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Volumn 65, Issue 1, 2010, Pages 5-8

Insulin-like growth factor-1 modulates Ca2+ homeostasis and apoptosis of cultured dorsal root ganglion neurons with excitotoxicity induced by glutamate

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CALCIUM; EXCITATORY AMINO ACID; GLUTAMIC ACID; PROCASPASE 3; SOMATOMEDIN C;

EID: 76149098516     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2010.9662     Document Type: Article
Times cited : (6)

References (50)
  • 1
    • 0030745199 scopus 로고    scopus 로고
    • IGF-I enhances neurite regeneration but is not required for its survival in adult DRG explant
    • Akahori Y, Horie H (1997) IGF-I enhances neurite regeneration but is not required for its survival in adult DRG explant. Neuroreport 8: 2265-2269.
    • (1997) Neuroreport , vol.8 , pp. 2265-2269
    • Akahori, Y.1    Horie, H.2
  • 3
    • 0033609658 scopus 로고    scopus 로고
    • The effects of changing intracellular Ca2+ buffering on the excitability of cultured dorsal root ganglion neurones
    • Ayar A, Storer C, Tatham EL, Scott RH (1999) The effects of changing intracellular Ca2+ buffering on the excitability of cultured dorsal root ganglion neurones. Neurosci Lett 271: 171-174.
    • (1999) Neurosci Lett , vol.271 , pp. 171-174
    • Ayar, A.1    Storer, C.2    Tatham, E.L.3    Scott, R.H.4
  • 4
    • 14744278073 scopus 로고    scopus 로고
    • Central penetration and stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat
    • Baker AM, Batchelor DC, Thomas GB, Wen JY, Rafiee M, Lin H, Guan J (2005) Central penetration and stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat. Neuropeptides 39: 81-87.
    • (2005) Neuropeptides , vol.39 , pp. 81-87
    • Baker, A.M.1    Batchelor, D.C.2    Thomas, G.B.3    Wen, J.Y.4    Rafiee, M.5    Lin, H.6    Guan, J.7
  • 6
    • 0035828123 scopus 로고    scopus 로고
    • Delayed application of IGF-I and GDNF can rescue already injured postnatal motor neurons
    • Bilak MM, Kuncl RW (2001) Delayed application of IGF-I and GDNF can rescue already injured postnatal motor neurons. Neuroreport 12: 2531-2535.
    • (2001) Neuroreport , vol.12 , pp. 2531-2535
    • Bilak, M.M.1    Kuncl, R.W.2
  • 7
    • 0035156362 scopus 로고    scopus 로고
    • Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons
    • Bomze HM, Bulsara KR, Iskandar BJ, Caroni P, Skene JH (2001) Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons. Nat Neurosci 4: 38-43.
    • (2001) Nat Neurosci , vol.4 , pp. 38-43
    • Bomze, H.M.1    Bulsara, K.R.2    Iskandar, B.J.3    Caroni, P.4    Skene, J.H.5
  • 10
    • 22144488038 scopus 로고    scopus 로고
    • Proinflammatory cytokines and apoptosis following glutamate-induced excitotoxicity mediated by p38 MAPK in the hippocampus of neonatal rats
    • Chaparro-Huerta V, Rivera-Cervantes MC, Flores-Soto ME, Gómez-Pinedo U, Beas-Zárate C (2005) Proinflammatory cytokines and apoptosis following glutamate-induced excitotoxicity mediated by p38 MAPK in the hippocampus of neonatal rats. J Neuroimmunol 165: 53-62.
    • (2005) J Neuroimmunol , vol.165 , pp. 53-62
    • Chaparro-Huerta, V.1    Rivera-Cervantes, M.C.2    Flores-Soto, M.E.3    Gómez-Pinedo, U.4    Beas-Zárate, C.5
  • 11
    • 0037120230 scopus 로고    scopus 로고
    • Preferential expression of IGF-I in small DRG neurons and down-regulation following injury
    • Craner MJ, Klein JP, Black JA,Waxman SG (2005) Preferential expression of IGF-I in small DRG neurons and down-regulation following injury. Neuroreport 13: 1649-1652.
    • (2005) Neuroreport , vol.13 , pp. 1649-1652
    • Craner, M.J.1    Klein, J.P.2    Black, J.A.3    Waxman, S.G.4
  • 12
    • 0033625082 scopus 로고    scopus 로고
    • Mobilisation of intracellular Ca2+ by mGluR5 metabotropic glutamate receptor activation in neonatal rat cultured dorsal root ganglia neurones
    • Crawford JH, Wainwright A, Heavens R, Pollock J, Martin DJ, Scott RH, Seabrook GR (2000) Mobilisation of intracellular Ca2+ by mGluR5 metabotropic glutamate receptor activation in neonatal rat cultured dorsal root ganglia neurones. Neuropharmacology 39: 621-630.
