메뉴 건너뛰기




Volumn 21, Issue 5, 2009, Pages 1243-1249

Inhibition of proliferation and apoptosis induced by a Na+/H+ exchanger-1 (NHE-1) antisense gene on drug-resistant human small cell lung cancer cells

Author keywords

Antisense gene; Drug resistance; NHE 1; Small cell lung cancer

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE SODIUM PROTON EXCHANGE PROTEIN 1; CASPASE 3; CISPLATIN; ETOPOSIDE; FLUOROURACIL; TOPOTECAN; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 67649365855     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000347     Document Type: Article
Times cited : (31)

References (41)
  • 1
    • 35448929533 scopus 로고    scopus 로고
    • Phase III study of cyclophosphamide, doxorubicin, and etoposide compared with carboplatin and paclitaxel in patients with extensive disease small-cell lung cancer
    • De Jong WK, Groen HJ, Koolen MG, Biesma B, Willems LN, Kwa HB, van Bochove A, van Tinteren H and Smit EF: Phase III study of cyclophosphamide, doxorubicin, and etoposide compared with carboplatin and paclitaxel in patients with extensive disease small-cell lung cancer. Eur J Cancer 43: 2345-2350, 2007.
    • (2007) Eur J Cancer , vol.43 , pp. 2345-2350
    • De Jong, W.K.1    Groen, H.J.2    Koolen, M.G.3    Biesma, B.4    Willems, L.N.5    Kwa, H.B.6    van Bochove, A.7    van Tinteren, H.8    Smit, E.F.9
  • 2
    • 34248578455 scopus 로고    scopus 로고
    • Targeting receptor tyrosine kinase signalling in small cell lung cancer (SCLC): What have we learned so far?
    • Fischer B, Marinov M and Arcaro A: Targeting receptor tyrosine kinase signalling in small cell lung cancer (SCLC): what have we learned so far? Cancer Treat Rev 33: 391-406, 2007.
    • (2007) Cancer Treat Rev , vol.33 , pp. 391-406
    • Fischer, B.1    Marinov, M.2    Arcaro, A.3
  • 4
    • 36849038378 scopus 로고    scopus 로고
    • Extracellular matrix regulation of drug resistance in small-cell lung cancer
    • Hodkinson PS, Mackinnon AC and Sethi T: Extracellular matrix regulation of drug resistance in small-cell lung cancer. Int J Radiat Biol 83: 733-741, 2007.
    • (2007) Int J Radiat Biol , vol.83 , pp. 733-741
    • Hodkinson, P.S.1    Mackinnon, A.C.2    Sethi, T.3
  • 5
    • 0035411293 scopus 로고    scopus 로고
    • The role of extracellular matrix in small-cell lung cancer
    • Rintoul RC and Sethi T: The role of extracellular matrix in small-cell lung cancer. Lancet Oncol 2: 437-442, 2001.
    • (2001) Lancet Oncol , vol.2 , pp. 437-442
    • Rintoul, R.C.1    Sethi, T.2
  • 6
    • 0035880708 scopus 로고    scopus 로고
    • Metallothionein expression in patients with small cell carcinoma of the lung: Correlation with other molecular markers and clinical outcome
    • Joseph MG, Banerjee D, Kocha W, Feld R, Stitt LW and Cherian MG: Metallothionein expression in patients with small cell carcinoma of the lung: correlation with other molecular markers and clinical outcome. Cancer 92: 836-842, 2001.
    • (2001) Cancer , vol.92 , pp. 836-842
    • Joseph, M.G.1    Banerjee, D.2    Kocha, W.3    Feld, R.4    Stitt, L.W.5    Cherian, M.G.6
  • 8
    • 33751104270 scopus 로고    scopus 로고
    • Multi-drug resistance in small cell lung cancer: Expression of P-glycoprotein, multidrug resistance protein 1 and lung resistance protein in chemo-naive patients and in relapsed disease
    • Triller N, Korosec P, Kern I, Kosnik M and Debeljak A: Multi-drug resistance in small cell lung cancer: expression of P-glycoprotein, multidrug resistance protein 1 and lung resistance protein in chemo-naive patients and in relapsed disease. Lung Cancer 54: 235-240, 2006.
    • (2006) Lung Cancer , vol.54 , pp. 235-240
    • Triller, N.1    Korosec, P.2    Kern, I.3    Kosnik, M.4    Debeljak, A.5
  • 10
    • 0036729867 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy
    • Krystal GW, Sulanke G and Litz J: Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy. Mol Cancer Ther 1: 913-922, 2002.
