Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission

Nutritional Neuroscience

Volumn 8, Issue 4, 2005, Pages 219-226

  Yamada, Takashi ^a   Terashima, Takehiko ^a   Okubo, Tsutomu ^b   Juneja, Lekh Raj ^b   Yokogoshi, Hidehiko ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b TAIYO KAGAKU CO LTD   (Japan)

Author keywords

Dopamine; Glutamic acid; Glycine; L theanine; Microdialysis; Neurotransmission

Indexed keywords

2,4 PYRROLIDINEDICARBOXYLIC ACID; AMINO ACID; ASPARTIC ACID; DOPAMINE; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; NEUROTRANSMITTER; THEANINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN PERFUSION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; DRUG EFFECT; DRUG MECHANISM; IN VIVO STUDY; INHIBITION KINETICS; MALE; MICRODIALYSIS; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ASPARTIC ACID; BRAIN; DICARBOXYLIC ACIDS; DOPAMINE; GLUTAMATES; GLUTAMIC ACID; GLYCINE; MALE; MICRODIALYSIS; NEUROTRANSMITTER AGENTS; NEUROTRANSMITTER UPTAKE INHIBITORS; PYRROLIDINES; RATS; RATS, WISTAR;

ANIMALIA;

EID: 32844472058     PISSN: 1028415X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10284150500170799     Document Type: Article

References (52)