    • (2000) Neuropharmacology , vol.39 , pp. 621-630
    • Crawford, J.H.1    Wainwright, A.2    Heavens, R.3    Pollock, J.4    Martin, D.J.5    Scott, R.H.6    Seabrook, G.R.7
  • 13
    • 46249101510 scopus 로고    scopus 로고
    • Contribution of NMDA and non-NMDA receptors to in vivo glutamate-induced calpain activation in the rat striatum. Relation to neuronal damage
    • Del Río P, Montiel T, Massieu L (2008) Contribution of NMDA and non-NMDA receptors to in vivo glutamate-induced calpain activation in the rat striatum. Relation to neuronal damage. Neurochem Res 33: 1475-1483.
    • (2008) Neurochem Res , vol.33 , pp. 1475-1483
    • Del Río, P.1    Montiel, T.2    Massieu, L.3
  • 14
    • 33846863563 scopus 로고    scopus 로고
    • Glutamate activates c-fos in glial cells via a novel mechanism involving the glutamate receptor subtype mGlu5 and the transcriptional repressor DREAM
    • Edling Y, Ingelman-Sundberg M, Simi A (2007) Glutamate activates c-fos in glial cells via a novel mechanism involving the glutamate receptor subtype mGlu5 and the transcriptional repressor DREAM. Glia 55: 328-340.
    • (2007) Glia , vol.55 , pp. 328-340
    • Edling, Y.1    Ingelman-Sundberg, M.2    Simi, A.3
  • 15
    • 0035879026 scopus 로고    scopus 로고
    • Activation of caspase-3/caspase-3-like activity in rat cardiomyocytes by an RGD peptide, but not the GPIIb/IIIa antagonist lotrafiban
    • Erhardt JA, Ohlstein EH, Toomey JR, Gabriel MA, Willette RN, Yue TL, Barone FC, Parsons AA (2001) Activation of caspase-3/caspase-3-like activity in rat cardiomyocytes by an RGD peptide, but not the GPIIb/IIIa antagonist lotrafiban. Thromb Res 103: 143-148.
    • (2001) Thromb Res , vol.103 , pp. 143-148
    • Erhardt, J.A.1    Ohlstein, E.H.2    Toomey, J.R.3    Gabriel, M.A.4    Willette, R.N.5    Yue, T.L.6    Barone, F.C.7    Parsons, A.A.8
  • 16
    • 34548802991 scopus 로고    scopus 로고
    • IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats
    • Escartin C, Boyer F, Bemelmans AP, Hantraye P, Brouillet E (2007) IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats. Neurosci Lett 425: 167-172.
    • (2007) Neurosci Lett , vol.425 , pp. 167-172
    • Escartin, C.1    Boyer, F.2    Bemelmans, A.P.3    Hantraye, P.4    Brouillet, E.5
  • 19
    • 7444268526 scopus 로고    scopus 로고
    • Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic-ischemic adult rats
    • Guan J, Thomas GB, Lin H, Mathai S, Bachelor DC, George S, Gluckman PD (2004) Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic-ischemic adult rats. Neuropharmacology 47: 892-903.
    • (2004) Neuropharmacology , vol.47 , pp. 892-903
    • Guan, J.1    Thomas, G.B.2    Lin, H.3    Mathai, S.4    Bachelor, D.C.5    George, S.6    Gluckman, P.D.7
  • 20
    • 34848851402 scopus 로고    scopus 로고
    • 2+ homeostasis and GAP43 mRNA expression in cultured dorsal root ganglion neurons with excitotoxicity induced by glutamate
    • 2+ homeostasis and GAP43 mRNA expression in cultured dorsal root ganglion neurons with excitotoxicity induced by glutamate. Nutr Neurosci 10: 105-111.
    • (2007) Nutr Neurosci , vol.10 , pp. 105-111
    • Huang, F.1    Liu, Z.2    Liu, H.3    Wang, L.4    Wang, H.5    Li, Z.6
  • 21
    • 0041430783 scopus 로고    scopus 로고
    • The synergistic effects of NGF and IGF-1 on neurite growth in adult sensory neurons: Convergence on the PI 3-kinase signaling pathway
    • Jones DM, Tucker BA, Rahimtula M, Mearow KM (2003) The synergistic effects of NGF and IGF-1 on neurite growth in adult sensory neurons: convergence on the PI 3-kinase signaling pathway. J Neurochem 86: 1116-1128.
