Mono(2-ethylhexyl) phthalate induces both pro- and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase pathway and PPARα

Inhalation Toxicology

Volumn 22, Issue 2, 2010, Pages 140-150

  Rakkestad, Kirsten E ^a   Holme, Jørn A ^a   Paulsen, Ragnhild E ^b   Schwarze, Per E ^a   Becher, Rune ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Alveolar macrophages; Inflammatory responses; Phthalates

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ARACHIDONATE 5 LIPOXYGENASE; LEUKOTRIENE B4; LIPOXYGENASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NORDIHYDROGUAIARETIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; DRUG EXPOSURE; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL DEATH; CELL MEMBRANE; CELL SEPARATION; CYCLOOXYGENASE 2; CYTOKINES; DIETHYLHEXYL PHTHALATE; INFLAMMATION; LEUKOTRIENES; LIPOXYGENASE; MACROPHAGES, ALVEOLAR; MALE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PPAR ALPHA; RATS; RATS, INBRED WKY; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RECEPTOR CROSS-TALK; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 75449110545     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958370903019885     Document Type: Article

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