The opioid system in alcohol and drug dependence: Family-based association study

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 144, Issue 7, 2007, Pages 877-884

  Xuei, Xiaoling ^a   Flury Wetherill, Leah ^a   Bierut, Laura ^b   Dick, Danielle ^b   Nurnberger Jr , John ^a   Foroud, Tatiana ^a   Edenberg, Howard J ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

and opioid receptors; Alcoholism; Endorphins; Enkephalins; Genetics

Indexed keywords

DELTA OPIATE RECEPTOR; ILLICIT DRUG; MU OPIATE RECEPTOR; OPIATE RECEPTOR;

ALCOHOLISM; ARTICLE; DRUG DEPENDENCE; EUROPEAN AMERICAN; FAMILY STUDY; GENETIC ASSOCIATION; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; OPIATE ADDICTION; OPRD1 GENE; OPRM1 GENE; PENK GENE; PHENOTYPE; POMC GENE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ALCOHOLISM; FAMILY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; OPIOID PEPTIDES; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; VARIATION (GENETICS);

EID: 35148848178     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30531     Document Type: Article

References (67)

1. American Psychiatric Association. 1987. Diagnostic and Statistical manual of mental disorders, 3rd edition, editors. Washington, DC: American Psychiatric Association Press.
2. Arias A, Feinn R, Kranzler HR. 2006. Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: A meta-analysis. Drug Alcohol Depend 83(3):262-268.
3. Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263-265.
4. Bart G, Heilig M, LaForge KS, Pollak L, Leal SM, Ott J, Kreek MJ. 2004. Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Mol Psychiatry 9(6):547-549.
5. Bart G, Kreek MJ, Ott J, LaForge KS, Proudnikov D, Pollak L, Heilig M. 2005. Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology 30(2):417-422.
6. Befort K, Filliol D, Decaillot FM, Gaveriaux-Ruff C, Hoehe MR, Kieffer BL. 2001. A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling. J Biol Chem 276(5):3130-3137.
7. Begleiter H, Reich T, Hesselbrock V, Porjesz B, Li T-K, Schuckit MA, Edenberg HJ, Rice AP. 1995. The Collaborative Study on the Genetics of Alcoholism. AlcHealthResWorld 19:228-236.
8. Bergen AW, Kokoszka J, Peterson R, Long JC, Virkkunen M, Linnoila M, Goldman D. 1997. Mu opioid receptor gene variants: Lack of association with alcohol dependence. Mol Psychiatry 2(6):490-494.
9. Beyer A, Koch T, Schroder H, Schulz S, Hollt V. 2004. Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human muopioid receptor. J Neurochem 89(3):553-560.
10. Boehnke M. 1991. Allele frequency estimation from data on relatives. Am J Hum Genet 48(1):22-25.
11. Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, Gong J, Schluger J, Strong JA, Leal SM. et al. 1998. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction. Proc Natl Acad Sci USA 95(16):9608-9613.
12. Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger JI Jr, Reich T, Schmidt I, Schuckit MA. 1994. A new, semi-structured psychiatric interview for use in genetic linkage studies: A report on the reliability of the SSAGA. J Stud Alcohol 55(2):149-158.
13. Comb M, Seeburg PH, Adelman J, Eiden L, Herbert E. 1982. Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA. Nature 295:663-666.
14. Comings DE, Blake H, Dietz G, Gade-Andavolu R, Legro RS, Saucier G, Johnson P, Verde R, MacMurray JP. 1999. The proenkephalin gene (PENK) and opioid dependence. Neuroreport 10(5):1133-1135.
15. Crowley JJ, Oslin DW, Patkar AA, Gottheil E, DeMaria PA Jr, O'Brien CP, Berrettini WH, Grice DE. 2003. A genetic association study of the mu opioid receptor and severe opioid dependence. Psychiatr Genet 13(3):169-173.
16. de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D. 2005. Efficiency and power in genetic association studies. Nat Genet 37(11):1217-1223.
17. Di Chiara G, Acquas E, Tanda G. 1996. Ethanol as a neurochemical surrogate of conventional reinforcers: The dopamine-opioid link. Alcohol 13:13-17.
18. Drakenberg K, Nikoshkov A, Horvath MC, Fagergren P, Gharibyan A, Saarelainen K, Rahman S, Nylander I, Bakalkin G, Rajs J, et al. 2006. Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers. Proc Natl Acad Sci USA 103(20):7883-7888.
19. Dudbridge F. 2003. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25(2):115-121.
20. Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, Crowe RR, Goate A, Hesselbrock V, Jones K, et al. 2004. Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet 74(4):705-714.
21. Feighner JP, Robins E, Guze SB, Woodruff RA Jr, Winokur G, Munoz R. 1972. Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry 26(1):57-63.
22. Foroud T, Edenberg HJ, Goate A, Rice J, Flury L, Koller DL, Bierut LJ, Conneally PM, Nurnberger JI, Bucholz KK, et al. 2000. Alcoholism susceptibility loci: Confirmation studies in a replicate sample and further mapping. Alcohol Clin Exp Res 24(7):933-945.
23. Franke P, Nothen MM, Wang T, Neidt H, Knapp M, Lichtermann D, Weiffenbach O, Mayer P, Hollt V, Propping P, et al. 1999. Human delta-opioid receptor gene and susceptibility to heroin and alcohol dependence. Am J Med Genet 88(5):462-464.
24. Franke P, Wang T, Nothen MM, Knapp M, Neidt H, Albrecht S, Jahnes E, Propping P, Maier W. 2001. Nonreplication of association between muopioid-receptor gene (OPRM1) A118G polymorphism and substance dependence. Am J Med Genet 105(1):114-119.
25. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, et al. 2002. The structure of haplotype blocks in the human genome. Science 296(5576):2225-2229.
26. Gelernter J, Kranzler H, Cubells J. 1999. Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: Population studies, and allele frequencies in alcohol- and drug-dependent subjects. Mol Psychiatry 4(5):476-483.
27. Grisel JE, Mogil JS, Grahame NJ, Rubinstein M, Belknap JK, Crabbe JC, Low MJ. 1999. Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression. Brain Res 835(1):62-67.
28. Gscheidel N, Sander T, Wendel B, Heere P, Schmidt LG, Rommelspacher H, Hoehe MR, Samochowiec J. 2000. Five exon 1 variants of mu opioid receptor and vulnerability to alcohol dependence. Pol J Pharmacol 52(1):27-31.
29. Hall FS, Sora I, Uhl GR. 2001. Ethanol consumption and reward are decreased in mu-opiate receptor knockout mice. Psychopharmacology 154(1):43-49.
30. Hayward MD, Hansen ST, Pintar JE, Low MJ. 2004. Operant self-administration of ethanol in C57BL/6 mice lacking beta-endorphin and enkephalin. Pharmacol Biochem Behav 79(1):171-181.
31. Herz A. 1997. Endogenous opioid systems and alcohol addiction. Psychopharmacology (Berl) 129(2):99-111.
32. Herz A, Spanagel R. 1995. Endogenous opiois and addiction. In: Tseng LF, editor. The pharmacology of opioids. Germany: Warwood. p 445-462.
33. Hesselbrock M, Easton C, Bucholz KK, Schuckit M, Hesselbrock V. 1999. A validity study of the SSAGA - a comparison with the SCAN. Addiction 94(9):1361-1370.
34. Ide S, Kobayashi H, Tanaka K, Ujike H, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, et al. 2004. Gene polymorphisms of the mu opioid receptor in methamphetamine abusers. Ann N Y Acad Sci 1025:316-324.
35. Kakidani H, Furutani Y, Takahashi H, Noda M, Morimoto Y, Hirose T, Asai M, Inayama S, Nakanishi S, Numa S. 1982. Cloning and sequence analysis of cDNA for porcine beta-neo-endorphin/dynorphin precursor. Nature 298(5871):245-249.
36. Khachaturian IL, Lewis ME, Schafer MKH, Watson SJ. 1985. Anatomy of the CNS opioid systems. Trends Neurol Sci 10:111-119.
37. Kim SG, Kim CM, Kang DH, Kim YJ, Byun WT, Kim SY, Park JM, Kim MJ, Oslin DW. 2004. Association of functional opioid receptor genotypes with alcohol dependence in Koreans. Alcohol Clin Exp Res 28(7):986-990.
38. Kobayashi H, Hata H, Ujike H, Harano M, Inada T, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, et al. 2006. Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. Am J Med Genet B Neuropsychiatr Genet 141(5):482-486.
39. Koenig HN, Olive MF. 2002. Ethanol consumption patterns and conditioned place preference in mice lacking preproenkephalin. Neurosci Lett 325(2):75-78.
40. Koob GF, Roberts AJ, Kieffer BL, Heyser CJ, Katner SN, Ciccocioppo R, Weiss F. 2003. Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology. Recent Dev Alcohol 16:263-281.
41. Kreek M. 2002. Gene diversity in the endorphin system: SNPs, chips and possible implications. In: Yudell M, DeSalle R, editors. The Genomic Revolution: Unveiling the Unity of Life. Washington, DC: National Academy Press/Joseph Henry Press. p 97-108.
42. Kreek MJ. 1996. Opioid receptors: some perspectives from early studies of their role in normal physiology, stress responsivity, and in specific addictive diseases. Neurochem Res 21(11):1469-1488.
