-
1
-
-
0032742992
-
Pratley RE The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
-
Weyer C., Bogardus C., and Mott D.M. Pratley RE The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104 (1999) 787-794
-
(1999)
J Clin Invest
, vol.104
, pp. 787-794
-
-
Weyer, C.1
Bogardus, C.2
Mott, D.M.3
-
2
-
-
42349106044
-
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
-
Zeggini E., Scott L.J., Saxena R., Voight B.F., Marchini J.L., Hu T., de Bakker P.I., Abecasis G.R., Almgren P., Andersen G., Ardlie K., Bostrom K.B., Bergman R.N., Bonnycastle L.L., Borch-Johnsen K., Burtt N.P., Chen H., Chines P.S., Daly M.J., Deodhar P., et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40 (2008) 638-645
-
(2008)
Nat Genet
, vol.40
, pp. 638-645
-
-
Zeggini, E.1
Scott, L.J.2
Saxena, R.3
Voight, B.F.4
Marchini, J.L.5
Hu, T.6
de Bakker, P.I.7
Abecasis, G.R.8
Almgren, P.9
Andersen, G.10
Ardlie, K.11
Bostrom, K.B.12
Bergman, R.N.13
Bonnycastle, L.L.14
Borch-Johnsen, K.15
Burtt, N.P.16
Chen, H.17
Chines, P.S.18
Daly, M.J.19
Deodhar, P.20
more..
-
3
-
-
12144268251
-
Dynamic changes in {beta}-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in psammomys obesus: impact of glycemic control
-
Kaiser N., Yuli M., Uckaya G., Oprescu A.I., Berthault M.F., Kargar C., Donath M.Y., Cerasi E., and Ktorza A. Dynamic changes in {beta}-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in psammomys obesus: impact of glycemic control. Diabetes 54 (2005) 138-145
-
(2005)
Diabetes
, vol.54
, pp. 138-145
-
-
Kaiser, N.1
Yuli, M.2
Uckaya, G.3
Oprescu, A.I.4
Berthault, M.F.5
Kargar, C.6
Donath, M.Y.7
Cerasi, E.8
Ktorza, A.9
-
4
-
-
0022482184
-
Characterization of stages in development of obesity-diabetes syndrome in sand rat (Psammomys obesus)
-
Kalderon B., Gutman A., Levy E., Shafrir E., and Adler J.H. Characterization of stages in development of obesity-diabetes syndrome in sand rat (Psammomys obesus). Diabetes 35 (1986) 717-724
-
(1986)
Diabetes
, vol.35
, pp. 717-724
-
-
Kalderon, B.1
Gutman, A.2
Levy, E.3
Shafrir, E.4
Adler, J.H.5
-
5
-
-
0021248878
-
Diabetes mellitus in sand rats (Psammomys obesus). Metabolic pattern during development of the diabetic syndrome
-
Marquie G., Duhault J., and Jacotot B. Diabetes mellitus in sand rats (Psammomys obesus). Metabolic pattern during development of the diabetic syndrome. Diabetes 33 (1984) 438-443
-
(1984)
Diabetes
, vol.33
, pp. 438-443
-
-
Marquie, G.1
Duhault, J.2
Jacotot, B.3
-
6
-
-
32944473200
-
Diabetes mellitus in the sand rat induced by standard laboratory diets
-
Schmidt-Nielsen K., Haines H.B., and Hackel D.B. Diabetes mellitus in the sand rat induced by standard laboratory diets. Science 143 (1964) 689-690
-
(1964)
Science
, vol.143
, pp. 689-690
-
-
Schmidt-Nielsen, K.1
Haines, H.B.2
Hackel, D.B.3
-
7
-
-
33745626115
-
Nutritionally induced diabetes in desert rodents as models of type 2 diabetes: Acomys cahirinus (spiny mice) and Psammomys obesus (desert gerbil)
-
Shafrir E., Ziv E., and Kalman R. Nutritionally induced diabetes in desert rodents as models of type 2 diabetes: Acomys cahirinus (spiny mice) and Psammomys obesus (desert gerbil). Ilar J 47 (2006) 212-224
-
(2006)
Ilar J
, vol.47
, pp. 212-224
-
-
Shafrir, E.1
Ziv, E.2
Kalman, R.3
-
8
-
-
0034570349
-
Characterization of obesity phenotypes in Psammomys obesus (Israeli sand rats)
-
Walder K.R., Fahey R.P., Morton G.J., Zimmet P.Z., and Collier G.R. Characterization of obesity phenotypes in Psammomys obesus (Israeli sand rats). Int J Exp Diabetes Res 1 (2000) 177-184
