Cysteine-Zn2+ complexes: Unique molecular switches for inducible nitric oxide synthase-derived NO

FASEB Journal

Volumn 15, Issue 13, 2001, Pages 2503-2507

  Kröncke, Klaus D ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Chaperone; Cysteine switch; Metalloproteinase; Nitric oxide; Transcription; Zinc

Indexed keywords

CYSTEINE DERIVATIVE; MATRIX METALLOPROTEINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TRANSCRIPTION FACTOR; ZINC COMPLEX; CYSTEINE; INDUCIBLE NITRIC OXIDE SYNTHASE; NOS2A PROTEIN, HUMAN; PROTEIN; ZINC; ZINC FINGER PROTEIN;

ARTICLE; COMPLEX FORMATION; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; CYSTEINE; HUMANS; MATRIX METALLOPROTEINASES; MODELS, BIOLOGICAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN FOLDING; PROTEINS; TRANSCRIPTION FACTORS; ZINC; ZINC FINGERS;

EID: 0035172901     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0240hyp     Document Type: Article

References (27)

1. Inducible nitric oxide synthase in human diseases
2. Zinc fingers
3. RING fingers and B-boxes: Zinc-binding protein-protein interaction domains
4. Solution structures of the PHD domain from the KAP-1 corepressor: Structural determinants for PHD. RING and LIM zinc-binding domains
5. Treble clef finger - A functionally diverse zinc-binding structural motif
6. Nitric oxide destroys zinc-sulfur clusters inducing zinc release from metallothionein and inhibition of the zinc finger-type yeast transcription activator LAC9
7. 2+ release from metallothionein by destroying zinc-sulphur clusters without concomitant formation of S-nitrosothiol
8. Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons
9. Nitric oxide-dependent pro-oxidant and pro-apoptotic effect of metallothioneins in HL-60 cells challenged with cupric nitrilotriacetate
10. Nitric oxide inhibits the cochaperone activity of the RING finger-like protein DnaJ
11. Zinc finger transcription factors as molecular targets for nitric oxide-mediated immunosuppression: Inhibition of IL-2 gene expression in murine lymphocytes
12. Inactivation of zinc finger transcription factors provides a mechanism for a gene-regulatory role of nitric oxide
13. Nitric oxide inhibits endothelial ICAM-1 synthesis at the transcriptional level
14. A Sp1 binding site of the tumor necrosis factor α promoter functions as a nitric oxide response element
15. Solution structure of the cysteine-rich domain of the Escherichia coli chaperone protein DnaJ
16. A zinc finger-like domain of the molecular chaperone DnaJ is involved in binding to denatured protein substrates
17. Structure-function analysis of the zinc finger region of the DnaJ molecular chaperone
18. Chaperone activity with a redox switch
19. Mass spectrometry unravels disulfide bond formation as the mechanism that activates a molecular chaperone
20. Activation of the redox-regulated molecular chaperone Hsp33 - A two-step mechanism
21. Crystal structure of proteolytic fragments of the redox-sensitive Hsp33 with constitutive chaperone activity
22. Matrix metalloproteinases: Structures, evolution, and diversification
23. The cysteine switch: A principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family
24. Human matrix metalloproteinase activation by insults of bacterial infection involving proteases and free radicals
25. ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain: Multipotential functions in cell-cell and cell-matrix interactions
26. Activation of tumor necrosis factor-α-converting enzyme-mediated ectodomain shedding by nitric oxide
27. Inhibition of the catalytic activity of alcohol dehydrogenase by nitric oxide is associated with S nitrosylation and the release of zinc