Na+/H+ exchanger blockade inhibits the expression of vascular endothelial growth factor in SGC7901 cells

Oncology Reports

Volumn 23, Issue 1, 2010, Pages 79-87

  He, Bingyan ^a   Zhang, Ming ^b   Zhu, Rui ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Intracellular pH; Na+ h+ exchanger isoform; SGC7901 cell; Vascular endothelial growth factor

Indexed keywords

AMILORIDE; MESSENGER RNA; SODIUM PROTON EXCHANGE PROTEIN; VASCULOTROPIN;

ARTICLE; CARCINOGENESIS; CELL PH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; INHIBITION KINETICS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; TREATMENT RESPONSE; WESTERN BLOTTING;

CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOHISTOCHEMISTRY; K562 CELLS; NEOVASCULARIZATION, PATHOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SODIUM-HYDROGEN ANTIPORTER; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 76049091412     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000608     Document Type: Article

References (37)

1. Carmeliet P and Jain RK: Angiogenesis in cancer and other diseases. Nature 407: 249-257, 2000.
2. Hanahan D and Weinberg RA: The hallmarks of cancer. Cell 100: 57-70, 2000.
3. Bergers G and Benjamin LE: Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3: 401-410, 2003.
4. Zhang LL, Hannay JAF, Liu J, Das P, Zhan M and Nguyen T: Vascular endothelial growth overexpression by soft tissue sarcoma cells: implications for tumor growth, metastasis, and chemo-resistance. Cancer Res 66: 5597-5607, 2006.
5. Lesslie DP III, Summy JM, Parikh NU, Fan F, Trevino JG and Sawyer TK: Vascular endothelial growth factor expression receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases. Br J Cancer 94: 1710-1717, 2006.
6. Mclean LA, Roscoe J, Jorgensen NK, Gorin FA and Cala PM: Malignant gliomas display altered pH regulation by NHE1 compared with non-transformed astrocytes. Am J Physiol Cell Physiol 278: C676-C688, 2000.
7. Wong P, Lee C and Tonnock IF: Reduction of intracellular pH as a strategy to enhance pH-dependent cytotoxic effects of melphalan for human breast cancer cells. Clin Cancer Res 11: 3553-3557, 2005.
8. + exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-association phenotypes. FASEB J 14: 2185-2197, 2000.
9. + exchanger. Blood 95: 1427-1434, 2000.
10. + exchanger isoform NHE8. Am J Physiol Renal Physiol 284: 466-473, 2003.
11. + exchanger in metastasis. Nat Rev Cancer 5: 786-795, 2005.
12. + exchanger (NHE) NHE isoform 1 in human breast cancer cells. Clin Cancer Res 9: 2366-2373, 2003.
13. + exchanger. Leuk Res 31: 507-514, 2007.
14. Ge Y, Zhang X, Zhang J, Hou L and Tian R: The mechanisms on apoptosis by inhibiting VEGF expression in human breast cancer cells. Int Immunopharmacol 9: 389-395, 2009.
15. Ohta M, Konno H, Tanaka T, et al: The significance of ciuculating vascular endothelial growth factor (VEGF) protein in gastric cancer. Cancer Lett 192: 215-225, 2003.
16. Takayama T, Sato Y, Sagawa T, Okamoto T, Nagashima H, Takahashi Y, Ohnuma H, Kuroiwa G, Miyanishi K, Takimoto R, Matsunaga T, Kato J, Yamaguchi K, Hirata K and Niitsu Y: Phase I study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer. Br J Cancer 97: 851-856, 2007.
17. Gretschel S, Astrosini C, Vieth M, et al: Markers of tumor angiogenesis and tumor cells in bone marrow in gastric cancer patients. J Cancer Surg 34: 642-647, 2008.
18. Pirkebner D, Fuetsch M, Wittmann W, Weiss H, Haller T, Schramek H, Margreiter R and Amberger A: Reduction of intracellular pH inhibits constitive expression of cyclooxygenase-2 in human cancer cells. J Cell Chem 198: 295-301, 2004.
19. Lee CH, Cragoe E and Edwards AM: Control of hepatocyte DNA synthesis by intracellular pH and its role in the action of tumor promoters. J Cell Physiol 195: 61-69, 2003.
20. + exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim Biophys Acta 988: 73-97, 1989.
21. Puceat M: pHi regulatory ion transporters: an update on structure, regulation, and cell function. Cell Mol Life Sci 55: 1216-1229, 1999.
22. Lagadic-Gossmann D: Alteration of intracellular pH homeastasis in apoptosis, origins and roles. Cell Death Differ 11: 953-960, 2004.
23. + exchanger 1 (NHE1) functional and clinical implications. J Biol Chem 52: 37854-37863, 2007.
24. Evans DM and Sloan-Stakleff K: Suppression of the invasive capacity of human breast cancer cells by inhibition of urokinase plasminigen activator via amiloride and B428. Am Surg 66: 460-464, 2000.
25. Seksek O and Bolard J: Nuclear pH gradient in mammalian cells revealed by laser microspectrofluorimetry. J Cell Sci 109: 257-262, 1996.
26. Maidorn RP, Cragoe E and Tannock IF: Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumor selective therapy. Br J Cancer 67: 297-303, 1993.
27. Perez-Sala D, Colores-Escobar D and Mollinedo F: Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease. J Biol Chem 270: 6235-6242, 1995.
28. + exchanger activity is increased in doxorubicin-resistant human colon cancer cells and its modulation modities the sensitivity of the cells to doxorubicin. Int J Cancer 115: 924-929, 2005.
29. + exchanger-1 (NHE-1) antisense gene on drug-resistant human small cell lung cancer cells. Oncol Rep 21: 1243-1249, 2009.
30. Cho Y, Lee K, Lee S, Namkoong S, Kim Y, Lee H, Ha K, Han J, Kwon Y and Kim Y: Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inativation. Biochem Biophys Res Commun 326: 752-758, 2005.
31. Kim KM and Lee YJ: Amiloride augements TRALL-induced apoptotic death by inhibiting phosphorylation of kinases and phosphatases associated with the PI3K AKT pathway. Oncogene 24: 355-366, 2005.
32. Nathan P, Chao D, Brock C, et al: The place of VEGF inhibition in the current management of renal cell carcinoma. Br J Cancer 94: 1217-1220, 2006.
33. Koliakos G, Befani C, Paletas K and Kaloyianni M: Effect of endothelin on sodium/hydrogen exchanger activity of human monocytes and atherosclerosis- related functions. Ann N Y Acad Sci 1095: 274-291, 2007.
34. + exchanger and pyruvate kinase activity through protein kinase C in isolated mantle/gonad cells of Mytilus galloprovincialis. Comp Biochem Physiol C Toxicol Pharmacol 141: 257-266, 2005.
35. + exchanger-1 in esophageal epithelial defense against acid-induced injury. Am J Physiol Gastrointest Liver Physiol 290: G665-G673, 2006.
36. Worden B, Yang XP, Lee TL, et al: Hepatocyte growth factor/scatter factor differentially regulates expression of pro-angiogenic factors through Egr-1 in head and neck squamous cell carcinoma. Cancer Res 65: 7071-7080, 2005.
37. + exchanger isoform 1 activation controls hexokinase expression in benzo(a)pyrene-induced apoptosis. Cancer Res 67: 1696-1705, 2007.