    • (2003) J Neurochem , vol.86 , pp. 1116-1128
    • Jones, D.M.1    Tucker, B.A.2    Rahimtula, M.3    Mearow, K.M.4
  • 22
    • 9444237919 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons
    • Leinninger GM, Backus C, Uhler MD, Lentz SI, Feldman EL (2004) Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons. FASEB J 18: 1544-1546.
    • (2004) FASEB J , vol.18 , pp. 1544-1546
    • Leinninger, G.M.1    Backus, C.2    Uhler, M.D.3    Lentz, S.I.4    Feldman, E.L.5
  • 23
    • 2442628592 scopus 로고    scopus 로고
    • Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neurons
    • Li J, McRoberts JA, Nie J, Ennes HS, Mayer EA (2004) Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neurons. Pain 109: 443-452.
    • (2004) Pain , vol.109 , pp. 443-452
    • Li, J.1    McRoberts, J.A.2    Nie, J.3    Ennes, H.S.4    Mayer, E.A.5
  • 24
    • 0038751852 scopus 로고    scopus 로고
    • Versatile regulation of cytosolic Ca2+ by vanilloid receptor I in rat dorsal root ganglion neurons
    • Liu M, Liu MC, Magoulas C, Priestley JV, Willmott NJ (2003) Versatile regulation of cytosolic Ca2+ by vanilloid receptor I in rat dorsal root ganglion neurons. J Biol Chem 278: 5462-5472.
    • (2003) J Biol Chem , vol.278 , pp. 5462-5472
    • Liu, M.1    Liu, M.C.2    Magoulas, C.3    Priestley, J.V.4    Willmott, N.J.5
  • 25
    • 33744534577 scopus 로고    scopus 로고
    • Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800
    • TominagaM
    • Mandadi S, Tominaga T, Numazaki M, Murayama N, Saito N, Armati PJ, Roufogalis BD, TominagaM(2006) Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800. Pain 123: 106-116.
    • (2006) Pain , vol.123 , pp. 106-116
    • Mandadi, S.1    Tominaga, T.2    Numazaki, M.3    Murayama, N.4    Saito, N.5    Armati, P.J.6    Roufogalis, B.D.7
  • 26
    • 33748954225 scopus 로고    scopus 로고
    • Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons
    • McCusker RH, McCrea K, Zunich S, Dantzer R, Broussard SR, JohnsonRW, Kelley KW (2006) Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons. J Neuroimmunol 179: 186-190.
    • (2006) J Neuroimmunol , vol.179 , pp. 186-190
    • McCusker, R.H.1    McCrea, K.2    Zunich, S.3    Dantzer, R.4    Broussard, S.R.5    Johnson, R.W.6    Kelley, K.W.7
  • 27
    • 22744442897 scopus 로고    scopus 로고
    • The latest waves in calcium signaling
    • Montell C (2005) The latest waves in calcium signaling. Cell 122: 157-163.
    • (2005) Cell , vol.122 , pp. 157-163
    • Montell, C.1
  • 28
    • 0034960061 scopus 로고    scopus 로고
    • Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons
    • Nath R, McGinnis K, Dutta S, Shivers B, Wang KK (2001) Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons. Cell Mol Biol Lett 6: 173-184.
    • (2001) Cell Mol Biol Lett , vol.6 , pp. 173-184
    • Nath, R.1    McGinnis, K.2    Dutta, S.3    Shivers, B.4    Wang, K.K.5
  • 29
    • 2342592444 scopus 로고    scopus 로고
    • IGF-I prevents glutamate-mediated bax translocation and cytochrome C release in O4+ oligodendrocyte progenitors
    • Ness JK, Scaduto RC Jr, Wood TL (2004) IGF-I prevents glutamate-mediated bax translocation and cytochrome C release in O4+ oligodendrocyte progenitors. Glia 46: 183-194.
    • (2004) Glia , vol.46 , pp. 183-194
    • Ness, J.K.1    Scaduto Jr, R.C.2    Wood, T.L.3
  • 30
    • 0036355914 scopus 로고    scopus 로고
    • Insulin-like growth factor I, but not neurotrophin-3, sustains Akt activation and provides long-term protection of immature oligodendrocytes from glutamate-mediated apoptosis
    • Ness JK, Wood TL (2002) Insulin-like growth factor I, but not neurotrophin-3, sustains Akt activation and provides long-term protection of immature oligodendrocytes from glutamate-mediated apoptosis. Mol Cell Neurosci 20: 476-488.
