Exogenous zinc protects cardiac cells from reperfusion injury by targeting mitochondrial permeability transition pore through inactivation of glycogen synthase kinase-3β

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 3, 2008, Pages

  Chanoit, Guillaume ^a   Lee, SungRyul ^a   Xi, Jinkun ^a   Zhu, Min ^a   McIntosh, Rachel A ^a   Mueller, Robert A ^a   Norfleet, Edward A ^a   Xu, Zhelong ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

H9c2 cell; Oxidant stress; Simulated ischemia

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 5 HYDROXYDECANOIC ACID; CHELERYTHRINE; GLYCOGEN SYNTHASE KINASE 3BETA; MAMMALIAN TARGET OF RAPAMYCIN; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PYRITHIONE ZINC; RAPAMYCIN; SERINE; ZINC CHLORIDE; CARDIOTONIC AGENT; DNA; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; ZINC;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG TARGETING; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SIMULATION; TREATMENT DURATION; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL SURVIVAL; CONFOCAL MICROSCOPY; CYTOSOL; DRUG ANTAGONISM; GENETICS; HEART MITOCHONDRION; METABOLISM; PERMEABILITY; PHOSPHORYLATION; PLASMID; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARDIOTONIC AGENTS; CELL LINE; CELL SURVIVAL; CYTOSOL; DNA; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; MICROSCOPY, CONFOCAL; MITOCHONDRIA, HEART; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PERMEABILITY; PHOSPHORYLATION; PLASMIDS; RATS; SIGNAL TRANSDUCTION; ZINC;

EID: 54049150041     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00610.2008     Document Type: Article

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