Genetic influences on addiction

Primary Psychiatry

Volumn 16, Issue 8, 2009, Pages 40-46

  Edwards, Alexis C ^a   Svikis, Dace S ^b   Pickens, Roy W ^a   Dick, Danielle M ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b Department of Psychology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ALCOHOL; DOPAMINE; MUSCARINIC RECEPTOR; NEUROPEPTIDE Y; NICOTINE; NICOTINIC RECEPTOR; OPIATE;

ADDICTION; ALCOHOL METABOLISM; ALCOHOLISM; COMORBIDITY; DRUG ABUSE; ENVIRONMENTAL FACTOR; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENOME; HEREDITY; HERITABILITY; HUMAN; PHARMACOGENETICS; REVIEW; REWARD; TOBACCO DEPENDENCE;

EID: 75349107776     PISSN: 10826319     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (79)

1. Executive Summary. Available at: http://staging.whitehousedrugpolicy.gov/ publications/economic-costs/e-summary.pdf. Accesed July 8, 2009.
2. Hasin DS, Stinson FS, Ogburn E, Grant BF. Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry. 2007;64(7):830-842.
3. Kendler KS, Prescott CA. Genes, Environment, and Psychopathology. 1st ed. New York, NY: The Guilford Press; 2006.
4. Prescott CA, Kendler KS. Influence of ascertainment strategy on finding sex differences in genetic estimates from twin studies of alcoholism. Am J Med Genet. 2000;96(6):754-761.
5. Hansell NK, Agrawal A, Whitfield JB, et al. Long-term stability and heritability of telephone interview measures of alcohol consumption and dependence. Twin Res Hum Genet. 2008;11(3):287-305.
6. Broms U, Madden PA, Heath AC, Pergadia ML, Shiffman S, Kaprio J. The Nicotine Dependence Syndrome Scale in Finnish smokers. Drug Alcohol Depend. 2007;89(1):42-51.
7. Vink JM, Willemsen G, Boomsma DI. Heritability of smoking initiation and nicotine dependence. Behav Genet. 2005;35(4):397-406.
8. Kendler KS, Prescott CA. Cannabis use, abuse, and dependence in a population-based sample of female twins. Am J Psychiatry. 1998;155(8):1016-1022.
9. Tsuang MT, Lyons MJ, Meyer JM, et al. Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch Gen Psychiatry. 1998;55(11):967-972.
10. Kendler KS, Schmitt E, Aggen SH, Prescott CA. Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood. Arch Gen Psychiatry. 2008;65(6):674-682.
11. Kendler KS, Jacobson KC, Prescott CA, Neale MC. Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. Am J Psychiatry. 2003;160(4):687-695.
12. Kendler KS, Prescott CA, Myers J, Neale MC. The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Arch Gen Psychiatry. 2003;60(9):929-937.
13. Sun F, Tsuritani I, Honda R, Ma Z, Yamada Y. Association of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men. Hum Genet. 1999;105(4):295-300.
14. Edenberg HJ. The genetics of alcohol metabolism. Role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health. 2007;30(1):5-13.
15. Reich T, Edenberg HJ, Goate A, et al. Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet. 1998;81(3):207-215.
16. Uhl GR, Liu QR, Walther D, Hess J, Naiman D. Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. Am J Hum Genet. 2001;69(6):1290-1300.
17. Edenberg HJ, Xuei X, Chen H-J, et al. Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. Hum Mol Genet. 2006;15(9):1539-1549.
18. Kuo PH, Kalsi G, Prescott CA, et al. Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. Alcohol Clin Exp Res. 2008;32(5):785-795.
19. Prescott CA, Sullivan PF, Kuo PH, et al. Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. Mol Psychiatry. 2006;11(6):603-611.
20. Grobin AC, Matthews DB, Devaud LL, Morrow AL. The role of GABAA receptors in the acute and chronic effects of ethanol. Psychopharmacology (Berl). 1998;139(1-2):2-19.
21. Dick DM, Agrawal A. The genetics of alcohol and other drug dependence. Alcohol Res Health, 2008;31(2):111-118.
22. Edenberg HJ, Dick DM, Xuei X, et al. Variations in GABRA2, Encoding the ±2 Subunit of the GABAA Receptor, Are Associated with Alcohol Dependence and with Brain Oscillations. Am J Hum Genet. 2004;74(4):705-714.
23. Agrawal A, Edenberg HJ, Foroud T, et al. Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Behav Genet. 2006;36(5):640-650.
24. Dick D, Bierut L, Hinrichs A, et al. The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. Behav Genet. 2006;36(4):577-590.
25. Enoch MA, Hodgkinson CA, Yuan Q, Albaugh B, Virkkunen M, Goldman D. GABRG1 and GABRA2 as independent predictors for alcoholism in two populations. Neuropsychopharmacology. 2009;34(5):1245-1254.