    • (2002) Mol Cell Neurosci , vol.20 , pp. 476-488
    • Ness, J.K.1    Wood, T.L.2
  • 31
    • 0031691771 scopus 로고    scopus 로고
    • Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal
    • Russell JW, Windebank AJ, Schenone A, Feldman EL (1998) Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal. J Neurobiol 36: 455-467.
    • (1998) J Neurobiol , vol.36 , pp. 455-467
    • Russell, J.W.1    Windebank, A.J.2    Schenone, A.3    Feldman, E.L.4
  • 32
    • 2142697164 scopus 로고    scopus 로고
    • Neuronal protection from glucose deprivation via modulation of glucose transport and inhibition of apoptosis: A role for the insulin-like growth factor system
    • Russo VC, Kobayashi K, Najdovska S, Baker NL, Werther GA (2004) Neuronal protection from glucose deprivation via modulation of glucose transport and inhibition of apoptosis: a role for the insulin-like growth factor system. Brain Res 1009: 40-53.
    • (2004) Brain Res , vol.1009 , pp. 40-53
    • Russo, V.C.1    Kobayashi, K.2    Najdovska, S.3    Baker, N.L.4    Werther, G.A.5
  • 33
    • 34147127042 scopus 로고    scopus 로고
    • Calcium mediated excitotoxicity in neurofilament aggregate-bearing neurons in vitro is NMDA receptor dependant
    • Sanelli T, Ge W, Leystra-Lantz C, Strong MJ (2007) Calcium mediated excitotoxicity in neurofilament aggregate-bearing neurons in vitro is NMDA receptor dependant. J Neurol Sci 256: 39-51.
    • (2007) J Neurol Sci , vol.256 , pp. 39-51
    • Sanelli, T.1    Ge, W.2    Leystra-Lantz, C.3    Strong, M.J.4
  • 36
    • 0028177361 scopus 로고
    • Nuclear and cytoplasmic Ca2+ signals in developing rat dorsal root ganglion neurons studied in excised tissue
    • Utzschneider DA, Rand MN, Waxman SG, Kocsis JD (1994) Nuclear and cytoplasmic Ca2+ signals in developing rat dorsal root ganglion neurons studied in excised tissue. Brain Res 635: 231-237.
    • (1994) Brain Res , vol.635 , pp. 231-237
    • Utzschneider, D.A.1    Rand, M.N.2    Waxman, S.G.3    Kocsis, J.D.4
  • 39
    • 2942695980 scopus 로고    scopus 로고
    • IGF-I prevents glutamate-induced motor neuron programmed cell death
    • Vincent AM, Mobley BC, Hiller A, Feldman EL (2004b) IGF-I prevents glutamate-induced motor neuron programmed cell death. Neurobiol Dis 16: 407-416.
    • (2004) Neurobiol Dis , vol.16 , pp. 407-416
    • Vincent, A.M.1    Mobley, B.C.2    Hiller, A.3    Feldman, E.L.4
  • 40
    • 7244242544 scopus 로고    scopus 로고
    • Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: Rescue by GM1 and LIGA20
    • Wu G, Lu ZH, Xie X, Ledeen RW (2004) Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20. Glycoconj J 21: 305-313.
    • (2004) Glycoconj J , vol.21 , pp. 305-313
    • Wu, G.1    Lu, Z.H.2    Xie, X.3    Ledeen, R.W.4
  • 41
    • 27644537029 scopus 로고    scopus 로고
    • Effects of insulin-like growth factor-1 on okadaic acid-induced apoptosis in SH-SY5Y cells
    • Xing C, Peng Y, Chang R, Yin Y, Xie Z (2005) Effects of insulin-like growth factor-1 on okadaic acid-induced apoptosis in SH-SY5Y cells. Cell Biol Int 29: 803-808.
    • (2005) Cell Biol Int , vol.29 , pp. 803-808
    • Xing, C.1    Peng, Y.2    Chang, R.3    Yin, Y.4    Xie, Z.5
  • 42
    • 85157157111 scopus 로고    scopus 로고
    • XingY, Liu Z, Wang LH, Huang F, Huaijing Wang HJ, Li ZZ (2006) Butyrate sensitizes the release of substance P and calcitonin gene-related peptide evoked by capsaicin from primary cultured rat dorsal root ganglion neurons. Neuroendocrinol Lett 27: 695-701.