    • (2002) Mol Cancer Ther , vol.1 , pp. 913-922
    • Krystal, G.W.1    Sulanke, G.2    Litz, J.3
  • 12
    • 38049188238 scopus 로고    scopus 로고
    • + exchanger 1 (NHE1): Functional and clinical implications
    • + exchanger 1 (NHE1): functional and clinical implications. J Biol Chem 282: 37854-37863, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 37854-37863
    • Landau, M.1    Herz, K.2    Padan, E.3    Ben-Tal, N.4
  • 14
    • 18644369908 scopus 로고    scopus 로고
    • Polymorphic forms of prostate specific antigen and their interaction with androgen receptor trinucleotide repeats in prostate cancer
    • Binnie MC, Alexander FE, Heald C and Habib FK: Polymorphic forms of prostate specific antigen and their interaction with androgen receptor trinucleotide repeats in prostate cancer. Prostate 63: 309-315, 2005.
    • (2005) Prostate , vol.63 , pp. 309-315
    • Binnie, M.C.1    Alexander, F.E.2    Heald, C.3    Habib, F.K.4
  • 15
    • 0034780077 scopus 로고    scopus 로고
    • Trophic factor withdrawal: P38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization
    • Khaled AR, Moor AN, Li A, Kim K, Ferris DK, Muegge K, Fisher RJ, Fliegel L and Durum SK: Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization. Mol Cell Biol 21: 7545-7557, 2001.
    • (2001) Mol Cell Biol , vol.21 , pp. 7545-7557
    • Khaled, A.R.1    Moor, A.N.2    Li, A.3    Kim, K.4    Ferris, D.K.5    Muegge, K.6    Fisher, R.J.7    Fliegel, L.8    Durum, S.K.9
  • 16
    • 3042692979 scopus 로고    scopus 로고
    • + exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion
    • + exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. J Biol Chem 279: 26991-27007, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 26991-27007
    • Bourguignon, L.Y.1    Singleton, P.A.2    Diedrich, F.3    Stern, R.4    Gilad, E.5
  • 17
    • 0027054949 scopus 로고
    • + antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism
    • + antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism. J Biol Chem 267: 23823-23828, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 23823-23828
    • Grinstein, S.1    Woodside, M.2    Sardet, C.3    Pouyssegur, J.4    Rotin, D.5
  • 19
    • 0036729475 scopus 로고    scopus 로고
    • Mechanisms of activation of NHE by cell shrinkage and by calyculin A in Ehrlich ascites tumor cells
    • Pederson SF, Varming C, Christensen ST and Hoffmann EK: Mechanisms of activation of NHE by cell shrinkage and by calyculin A in Ehrlich ascites tumor cells. J Membr Biol 189: 67-81, 2002.
    • (2002) J Membr Biol , vol.189 , pp. 67-81
    • Pederson, S.F.1    Varming, C.2    Christensen, S.T.3    Hoffmann, E.K.4
  • 20
    • 0033739497 scopus 로고    scopus 로고
    • Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1
    • Lagana A, Vadnais J, Le PU, Nguyen TN, Laprade R, Nabi IR and Noel J: Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1. J Cell Sci 113 (Pt 20): 3649-3662, 2000.
    • (2000) J Cell Sci , vol.113 , Issue.PART 20 , pp. 3649-3662
    • Lagana, A.1    Vadnais, J.2    Le, P.U.3    Nguyen, T.N.4    Laprade, R.5    Nabi, I.R.6    Noel, J.7
  • 21
    • 33846356039 scopus 로고    scopus 로고
    • DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH
    • Zhao R, Oxley D, Smith TS, Follows GA, Green AR and Alexander DR: DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH. PLoS Biol 5: e1, 2007.
    • (2007) PLoS Biol , vol.5
    • Zhao, R.1    Oxley, D.2    Smith, T.S.3    Follows, G.A.4    Green, A.R.5    Alexander, D.R.6
  • 22
    • 0034129031 scopus 로고    scopus 로고
    • Malignant gliomas display altered pH regulation by NHE1 compared with non-transformed astrocytes
    • McLean LA, Roscoe J, Jorgensen NK, Gorin FA and Cala PM: Malignant gliomas display altered pH regulation by NHE1 compared with non-transformed astrocytes. Am J Physiol 278: C676-C688, 2000.
    • (2000) Am J Physiol , vol.278
    • McLean, L.A.1    Roscoe, J.2    Jorgensen, N.K.3    Gorin, F.A.4    Cala, P.M.5
  • 23
    • 0037070169 scopus 로고    scopus 로고
    • Anion exchanger isoform 2 operates in parallel with Na(+)/H(+) exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells
    • Shen MR, Wilkins RJ, Chou CY and Ellory JC: Anion exchanger isoform 2 operates in parallel with Na(+)/H(+) exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells. FEBS Lett 512: 52-58, 2002.
