The retinoblastoma protein, RB, is required for gastrointestinal endocrine cells to exit the cell cycle, but not for hormone expression

Developmental Biology

Volumn 311, Issue 2, 2007, Pages 478-486

  Wang, Yang ^a   Ray, Subir K ^a   Hinds, Philip W ^a   Leiter, Andrew B ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

Enteroendocrine cell; NeuroD; Neurogenin 3; Retinoblastoma protein

Indexed keywords

GASTRIN; GENE PRODUCT; GHRELIN; NEUROGENIC DIFFERENTIATION FACTOR; NEUROGENIN 3; PROTEIN P107; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA PROTEIN RB; SEROTONIN; SOMATOSTATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; COLON; CONTROLLED STUDY; ENTEROENDOCRINE CELL; GENE; GENE DELETION; GENE DISRUPTION; HORMONE ACTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; RB GENE; SEROTONIN RELEASE; SMALL INTESTINE; STOMACH; STOMACH ANTRUM;

MUS;

EID: 35748930599     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2007.08.052     Document Type: Article

References (35)

1. Aiken K.D., and Roth K.A. Temporal differentiation and migration of substance P, serotonin, and secretin immunoreactive enteroendocrine cells in the mouse proximal small intestine. Dev. Dyn. 194 (1992) 303-310
2. Batsche E., Moschopoulos P., Desroches J., Bilodeau S., and Drouin J. Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription. J. Biol. Chem. 280 (2005) 16088-16095
3. Cameron I.L. Cell renewal in the organs and tissues of the nongrowing adult mouse. Tex. Rep. Biol. Med. 28 (1970) 203-248
4. Cheng H., and Leblond C.P. Origin, differentiation, and renewal of the four main epithelial cell types in the mouse small intestine: V. Unitarian theory of the origin of the four epithelial cell types. Am. J. Anat. 141 (1974) 537-562
5. Dacic S., Finkelstein S.D., Baksh F.K., Swalsky P.A., Barnes L.E., and Yousem S.A. Small-cell neuroendocrine carcinoma displays unique profiles of tumor-suppressor gene loss in relationship to the primary site of formation. Hum. Pathol. 33 (2002) 927-932
6. Dor Y., Brown J., Martinez O.I., and Melton D.A. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429 (2004) 41-46
7. Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev. 12 (1998) 2245-2262
8. Fujimoto S., Hattori T., Kimoto K., Yamashita S., Fujita S., and Kawai K. Tritiated thymidine autoradiographic study on origin and renewal of gastrin cells in antral area of hamsters. Gastroenterology 79 (1980) 785-791
9. Gradwohl G., Dierich A., LeMeur M., and Guillemot F. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 1607-1611
10. Haigis K., Sage J., Glickman J., Shafer S., and Jacks T. The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. J. Biol. Chem. 281 (2006) 638-647
11. Hall P.A., Coates P.J., Ansari B., and Hopwood D. Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J. Cell Sci. 107 Pt 12 (1994) 3569-3577
12. Inokuchi H., Fujimoto S., Hattori T., and Kawai K. Tritiated thymidine radioautographic study on the origin and renewal of secretin cells in the rat duodenum. Gastroenterology 89 (1985) 1014-1020
13. Jenny M., Uhl C., Roche C., Duluc I., Guillermin V., Guillemot F., Jensen J., Kedinger M., and Gradwohl G. Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J. 21 (2002) 6338-6347
14. Karam S.M., and Leblond C.P. Dynamics of epithelial cells in the corpus of the mouse stomach: V. Behavior of entero-endocrine and caveolated cells: general conclusions on cell kinetics in the oxyntic epithelium. Anat. Rec. 236 (1993) 333-340
15. Lee M.H., Williams B.O., Mulligan G., Mukai S., Bronson R.T., Dyson N., Harlow E., and Jacks T. Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 10 (1996) 1621-1632
16. Lee C.S., Perreault N., Brestelli J.E., and Kaestner K.H. Neurogenin3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev. 16 (2002) 1488-1497
17. Lipinski M.M., and Jacks T. The retinoblastoma gene family in differentiation and development. Oncogene 18 (1999) 7873-7882
18. Magami Y., Azuma T., Inokuchi H., Moriyasu F., Kawai K., and Hattori T. Heterogeneous cell renewal of pancreas in mice: [(3)H]-thymidine autoradiographic investigation. Pancreas 24 (2002) 153-160
19. Meuwissen R., Linn S.C., Linnoila R.I., Zevenhoven J., Mooi W.J., and Berns A. Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer Cell 4 (2003) 181-189
20. Mulligan G.J., Wong J., and Jacks T. p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB. Mol. Cell. Biol. 18 (1998) 206-220
21. Mutoh H., Fung B., Naya F., Tsai M.-J., Nishitani J., and Leiter A.B. The basic helix-loop-helix transcription factor BETA2/NeuroD is expressed in mammalian enteroendocrine cells and activates secretin gene expression. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 3560-3564
22. Mutoh H., Naya F.J., Tsai M.J., and Leiter A.B. The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 12 (1998) 820-830
23. Naya F.J., Huang H., Qiu Y., Mutoh H., DeMayo F., Leiter A.B., and Tsai M.-J. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice. Genes Dev. 11 (1997) 2323-2334
24. Pizzi S., Azzoni C., Bassi D., Bottarelli L., Milione M., and Bordi C. Genetic alterations in poorly differentiated endocrine carcinomas of the gastrointestinal tract. Cancer 98 (2003) 1273-1282
25. Ray S.K., Nishitani J., Petry M.W., Fessing M.Y., and Leiter A.B. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. Mol. Cell. Biol. 23 (2003) 259-271
26. Sage J., Miller A.L., Perez-Mancera P.A., Wysocki J.M., and Jacks T. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424 (2003) 223-228
27. Schonhoff S.E., Giel-Moloney M., and Leiter A.B. Neurogenin3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Dev. Biol. 270 (2004) 443-454
28. Sherr C.J. Cancer cell cycles. Science 274 (1996) 1672-1677
29. Smith R.C., Wills K.N., Antelman D., Perlman H., Truong L.N., Krasinski K., and Walsh K. Adenoviral constructs encoding phosphorylation-competent full-length and truncated forms of the human retinoblastoma protein inhibit myocyte proliferation and neointima formation. Circulation 96 (1997) 1899-1905
30. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21 (1999) 70-71
31. Tsubouchi S., Kano E., and Suzuki H. Demonstration of expanding cell populations in mouse pancreatic acini and islets. Anat. Rec. 218 (1987) 111-115
32. Vooijs M., van der Valk M., te Riele H., and Berns A. Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse. Oncogene 17 (1998) 1-12
33. Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell 81 (1995) 323-330
34. Wheeler M.B., Nishitani J., Buchan A.M., Kopin A.S., Chey W.Y., Chang T.M., and Leiter A.B. Identification of a transcriptional enhancer important for enteroendocrine and pancreatic islet cell-specific expression of the secretin gene. Mol. Cell. Biol. 12 (1992) 3531-3539
35. Yang H.S., and Hinds P.W. pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development. BMC Dev. Biol. 7 (2007) 6