    • XingY, Liu Z, Wang LH, Huang F, Huaijing Wang HJ, Li ZZ (2006) Butyrate sensitizes the release of substance P and calcitonin gene-related peptide evoked by capsaicin from primary cultured rat dorsal root ganglion neurons. Neuroendocrinol Lett 27: 695-701.
  • 43
    • 43949100274 scopus 로고    scopus 로고
    • Glutamate-induced losses of oligodendrocytes and neurons and activation of caspase-3 in the rat spinal cord
    • Xu GY, Liu S, Hughes MG, McAdoo DJ (2008) Glutamate-induced losses of oligodendrocytes and neurons and activation of caspase-3 in the rat spinal cord. Neuroscience 153: 1034-1047.
    • (2008) Neuroscience , vol.153 , pp. 1034-1047
    • Xu, G.Y.1    Liu, S.2    Hughes, M.G.3    McAdoo, D.J.4
  • 44
    • 32844472058 scopus 로고    scopus 로고
    • Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission
    • Yamada T, Terashima T, Okubo T, Juneja LR, Yokogoshi H (2005) Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission. Nutr Neurosci 8: 219-226.
    • (2005) Nutr Neurosci , vol.8 , pp. 219-226
    • Yamada, T.1    Terashima, T.2    Okubo, T.3    Juneja, L.R.4    Yokogoshi, H.5
  • 45
    • 59849128672 scopus 로고    scopus 로고
    • Exogenous galanin regulates capsaicin-evoked substance P release from primary cultured dorsal root ganglion neurons
    • Yang X, Liu Z, Wang L, Liu H, Wang H, Li ZZ (2008) Exogenous galanin regulates capsaicin-evoked substance P release from primary cultured dorsal root ganglion neurons. Neuro Endocrinol Lett 29: 911-916.
    • (2008) Neuro Endocrinol Lett , vol.29 , pp. 911-916
    • Yang, X.1    Liu, Z.2    Wang, L.3    Liu, H.4    Wang, H.5    Li, Z.Z.6
  • 46
    • 33747012605 scopus 로고    scopus 로고
    • Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens
    • Zhang Y, Bhavnani BR (2006) Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens. BMC Neurosci 7: 49.
    • (2006) BMC Neurosci , vol.7 , pp. 49
    • Zhang, Y.1    Bhavnani, B.R.2
  • 47
    • 11144221337 scopus 로고    scopus 로고
    • Combining insulin-like growth factor derivatives plus caffeinol produces robust neuroprotection after stroke in rats
    • Zhao X, Liu SJ, Zhang J, Strong R, Aronowski J, Grotta JC (2005) Combining insulin-like growth factor derivatives plus caffeinol produces robust neuroprotection after stroke in rats. Stroke 36: 129-134.
    • (2005) Stroke , vol.36 , pp. 129-134
    • Zhao, X.1    Liu, S.J.2    Zhang, J.3    Strong, R.4    Aronowski, J.5    Grotta, J.C.6
  • 48
    • 33747158234 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 (IGF-1) induces the activation/phosphorylation of Akt kinase and cAMP response element-binding protein (CREB) by activating different signaling pathways in PC12 cells
    • Zheng WH, Quirion R (2006) Insulin-like growth factor-1 (IGF-1) induces the activation/phosphorylation of Akt kinase and cAMP response element-binding protein (CREB) by activating different signaling pathways in PC12 cells. BMC Neurosci 7: 51.
    • (2006) BMC Neurosci , vol.7 , pp. 51
    • Zheng, W.H.1    Quirion, R.2
  • 49
    • 1542304449 scopus 로고    scopus 로고
    • High K+ and IGF-1 protect cerebellar granule neurons via distinct signaling pathways
    • Zhong J, Deng J, Huang S, Yang X, Lee WH (2004) High K+ and IGF-1 protect cerebellar granule neurons via distinct signaling pathways. J Neurosci Res 75: 794-806.
    • (2004) J Neurosci Res , vol.75 , pp. 794-806
    • Zhong, J.1    Deng, J.2    Huang, S.3    Yang, X.4    Lee, W.H.5
  • 50
    • 20344375969 scopus 로고    scopus 로고
    • Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice
    • Zhong J, Deng J, Phan J, Dlouhy S, Wu H, Yao W, Ye P, D'Ercole AJ, Lee WH (2005) Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice. J Neurosci Res 80: 481-490.
    • (2005) J Neurosci Res , vol.80 , pp. 481-490
    • Zhong, J.1    Deng, J.2    Phan, J.3    Dlouhy, S.4    Wu, H.5    Yao, W.6    Ye, P.7    D'Ercole, A.J.8    Lee, W.H.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.