26. Rangaswamy M, Porjesz B. Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes. Brain Res. 2008;1235:153-171.
27. Dick DM. Identification of genes influencing a spectrum of externalizing psychopathology. Curr Dir Psychol Sci. 2007;16(6):331-335.
28. Dick DM, Plunkett J, Wetherill LF, et al. Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample. Alcohol Clin Exp Res. 2006;30(7):1101-1110.
29. Kuo PH, Kalsi G, Prescott CA, et al. Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence. Drug Alcohol Depend. 2009;101(1-2):80-87.
30. Dick DM, Edenberg HJ, Xuei X, et al. Association of GABRG3 with alcohol dependence. Alcohol Clin Exp Res. 2004;28(1):4-9.
31. Saccone SF, Hinrichs AL, Saccone NL, et al. Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet. 2007;16(1):36-49.
32. Thorsell A. Central neuropeptide Y in anxiety- and stress-related behavior and in ethanol intake. Ann N Y Acad Sci. Dec 2008;1148:136-140.
33. Thiele TE, Marsh DJ, Ste Marie L, Bernstein IL, Palmiter RD. Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature. 1998;396(6709):366-369.
34. Kauhanen J, Karvonen MK, Pesonen U, et al. Neuropeptide Y polymorphism and alcohol consumption in middle-aged men. Am J Med Genet. 2000;93(2):117-121.
35. Eva C, Serra M, Mele P, Panzica G, Oberto A. Physiology and gene regulation of the brain NPY Y1 receptor. Front Neuroendocrinol. 2006;27(3):308-339.
36. Wetherill L, Schuckit MA, Hesselbrock V, et al. Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. Alcohol Clin Exp Res. 2008;32(12):2031-2040.
37. Sullivan PF, Neale BM, van den Oord E, et al. Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics. Am J Med Genet B Neuropsychiatr Genet. 2004;126B(1):23-36.
38. Rylkova D, Boissoneault J, Isaac S, Prado M, Shah HP, Bruijnzeel AW. Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats. Neuropeptides. 2008;42(3):215-227.
39. Chen H, Hansen MJ, Jones JE, et al. Regulation of hypothalamic NPY by diet and smoking. Peptides. 2007;28(2):384-389.
40. Adinoff B. Neurobiologic processes in drug reward and addiction. Harv Rev Psychiatry. 2004;12(6):305-320.
41. Han DH, Yoon SJ, Sung YH, et al. A preliminary study: novelty seeking, frontal executive function, and dopamine receptor (D2) TaqI A gene polymorphism in patients with methamphetamine dependence. Compr Psychiatry. 2008;49(4):387-392.
42. Xu K, Lichtermann D, Lipsky RH, et al. Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch Gen Psychiatry. 2004;61(6):597-606.
43. Radwan GN, El-Setouhy M, Mohamed MK, et al. DRD2/ANKK1 TaqI polymorphism and smoking behavior of Egyptian male cigarette smokers. Nicotine Tob Res. 2007;9(12):1325-1329.
44. Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. Alcohol Clin Exp Res. 2008;32(12):2117-2127.
45. Dick DM, Wang JC, Plunkett J, et al. Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. Alcohol Clin Exp Res. 2007;31(10):1645-1653.
46. Gelernter J, Yu Y, Weiss R, et al. Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. Hum Mol Genet. 2006;15(24):3498-3507.
47. Persico AM, Bird G, Gabbay FH, Uhl GR. D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: enhanced frequencies in psychostimulant-preferring polysubstance abusers. Biol Psychiatry. 1996;40(8):776-784.
48. Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJ, Comings DE. Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour. Pharmacogenetics. 1995;5(3):121-141.
49. Li T, Zhu ZH, Liu X, et al. Association analysis of polymorphisms in the DRD4 gene and heroin abuse in Chinese subjects. Am J Med Genet. 2000;96(5):616-621.
50. Perkins KA, Lerman C, Grottenthaler A, et al. Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood. Behav Pharmacol. 2008;19(5-6):641-649.
51. Ray LA, Bryan A, Mackillop J, McGeary J, Hesterberg K, Hutchison KE. The dopamine D(4) Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects. Addict Biol. 2008;14(2):238-244.
52. Schmack K, Schlagenhauf F, Sterzer P, et al. Catechol-O-methyltransferase val158met genotype influences neural processing of reward anticipation. Neuroimage. 2008;42(4):1631-1638.
53. Oosterhuis BE, LaForge KS, Proudnikov D, et al. Catechol-O- methyltransferase (COMT) gene variants: possible association of the Val158Met variant with opiate addiction in Hispanic women. Am J Med Genet B Neuropsychiatr Genet. 2008;147B(6):793-798.