    • (2002) FEBS Lett , vol.512 , pp. 52-58
    • Shen, M.R.1    Wilkins, R.J.2    Chou, C.Y.3    Ellory, J.C.4
  • 24
    • 15944375520 scopus 로고    scopus 로고
    • Chemotherapy strategies in the treatment of small cell lung cancer
    • Popat S and O'Brien M: Chemotherapy strategies in the treatment of small cell lung cancer. Anticancer Drugs 16: 361-372, 2005.
    • (2005) Anticancer Drugs , vol.16 , pp. 361-372
    • Popat, S.1    O'Brien, M.2
  • 25
    • 0023851785 scopus 로고
    • Cisplatin plus etoposide consolidation following cyclophosphamide, doxorubicin, and vincristine in limited small-cell lung cancer
    • Einhorn LH, Crawford J, Birch R, Omura G, Johnson DH and Greco FA: Cisplatin plus etoposide consolidation following cyclophosphamide, doxorubicin, and vincristine in limited small-cell lung cancer. J Clin Oncol 6: 451-456, 1988.
    • (1988) J Clin Oncol , vol.6 , pp. 451-456
    • Einhorn, L.H.1    Crawford, J.2    Birch, R.3    Omura, G.4    Johnson, D.H.5    Greco, F.A.6
  • 26
    • 0022973772 scopus 로고
    • The use of VP-16 plus cisplatin during induction chemotherapy for small-cell lung cancer
    • Evans WK, Feld R, Murray N, et al: The use of VP-16 plus cisplatin during induction chemotherapy for small-cell lung cancer. Semin Oncol 13: 10-16, 1986.
    • (1986) Semin Oncol , vol.13 , pp. 10-16
    • Evans, W.K.1    Feld, R.2    Murray, N.3
  • 27
    • 48749099976 scopus 로고    scopus 로고
    • Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins
    • Wangpaichitr M, Wu C, You M, Kuo MT, Feun L, Lampidis T and Savaraj N: Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins. Eur J Pharmacol 591: 124-127, 2008.
    • (2008) Eur J Pharmacol , vol.591 , pp. 124-127
    • Wangpaichitr, M.1    Wu, C.2    You, M.3    Kuo, M.T.4    Feun, L.5    Lampidis, T.6    Savaraj, N.7
  • 28
    • 67649355881 scopus 로고    scopus 로고
    • Involvement of bcl-2 in multidrug resistance in human small cell lung cancer cell subline H446/DDP
    • Ji FY, Qian GS, Qian P, Chen Y, Guo RL, Li SP and Huang GJ: Involvement of bcl-2 in multidrug resistance in human small cell lung cancer cell subline H446/DDP. Chin J Tuberc Respir Dis 29: 156-160, 2006.
    • (2006) Chin J Tuberc Respir Dis , vol.29 , pp. 156-160
    • Ji, F.Y.1    Qian, G.S.2    Qian, P.3    Chen, Y.4    Guo, R.L.5    Li, S.P.6    Huang, G.J.7
  • 29
    • 0042352409 scopus 로고    scopus 로고
    • Expression of a new lung cancer drug resistance-related gene in lung cancer tissues and lung cancer cell strains
    • Liu LZ, Qian GS and Zhou XD: Expression of a new lung cancer drug resistance-related gene in lung cancer tissues and lung cancer cell strains. Chin J Cancer 22: 171-174, 2003.
    • (2003) Chin J Cancer , vol.22 , pp. 171-174
    • Liu, L.Z.1    Qian, G.S.2    Zhou, X.D.3
  • 30
    • 59249105606 scopus 로고    scopus 로고
    • Polymer-based gene delivery: A current review on the uptake and intracellular trafficking of polyplexes
    • Midoux P, Breuzard G, Gomez JP and Pichon C: Polymer-based gene delivery: a current review on the uptake and intracellular trafficking of polyplexes. Curr Gene Ther 8: 335-352, 2008.
    • (2008) Curr Gene Ther , vol.8 , pp. 335-352
    • Midoux, P.1    Breuzard, G.2    Gomez, J.P.3    Pichon, C.4
  • 31
    • 0035237389 scopus 로고    scopus 로고
    • pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth
    • Pouyssegur J, Franchi A and Pages G: pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth. Novartis Found Symp 240: 186-196, 2001.
