Exhaustive computational search of ionic-charge clusters that mediate interactions between mammalian cytochrome P450 (CYP) and P450-oxidoreductase (POR) proteins

Computational Biology and Chemistry

Volumn 34, Issue 1, 2010, Pages 42-52

  Zawaira, Alexander ^a   Gallotta, Marco ^b   Beeton Kempen, Natasha ^a   Coulson, Lauren ^a   Marais, Patrick ^b   Kuttel, Michelle ^b   Blackburn, Jonathan ^a  

^a Faculty of Health Sciences   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Computational modelling; Cytochrome P450; Cytochrome P450 reductase; Ionic interactions; P450 oxidoreductase; Protein protein interfaces

Indexed keywords

COMPUTATIONAL MODELLING; CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; IONIC INTERACTION; OXIDOREDUCTASES; PROTEIN-PROTEIN INTERFACE;

AMINO ACIDS; BACTERIOLOGY; MAMMALS; ORGANIC ACIDS; PROTEINS;

COMPLEXATION;

CYTOCHROME P450; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMISTRY; COMPUTER SIMULATION; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN BINDING; PROTEIN CONFORMATION; RAT; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; STATIC ELECTRICITY;

AMINO ACID SEQUENCE; ANIMALS; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN; STATIC ELECTRICITY;

BACTERIA (MICROORGANISMS); MAMMALIA; RATTUS;

EID: 75149138842     PISSN: 14769271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.compbiolchem.2009.10.006     Document Type: Article

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