Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine- homocysteine methyltransferase

Journal of Biological Chemistry

Volumn 283, Issue 14, 2008, Pages 8939-8945

  Szegedi, Sandra S ^a   Castro, Carmen C ^b,d   Koutmos, Markos ^c   Garrow, Timothy A ^a,e  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF CÁDIZ   (Spain)

^c UNIVERSITY OF MICHIGAN   (United States)

^d Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA   (France)

^e 359 ERML ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; AMINO ACIDS; METHYLATION;

DIMETHYLGLYCINE; HOMOCYSTEINES; METHYLTRANSFERASE ACTIVITY; METHYLTRANSFERASES; POTENT INHIBITOR; S-ADENOSYLMETHIONINE; TURNOVER NUMBER; ZINC METALLOENZYME;

BETAINES;

BETAINE; BETAINE HOMOCYSTEINE METHYLTRANSFERASE; BETAINE HOMOCYSTEINE METHYLTRANSFERASE 2; DIMETHYLGLYCINE; HOMOCYSTEINE METHYLTRANSFERASE; S METHYLMETHIONINE; UNCLASSIFIED DRUG; BHMT PROTEIN, HUMAN; BHMT2 PROTEIN, HUMAN; HOMOCYSTEINE; METALLOPROTEIN; RECOMBINANT PROTEIN; S ADENOSYLMETHIONINE; SARCOSINE; ZINC;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME PURIFICATION; METHYLATION; NONHUMAN; PRIORITY JOURNAL; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY;

BETAINE; BETAINE-HOMOCYSTEINE S-METHYLTRANSFERASE; HOMOCYSTEINE; HOMOCYSTEINE S-METHYLTRANSFERASE; HUMANS; METALLOPROTEINS; METHYLATION; RECOMBINANT PROTEINS; S-ADENOSYLMETHIONINE; SARCOSINE; SUBSTRATE SPECIFICITY; VITAMIN U; ZINC;

EID: 44049092351     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M710449200     Document Type: Article

References (35)

1. Finkelstein, J. D., Harris, B. J., and Kyle, W. E. (1972) Arch. Biochem. Biophys. 153, 320-324
2. Finkelstein, J. D., and Martin, J. J. (1984) J. Biol. Chem. 259, 9508-9513
3. Garrow, T. A. (1996) J. Biol. Chem. 271, 22831-22838
4. Shapiro, S. K., and Yphantis, D. A. (1959) Biochim. Biophys. Acta 36, 241-244
5. Kim, G. (2003) Food Sci. Tech. Res. 9, 316-319
6. Hanson, A. D., Rivoal, J., Paquet, L., and Gage, D. A. (1994) Plant Physiol. 105, 103-110
7. Grunau, J. M. (1991) Commun. Soil Sci. Plant Anal. 22, 1873-1882
8. Chadwick, L. H., McCandless, S. E., Silverman, G. L., Schwartz, S., Westaway, D., and Nadeau, J. H. (2000) Genomics 70, 66-73
9. Breksa, A. P., 3rd, and Garrow, T. A. (1999) Biochemistry 38, 13991-13998
10. Lavine, T. F., Floyd, N. F., and Cammaroti, M. S. (1954) J. Biol. Chem. 207, 107-117
11. Awad, W. M., Jr., Whitney, P. L., Skiba, W. E., Mangum, J. H., and Wells, M. S. (1983) J. Biol. Chem. 258, 12790-12792
12. Holcomb, E. R., and Shapiro, S. K. (1975) J. Bacteriol. 121, 267-271
13. Evans, J. C., Huddler, D. P., Jiracek, J., Castro, C., Millian, N. S., Garrow, T. A., and Ludwig, M. L. (2002) Structure 10, 1159-1171
14. Szegedi, S. S., and Garrow, T. A. (2004) Arch. Biochem. Biophys. 426, 32-42
15. Gonzalez, B., Pajares, M. A., Martinez-Ripoll, M., Blundell, T. L., and Sanz-Aparicio, J. (2004) J. Mol. Biol. 338, 771-782
16. Castro, C., Gratson, A. A., Evans, J. C., Jiracek, J., Collinsova, M., Ludwig, M. L., and Garrow, T. A. (2004) Biochemistry 43, 5341-5351
17. Steele, W., Allegrucci, C., Singh, R., Lucas, E., Priddle, H., Denning, C., Sinclair, K., and Young, L. (2005) Reprod. Biomed. Online 10, 755-766
18. Collinsova, M., Castro, C., Garrow, T. A., Yiotakis, A., Dive, V., and Jiracek, J. (2003) Chem. Biol. 10, 113-122
19. Millian, N. S., and Garrow, T. A. (1998) Arch. Biochem. Biophys. 356, 93-98
20. Nakajima, K. (2006) J. Nutr. Sci. Vitaminol. 52, 61-65
21. Koc, H., Mar, M. H., Ranasinghe, A., Swenberg, J. A., and Zeisel, S. H. (2002) Anal. Chem. 74, 4734-4740
22. Bose, N., Greenspan, P., and Momany, C. (2002) Protein Expression Purif. 25, 73-80
23. Ranocha, P., Bourgis, F., Ziemak, M. J., Rhodes, D., Gage, D. A., and Hanson, A. D. (2000) J. Biol. Chem. 275, 15962-15968
24. Neuhierl, B., Thanbichler, M., Lottspeich, F., and Bock, A. (1999) J. Biol. Chem. 274, 5407-5414
25. Thomas, D., Becker, A., and Surdin-Kerjan, Y. (2000) J. Biol. Chem. 275, 40718-40724
26. Ulrey, C. L., Liu, L., Andrews, L. G., and Tollefsbol, T. O. (2005) Hum. Mol. Genet. 14, R139-R147
27. Martin, J. L., and McMillan, F. M. (2002) Curr. Opin. Struct. Biol. 12, 783-793
28. Dubnoff, J. W., and Borsook, H. (1948) J. Biol. Chem. 176, 789-796
29. Ericson, L. E. (1960) Acta Chem. Scand. 14, 2127-2134
30. Miller, C. M., Szegedi, S. S., and Garrow, T. A. (2005) Biochem. J. 392, 443-448
31. Gonzalez, B., Campillo, N., Garrido, F., Gasset, M., Sanz-Aparicio, J., and Pajares, M. A. (2003) Biochem. J. 370, 945-952
32. Augspurger, N. R., Scherer, C. S., Garrow, T. A., and Baker, D. H. (2005) J. Nutr. 135, 1712-1717
33. Hegedus, M., Fekete, S., Andrasofszky, E., Tamas, J., and Kovari, L. (1992) Acta Vet. Hung. 40, 145-150
34. Matsuo, T., Seri, K., and Kato, T. (1980) Arzneim.-Forsch. 30, 68-69
35. Schwede, T., Kopp, J., Guex, N., and Peitsch, M. C. (2003) Nucleic Acids Res. 31, 3381-3385