    • (2001) Novartis Found Symp , vol.240 , pp. 186-196
    • Pouyssegur, J.1    Franchi, A.2    Pages, G.3
  • 32
    • 0030070906 scopus 로고    scopus 로고
    • Reconstitution of the hippocampal mossy fiber and associational-commissural pathways in a novel dissociated cell culture system
    • Baranes D, Lopez-Garcia JC, Chen M, Bailey CH and Kandel ER: Reconstitution of the hippocampal mossy fiber and associational-commissural pathways in a novel dissociated cell culture system. Proc Natl Acad Sci USA 93: 4706-4711, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4706-4711
    • Baranes, D.1    Lopez-Garcia, J.C.2    Chen, M.3    Bailey, C.H.4    Kandel, E.R.5
  • 33
    • 0022445670 scopus 로고
    • Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
    • Denizot F and Lang R: Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 89: 271-277, 1986.
    • (1986) J Immunol Methods , vol.89 , pp. 271-277
    • Denizot, F.1    Lang, R.2
  • 34
    • 0025653461 scopus 로고
    • An integrated set of methods for routine flow cytometric DNA analysis
    • Vindelov L and Christensen IJ: An integrated set of methods for routine flow cytometric DNA analysis. Methods Cell Biol 33: 127-137, 1990.
    • (1990) Methods Cell Biol , vol.33 , pp. 127-137
    • Vindelov, L.1    Christensen, I.J.2
  • 35
    • 34548638003 scopus 로고    scopus 로고
    • Small cell lung cancer - state of the art and future perspectives
    • Fernando JB and Costa AF: Small cell lung cancer - state of the art and future perspectives. Rev Port Pneumol 13: 587-604, 2007.
    • (2007) Rev Port Pneumol , vol.13 , pp. 587-604
    • Fernando, J.B.1    Costa, A.F.2
  • 36
    • 39449132524 scopus 로고    scopus 로고
    • Current status of clinical trials for small cell lung cancer
    • Fischer B and Arcaro A: Current status of clinical trials for small cell lung cancer. Rev Recent Clin Trials 3: 40-61, 2008.
    • (2008) Rev Recent Clin Trials , vol.3 , pp. 40-61
    • Fischer, B.1    Arcaro, A.2
  • 37
    • 35649024810 scopus 로고    scopus 로고
    • Understanding cisplatin resistance using cellular models
    • Stordal B and Davey M: Understanding cisplatin resistance using cellular models. IUBMB Life 59: 696-699, 2007.
    • (2007) IUBMB Life , vol.59 , pp. 696-699
    • Stordal, B.1    Davey, M.2
  • 38
    • 34547754100 scopus 로고    scopus 로고
    • Targeting the Na(+)/H(+) exchanger: An old concept with new perspectives in the treatment of hematological malignancies
    • Turturro F, Lawson M, Friday E and Welbourne T: Targeting the Na(+)/H(+) exchanger: an old concept with new perspectives in the treatment of hematological malignancies. Leuk Res 31: 1449-1450, 2007.
    • (2007) Leuk Res , vol.31 , pp. 1449-1450
    • Turturro, F.1    Lawson, M.2    Friday, E.3    Welbourne, T.4
  • 39
    • 4344689614 scopus 로고    scopus 로고
    • The effect of Na(+)/ H(+) exchanger-1 (NHE-1) antisense expression vector on NHE-1 gene expression in human lung adenocarcinoma cells and its biological significance
    • Wu GM, Qian GS, Huang GJ, Li SP, Yao W and Lu JY: The effect of Na(+)/ H(+) exchanger-1 (NHE-1) antisense expression vector on NHE-1 gene expression in human lung adenocarcinoma cells and its biological significance. Chin J Tuberc Respir Dis 27: 191-194, 2004.
    • (2004) Chin J Tuberc Respir Dis , vol.27 , pp. 191-194
    • Wu, G.M.1    Qian, G.S.2    Huang, G.J.3    Li, S.P.4    Yao, W.5    Lu, J.Y.6
  • 40
    • 0036272649 scopus 로고    scopus 로고
    • Na(+)/H(+) exchange subtype 1 inhibition during extracellular acidification and hypoxia in glioma cells
    • Glunde K, Dussmann H, Juretschke HP and Leibfritz D: Na(+)/H(+) exchange subtype 1 inhibition during extracellular acidification and hypoxia in glioma cells. J Neurochem 80: 36-44, 2002.
    • (2002) J Neurochem , vol.80 , pp. 36-44
    • Glunde, K.1    Dussmann, H.2    Juretschke, H.P.3    Leibfritz, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.