-
(2000)
Int J Exp Diabetes Res
, vol.1
, pp. 177-184
-
-
Walder, K.R.1
Fahey, R.P.2
Morton, G.J.3
Zimmet, P.Z.4
Collier, G.R.5
-
9
-
-
0029797540
-
Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig
-
Deacon C.F., Pridal L., Klarskov L., Olesen M., and Holst J.J. Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig. Am J Physiol 271 (1996) E458-E464
-
(1996)
Am J Physiol
, vol.271
-
-
Deacon, C.F.1
Pridal, L.2
Klarskov, L.3
Olesen, M.4
Holst, J.J.5
-
10
-
-
0022971804
-
Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas
-
Orskov C., Holst J.J., Knuhtsen S., Baldissera F.G., Poulsen S.S., and Nielsen O.V. Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas. Endocrinology 119 (1986) 1467-1475
-
(1986)
Endocrinology
, vol.119
, pp. 1467-1475
-
-
Orskov, C.1
Holst, J.J.2
Knuhtsen, S.3
Baldissera, F.G.4
Poulsen, S.S.5
Nielsen, O.V.6
-
11
-
-
0027248866
-
Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
-
Nauck M.A., Kleine N., Orskov C., Holst J.J., Willms B., and Creutzfeldt W. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 36 (1993) 741-744
-
(1993)
Diabetologia
, vol.36
, pp. 741-744
-
-
Nauck, M.A.1
Kleine, N.2
Orskov, C.3
Holst, J.J.4
Willms, B.5
Creutzfeldt, W.6
-
12
-
-
0029907680
-
Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM
-
Nauck M.A., Wollschlager D., Werner J., Holst J.J., Orskov C., Creutzfeldt W., and Willms B. Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM. Diabetologia 39 (1996) 1546-1553
-
(1996)
Diabetologia
, vol.39
, pp. 1546-1553
-
-
Nauck, M.A.1
Wollschlager, D.2
Werner, J.3
Holst, J.J.4
Orskov, C.5
Creutzfeldt, W.6
Willms, B.7
-
13
-
-
0031740718
-
Normalization of fasting glycaemia by intravenous GLP-1 ([7-36 amide] or [7-37]) in type 2 diabetic patients
-
Nauck M.A., Weber I., Bach I., Richter S., Orskov C., Holst J.J., and Schmiegel W. Normalization of fasting glycaemia by intravenous GLP-1 ([7-36 amide] or [7-37]) in type 2 diabetic patients. Diabet Med 15 (1998) 937-945
-
(1998)
Diabet Med
, vol.15
, pp. 937-945
-
-
Nauck, M.A.1
Weber, I.2
Bach, I.3
Richter, S.4
Orskov, C.5
Holst, J.J.6
Schmiegel, W.7
-
14
-
-
0030754176
-
Glucagon-like peptide-1 (GLP-1): a trial of treatment in non-insulin-dependent diabetes mellitus
-
Todd J.F., Wilding J.P., Edwards C.M., Khan F.A., Ghatei M.A., and Bloom S.R. Glucagon-like peptide-1 (GLP-1): a trial of treatment in non-insulin-dependent diabetes mellitus. Eur J Clin Invest 27 (1997) 533-536
-
(1997)
Eur J Clin Invest
, vol.27
, pp. 533-536
-
-
Todd, J.F.1
Wilding, J.P.2
Edwards, C.M.3
Khan, F.A.4
Ghatei, M.A.5
Bloom, S.R.6
-
15
-
-
33846477446
-
Small-molecule agonists for the glucagon-like peptide 1 receptor
-
Knudsen L.B., Kiel D., Teng M., Behrens C., Bhumralkar D., Kodra J.T., Holst J.J., Jeppesen C.B., Johnson M.D., de Jong J.C., Jorgensen A.S., Kercher T., Kostrowicki J., Madsen P., Olesen P.H., Petersen J.S., Poulsen F., Sidelmann U.G., Sturis J., Truesdale L., et al. Small-molecule agonists for the glucagon-like peptide 1 receptor. Proc Natl Acad Sci USA 104 (2007) 937-942
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 937-942
-
-
Knudsen, L.B.1
Kiel, D.2
Teng, M.3
Behrens, C.4
Bhumralkar, D.5
Kodra, J.T.6
Holst, J.J.7
Jeppesen, C.B.8
Johnson, M.D.9
de Jong, J.C.10
Jorgensen, A.S.11
Kercher, T.12
Kostrowicki, J.13
Madsen, P.14
Olesen, P.H.15
Petersen, J.S.16
Poulsen, F.17
Sidelmann, U.G.18
Sturis, J.19
Truesdale, L.20
more..