1. Billie, JS.(2004) Thianine the relaxation amino acid. Texas: Pain and Stress Publications.
2. Biss, TV and Collingridge, GL. (1993) A synaptic model of memory: Long-term potentiation in the hippocampus Nature, 361, pp. 31 - 39.
3. Bosboom, JL and Stoffers, D and Wolters, ECh. (2003) The role of acetylcholine and dopamine in dementia and psychosis in Parkinson's disease J Neural Transm Suppl, 65, pp. 185 - 195.
4. Brambilla, P and Perez, J and Barale, J and Schettini, G and Soares, JC. (2003) GABAergic dysfunction in mood disorders Mol Psychiatr, 715, pp. 721 - 737.
5. Brian, S and Meldrum. (2000) Glutamate as a neurotransmitter in the brain: Review of physiology and pathology J Nutr, 130, pp. 1007S - 1015S.
6. Bureau, I and Mulle, C. (1998) Potentiation of GABAergic synaptic transmission by AMPA receptors in mouse cerebellar stellate cells: Changes during development J Physiol, 509, pp. 817 - 831.
7. Coyle, JT and Tsai, G and Goff, DC. (2002) Ionotropic glutamate receptors as therapeutic targets in schizophrenia Curr Drug Targets CNS Neurol Disord, 1, pp. 183 - 189.
8. Da Cunha, C and Angelucci, ME and Canteras, NS and Wonnacott, S and Takahashi, RN. (2002) The lesion of the rat substantia nigra pars compacta dopaminergic neurons as a model for Parkinson's disease memory disabilities Cell Mol Neurobiol, 22, pp. 227 - 237.
9. Globus, MY and Busto, R and Dietrich, WD and Martinez, E and Valdes, I and Ginsberg, MD. (1988) Intra-ischemic extracellular release of dopamine and glutamate is associated with striatal vulnerability to ischemia Neurosci Lett, 91, pp. 36 - 40.
10. Hibino, G and Moritani, T and Kawada, T and Fushiki, T. (1997) Caffeine enhances modulation of parasympathetic nerve activity in humans: Quantification using power spectral analysis J Nutr, 127, pp. 1422 - 1427.
11. Jankun, J and Selman, SH and Swiercz, R and Skrzypczak-Jankun, E. (1997) Why drinking green tea could prevent cancer Nature, 387, pp. 561.
12. Kakuda, T and Yanase, H and Utsunomiya, K and Nozawa, A and Unno, T and Kataoka, K. (2000a) Protective effect of γ-glutamylethylamide (theanine) on ischmic delayed neuronal death in gerbils Neurosci Lett, 289, pp. 189 - 192.
13. Kakuda, T and Nozawa, A and Unno, T and Okamura, N and Okai, O. (2000b) Inhibiting effects of theanine on caffeine stimulation evaluated by EEG in the rat Biosci Biotechnol Biochem, 64, pp. 287 - 293.
14. Kakuda, T and Nozawa, A and Sugimoto, A and Niino, H. (2002a) Inhibition by theanine of [3H]AMPA, [3H]kainite, and [3H]MDL105,519 to glutamate receptors Biosci Biotechnol Biochem, 66, pp. 2683 - 2686.
15. Kakuda, T. (2002b) Neuroprotective effects of the green tea components theanine and catechins Biol Pharm Bull, 25, pp. 1513 - 1518.
16. Kimura, R and Murata, T. (1971) Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. central depressant effect of theanine Chem Pharm Bull, 19, pp. 1257 - 1261.
17. Kimura, R and Murata, T. (1985) Effect of theanine on norepinephrine and serotonin levels in rat brain Chem Pharm Bull, 34, pp. 3053 - 3057.
18. 2-like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurons J Physiol, 523, pp. 163 - 173.
19. Kuhse, J and Betz, H and Kirsch, J. (1995) The inhibitory glycine receptor: Architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex Curr Opin Neurobiol, 5, pp. 318 - 323.
20. Legendre, P. (2001) The glycinergic inhibitory synapse Cell Mol Life Sci, 58, pp. 760 - 793.
21. Levi, G and Patrizio, M. (1992) Astrocyte heterogeneity: Endogenous amino acid levels and release evoked by non-N-methyl-d-aspartate receptor agonists and by potassium-induced swelling in type-1 and type-2 astrocytes J Neurochem, 58, pp. 1943 - 1952.
22. Lorist, MM and Tops, M. (2003) Caffeine, fatigue, and cognition Brain Cogn, 53, pp. 82 - 94.
23. Mathew, JS and Coplan, DJ and Gorman, MJ. (2001) Neurobiological mechanisms of social anxiety disorder Am J Psychiatr, 158, pp. 1558 - 1567.
24. Moghaddam, B and Gruen, RJ and Roth, RH and Bunney, BS and Adams, RN. (1990) Effect of l-glutamate on the release of striatal dopamine: In vivo dialysis and electrochemical studies Brain Res, 518, pp. 55 - 60.
25. Muramatsu, K and Fukuyo, M and Hara, Y. (1986) Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats J Nutr Sci Vitaminol, 32, pp. 613 - 622.
26. Nanjo, F and Mori, M and Goto, K and Hara, Y. (1999) Radical scavenging activity of tea catechins and their related compounds Biosci Biotechnol Biochem, 63, pp. 1621 - 1623.
