Overexpression of cell division cycle 7 homolog is associated with gene amplification frequency in breast cancer

Human Pathology

Volumn 41, Issue 3, 2010, Pages 358-365

  Choschzick, Matthias ^a   Lebeau, Annette ^a   Marx, Andreas H ^a   Tharun, Lars ^a   Terracciano, Luigi ^b   Heilenkötter, Uwe ^c   Jaenicke, Fritz ^a   Bokemeyer, Carsten ^d   Simon, Ronald ^a   Sauter, Guido ^a   Schwarz, Jörg ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c Hospital Itzehoe   (Germany)

^d Department of Oncology   (Germany)

Author keywords

Amplification; Anticancer drugs; Breast cancer; Cdc7

Indexed keywords

CELL CYCLE PROTEIN; CELL DIVISION CYCLE PROTEIN 7; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; KI 67 ANTIGEN; MYC PROTEIN; PROTEIN MDM2; PROTEIN P16; PROTEIN P53; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; CELL PROLIFERATION; CONTROLLED STUDY; GENE AMPLIFICATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MOLECULAR BIOLOGY; PHENOTYPE; PROGNOSIS; PROTEIN EXPRESSION; SURVIVAL; TISSUE MICROARRAY;

BREAST NEOPLASMS; CARCINOMA; CELL CYCLE; CELL CYCLE PROTEINS; CHI-SQUARE DISTRIBUTION; DISEASE PROGRESSION; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC ASSOCIATION STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; PHENOTYPE; PROGNOSIS; PROTEIN-SERINE-THREONINE KINASES; TISSUE ARRAY ANALYSIS;

EID: 75949114139     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.08.008     Document Type: Article

References (35)

1. Sclafani R.A. Cdc7p-Dbf4p becomes famous in the cell cycle. J Cell Sci 113 Pt 12 (2000) 2111-2117
2. Kim J.M., Yamada M., and Masai H. Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development. Mutat Res 532 (2003) 29-40
3. Masai H., and Arai K. Cdc7 kinase complex: a key regulator in the initiation of DNA replication. J Cell Physiol 190 (2002) 287-296
4. Masai H., Taniyama C., Ogino K., et al. Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin. J Biol Chem 281 (2006) 39249-39261
5. Tsuji T., Ficarro S.B., and Jiang W. Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. Mol Biol Cell 17 (2006) 4459-4472
6. Charych D.H., Coyne M., Yabannavar A., et al. Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells. J Cell Biochem 104 (2008) 1075-1086
7. Montagnoli A., Tenca P., Sola F., et al. Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells. Cancer Res 64 (2004) 7110-7116
8. Yoshizawa-Sugata N., Ishii A., Taniyama C., Matsui E., Arai K., and Masai H. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. J Biol Chem 280 (2005) 13062-13070
9. Im J.S., and Lee J.K. ATR-dependent activation of p38 MAP kinase is responsible for apoptotic cell death in cells depleted of Cdc7. J Biol Chem 283 (2008) 25171-25177
10. Kim J.M., Kakusho N., Yamada M., Kanoh Y., Takemoto N., and Masai H. Cdc7 kinase mediates claspin phosphorylation in DNA replication checkpoint. Oncogene 27 (2008) 3475-3482
11. Montagnoli A., Valsasina B., Croci V., et al. A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol 4 (2008) 357-365
12. Vanotti E., Amici R., Bargiotti A., et al. Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships. J Med Chem 51 (2008) 487-501
13. Menichincheri M., Bargiotti A., Berthelsen J., et al. First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem (2009)
14. Bonte D., Lindvall C., Liu H., Dykema K., Furge K., and Weinreich M. Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation. Neoplasia 10 (2008) 920-931
15. Clarke L.E., Fountaine T.J., Hennessy J., et al. Cdc7 expression in melanomas, Spitz tumors and melanocytic nevi. J Cutan Pathol 36 (2009) 433-438
16. Kulkarni A.A., Kingsbury S.R., Tudzarova S., et al. Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma. Clin Cancer Res (2009)
17. Sauter G., Simon R., and Hillan K. Tissue microarrays in drug discovery. Nat Rev Drug Discov 2 (2003) 962-972
18. Al-Kuraya K., Schraml P., Torhorst J., et al. Prognostic relevance of gene amplifications and coamplifications in breast cancer. Cancer Res 64 (2004) 8534-8540
19. Ruiz C., Seibt S., Al Kuraya K., et al. Tissue microarrays for comparing molecular features with proliferation activity in breast cancer. Int J Cancer 118 (2006) 2190-2194
20. Holst F., Stahl P.R., Ruiz C., et al. Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer. Nat Genet 39 (2007) 655-660
21. Simon R., Panussis S., Maurer R., et al. KIT (CD117)-positive breast cancers are infrequent and lack KIT gene mutations. Clin Cancer Res 10 (2004) 178-183
22. Matkovic B., Juretic A., Separovic V., et al. Immunohistochemical analysis of ER, PR, HER-2, CK 5/6, p63 and EGFR antigen expression in medullary breast cancer. Tumori 94 (2008) 838-844
23. Park K., Kwak K., Kim J., Lim S., and Han S. c-myc Amplification is associated with HER2 amplification and closely linked with cell proliferation in tissue microarray of nonselected breast cancers. Hum Pathol 36 (2005) 634-639
24. Courjal F., and Theillet C. Comparative genomic hybridization analysis of breast tumors with predetermined profiles of DNA amplification. Cancer Res 57 (1997) 4368-4377
25. Yoshida K., Takisawa H., and Kubota Y. Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs. Genes Cells 10 (2005) 63-73
26. Zimmer W.E. Amplification of chicken actin genes during myogenesis. In: Schimke R.T. (Ed). Gene amplification (1982), Cold Spring Harbor Press, Cold Spring Harbor (NY) 137-146
27. Schwed G., May N., Pechersky Y., and Calvi B.R. Drosophila minichromosome maintenance 6 is required for chorion gene amplification and genomic replication. Mol Biol Cell 13 (2002) 607-620
28. Cavaliere V., Bernardi F., Romani P., Duchi S., and Gargiulo G. Building up the Drosophila eggshell: first of all the eggshell genes must be transcribed. Dev Dyn 237 (2008) 2061-2072
29. Spradling A.C. The organization and amplification of two chromosomal domains containing Drosophila chorion genes. Cell 27 (1981) 193-201
30. Landis G., and Tower J. The Drosophila chiffon gene is required for chorion gene amplification, and is related to the yeast Dbf4 regulator of DNA replication and cell cycle. Development 126 (1999) 4281-4293
31. Boskovic J., Coloma J., Aparicio T., et al. Molecular architecture of the human GINS complex. EMBO Rep 8 (2007) 678-684
32. Bauerschmidt C., Pollok S., Kremmer E., Nasheuer H.P., and Grosse F. Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase. Genes Cells 12 (2007) 745-758
33. Halazonetis T.D., Gorgoulis V.G., and Bartek J. An oncogene-induced DNA damage model for cancer development. Science 319 (2008) 1352-1355
34. Ito S., Taniyami C., Arai N., and Masai H. Cdc7 as a potential new target for cancer therapy. Drug News Perspect 21 (2008) 481-488
35. Bartek J., Bartkova J., and Lukas J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 26 (2007) 7773-7779