The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages

Behavior Genetics

Volumn 36, Issue 4, 2006, Pages 577-590

  Dick, Danielle M ^a,i   Bierut, Laura ^a   Hinrichs, Anthony ^a   Fox, Louis ^a   Bucholz, Kathleen K ^a   Kramer, John ^b   Kuperman, Samuel ^b   Hesselbrock, Victor ^c   Schuckit, Marc ^d   Almasy, Laura ^e   Tischfield, Jay ^f   Porjesz, Bernice ^g   Begleiter, Henri ^g   Nurnberger Jr , John ^h   Xuei, Xiaoling ^h   Edenberg, Howard J ^h   Foroud, Tatiana ^h  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^f RUTGERS UNIVERSITY   (United States)

^g SUNY DOWNSTATE MEDICAL CENTER   (United States)

^h INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ WUSM   (United States)

Author keywords

Alcohol; Conduct disorder; Dependence; Drug; GABA; Substance use

Indexed keywords

4 AMINOBUTYRIC ACID; ALCOHOL; CANNABIS; DNA; ILLICIT DRUG;

ADOLESCENCE; ADULT; ADULTHOOD; AGED; ALCOHOLISM; ARTICLE; CANNABIS ADDICTION; CONDUCT DISORDER; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DNA DETERMINATION; DRUG DEPENDENCE; FEMALE; GABRA2 GENE; GENE; GENETIC LINKAGE; GENOTYPE; HUMAN; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PHENOTYPE; REGRESSION ANALYSIS; RISK; STATISTICAL ANALYSIS; SUBSTANCE ABUSE; SURVIVAL RATE; SYMPTOMATOLOGY;

ADOLESCENT; ADULT; AGE OF ONSET; AGING; ALCOHOLISM; CHILD; HUMANS; MENTAL DISORDERS; MIDDLE AGED; RECEPTORS, GABA-A; REGRESSION ANALYSIS; RISK FACTORS; SUBSTANCE-RELATED DISORDERS; SURVIVAL ANALYSIS; UNITED STATES;

TACCA LEONTOPETALOIDES;

EID: 33745659406     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10519-005-9041-8     Document Type: Article

References (39)