-
16
-
-
59449101432
-
Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial
-
Garber A., Henry R., Ratner R., Garcia-Hernandez P.A., Rodriguez-Pattzi H., Olvera-Alvarez I., Hale P.M., Zdravkovic M., and Bode B. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 373 9662 (2009) 473-481
-
(2009)
Lancet
, vol.373
, Issue.9662
, pp. 473-481
-
-
Garber, A.1
Henry, R.2
Ratner, R.3
Garcia-Hernandez, P.A.4
Rodriguez-Pattzi, H.5
Olvera-Alvarez, I.6
Hale, P.M.7
Zdravkovic, M.8
Bode, B.9
-
17
-
-
0037072573
-
NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose-intolerant pigs
-
Ribel U., Larsen M.O., Rolin B., Carr R.D., Wilken M., Sturis J., Westergaard L., Deacon C.F., and Knudsen L.B. NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose-intolerant pigs. Eur J Pharmacol 451 (2002) 217-225
-
(2002)
Eur J Pharmacol
, vol.451
, pp. 217-225
-
-
Ribel, U.1
Larsen, M.O.2
Rolin, B.3
Carr, R.D.4
Wilken, M.5
Sturis, J.6
Westergaard, L.7
Deacon, C.F.8
Knudsen, L.B.9
-
18
-
-
0036784675
-
The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice
-
Rolin B., Larsen M.O., Gotfredsen C.F., Deacon C.F., Carr R.D., Wilken M., and Knudsen L.B. The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice. Am J Physiol Endocrinol Metab 283 (2002) E745-E752
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
-
-
Rolin, B.1
Larsen, M.O.2
Gotfredsen, C.F.3
Deacon, C.F.4
Carr, R.D.5
Wilken, M.6
Knudsen, L.B.7
-
19
-
-
15744381238
-
The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro
-
Bregenholt S., Moldrup A., Blume N., Karlsen A.E., Nissen Friedrichsen B., Tornhave D., Knudsen L.B., and Petersen J.S. The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro. Biochem Biophys Res Commun 330 (2005) 577-584
-
(2005)
Biochem Biophys Res Commun
, vol.330
, pp. 577-584
-
-
Bregenholt, S.1
Moldrup, A.2
Blume, N.3
Karlsen, A.E.4
Nissen Friedrichsen, B.5
Tornhave, D.6
Knudsen, L.B.7
Petersen, J.S.8
-
20
-
-
2442482515
-
Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes
-
Ahren B., Landin-Olsson M., Jansson P.A., Svensson M., Holmes D., and Schweizer A. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes. J Clin Endocrinol Metab 89 (2004) 2078-2084
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 2078-2084
-
-
Ahren, B.1
Landin-Olsson, M.2
Jansson, P.A.3
Svensson, M.4
Holmes, D.5
Schweizer, A.6
-
21
-
-
0344357096
-
Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line
-
Drucker D.J., Philippe J., Mojsov S., Chick W.L., and Habener J.F. Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci USA 84 (1987) 3434-3438
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 3434-3438
-
-
Drucker, D.J.1
Philippe, J.2
Mojsov, S.3
Chick, W.L.4
Habener, J.F.5
-
22
-
-
0037414781
-
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis
-
Li Y., Hansotia T., Yusta B., Ris F., Halban P.A., and Drucker D.J. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278 (2003) 471-478
-
(2003)
J Biol Chem
, vol.278
, pp. 471-478
-
-
Li, Y.1
Hansotia, T.2
Yusta, B.3
Ris, F.4
Halban, P.A.5
Drucker, D.J.6
-
23
-
-
0034522773
-
Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
-
Perfetti R., Zhou J., Doyle M.E., and Egan J.M. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 141 (2000) 4600-4605
-
(2000)
Endocrinology
, vol.141
, pp. 4600-4605
-
-
Perfetti, R.1
Zhou, J.2
Doyle, M.E.3
Egan, J.M.4