27. Nong, Y and Huang, QY and Ju, W and Kalia, VL and Ahmadian, G and Wang, TY and Salter, WM. (2003) Glycine binding primes NMDA receptor internalization Nature, 422, pp. 302 - 307.
28. Oda, Y and Taguchi, H and Masaoka, N and Minami, K and Honda, S and Okada, K. (1980) Synthesis and antibacterial activities of theanine-containing oligopeptides Chem Pharm Bull, 28, pp. 3549 - 3554.
29. D 2-amino-5-phosphonopentanoic acid binding in rat brain membranes Neuroscience, 26, pp. 17 - 31.
30. Paxinos, G and Watoson, C.(1986) The rat brain in stereotaxic coordinates. New York: Academic Press.
31. Rao, ST and Lariosa-Willingham, DK and Yu, N. (2003) Glutamate-dependent glutamine, aspartate and serine release from rat cortical glial cell cultures Brain Res, 978, pp. 213 - 222.
32. Ross, ST and Soltesz, I. (2001) Long-term plasticity in interneurons of the dentate gyrus Proc Natl Acad Sci USA, 98, pp. 8874 - 8879.
33. Sazduka, Y and Sugiyama, T and Suzuki, T and Sonobe, T. (2001) Enhancement of the activity of doxorubicin by inhibition of glutamate transporter Toxicol Lett, 123, pp. 159 - 167.
34. Serafini, M and Ghiselli, A and Ferro-Luzzi, A. (1994) Red wine, tea, and antioxdants Lancet, 344, pp. 626.
35. 4 receptors decreases fear-related behavior in rats Eur J Pharmacol, 19, pp. 3393 - 3397.
36. Sonnewald, U and Westergaard, N and Schousboe, A. (1997) Glutamate transport and metabolism in astrocyte Glia, 21, pp. 56 - 63.
37. Sugiyama, T and Sadzuka, Y. (1998) Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian sarcoma Cancer Lett, 133, pp. 19 - 26.
38. Sugiyama, T and Sadzuka, Y and Tanaka, K and Sonobe, T. (2001) Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin Toxicol Lett, 121, pp. 89 - 96.
39. Sugiyama, T and Sadzuka, Y. (2003) Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents Biochimica Biophysica Acta, 1653, pp. 47 - 59.
40. Tang, Y and Shimizu, E and Dube, RG and Rampan, C and Kerchner, AG and Zhuo, M and Liu, G and Tsien, ZJ. (1999) Genetic enhancement of learning and memory in mice Nature, 401, pp. 63 - 69.
41. Terashima, T and Takido, J and Yokogoshi, H. (1999) Time-dependent changes of amino acids in the serum, liver, brain and urine of rats administrated with theanine Biosci Biotechnol Biochem, 63, pp. 615 - 618.
42. Tessitore, A and Hariri, RA and Fera, F and Smith, GW and Chase, NT and Hyde, MT and Weinberger, RD and Mattay, SV. (2002) Dopamine modulates the response of the human amygdala: A study in Parkinson's disease J Neurosci, 22, pp. 9099 - 9103.
43. Triller, A and Cluzeaud, F and Korn, H. (1987) gamma-Aminobutyric acid-containing terminals can be appose to glycine receptors at central synapses J Cell Biol, 104, pp. 947 - 956.
44. Tsuge, H and Sano, S and Hayakawa, T and Kakuda, T and Unno, T. (2003) Theanine, gamma-glutamylethylamide, is metabolized by renal phosphate-independent glutaminase Biochimica Biophysica Acta, 1620, pp. 47 - 53.
45. Wong, CG and Bottiglieri, T and Snead, OC, 3rd. (2003) GABA, r-Hydroxybutyric acid, and neurological disease Ann Neurol, 54, pp. S3 - S12.
46. 2+-permeable AMPA receptors in rat spinal neurons J Physiol, 514.3, pp. 701 - 711.
47. Yadid, G and Pacak, K and Golomb, E and Harvey-White, DJ and Lieberman, MD and Kopin, JI and Goldstein, SD. (1993) Glycine stimulates striatal dopamine release in conscious rats Br J Pharmacol, 110, pp. 50 - 53.
48. Yokogoshi, H and Kato, Y and Sagesaka, MY and Takihara-Matsuura, T and Kakuda, T and Takeuchi, N. (1995) Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats Biosci Biotechnol Biochem, 59, pp. 615 - 618.
49. Yokogoshi, H and Kobayashi, M and Mochizuki, M and Terashima, T. (1998a) Effect of Theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in coscious rats Neurochem Res, 23, pp. 667 - 673.
50. Yokogoshi, H and Mochizuki, M and Saito, K. (1998b) Theanine-induced reduction of brain serotonin concentration in rats Biosci Biotechnol Biochem, 62, pp. 816 - 817.
51. Zheng, G and Sayama, K and Okubo, T and Juneja, LR and Oguni, I. (2004) Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice In Vivo, 18, pp. 55 - 62.
52. Zuiderwijk, M and Veenstra, E and Fernando, H and Silva, DL and Ghijsen, EJMW. (1996) Effects of uptake carrier blockers SK&F 89976-A and l-trans-PDC on in vivo release of amino acids in rat hippocampus Eur J Pharmacol, 307, pp. 275 - 282.