Brain serotonin-2 receptors in acute mania

British Journal of Psychiatry

Volumn 196, Issue 1, 2010, Pages 47-51

  Yatham, Lakshmi N ^a   Liddle, Peter F ^b   Erez, Jonathan ^a   Kauer Sant'Anna, Marcia ^a   Lam, Raymond W ^a   Imperial, Miguel ^a   Sossi, Vesna ^c   Ruth, Thomas J ^c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c TRIUMF   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CONTRAST MEDIUM; SEROTONIN 2 RECEPTOR; SERTRALINE; SETOPERONE F 18; UNCLASSIFIED DRUG;

ACUTE DISEASE; ADULT; AGED; ARTICLE; BIPOLAR I DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE DURATION; FRONTAL CORTEX; HUMAN; MANIA; OCCIPITAL CORTEX; PARIETAL LOBE; POSITRON EMISSION TOMOGRAPHY; RECEPTOR BINDING; SEROTONIN BRAIN LEVEL; TEMPORAL CORTEX;

ADULT; AGE FACTORS; BIPOLAR DISORDER; BRAIN; BRAIN MAPPING; CASE-CONTROL STUDIES; CEREBELLUM; FEMALE; HUMANS; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, SEROTONIN, 5-HT2; YOUNG ADULT;

EID: 74949122131     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.108.057919     Document Type: Article

References (43)