-
24
-
-
52749096469
-
Exendin-4 stimulation of cyclin A2 in beta-cell proliferation
-
Song W.J., Schreiber W.E., Zhong E., Liu F.F., Kornfeld B.D., Wondisford F.E., and Hussain M.A. Exendin-4 stimulation of cyclin A2 in beta-cell proliferation. Diabetes 57 (2008) 2371-2381
-
(2008)
Diabetes
, vol.57
, pp. 2371-2381
-
-
Song, W.J.1
Schreiber, W.E.2
Zhong, E.3
Liu, F.F.4
Kornfeld, B.D.5
Wondisford, F.E.6
Hussain, M.A.7
-
25
-
-
0035405821
-
Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age
-
Tourrel C., Bailbe D., Meile M.J., Kergoat M., and Portha B. Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. Diabetes 50 (2001) 1562-1570
-
(2001)
Diabetes
, vol.50
, pp. 1562-1570
-
-
Tourrel, C.1
Bailbe, D.2
Meile, M.J.3
Kergoat, M.4
Portha, B.5
-
26
-
-
0036312680
-
Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4
-
Tourrel C., Bailbe D., Lacorne M., Meile M.J., Kergoat M., and Portha B. Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4. Diabetes 51 (2002) 1443-1452
-
(2002)
Diabetes
, vol.51
, pp. 1443-1452
-
-
Tourrel, C.1
Bailbe, D.2
Lacorne, M.3
Meile, M.J.4
Kergoat, M.5
Portha, B.6
-
27
-
-
0033513455
-
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
-
Xu G., Stoffers D.A., Habener J.F., and Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48 (1999) 2270-2276
-
(1999)
Diabetes
, vol.48
, pp. 2270-2276
-
-
Xu, G.1
Stoffers, D.A.2
Habener, J.F.3
Bonner-Weir, S.4
-
28
-
-
33646492251
-
GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts
-
Xu G., Kaneto H., Lopez-Avalos M.D., Weir G.C., and Bonner-Weir S. GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts. Diabetes Res Clin Pract 73 1 (2006) 107-110
-
(2006)
Diabetes Res Clin Pract
, vol.73
, Issue.1
, pp. 107-110
-
-
Xu, G.1
Kaneto, H.2
Lopez-Avalos, M.D.3
Weir, G.C.4
Bonner-Weir, S.5
-
29
-
-
32944455013
-
Diabetes outfoxed by GLP-1?
-
Holz G.G., and Chepurny O.G. Diabetes outfoxed by GLP-1?. Sci STKE 268 (2005) pe2
-
(2005)
Sci STKE
, vol.268
-
-
Holz, G.G.1
Chepurny, O.G.2
-
30
-
-
33751083259
-
No pharmacokinetic interactions or acute clinical safety issues preclude combination of the DPP-4 inhibitor LAF237 with glyburide
-
Barilla D., He Y., Balez B., Bullock J., Ho Y., Guiterrez M., and Ligueros-Saylan M. No pharmacokinetic interactions or acute clinical safety issues preclude combination of the DPP-4 inhibitor LAF237 with glyburide. 64th Scientific Session of American Diabetes Association Orlando, FL, p. 1967-PO (2004)
-
(2004)
64th Scientific Session of American Diabetes Association Orlando, FL, p. 1967-PO
-
-
Barilla, D.1
He, Y.2
Balez, B.3
Bullock, J.4
Ho, Y.5
Guiterrez, M.6
Ligueros-Saylan, M.7
-
31
-
-
9444285818
-
Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes
-
Ahren B., Gomis R., Standl E., Mills D., and Schweizer A. Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes. Diabetes Care 27 (2004) 2874-2880
-
(2004)
Diabetes Care
, vol.27
, pp. 2874-2880
-
-
Ahren, B.1
Gomis, R.2
Standl, E.3
Mills, D.4
Schweizer, A.5
-
32
-
-
26444501029
-
Beta-cell expression of a dominant-negative HNF-1alpha compromises the ability of inhibition of dipeptidyl peptidase-4 to elicit a long-term augmentation of insulin secretion in mice
-
Ahren B., Winzell M.S., Burkey B., and Hughes T.E. Beta-cell expression of a dominant-negative HNF-1alpha compromises the ability of inhibition of dipeptidyl peptidase-4 to elicit a long-term augmentation of insulin secretion in mice. Eur J Pharmacol 521 (2005) 164-168