1. American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders: IIIR. Washington DC: American Psychiatric Association.
2. Bierut, L., Dinwiddle, S. H., Begleiter, H., Crowe, R., Hesselbrock, V., Nurnberger, J. I. Jr., Porjesz, B., Schuckit, M., and Reich, T. (1998). Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism. Arch. Gen. Psychiatry 55:982-988.
3. Boehnke, M. (1991). Allele frequency estimation from pedigree data. Am. J. Hum. Genet. 48:22-25.
4. Bucholz, K. K., Cadoret, R., Cloninger, C. R., Dinwiddie, S. H., Hesselbrock, V. M., Nurnberger, J. J. I., Reich, T., Schmidt, I., and Schuckit, M. A. (1994). A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J. Stud. Alcohol 55:149-158.
5. Chen, L., Yang, C., and Mower, G. D. (2001). Developmental changes in the expression of GABA(A) receptor subunits (alpha(1), alpha(2), alpha(3)) in the cat visual cortex and the effects of dark rearing. Brain Res. Mol. Brain Res. 88:135-143.
6. Claus, E. B., Risch, N. J., and Thompson, W. D. (1990). Using age of onset to distinguish between subforms of breast cancer. Ann. Hum. Genet. 54:169-177.
7. Cleves, M. A., Gould, W. W., and Gutierrex, R. C. (2004). An Introduction to Survival Analysis using Stata. College Station, TX: Stata Corporation.
8. Cloninger, C. R., Bohman, M., and Sigvardsson, S. (1981). Inheritance of alcohol abuse: cross-fostering analysis of adopted men. Arch. Gen. Psychiatry 38:861-868.
9. Covault, J., Gelernter, J., Hesselbrock, V., Nellissery, M., and Kranzler, H. R. (2004). Allelic and haplotypic association of GABRA2 with alcohol dependence. Am. J. Med. Genet. B Neuropsychiatr. Genet. 129B:104-109.
10. Dick, D. M., Agrawal, A., Schuckit, M., Bierut, L., Hinrichs, A. L., Cloninger, C. R., Fox, L., Mullaney, J., Hesselbrock, V., Nurnberger Jr., J. I., Almasy, L., Foroud, T., Porjesz, B., Edenberg, H. J., and Begleiter, H. (2005, in press). Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction. J. Stud. Alcohol
11. Dick, D. M., Li, T. K., Edenberg, H. J., Hesselbrock, V., Kramer, J. R., and Foroud, T. (2003). A genome-wide screen for genes influencing conduct disorder. Mol. Psychiatry 9:81-86.
12. Edenberg, H. J., Dick, D. M., Xuei, X., Tian, H., Almasy, L., Bauer, L. O., Crowe, R., Goate, A., Hesselbrock, V., Jones, K. A., Kwon, J., Li, T. K., Nurnberger, J. I. Jr., O'Connor, S. J., Reich, T., Rice, J., Schuckit, M., Porjesz, B., Foroud, T., and Begleiter, H. (2004). Variations in GABRA2, encoding the α2 subunit of the GABA-A receptor are associated with alcohol dependence and with brain oscillations. Am. J. Hum. Genet. 74:705-714.
13. Fisher, S. L., Bucholz, K. K., Reich, W., Fox, L., Kuperman, S., Kramer, J. R., Hesselbrock, V., Dick, D. M., Nurnberger, J. I. Jr., Edenberg, H. J., and Bierut, L. (2005, under review). Teenagers are right - Parents don't know much: an analysis of adolescent-parent agreement on reports of adolescent substance use, abuse, and dependence
14. Goldstein, R. B., Prescott, C., and Kendler, K. S. (2001). Genetic and environmental factors in conduct problems and adult antisocial behavior among adult female twins. J. Nerv. Ment. Dis. 189:201-209.
15. Heath, A. C., Bucholz, K. K., Madden, P. A., Dinwiddle, S. H., Slutske, W. S., Bierut, L., Statham, D. J., Dunne, M. P., Whitfield, J. B., and Martin, N. G. (1997). Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychol. Med. 27:1381-1396.
16. Hesselbrock, M., Easton, C., Bucholz, K. K., Schuckit, M., and Hesselbrock, V. (1999). A validity study of the SSAGA - a comparison with the SCAN. Addiction 94:1361-1370.
17. Institute, S. (2001) Version 8 of the SAS System for Windows. SAS Institute Inc., Cary, NC
18. Kendler, K. S., Prescott, C., Myers, J., and Neale, M. C. (2003). The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Arch. Gen. Psychiatry 60:929-937.
19. Knopik, V. (2005) Alcoholism and externalizing disorders: comorbidity risk mediated via intrauterine exposure. Paper presented at the Fifth Annual Guze Symposium on Alcoholism, St. Louis, MO, 2005
