Prediction of sites under adaptive evolution in cytochrome P450 sequences and their relationship to substrate recognition sites

Pharmacogenetics and Genomics

Volumn 18, Issue 6, 2008, Pages 467-476

  Zawaira, Alexander ^a,b,d   Matimba, Alice ^a,c   Masimirembwa, Collen ^a  

^a African Institute of Biomedical Science and Technology   (Zimbabwe)

^b Kapa Biosystems   (South Africa)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d Kapa Biosystems Research   (South Africa)

Author keywords

Adaptive evolution; Cytochrome P450; Positive darwinian selection; Selection; Substrate recognition site

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2B; CYTOCHROME P450 2C; CYTOCHROME P450 2D; CYTOCHROME P450 3A;

AMINO ACID SEQUENCE; ARTICLE; GENE SEQUENCE; LAGOMORPH; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RODENT; STATISTICAL SIGNIFICANCE; UNINDEXED SEQUENCE;

ALKANE 1-MONOOXYGENASE; AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; CODON; CYTOCHROME P-450 ENZYME SYSTEM; EVOLUTION, MOLECULAR; HUMANS; LIKELIHOOD FUNCTIONS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; PHARMACOGENETICS; PHYLOGENY; RABBITS; RATS; SELECTION (GENETICS); SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

LAGOMORPHA; ORYCTOLAGUS CUNICULUS; PRIMATES; RATTUS; RODENTIA;

EID: 44649143137     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3282f9b68e     Document Type: Article

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