-
(2005)
Eur J Pharmacol
, vol.521
, pp. 164-168
-
-
Ahren, B.1
Winzell, M.S.2
Burkey, B.3
Hughes, T.E.4
-
33
-
-
34547673164
-
DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide
-
Ahren B., Winzell M.S., Wierup N., Sundler F., Burkey B., and Hughes T.E. DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide. Regul Pept 143 (2007) 97-103
-
(2007)
Regul Pept
, vol.143
, pp. 97-103
-
-
Ahren, B.1
Winzell, M.S.2
Wierup, N.3
Sundler, F.4
Burkey, B.5
Hughes, T.E.6
-
34
-
-
27144460925
-
-
Burkey, B.F., Li, X., Bolognese, L., Balkan, B., Mone, M., Russell, M., Hughes, T.E., Wang, P.R. Acute and chronic effects of the incretin enhancer vildagliptin in insulin-resistant rats. J Pharmacol Exp Ther 2005;315:688-69541. 35. Flock, G., Baggio, L.L., Longuet, C., Drucker, D.J. Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice. Diabetes 2007; 56:3006-3013.
-
Burkey, B.F., Li, X., Bolognese, L., Balkan, B., Mone, M., Russell, M., Hughes, T.E., Wang, P.R. Acute and chronic effects of the incretin enhancer vildagliptin in insulin-resistant rats. J Pharmacol Exp Ther 2005;315:688-69541. 35. Flock, G., Baggio, L.L., Longuet, C., Drucker, D.J. Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice. Diabetes 2007; 56:3006-3013.
-
-
-
-
35
-
-
0033619675
-
Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides
-
Mentlein R. Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides. Regul Pept 85 (1999) 9-24
-
(1999)
Regul Pept
, vol.85
, pp. 9-24
-
-
Mentlein, R.1
-
36
-
-
57349099271
-
Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2′-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl]methyl]-L-valine] enhances pancreatic islet morphology and function in a mouse model of type 2 diabetes.
-
Cheng Q., Law P.K., de Gasparo M., and Leung P.S. Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2′-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl]methyl]-L-valine] enhances pancreatic islet morphology and function in a mouse model of type 2 diabetes. J Pharmacol Exp Ther 327 (2008) 683-691
-
(2008)
J Pharmacol Exp Ther
, vol.327
, pp. 683-691
-
-
Cheng, Q.1
Law, P.K.2
de Gasparo, M.3
Leung, P.S.4
-
37
-
-
46549087133
-
Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice
-
Moritoh Y., Takeuchi K., Asakawa T., Kataoka O., and Odaka H. Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice. Eur J Pharmacol 588 (2008) 325-332
-
(2008)
Eur J Pharmacol
, vol.588
, pp. 325-332
-
-
Moritoh, Y.1
Takeuchi, K.2
Asakawa, T.3
Kataoka, O.4
Odaka, H.5
-
38
-
-
33748331194
-
Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes
-
Mu J., Woods J., Zhou Y.P., Roy R.S., Li Z., Zycband E., Feng Y., Zhu L., Li C., Howard A.D., Moller D.E., Thornberry N.A., and Zhang B.B. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes 55 (2006) 1695-1704
-
(2006)
Diabetes
, vol.55
, pp. 1695-1704
-
-
Mu, J.1
Woods, J.2
Zhou, Y.P.3
Roy, R.S.4
Li, Z.5
Zycband, E.6
Feng, Y.7
Zhu, L.8
Li, C.9
Howard, A.D.10
Moller, D.E.11
Thornberry, N.A.12
Zhang, B.B.13
-
39
-
-
0037342614
-
Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
-
Pospisilik J.A., Martin J., Doty T., Ehses J.A., Pamir N., Lynn F.C., Piteau S., Demuth H.U., McIntosh C.H., and Pederson R.A. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats. Diabetes 52 (2003) 741-750
