Morphine prevents the mitochondrial permeability transition pore opening through NO/cGMP/PKG/Zn2+/GSK-3β signal pathway in cardiomyocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 2, 2010, Pages

  Xi, Jinkun ^a,b   Tian, Wei ^b   Zhang, Lei ^b   Jin, Yulan ^b   Xu, Zhelong ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NORTH CHINA COAL MEDICAL COLLEGE   (China)

Author keywords

Glycogen synthase kinase 3 ; Guanosine 3 ,5 cyclic monophosphate; Nitric oxide; Protein kinase G

Indexed keywords

CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; DICHLOROFLUORESCEIN; FLUORESCENT DYE; GLYCOGEN SYNTHASE KINASE 3BETA; GUANYLATE CYCLASE INHIBITOR; KT 5823; MORPHINE; N(G) NITROARGININE METHYL ESTER; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; SMALL INTERFERING RNA; TETRAMETHYLRHODAMINE ETHYL ESTER; ZINC ION;

ADOLESCENT; ANIMAL CELL; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG MECHANISM; FLUORESCENCE; HEART MUSCLE CELL; HEART PROTECTION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALGESICS, OPIOID; ANIMALS; CARBAZOLES; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ETHYLENEDIAMINES; FLUORESCENT DYES; GLYCOGEN SYNTHASE KINASE 3; MALE; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MODELS, ANIMAL; MORPHINE; MYOCYTES, CARDIAC; NITRIC OXIDE; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; ZINC;

EID: 74949108660     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00453.2009     Document Type: Article

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