Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development

EMBO Journal

Volumn 22, Issue 15, 2003, Pages 3865-3875

  Weng, Li ^a   Zhu, Chenwen ^a   Xu, Jinhua ^a   Du, Wei ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Active repression; E2F; Endoreplication; Genetic screen; Rb

Indexed keywords

CYCLIN E; PROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CELL CYCLE; CELL DIVISION; DOWN REGULATION; DROSOPHILA; GENE FUNCTION; GENE INTERACTION; GENETIC TRANSCRIPTION; INSECT DEVELOPMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; DROSOPHILA; E2F TRANSCRIPTION FACTORS; FERTILITY; GENES, LETHAL; MICROSCOPY, ELECTRON, SCANNING; MUTATION; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTORS;

HEXAPODA; INSECTA;

EID: 0043026892     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg373     Document Type: Article

References (39)

1. Brook, A., Xie, J.-E., Du, W. and Dyson, N. (1996) Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells. EMBO J., 15, 3676-3683.
2. Cayirlioglu, P., Bonnette, P.C., Dickson, M.R. and Duronio, R.J. (2001) Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells, Development, 128, 5085-5098.
3. de Nooij, J.C., Letendre, M.A. and Hariharan, I.K. (1996) A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell, 87, 1237-1247.
4. Du, W. (2000) Suppression of the rbf null mutants by a de2fl allele that lacks transactivation domain. Development, 127, 367-379.
5. i regulation during Drosophila embryogenesis, EMBO J., 18, 916-925.
6. Du, W., Vidal, M., Xie, J.E. and Dyson, N. (1996a) RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev., 10, 1206-1218.
7. Du, W., Xie, J.-E. and Dyson, N. (1996b) Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye, EMBO J., 15, 3684-3692.
8. Duman-Scheel, M., Weng, L., Xin, S. and Du, W. (2002) Hedgehog regulates cell growth and proliferation by inducing cyclin D and cyclin E. Nature, 417, 299-304.
9. Duronio, R.J. and O'Farrell, P.H. (1995) Developmental control of the G, to S transition in Drosophila; cyclin E is a limiting downstream target of E2F. Genes Dev., 9, 1456-1468.
10. Duronio, R.J., O'Farrell, P.H., Xie, J.-E., Brook, A. and Dyson, N. (1995) The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev., 9, 1445-1455.
11. Duronio, R.J., Brook, A., Dyson, N. and O'Farrell, P.H. (1996) E2F-induced S phase requires cyclin E. Genes Dev., 10, 2505-2513.
12. Dynlacht, B.D., Brook, A., Dembski, M.S., Yenush, L. and Dyson, N. (1994) DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Proc. Natl Acad. Sci. USA, 91, 6359-6363.
13. Dyson, N. (1998) The regulation of E2F by pRB-family proteins. Genes Dev., 12, 2245-2262.
14. Edgar, B.A. and Orr-Weaver, T.L. (2001) Endoreplication cell cycles: more for less. Cell, 105, 297-306.
15. Follette, P.J., Duronio, R.J. and O'Farrell, P.H. (1998) Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila. Curr. Biol., 8, 235-238.
16. Frolov, M.V., Huen, D.S., Stevaux, O., Dimova, D., Balczarek-Strang, K., Elsdon, M. and Dyson, N.J. (2001) Functional antagonism between E2F family members. Genes Dev., 15, 2146-2160.
17. 1 control. Mol. Cell, 6, 729-735.
18. Guy, C.T., Zhou, W., Kaufman, S. and Robinson, M.O. (1996) E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes. Mol. Cell. Biol., 16, 685-693.
19. Hartenstein, V. and Posakony, J.W. (1989) Development of adult sensilla on the wing and notum of Drosophila melanogaster. Development, 107, 389-405.
20. He, S., Cook, B.L., Deverman, B.E., Weihe, U., Zhang, F., Prachand, V., Zheng, J. and Weintraub, S.J. (2000) E2F is required to prevent inappropriate S-phase entry of mammalian cells. Mol. Cell. Biol., 20, 363-371.
21. Knoblich, J.A., Sauer, K., Jones, L., Richardson, H., Saint, R. and Lehner, C.F. (1994) Cyclin E controls S-phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation, Cell, 77, 107-120.
22. Kohn, M.J., Bronson, R.T., Harlow, E., Dyson, N.J. and Yamasaki, L. (2003) Dpl is required for extra-embryonic development. Development, 130, 1295-1305.
23. Lilly, M.A. and Spradling, A.C. (1996) The Drosophila endocycle is controlled by cyclin E and lacks a checkpoint ensuring S-phase completion. Genes Dev., 10, 2514-2526.
24. Ohtani, K. and Nevins, J.R. (1994) Functional properties of a Drosophila homolog of the E2F1 gene. Mol. Cell. Biol., 14, 1603-1612.
25. Posakony, J.W. (1994) Nature versus nurture: asymmetric cell divisions in Drosophila bristle development. Cell, 76, 415-418.
26. 1-S progression from an associated transcriptional program. Genes Dev., 11, 1999-2011.
27. Rudkin, G.T. (1972) Replication in polytene chromosomes. Results Probl. Cell Differ., 4, 59-85.
28. Sauer, K., Knoblich, J.A., Richardson, H. and Lehner, C.F. (1995) Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis, Genes Dev., 9, 1327-1339.
29. Sawado, T., Yamaguchi, M., Nishimoto, Y., Ohno, K., Sakaguchi, K. and Matsukage, A. (1998) dE2F2, a novel E2F-family transcription factor in Drosophila melanogaster. Biochem. Biophys. Res. Commun. 251, 409-415.
30. Smith, A.V. and Orr-Weaver, T.L. (1991) The regulation of the cell cycle during Drosophila embryogenesis: the transition to polyteny. Development, 112, 997-1008.
31. Stevaux, O., Dimova, D., Frolov, M.V., Taylor-Harding, B., Morris, E. and Dyson, N. (2002) Distinct mechanisms of E2F regulation by Drosophila RBFI and RBF2, EMBO J., 21, 4927-4937.
32. Trimarchi, J.M. and Lees, J.A. (2002) Sibling rivalry in the E2F family. Nat. Rev. Mol. Cell Biol., 3, 11-20.
33. Trimarchi, J.M., Fairchild, B., Wen, J. and Lees, J.A. (2001) The E2F6 transcription factor is a component of the mammalian Bmil-containing polycomb complex. Proc. Natl Acad. Sci. USA, 98, 1519-1524.
34. Weintraub, S.J., Prater, C.A. and Dean, D.C. (1992) Retinoblastoma protein switches the E2F site from positive to negative element. Nature, 358, 259-261.
35. Weintraub, S.J., Chow, K.N.B., Luo, R.X., Zhang, S.H., He, S. and Dean, D.C. (1995) Mechanism of active transcriptional repression by the retinoblastoma protein. Nature, 375, 812-815.
36. Weiss, A., Herzig, A., Jacobs, H. and Lehner, C.F. (1998) Continuous cyclin E expression inhibits progression through endoreduplication cycles in Drosophila. Curr. Biol., 8, 239-242.
37. Wu, L. et al. (2003) Extra-embryonic function of Rb is essential for embryonic development and viability. Nature, 421, 942-947.
38. Xin, S., Weng, L., Xu, J. and Du, W. (2002) The role of RBF in developmentally regulated cell proliferation in the eye disc and in cyclin D/Cdk4 induced cellular growth. Development, 129, 1345-1356.
39. 1 arrest triggered by p16INK4a, TGFβ and contact inhibition. Cell, 97, 53-61.