-
(2003)
Diabetes
, vol.52
, pp. 741-750
-
-
Pospisilik, J.A.1
Martin, J.2
Doty, T.3
Ehses, J.A.4
Pamir, N.5
Lynn, F.C.6
Piteau, S.7
Demuth, H.U.8
McIntosh, C.H.9
Pederson, R.A.10
-
40
-
-
74749108755
-
Liraglutide reverses diabetes in Psammomys obesus, a model of type 2 diabetes
-
Bödvarsdóttir T.B., Jensen-Holm H.B., Jørgensen M.S., Buccholz T.T., and Knudsen L.B. Liraglutide reverses diabetes in Psammomys obesus, a model of type 2 diabetes. 65th Scientific Session of American Diabetes Association San Diego, CA (2005)
-
(2005)
65th Scientific Session of American Diabetes Association San Diego, CA
-
-
Bödvarsdóttir, T.B.1
Jensen-Holm, H.B.2
Jørgensen, M.S.3
Buccholz, T.T.4
Knudsen, L.B.5
-
41
-
-
0036381089
-
The smooth fractionator
-
Gundersen H.J. The smooth fractionator. J Microsc 207 (2002) 191-210
-
(2002)
J Microsc
, vol.207
, pp. 191-210
-
-
Gundersen, H.J.1
-
42
-
-
0029095263
-
Comparison of sandwich-linked immunoabsorbent assay radioimmunoassay for determination of exogenous glucagon-like peptide-1(7-36)amide in plasma
-
Pridal L., Ingwersen S.H., Larsen F.S., Holst J.J., Adelhorst K., and Kirk O. Comparison of sandwich-linked immunoabsorbent assay radioimmunoassay for determination of exogenous glucagon-like peptide-1(7-36)amide in plasma. J Pharm Biomed Anal 13 (1995) 841-850
-
(1995)
J Pharm Biomed Anal
, vol.13
, pp. 841-850
-
-
Pridal, L.1
Ingwersen, S.H.2
Larsen, F.S.3
Holst, J.J.4
Adelhorst, K.5
Kirk, O.6
-
43
-
-
4244188766
-
New highly specific immunoassay for glucagon-like peptide 1 (GLP-1)
-
Wilken M., Larsen F.S., Buckley D., and Holst J.J. New highly specific immunoassay for glucagon-like peptide 1 (GLP-1). Diabetologia 42 (1991) A196
-
(1991)
Diabetologia
, vol.42
-
-
Wilken, M.1
Larsen, F.S.2
Buckley, D.3
Holst, J.J.4
-
44
-
-
33847621227
-
A luminescent oxygen channeling immunoassay for the determination of insulin in human plasma
-
Poulsen F., and Jensen K.B. A luminescent oxygen channeling immunoassay for the determination of insulin in human plasma. J Biomol Screen 12 (2007) 240-247
-
(2007)
J Biomol Screen
, vol.12
, pp. 240-247
-
-
Poulsen, F.1
Jensen, K.B.2
-
45
-
-
0345257136
-
Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis
-
Drucker D.J. Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis. Endocrinology 144 (2003) 5145-5148
-
(2003)
Endocrinology
, vol.144
, pp. 5145-5148
-
-
Drucker, D.J.1
-
46
-
-
33645239679
-
Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways
-
Friedrichsen B.N., Neubauer N., Lee Y.C., Gram V.K., Blume N., Petersen J.S., Nielsen J.H., and Moldrup A. Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways. J Endocrinol 188 (2006) 481-492
-
(2006)
J Endocrinol
, vol.188
, pp. 481-492
-
-
Friedrichsen, B.N.1
Neubauer, N.2
Lee, Y.C.3
Gram, V.K.4
Blume, N.5
Petersen, J.S.6
Nielsen, J.H.7
Moldrup, A.8
-
47
-
-
0034652287
-
Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
-
Gradwohl G., Dierich A., LeMeur M., and Guillemot F. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 97 (2000) 1607-1611
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1607-1611
-
-
Gradwohl, G.1
Dierich, A.2
LeMeur, M.3
Guillemot, F.4
-
48
-
-
0036828227
-
Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
-