20. Kuperman, S., Schlosser, S. S., Kramer, J. R., Bucholz, K. K., Hesselbrock, V., Reich, T., and Reich, W. (2001a). Developmental sequence from disruptive behavior diagnosis to adolescent alcohol dependence. Am. J. Psychiatry 158:2022-2026.
21. Kuperman, S., Schlosser, S. S., Kramer, J. R., Bucholz, K. K., Hesselbrock, V., Reich, T., and Reich, W. (2001b). Risk domains associated with an adolescent alcohol dependence diagnosis. Addiction 96:629-636.
22. Lappalainen, J., Krupitsky, E., Remizov, M., Pchelina, S., Taraskina, A., Zvartau, E., Somberg, L. K., Covault, J., Kranzler, H. R., Krystal, J., and Gelernter, J. (2005). Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population. Alcohol. Clin. Exp. Res. 29:493-498.
23. Mantel, N., and McGue, M. (1999). The behavioral genetics of alcoholism. Curr. Dir. Psychol. Sci. 8:109-115.
24. McGue, M., and Bouchard, J. T. J. (1998). Genetic and environmental influences on human behavioral differences. Ann. Rev. Neurosci. 21:1-24.
25. McGuffin, P., Riley, B., and Plomin, R. (2001). Toward behavioral genomics. Science 291:1232-1249.
26. Molina, B. S. G., Bukstein, O. G., and Lynch, K. G. (2002). Attention-deficit/hyperactivity disorder and conduct disorder symptomatology in adolescents with alcohol use disorder. Psychol. Addict. Behav. 16:161-164.
27. Moss, H. B., and Lynch, K. G. (2001). Comorbid disruptive behavior disorder symptoms and their relationship to adolescent alcohol use disorders. Drug Alcohol Depend. 64:75-83.
28. Reich, T. (1996). A genomic survey of alcohol dependence and related phenotypes: results from the Collaborative Study on the Genetics of Alcoholism (COGA). Alcohol. Clin. Exp. Res. 20:133A-137A.
29. Rhee, S. H., Hewitt, J. K., Young, S. E., Corley, R. P., Crowley, T. J., and Stallings, M. C. (2003). Genetic and environmental influences on substance initiation, use, and problem use in adolescents. Arch. Gen. Psychiatry 60:1256-1264.
30. Rose, R. J. (1995). Genes and human behavior. Ann. Rev. Psychol. 46:625-654.
31. Rose, R. J., Dick, D. M., Viken, R. J., and Kaprio, J. (2001a). Gene-environment interaction in patterns of adolescent drinking: regional residency moderates longitudinal influences on alcohol use. Alcohol. Clin. Exp. Res. 25:637-643.
32. Rose, R. J., Dick, D. M., Viken, R. J., Pulkkinen, L., and Kaprio, J. (2001b). Drinking or abstaining at age 14: a genetic epidemiological study. Alcohol. Clin. Exp. Res. 25:1594-1604.
33. Rose, R. J., Dick, D. M., Viken, R. J., Pulkkinen, L., Nurnberger, J. I. Jr., and Kaprio, J. (2004). Genetic and environmental effects on conduct disorder, alcohol dependence symptoms, and their covariation at age 14. Alcohol. Clin. Exp. Res. 28:1541-1548.
34. Rose, R. J., Viken, R. J., Dick, D. M., Bates, J., Pulkkinen, L., and Kaprio, J. (2003). It does take a village: nonfamilial environments and children's behavior. Psychol. Sci. 14:273-277.
35. Simonoff, E., Pickles, A., Meyer, J. M., Silberg, J. L., and Maes, H. H. (1998). Genetic and environmental influences on subtypes of conduct disorder behavior in boys. J. Abnorm. Child Psychol. 26:495-509.
36. Slutske, W. S., Heath, A. C., Dinwiddie, S. H., Madden, P. A. F., Bucholz, K. K., Dunne, M. P., Statham, D. J., and Martin, N. G. (1997). Modeling genetic and environmental influences in the etiology of conduct disorder: a study of 2682 adult twin pairs. J. Abnorm. Psychol. 106:266-279.
37. Slutske, W. S., Heath, A. C., Dinwiddle, S. H., Madden, P. A. F., Bucholz, K. K., Dunne, M. P., Statham, D. J., and Martin, N. G. (1998). Common genetic risk factors for conduct disorder and alcohol dependence. J. Abnorm. Psychol. 107:363-374.
38. StataCorp (2003). Stata Statistical Software: Release 8.0. College Station, TX: Stata Corporation.
39. White, H. R., Zie, M., Thompson, W., Loeber, R., and Stouthamer-Loeber, M. (2001). Psychopathology as a predictor of adolescent drug use trajectories. Psychol. Addict. Behav. 15:210-218.