The mechanisms on apoptosis by inhibiting VEGF expression in human breast cancer cells

International Immunopharmacology

Volumn 9, Issue 4, 2009, Pages 389-395

  Ge, Yin Lin ^a   Zhang, Xiao ^a   Zhang, Jin Yu ^a   Hou, Lin ^a   Tian, Run Hua ^a  

^a QINGDAO UNIVERSITY   (China)

Author keywords

Cell apoptosis; MCF 7 cells; RNA interfering; VEGF

Indexed keywords

CASPASE 3; CYTOCHROME C; LIPOFECTAMINE; LIPOFECTAMINE2000; PROTEIN BAX; PROTEIN BCL 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG SYNTHESIS; DRUG TARGETING; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; CYTOCHROMES C; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 61649108963     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.11.020     Document Type: Article

References (25)

1. Folkman J. What is the evidence that tumors are angiogenesis dependent?. J Natl Cancer Inst 82 (1990) 4-6
2. Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nature reviews. Cancer 2 (2002) 795-803
3. Tomisawa M., Tokunaga T., Oshika Y., Tsuchida T., Fukushima Y., Sato H., et al. Expression pattern of vascular endothelial growth factor isoform is closely correlated with tumour stage and vascularisation in renal cell carcinoma. Eur J Cancer 35 (1999) 133-137
4. Kazuhiro T., Kazumasa I., Tohru Y., Hisato H., Kiyoaki I., Yasushi K., et al. Expression of vascular endothelial growth factor (VEGF) and its cognate receptors in human pheochromocytomas. Life Sci 74 (2004) 863-871
5. Rowe R.W., Tomoda M., Strebel F.R., Jenkins G.N., Stephens L.C., and Bull J.M. The natural progression of microvasculature in primary tumor and lymph node metastases in a breast carcinoma model: relationship between microvessel density, vascular endothelial growth factor expression, and metastatic invasion. Cancer Biol Ther 3 (2004) 408-414
6. Iovino F., Ferraraccio F., Orditura M., Antoniol G., Morgillo F., Cascone T., et al. Serum vascular endothelial growth factor (VEGF) levels correlate with tumor VEGF and p53 overexpression in endocrine positive primary breast cancer. Cancer Investig 26 (2008) 250-255
7. Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat Med 9 (2003) 669-676
8. Bange J., Zwick E., and Ullrich A. Molecular targets for breast cancer therapy and prevention. Nat Med 7 (2001) 548-552
9. Price D.J., Miralem T., Jiang S., Steinberg R., and Avraham H. Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells. Cell Growth Differ 12 (2001) 129-135
10. Ryden L., Linderholm B., Nielsen N.H., Emdin S., Jonsson P.E., and Landberg G. Tumor specific VEGF-A and VEGFR2/KDR protein are co-expressed in breast cancer. Breast Cancer Res Treat 82 (2003) 147-154
11. Sharp P.A. RNA interference. Genes Dev 15 (2001) 485-490
12. Zamore P.D. RNA interference. listening to the sound of silence. Nat Struct Mol Biol 8 (2001) 746-750
13. Yin J., and Wang Y. siRNA-mediated gene regulation system. now and the future. Int J Mol Med 10 (2002) 355-365
14. Robertson J., Fadeel B., Zhivotovsky B., and Orrenius S. "Centennial" Nobel conference on apoptosis and human disease. Cell Death Diff 9 4 (2002) 468-475
15. Minamino M., Sakaguchi I., Naka, Iked N., Katoa Y., Tomiyasu I., et al. Bacterial ceramides and sphingophospholipids induce apoptosis of human leukaemic cells. Microbiology 149 Pt 8 (2003) 2071-2081
16. Adams J.M., and Cory S. Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Curr Opin Immunol 19 (2007) 488-496
17. Kasukabe T., Okabe-Kado J., Kato N., Sassa T., and Honma Y. Effects of combined treatment with rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts. Breast Cancer Res 7 (2005) R1097-1110
18. Hunter A.M., LaCasse E.C., and Korneluk R.G. The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 12 (2007) 1543-1568
19. Kim W.U., Kang S.S., Yoo S.A., Hong K.H., Bae D.G., Lee M.S., et al. Interaction of vascular endothelial growth factor 165 with neuropilin-1 protects rheumatoid synoviocytes from apoptotic death by regulating Bcl-2 expression and Bax translocation. J Immunol 177 (2006) 5727-5735
20. Ruixing Y., Dezhai Y., Hai W., Kai H., Xianghong W., and Yuming C. Intramyocardial injection of vascular endothelial growth factor gene improves cardiac performance and inhibits cardiomyocyte apoptosis. Eur J Heart Fail 9 (2007) 343-351
21. Donovan M., and Cotter T.G. Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death. Biochim Biophys Acta 1644 2-3 (2004) 133-147
22. Tsujimoto Y. Cell death regulation by the Bcl-2 protein family in the mitochondria. J Cell Physiol 195 2 (2003) 158-167
23. 2-induced apoptosis via calcineurin pathways. J Bioenerg Biomemb 39 (2007) 186-194
24. Wong W.W., and Puthalakath H. Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway. IUBMB Life 60 (2008) 390-397
25. Fussenegger M., Bailey J.E., and Varner J. A mathematical model of caspase function in apoptosis. Nat Biotechnol 18 (2000) 768-774