43. Li T, Liu X, Zhu Z, Zhao J, Hu X, Sham P, Collier D. 2000. Association analysis of polymorphisms in the mu opioid gene and heroin abuse in Chinese. Addict Biol 5:181-186.
44. Loh EW, Fann CS, Chang YT, Chang CJ, Cheng AT. 2004. Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han. Alcohol Clin Exp Res 28(1):15-19.
45. Luo X, Kranzler HR, Zhao H, Gelernter J. 2003. Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans. Am J Med Genet B Neuropsychiatr Genet 120(1):97-108.
46. Martin ER, Bass MP, Kaplan NL. 2001. Correcting for a potential bias in the pedigree disequilibrium test. Am J Hum Genet 68(4):1065-1067.
47. Martin ER, Monks SA, Warren LL, Kaplan NL. 2000. A test for linkage and association in general pedigrees: The pedigree disequilibrium test. Am J Hum Genet 67(1):146-154.
48. Nakanishi S, Inoue A, Kita T, Nakamura M, Chang AC, Cohen SN. 1979. Nucleotide sequence of cloned cDNA for bovine corticotrophin-b-lipotropin precursor. Nature 278:423-427.
49. Nishizawa D, Han W, Hasegawa J, Ishida T, Numata Y, Sato T, Kawai A, Ikeda K. 2006. Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population. Neuropsychobiology 53(3):137-141.
50. O'Connell JR, Weeks DE. 1998. PedCheck: A program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63(1):259-266.
51. O'Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsavill B. 1992. Naltrexone and coping skills therapy for alcohol dependence: A controlled study. Arch Gen Psychiatry 49(11):881-887.
52. Oslin DW, Berrettini W, Kranzler HR, Pettinati H, Gelernter J, Volpicelli JR, O'Brien CP. 2003. A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. Neuropsychopharmacology 28(8):1546-1552.
53. Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, Van Eerdewegh P, Foroud T, Hesselbrock V, Schuckit MA, Bucholz K, et al. 1998. Genomewide search for genes affecting the risk for alcohol dependence. Am J Med Genet 81(3):207-215.
54. Reisine T, Bell GI. 1993. Molecular biology of opioid receptors. Trends Neurosci 16(12):506-510.
55. Roberts AJ, Gold LH, Polis I, McDonald JS, Filliol D, Kieffer BL, Koob GF. 2001. Increased ethanol self-administration in delta-opioid receptor knockout mice. Alcohol Clin Exp Res 25(9):1249-1256.
56. Roberts AJ, McDonald JS, Heyser CJ, Kieffer BL, Matthes HW, Koob GF, Gold LH. 2000. mu-Opioid receptor knockout mice do not self-administer alcohol. J Pharmacol Exp Therap 293(3):1002-1008.
57. Sander T, Gscheidel N, Wendel B, Samochowiec J, Smolka M, Rommelspacher H, Schmidt LG, Hoehe MR. 1998. Human mu-opioid receptor variation and alcohol dependence. Alcohol Clin Exp Res 22(9):2108-2110.
58. Schinka JA, Town T, Abdullah L, Crawford FC, Ordorica PI, Francis E, Hughes P, Graves AB, Mortimer JA, Mullan M. 2002. A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances. Mol Psychiatry 7(2):224-228.
59. Shi J, Hui L, Xu Y, Wang F, Huang W, Hu G. 2002. Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin. Hum Mutat 19(4):459-460.
60. Spanagel R, Herz A, Shippenberg TS. 1992. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc Natl Acad Sci USA 89(6):2046-2050.
61. Szeto CY, Tang NL, Lee DT, Stadlin A. 2001. Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts. Neuroreport 12(6):1103-1106.
62. Tan EC, Tan CH, Karupathivan U, Yap EP. 2003. Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations. Neuroreport 14(4):569-572.
63. Town T, Abdullah L, Crawford F, Schinka J, Ordorica PI, Francis E, Hughes P, Duara R, Mullan M. 1999. Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency. Am J Med Genet 88(5):458-4561.
64. Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP. 1992. Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49(11):876-880.
65. Xu K, Liu XH, Nagarajan S, Gu XY, Goldman D. 2002. Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case/control sample. Am J Med Genet 110(1):45-50.
66. Xuei X, Dick D, Flury-Wetherill L, Tian H-J, Agrawal A, Bierut L, Goate A, Bucholz K, Schuckit M, Nurnberger J Jr, Tischfield J, Kuperman S, Porjesz B, Begleiter H, Foroud T, Edenberg HJ. 2006. Association of the κ-opioid system with alcohol dependence. Mol Psychiatry Advance online publication August 22, 2006.
67. Zhang H, Luo X, Kranzler HR, Lappalainen J, Yang BZ, Krupitsky E, Zvartau E, Gelernter J. 2006. Association between two μ-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. Hum Mol Genet 15(6):807-819.