Persistent HIV-1-specific CTL clonal expansion despite high viral burden post in utero HIV-1 infection

Journal of Immunology

Volumn 162, Issue 8, 1999, Pages 4796-4800

  Brander, Christian ^a   Goulder, Philip J R ^a   Luzuriaga, Katherine ^b   Yang, Otto O ^a   Hartman, Kelly E ^a   Jones, Norman G ^a   Walker, Bruce D ^a   Kalams, Spyros A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; CD3 ANTIGEN; COMPLEMENTARY DNA; EPITOPE; HLA A ANTIGEN; HLA ANTIGEN CLASS 1; HLA B7 ANTIGEN; HLA C ANTIGEN; MONOCLONAL ANTIBODY; NELFINAVIR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; VIRUS ANTIGEN; VIRUS PROTEIN; ZIDOVUDINE;

ARTICLE; CASE REPORT; CHILD; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONONUCLEAR CELL; NUCLEOTIDE SEQUENCE; PRENATAL EXPOSURE; PRIORITY JOURNAL; VIRUS LOAD; VIRUS REPLICATION;

CHILD, PRESCHOOL; CLONE CELLS; CYTOTOXICITY TESTS, IMMUNOLOGIC; EPITOPES, T-LYMPHOCYTE; FEMALE; GENE PRODUCTS, GAG; HIV INFECTIONS; HIV-1; HUMANS; INFANT; LYMPHOCYTE COUNT; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PUERPERAL INFECTION; STEM CELLS; T-LYMPHOCYTES, CYTOTOXIC; VIRAL LOAD; VIRUS LATENCY; VIRUS REPLICATION;