1. Yatham LN, Liddle PF, Shiah IS, Scarrow G, Lam RW, Adam MJ, et al. Brain serotonin2 receptors in major depression: a positron emission tomography study. Arch Gen Psychiatry 2000; 57: 850-8.
2. Meyer JH. Applying neuroimaging ligands to study major depressive disorder. Semin Nucl Med 2008; 38: 287-304.
3. Bhagwagar Z, Whale R, Cowen PJ. State and trait abnormalities in serotonin function in major depression. Br J Psychiatry 2002; 180: 24-8.
4. Shiah IS, Yatham LN. Serotonin in mania and in the mechanism of action of mood stabilizers: a review of clinical studies. Bipolar Disord 2000; 2: 77-92.
5. Bhagwagar Z, Hinz R, Taylor M, Fancy S, Cowen P, Grasby P. Increased 5-HT2A receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [C-11] MDL 100,907. Am J Psychiatry 2006; 163: 1580-7.
6. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorder, (4th edn) (DSM-IV). APA, 1994.
7. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders: Research Version, Patient Edition (SCID-I/P). Biometrics Research, 2002.
8. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978; 133: 429-35.
9. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders: Research Version, Non-Patient Edition (SCID-I/NP). Biometrics Research, 2002.
10. Yatham LN, Liddle PF, Dennie J, Shiah IS, Adam MJ, Lane CJ, et al. Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperone. Arch Gen Psychiatry 1999; 56: 705-11.
11. Kapur S, Jones C, DaSilva J, Wilson A, Houle S. Reliability of a simple non-invasive method for the evaluation of 5-HT2 receptors using [18F]-setoperone PET imaging. Nucl Med Commun 1997; 18: 395-9.
12. Meyer JH, Kapur S, Houle S, DaSilva J, Owczarek B, Brown GM, et al. Prefrontal cortex 5-HT2 receptors in depression. An [F-18]setoperone PET imaging study. Am J Psychiatry 1999; 156: 1029-34.
13. Kapur S, Zipursky R, Remington G, Jones C, McKay G, Houle S. PET evidence that loxapine is an equlpotent blocker of 5-HT2 and D2 receptors: implications for the therapeutics of schizophrenia. Am J Psychiatry 1997; 154: 1525-9.
14. Velayudhan A, Sunitha TA, Balachander S, Reddy JY, Khanna S. A study of platelet serotonin receptor in mania. Biol Psychiatry 1999; 45: 1059-62.
15. Pandey GN, Pandey SC, Ren XG, Dwivedi Y, Janicak PG. Serotonin receptors in platelets of bipolar and schizoaffective patients: effect of lithium treatment Psychopharmacologyl 2003; 170: 115-23.
16. Cho R, Kapur S, Du LS, Hrdina P. Relationship between central and peripheral serotonin 5-HT2A receptors: a positron emission tomography study in healthy individuals. Neurosci Lett 1999; 261: 139-42.
17. Yatham LN, Steiner M, Liddle PF, Shiah IS, Lam RW, Zis AP, et al. A PET study of brain 5-HT2 receptors and their correlation with platelet 5-HT2 receptors in healthy humans. Psychopharmacology (Berl) 2000; 151: 424-7.
18. Hirani E, Sharp T, Sprakes M, Grasby P, Hume S. Fenfluramine evokes 5-HT2A receptor-mediated responses but does not displace [11C]MDL 100907: small animal PET and gene expression studies. Synapse 2003; 50: 251-60.
19. Hume S, Hirani E, Opacka-Juffry J, Myers R, Townsend C, Pike V, et al. Effect of 5-HT on binding of [(11)C] WAY 100635 to 5-HT(IA) receptors in rat brain, assessed using in vivo microdialysis nd PET after fenfluramine. Synapse 2001; 41: 150-9.
20. De Haes JIU, Harada N, Elsinga PH, Maguire RP, Tsukada H. Effect of fenfluramine-induced increases in serotonin release on [F-18]MPPF]binding. A continuous infusion PET study in conscious monkeys. Synapse 2006; 59: 18-26.
21. Biver F, Wikler D, Lotstra F, Damhaut P, Goldman S, Mendlewicz J. Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex. Br J Psychiatry 1997; 171: 444-8.
22. Attar-Levy D, Martinot JL, Blin J, Dao-Castellana MH, Crouzel C, Mazoyer B, et al. The cortical serotonin2 receptors studied with positron-emission tomography and [18F]-setoperone during depressive illness and antidepressant treatment with clomipramine. Biol Psychiatry 1999; 45: 180-6.
23. Messa C, Colombo C, Moresco RM, Gobbo C, Galli L, Lucignani G, et al. 5-HT2A receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: a PET study. Psychopharmacology 2003; 167: 72-8.
24. Meyer JH, Kapur S, Eisfeld B, Brown GM, Houle S, DaSilva J, et al. The effect of paroxetine on 5-HT2A receptors in depression. An [F-18]setoperone PET imaging study. Am J Psychiatry 2001; 158: 78-85.
25. Mischoulon D, Dougherty DD, Bottonari KA, Gresham RL, Sonawalla SB, Fischman AJ, et al. An open pilot study of nefazodone in depression with anger attacks: relationship between clinical response and receptor binding. Psychiat Res 2002; 116: 151-61.
26. Leverich GS, Altshuler LL, Frye MA, Suppes T, McElroy SL, Keck PE, et al. Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and Bupropion as adjuncts to mood stabilizers. Am J Psychiatry 2006; 163: 232-9.
27. Post RM, Altshuler LL, Leverich GS, Frye MA, Nolen WA, Kupka RW, et al. Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline. Br J Psychiatry 2006; 189: 124-31.
28. Yatham LN, Calabrese JR, Kusumakar V. Bipolar depression: criteria for treatment selection, definition of refractoriness, and treatment options. Bipolar Disord 2003; 5: 85-97.
29. Yatham LN, Liddle PF, Lam RW, Adam MJ, Solomons K, Chinnapalli M, et al. A positron emission tomography study of the effects of treatment with valproate on brain 5-HT2A receptors in acute mania. Bipolar Disord 2005; 7: 53-7.
30. Ranade SS, Mansour H, Wood J, Chowdari KV, Brar LK, Kupfer DJ, et al. Linkage and association between serotonin 2A receptor gene polymorphisms and bipolar I disorder. Am J Med Genet B 2003; 121B: 28-34.
31. Serretti A, Lilli R, Lorenzi C, Smeraldi E. No association between serotonin-2A receptor gene polymorphism and psychotic symptomatology of mood disorders. Psychiat Res 1999; 86: 203-9.
32. Bonnier B, Gorwood P, Hamon M, Sarfati Y, Boni C, Hardy-Bayle MC. Association of 5-HT2A receptor gene polymorphism with major affective disorders. The case of a subgroup of bipolar disorder with low suicide risk. Biol Psychiatry 2002; 51: 762-5.
33. Mahieu B, Souery D, Lipp O, Mendelbaum K, Verheyen G, DeMaertelaer V, et al. No association between bipolar affective disorder and a serotonin receptor (5-HT2A) polymorphism. Psychiat Res 1997; 70: 65-9.
34. Silverstone T. Dopamine in manic depressive illness. A pharmacological synthesis. J Affect Disord 1985; 8: 225-31.
35. EberleWang K, Mikeladze Z, Uryu K, Chesselet MF. Pattern of expression of the serotonin(2C) receptor messenger RNA in the basal ganglia of adult rats. J Comp Neurol 1997; 384: 233-47.
36. Ward RP, Dorsa DM. Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatum. J Comp Neurol 1996; 370: 405-14.
37. Doherty MD, Pickel VM. Ultrastructural localization of the serotonin 2A receptor in dopaminergic neurons in the ventral tegmental area. Brain Res 2000; 864: 176-85.
38. Schmidt CJ, Fadayel GM, Sullivan CK, Taylor VL. 5-Ht(2)-Receptors exert a state-dependent regulation of dopaminergic function - studies with Mdl-100,907 and the amphetamine analog, 3,4-methylenedioxymethamphetamine. Eur J Pharmacol 1992; 223: 65-74.
39. Schmidt CJ, Fadayel GM. Regional effects of MK-801 on dopamine release. Effects of competitive NMDA or 5-HT2A receptor blockade. J Pharmacol Exp Ther 1996; 277: 1541-9.
40. Di Giovanni G, De Deurwaerdere P, Di Mascio M, Di Matteo V, Esposito E, Spampinato U. Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study. Neuroscience 1999; 91: 587-97.
41. Di Matteo V, Di Giovanni G, Di Mascio M, Esposito E. SB 242 084, a selective serotonin(2C) receptor antagonist, increases dopaminergic transmission in the mesolimbic system. Neuropharmacology 1999; 38: 1195-205.
42. Di Matteo M, Di Giovanni G, Di Mascio M, Esposito E. Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin(2C) receptors. Brain Res 2000; 865: 85-90.
43. Yatham LN, Lyoo IK, Liddle P, Renshaw PF, Wan D, Lam RW, et al. A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naive first-episode mania. Bipolar Disord 2007; 9: 693-7.