54. Beuten J, Payne TJ, Ma JZ, Li MD. Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. Neuropsychopharmacology. 2006;31(3):675-684.
55. Hoft NR, Corley RP, McQueen MB, Schlaepfer IR, Huizinga D, Ehringer MA. Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample. Neuropsychopharmacology. 2009;34(3):698-706.
56. Bierut LJ, Madden PA, Breslau N, et al. Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet. 2007;16(1):24-35.
57. Lou XY, Ma JZ, Payne TJ, Beuten J, Crew KM, Li MD. Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. Hum Genet. 2006;120(3):381-389.
58. Jones KA, Porjesz B, Almasy L, et al. Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition. Int J Psychophysiol. 2004;53(2):75-90.
59. Wang JC, Hinrichs AL, Stock H, et al. Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. Hum Mol Genet. 2004;13(17):1903-1911.
60. Luo X, Kranzler HR, Zuo L, Wang S, Blumberg HP, Gelernter J. CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. Hum Mol Genet. 2005;14(16):2421-2434.
61. Dick D, Aliev F, Kramer J, et al. Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence. Behav Genet. 2007;37(2):265-272.
62. Giacomini KM, Brett CM, Altman RB, et al. The pharmacogenetics research network: from SNP discovery to clinical drug response. Clin Pharmacol Ther. 2007;81(3):328-345.
63. Rutter JL. Symbiotic relationship of pharmacogenetics and drugs of abuse. AAPS J. 2006;8(1):E174-E184.
64. Benowitz NL, Swan GE, Jacob P, 3rd, Lessov-Schlaggar CN, Tyndale RF. CYP2A6 genotype and the metabolism and disposition kinetics of nicotine. Clin Pharmacol Ther. 2006;80(5):457-467.
65. Swan GE, Lessov-Schlaggar CN, Bergen AW, He Y, Tyndale RF, Benowitz NL. Genetic and environmental influences on the ratio of 3'hydroxycotinine to cotinine in plasma and urine. Pharmacogenet Genomics. 2009;19(5):388-398.
66. Ho M, Mwenifumbo J, Al Koudsi N, et al. Association of Nicotine Metabolite Ratio and CYP2A6 Genotype With Smoking Cessation Treatment in African-American Light Smokers. Clin Pharmacol Ther. 2009;85(6):635-643.
67. Lerman C, Shields PG, Wileyto EP, et al. Pharmacogenetic investigation of smoking cessation treatment. Pharmacogenetics. 2002;12(8):627-634.
68. Tyndale RF, Droll KP, Sellers EM. Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence. Pharmacogenetics. 1997;7(5):375-379.
69. Perez de los Cobos J, Sinol N, Trujols J, et al. Association of CYP2D6 ultrarapid metabolizer genotype with deficient patient satisfaction regarding methadone maintenance treatment. Drug Alcohol Depend. 2007;89(2-3):190-194.
70. Kreek MJ, Bart G, Lilly C, LaForge KS, Nielsen DA. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol Rev. 2005;57(1):1-26.
71. Levran O, Londono D, O'Hara K, et al. Genetic susceptibility to heroin addiction: a candidate gene association study. Genes Brain Behav. 2008;7(7):720-729.
72. Williams TJ, LaForge KS, Gordon D, et al. Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence. Addict Biol. 2007;12(3-4):496-502.
73. Xuei X, Flury-Wetherill L, Bierut L, et al. The opioid system in alcohol and drug dependence: family-based association study. Am J Med Genet B Neuropsychiatr Genet. 2007;144B(7):877-884.
74. Haile CN, Kosten TA, Kosten TR. Pharmacogenetic treatments for drug addiction: alcohol and opiates. Am J Drug Alcohol Abuse. 2008;34(4):355-381.
75. Mayer P, Hollt V. Genetic disposition to addictive disorders--current knowledge and future perspectives. Curr Opin Pharmacol. 2005;5(1):4-8.
76. Oslin DW, Berrettini W, Kranzler HR, et al. A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. Neuropsychopharmacology. 2003;28(8):1546- 1552.
77. Kim SG, Kim CM, Choi SW, et al. A micro opioid receptor gene polymorphism (A118G) and naltrexone treatment response in adherent Korean alcohol-dependent patients. Psychopharmacology (Berl). 2009;201(4):611-618.
78. Tidey JW, Monti PM, Rohsenow DJ, et al. Moderators of naltrexone's effects on drinking, urge, and alcohol effects in non-treatment-seeking heavy drinkers in the natural environment. Alcohol Clin Exp Res. 2008;32(1):58-66.
79. Dick DM, Rose RJ, Kaprio J. The next challenge for psychiatric genetics: characterizing the risk associated with identified genes. Ann Clin Psychiatry. 2006;18(4):223-231.