Farilla L., Hui H., Bertolotto C., Kang E., Bulotta A., Di Mario U., and Perfetti R. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology 143 (2002) 4397-4408
-
(2002)
Endocrinology
, vol.143
, pp. 4397-4408
-
-
Farilla, L.1
Hui, H.2
Bertolotto, C.3
Kang, E.4
Bulotta, A.5
Di Mario, U.6
Perfetti, R.7
-
49
-
-
15844389890
-
Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new glucagon-like peptide 1 (GLP-1) analogue
-
Uckaya G., Delagrange P., Chavanieu A., Grassy G., Berthault M.F., Ktorza A., Cerasi E., Leibowitz G., and Kaiser N. Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new glucagon-like peptide 1 (GLP-1) analogue. J Endocrinol 184 (2005) 505-513
-
(2005)
J Endocrinol
, vol.184
, pp. 505-513
-
-
Uckaya, G.1
Delagrange, P.2
Chavanieu, A.3
Grassy, G.4
Berthault, M.F.5
Ktorza, A.6
Cerasi, E.7
Leibowitz, G.8
Kaiser, N.9
-
50
-
-
12744259876
-
beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1
-
Li Y., Cao X., Li L.X., Brubaker P.L., Edlund H., and Drucker D.J. beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1. Diabetes 54 (2005) 482-491
-
(2005)
Diabetes
, vol.54
, pp. 482-491
-
-
Li, Y.1
Cao, X.2
Li, L.X.3
Brubaker, P.L.4
Edlund, H.5
Drucker, D.J.6
-
51
-
-
0035431017
-
IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes
-
Leibowitz G., Ferber S., Apelqvist A., Edlund H., Gross D.J., Cerasi E., Melloul D., and Kaiser N. IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes. Diabetes 50 (2001) 1799-1806
-
(2001)
Diabetes
, vol.50
, pp. 1799-1806
-
-
Leibowitz, G.1
Ferber, S.2
Apelqvist, A.3
Edlund, H.4
Gross, D.J.5
Cerasi, E.6
Melloul, D.7
Kaiser, N.8
-
52
-
-
55749108692
-
The morphology of islets of Langerhans is only mildly affected by the lack of Pdx-1 in the pancreas of adult Meriones jirds
-
Gustavsen C.R., Chevret P., Krasnov B., Mowlavi G., Madsen O.D., and Heller R.S. The morphology of islets of Langerhans is only mildly affected by the lack of Pdx-1 in the pancreas of adult Meriones jirds. Gen Comp Endocrinol 159 (2008) 241-249
-
(2008)
Gen Comp Endocrinol
, vol.159
, pp. 241-249
-
-
Gustavsen, C.R.1
Chevret, P.2
Krasnov, B.3
Mowlavi, G.4
Madsen, O.D.5
Heller, R.S.6
-
53
-
-
0347125292
-
The endocrine pancreas in non-diabetic rats after short-term and long-term treatment with the long-acting GLP-1 derivative NN2211
-
Bock T., Pakkenberg B., and Buschard K. The endocrine pancreas in non-diabetic rats after short-term and long-term treatment with the long-acting GLP-1 derivative NN2211. APMIS 111 12 (2003) 1117-1124
-
(2003)
APMIS
, vol.111
, Issue.12
, pp. 1117-1124
-
-
Bock, T.1
Pakkenberg, B.2
Buschard, K.3
-
54
-
-
0033305746
-
Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells
-
Wang X., Cahill C.M., Pineyro M.A., Zhou J., Doyle M.E., and Egan J.M. Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells. Endocrinology 140 (1999) 4904-4907
-
(1999)
Endocrinology
, vol.140
, pp. 4904-4907
-
-
Wang, X.1
Cahill, C.M.2
Pineyro, M.A.3
Zhou, J.4
Doyle, M.E.5
Egan, J.M.6
-
55
-
-
0030913210
-
Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats
-
Wang Y., Perfetti R., Greig N.H., Holloway H.W., DeOre K.A., Montrose-Rafizadeh C., Elahi D., and Egan J.M. Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats. J Clin Invest 99 (1997) 2883-2889
-
(1997)
J Clin Invest
, vol.99
, pp. 2883-2889
-
-
Wang, Y.1
Perfetti, R.2
Greig, N.H.3
Holloway, H.W.4
DeOre, K.A.5
Montrose-Rafizadeh, C.6
Elahi, D.7
Egan, J.M.8
|