EID: 0033561632     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Yang, O. O., and B. D. Walker. 1997. CD8 cells in human immunodeficiency virus type 1 pathogenesis: cytolytic and noncytolytic inhibition of viral replication. Adv. Immunol. 66:273.
2. Moss, P. A., S. L. Rowland-Jones, P. M. Frodsham, S. McAdam, P. Giangrande, A. J. McMichael, and J. I. Bell. 1995. Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors. Proc. Natl. Acad Sci. USA 92:5773.
3. Kalams, S. A., R. P. Johnson, A. K. Trocha, M. J. Dynan, H. S. Ngo, R. T. Daquila, J. T. Kurnick, and B. D. Walker. 1994. Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. J. Exp. Med. 179:1261.
4. Pantaleo, G., J. F. Demarest, T. Schacker, M. Vaccarezza, O. J. Cohen, M. Daucher, C. Graziosi, S. S. Schnittman, T. C. Quinn, G. M. Shaw, L. Perrin, G. Tambussi, A. Lazzarin, R. P. Sekaly, H. Soudeyns, L. Corey, and A. S. Fauci. 1997. The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc. Natl. Acad. Sci. USA 94:254.
5. Luzuriaga, K., D. Holmes, A. Hereema, J. Wong, D. L. Panicali, and J. L. Sullivan. 1995. HIV-1-specific cytotoxic T lymphocyte responses in the first year of life. J. Immunol. 154:433.
6. Pikora, C. A., J. L. Sullivan, D. Panicali, and K. Luzuriaga. 1997. Early HIV-1 envelope-specific cytotoxic T lymphocyte responses in vertically infected infants. J. Exp. Med. 185:1153.
7. Cheynier, R., D. P. Langlade, M. R. Marescot, S. Blanche, G. Blondin, H. S. Wain, C. Griscelli, E. Vilmer, and F. Plata. 1992. Cytoloxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus-1-infected mothers. Eur. J. Immunol. 22:2211.
8. Buseyne, F., S. Blanche, D. Schmitt, C. Griscelli, and Y. Riviere. 1993. Detection of HIV-specific cell-mediated cytotoxicity in the peripheral blood from infected children. J. Immunol. 150:3569.
9. Walker, B. D., C. Flexner, K. Birch-Limberger, L. Fisher, T. J. Paradis, A. Aldovini, R. Young, B. Moss, and R. T. Schooley. 1989. Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 86:9514.
10. Walker, B. D., S. Chakrabarti, B. Moss, T. J. Paradis, T. Flynn, A. G. Durno, R. S. Blumberg, J. C. Kaplan, M. S. Hirsch, and R. T. Schooley. 1987. HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature 328:345.
11. + cells: evidence for HLA class 1-restricted triggering of cytolytic and noncytolytic mechanisms. J. Virol. 71:3120.
12. Brander, C., and B. D. Walker. 1996. The HLA class 1 restricted CTL response in HIV infection: systematic identification of optimal epitopes. In HIV Molecular Immunology Database. B. Korber, C. Brandes, B. Walker, R. Koup, J. Moore, B. Haynes, G. Meyers, eds. Los Alamos National Laboratory: Theoretical Biology and Biophysics, Los Alamos, NM, p. IV-50.
13. Brander, C., K. E. Hartman, A. K. Trocha, N. G. Jones, R. P. Johnson, B. Korber, P. Wentworth, S. P. Buchbinder, S. Wolinsky, B. D. Walker, and S. A. Kalams. 1998. Lack of strong immune selection pressure by the immunodominant, HLA-A*0201 restricted CTL response in chronic HIV-1 infection. J. Clin. Invest. 101: 2559.
14. Goulder, P. J. R., A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. 1997. Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses on two human histocompatibility leukocyte antigen identical siblings with HLA-A*0201 are influenced by epitope mutation. J. Exp. Med. 185:1423.
15. Moskophidis, D., F. Lechner, H. Pircher, and R. M. Zinkemagel. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362:758.
16. Ogg, G. S., X. Jin, S. Bonhoeffer, P. R. Durbar, M. A. Nowak, S. Monard, J. P. Segal, Y. Cao, S. L. Rowland-Jones, V. Cerundolo, A. Hurley, M. Markowitz, D. D. Ho, D. F. Nixon, and A. J. McMichael. 1998. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 279:2103.
17. + T cell responses associated with control of viremia. Science 278:1447.
18. Singh, R. R., B. H. Hahn, and E. E. Sercarz. 1996. Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity. J. Exp. Med. 183:1613.
19. Wilson, C. B., J. Westall, L. Johnston, D. B. Lewis, K. Dower, and A. R. Alpert. 1986. Decreased production of interferon-γ by human neonatal cells. J. Clin. Invest. 77:860.
20. Sarzotti, M., D. S. Robbins, and P. M. Hoffman. 1996. Induction of protective CTL responses in newborn mice by a murine retrovirus. Science 271:1726.
21. Rocha, B., and H. von Boehmer. 1991. Peripheral selection of the T cell repertoire. Science 251:1225.
22. Rocha, B., A. Grandien, and A. A. Freitas. 1995. Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J. Exp. Med. 181:993.
23. Roecken, M., and E. Shevach. 1996. Immune deviation: the third dimension of nondeletional T cell tolerance. Immunol. Rev. 149:175.
24. Kovarik, J., and C. A. Siegrist. 1998. Immunity in early life. Immunol. Today 19:150.
25. Brunell, P. A., and G. S. Kotchmar, Jr. 1981. Zoster in infancy: failure to maintain virus latency following intrauterine infection. J. Pediatr. 98:71.
26. Risdon, G., J. Gaddy, F. B. Stehman, and H. E. Broxmeyer. 1994. Proliferative and cytotoxic responses of human cord blood T lymphocytes following allogeneic stimulation. Cell. Immunol. 154:14.
27. Takahashi, N., K. Imanishi, H. Nishida, and T. Uchiyama. 1995. Evidence for immunologic immaturity of human cord blood T cells. J. Immunol. 155:5213.
28. Feeney, A. J., K. D. Victor, K. Vu, B. Nadel, and R. U. Chukwuocha. 1994. Influence of the V(D)J recombination mechanisms on the formation of the primary T and B cell repertoires. Semin. Immunol. 6:155.
29. Zinkernagel, R. M., and P. C. Doherty. 1979. MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv. Immunol. 27:51.
30. Zinkernagel, R. M., and H. Hengartner. 1994. T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS. Immunol. Today 15:262.