Central neuropeptide Y in anxiety- and stress-related behavior and in ethanol intake

Annals of the New York Academy of Sciences

Volumn 1148, Issue , 2008, Pages 136-140

  Thorsell, Annika ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Alcohol; Animal model; Anxiety; Neuropeptide Y; Stress; Y1 receptor

Indexed keywords

ALCOHOL; NEUROPEPTIDE Y;

ACUTE STRESS; ALCOHOL CONSUMPTION; AMYGDALOID NUCLEUS; ANXIETY DISORDER; BRAIN REGION; CENTRAL NERVOUS SYSTEM; CHRONIC STRESS; CONFERENCE PAPER; HIPPOCAMPUS; HUMAN; MAZE TEST; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; STRESS;

ANIMALIA;

EID: 57649217276     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1410.083     Document Type: Conference Paper

References (41)

1. Tatemoto, K., M. Carlquist & V. Mutt. 1982. Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 296 : 659 660.
2. Berglund, M.M., P.A. Hipskind & D.R. Gehlert. 2003. Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes. Exp. Biol. Med. (Maywood.) 228 : 217 244.
3. Heilig, M. & R. Murison. 1987. Intracerebroventricular neuropeptide Y suppresses open field and home cage activity in the rat. Regul. Pept. 19 : 221 231.
4. Heilig, M. & R. Murison. 1987. Intracerebroventricular neuropeptide Y protects against stress-induced gastric erosion in the rat. Eur. J Pharmacol. 137 : 127 129.
5. Broqua, P., J.G. Wettstein, M.N. Rocher, et al. 1995. Behavioral effects of neuropeptide Y receptor agonists in the elevated plus-maze and fear-potentiated startle procedures. Behav. Pharmacol. 6 : 215 222.
6. Heilig, M., B. Soderpalm, J.A. Engel & E. Widerlov. 1989. Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology (Berl) 98 : 524 529.
7. Sajdyk, T.J., M.G. Vandergriff & D.R. Gehlert. 1999. Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test. Eur. J Pharmacol. 368 : 143 147.
8. Heilig, M., S. Mcleod, G.K. Koob & K.T. Britton. 1992. Anxiolytic-like effect of neuropeptide Y (NPY), but not other peptides in an operant conflict test. Regul. Pept. 41 : 61 69.
9. Heilig, M., S. Mcleod, M. Brot, et al. 1993. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology 8 : 357 363.
10. Britton, K.T., S. Southerland, U.E. Van, et al. 1997. Anxiolytic activity of NPY receptor agonists in the conflict test. Psychopharmacology (Berl) 132 : 6 13.
11. Heilig, M. 1995. Antisense inhibition of neuropeptide Y (NPY)-Y1 receptor expression blocks the anxiolytic-like action of NPY in amygdala and paradoxically increases feeding. Regul. Pept. 59 : 201 205.
12. Kask, A., T. Kivastik, L. Rago & J. Harro. 1999. Neuropeptide Y Y1 receptor antagonist BIBP3226 produces conditioned place aversion in rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 23 : 705 711.
13. Kask, A., L. Rago & J. Harro. 1998. Anxiogenic-like effect of the NPY Y1 receptor antagonist BIBP3226 administered into the dorsal periaqueductal gray matter in rats. Regul. Pept. 75-76 : 255 262.
14. Kask, A., L. Rago & J. Harro. 1997. Alpha-helical CRF(9-41) prevents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226 in rats. Neuroreport 8 : 3645 3647.
15. Stogner, K.A. & P.V. Holmes. 2000. Neuropeptide-Y exerts antidepressant-like effects in the forced swim test in rats. Eur. J Pharmacol. 387 : R9 R10.
16. Redrobe, J.P., Y. Dumont, A. Fournier & R. Quirion. 2002. The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neuropsychopharmacology 26 : 615 624.
17. Redrobe, J.P., Y. Dumont & R. Quirion. 2002. Neuropeptide Y (NPY) and depression: from animal studies to the human condition. Life Sci. 71 : 2921 2937.
18. Stenfors, C., E. Theodorsson & A.A. Mathe. 1989. Effect of repeated electroconvulsive treatment on regional concentrations of tachykinins, neurotensin, vasoactive intestinal polypeptide, neuropeptide Y, and galanin in rat brain. J. Neurosci. Res. 24 : 445 450.
19. Wahlestedt, C., J.A. Blendy, K.J. Kellar, et al. 1990. Electroconvulsive shocks increase the concentration of neocortical and hippocampal neuropeptide Y (NPY)-like immunoreactivity in the rat. Brain Res. 507 : 65 68.
