hormone response to insulin, and the comparison of this procedure with other tests of pituitary and adrenal function. II. In patients with hypothalamic or pituitary dysfunction or anorexia nervosa. J. Clin. Invest. 1996, 45: 437.
7. O'Neal D.N., Kalfas A., Dunning P.L., Christopher M.J., Sawyer S.D., Ward G.M., Alford F.P. The effects of three months of recombinant human growth hormone (rhGH) therapy on insulin and glucose-mediated glucose disposal and insulin secretion in GH-deficient adults. J. Clin. Endocrinol. Metab. 1994, 79: 975.
8. Hew F.L., Koschmann M., Kreiger T., Christopher M., Rantzau C., Ward G., Alford P. Insulin tolerance test in patients with anterior pituitary hormone deficiency: reduced insulin sensitivity. Am. J. Physiol. 1995, 2: 93.
9. Weaver J.U., Monson J.P., Noonan K., John W.G., Edwards A., Evans K.A., Cunningham J. The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults. J. Clin. Endocrinol. Metab. 1995, 80: 153.
10. Johansson J.-O., Fowelin J., Landin K., Lager A., Bengtsson B.A. Growth hormone-deficient adults are insulin resistant. Metabolism 1995, 44: 1126.
11. Hew F.L., Koschmann M., Christopher M., Rantzau C., Vaag A., Ward G., Beck-Nielsen H., Alford F. Insulin resistance in growth hormone-deficient adults: defects in glucose utilization and glycogen synthase activity. J. Clin. Endocrinol. Metab. 1996, 81: 555.
12. Hwu C.-M., Kwok C.F., Lai T.-Y., Shih K.-C, Lee T.-S., Hsiao L.-C., Lee S.-H., Fang V.S., Ho L.-T. Growth hormone replacement reduces total body fat and normalizes insulin sensitivity in GH-deficient adults: a report of one year clinical experience. J. Clin. Endocrinol. Metab. 1997, 82: 3285.
13. Bengtsson B.-Á., Edén S., Lönn L., Kvist H., Stokland A., Lindstedt G., Bosaeus I., Tölli J., Sjöström L., Isaksson O. Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J. Clin. Endocrinol. Metab. 1993, 76: 309.
14. Fowelin J., Attvall S., Lager I., Bengtsson B.-Å. Effects of treatment with recombinant human growth hormone on insulin sensitivity and glucose metabolism in adults with growth hormone deficiency. Metabolism 1993, 42: 1443.
15. Vaag A., Damsbo P., Hother-Nielsen O., Beck-Nielsen H. Hyperglycaemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with type 2 (non-insulin dependent) diabetes mellitus. Diabetologia 1992, 35: 80.
16. Rothman D.L., Shulman R.G., Shulman G.I. 31P Nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. J. Clin. Invest. 1992, 89: 1069.
17. Vestergaard H., Bjorbaek C., Hansen T., Larsen F.S., Granner D.K., Pedersen O. Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients. J. Clin. Invest. 1995, 96: 2639.
18. Kelley D.E., Mintun M.A., Watkins S.C., Simoneau A., Jadali F., Fredrickson A., Beattie J., Theriault R. The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle. J. Clin. Invest. 1996, 97: 2705.
19. Christopher M., Hew F.L., Oakley M., Rantzau C., Alford F. Defects of insulin action and skeletal muscle glucose metabolism in growth hormone-deficient adults persist after 24 months of recombinant human growth hormone therapy. J. Clin. Endocrinol. Metab. 1998, 83: 1668.
20. Carey D.G., Jenkins A.B., Campbell L.V., Freund J., Chisholm D.J. Abdominal fat and insulin resistance in normal and overweight women. Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Diabetes 1996, 45: 633.
21. Sönksen P.H., Greenwood F.C., Ellis J.P., Lowy C., Rutherford A., Nabarro J.D.N. Changes in carbohydrate tolerance in acromegaly with progress of the disease and its response to treatment. J. Clin. Endocrinol. Metab. 1967, 27: 1418.
22. Julien D., Heydrick S.J., Gautier S.J., Van Obberghen E., Le Marchand-Brustel Y. Effect of IGF-I on phosphatidylinositol 3-kinase in soleus muscle of lean and insulin-resistant obese mice. Diabetes 1996, 45: 869.
23. Nikoulina S.E., Ciaraldi T.P., Abrams-Carter L., Madalier S., Park K.S., Henry R.R. Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes. Role of chronic hyperinsulinemia and hyperglycemia. Diabetes 1997, 46: 1017.
24. Del Prato S., Leonetti F., Simonsen D.C., Sheehan P., Matsuda M., De Fronzo R.A. Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia 1994, 37: 1025.