20. Wahlestedt, C., E.M. Pich, G.F. Koob, et al. 1993. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science 259 : 528 531.
21. Wahlestedt, C., N. Yanaihara & R. Hakanson. 1986. Evidence for different pre-and post-junctional receptors for neuropeptide Y and related peptides. Regul. Pept. 13 : 307 318.
22. Redrobe, J.P., Y. Dumont, H. Herzog & R. Quirion. 2003. Neuropeptide Y (NPY) Y2 receptors mediate behaviour in two animal models of anxiety: evidence from Y2 receptor knockout mice. Behav. Brain Res. 141 : 251 255.
23. Tschenett, A., N. Singewald, M. Carli, et al. 2003. Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors. Eur. J. Neurosci. 18 : 143 148.
24. Sajdyk, T.J., D.A. Schober & D.R. Gehlert. 2002. Neuropeptide Y receptor subtypes in the basolateral nucleus of the amygdala modulate anxiogenic responses in rats. Neuropharmacology 43 : 1165 1172.
25. Sajdyk, T.J., D.A. Schober, D.L. Smiley & D.R. Gehlert. 2002. Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala. Pharmacol. Biochem. Behav. 71 : 419 423.
26. Andrews, N., S.E. File, C. Fernandes, et al. 1997. Evidence that the median raphe nucleus-dorsal hippocampal pathway mediates diazepam withdrawal-induced anxiety. Psychopharmacology (Berl) 130 : 228 234.
27. Gonzalez, L.E., A.M. Ouagazzal & S.E. File. 1998. Stimulation of benzodiazepine receptors in the dorsal hippocampus and median raphe reveals differential GABAergic control in two animal tests of anxiety. Eur. J Neurosci. 10 : 3673 3680.
28. Thorsell, A., M. Michalkiewicz, Y. Dumont, et al. 2000. Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression. Proc. Natl. Acad. Sci. USA 97 : 12852 12857.
29. Bannon, A.W., J. Seda, M. Carmouche, et al. 2000. Behavioral characterization of neuropeptide Y knockout mice. Brain Res. 868 : 79 87.
30. Thorsell, A., V. Repunte-Canonigo, L.E. O'Dell, et al. 2007. Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats. Brain 130 : 1330 1337.
31. Thorsell, A., P. Svensson, L. Wiklund, et al. 1998. Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress. Regul. Pept. 75-76 : 247 254.
32. Thorsell, A., K. Carlsson, R. Ekman & M. Heilig. 1999. Behavioral and endocrine adaptation, and up-regulation of NPY expression in rat amygdala following repeated restraint stress. Neuroreport 10 : 3003 3007.
33. Moller, C., L. Wiklund, W. Sommer, et al. 1997. Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions. Brain Res. 760 : 94 101.
34. Heilig, M. & A. Thorsell. 2002. Brain neuropeptide Y (NPY) in stress and alcohol dependence. Rev. Neurosci. 13 : 85 94.
35. Thiele, T.E., D.J. Marsh, L. Ste Marie, et al. 1998. Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature 396 : 366 369.
36. Ehlers, C.L., C. Somes & D. Cloutier. 1998. Are some of the effects of ethanol mediated through NPY? Psychopharmacology (Berl) 139 : 136 144.
37. Hwang, B.H., R. Suzuki, L. Lumeng, et al. 2004. Innate differences in neuropeptide Y (NPY) mRNA expression in discrete brain regions between alcohol-preferring (P) and -nonpreferring (NP) rats: a significantly low level of NPY mRNA in dentate gyrus of the hippocampus and absence of NPY mRNA in the medial habenular nucleus of P rats. Neuropeptides 38 : 359 368.
38. Hwang, B.H., J.K. Zhang, C.L. Ehlers, et al. 1999. Innate differences of neuropeptide Y (NPY) in hypothalamic nuclei and central nucleus of the amygdala between selectively bred rats with high and low alcohol preference. Alcohol Clin. Exp. Res. 23 : 1023 1030.
39. Suzuki, R., L. Lumeng, W.J. Mcbride, et al. 2004. Reduced neuropeptide Y mRNA expression in the central nucleus of amygdala of alcohol preferring (P) rats: its potential involvement in alcohol preference and anxiety. Brain Res. 1014 : 251 254.
40. Thorsell, A., R. Rimondini & M. Heilig. 2002. Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats. Neurosci. Lett. 332 : 1 4.
41. Rimondini, R., A. Thorsell & M. Heilig. 2005. Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence. Neurosci. Lett. 375 : 129 133.