Pharmacological activation of guanine nucleotide exchange factors for the small GTPase Rap1 recruits high-affinity β1 integrins as coreceptors for parvovirus B19: Improved Ex Vivo Gene transfer to human erythroid progenitor cells

Human Gene Therapy

Volumn 20, Issue 12, 2009, Pages 1665-1678

  Weigel Van Aken, Kirsten A K ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 (4 CHLOROPHENYLTHIO)2' O METHYLADENOSINE 3',5' CYCLIC MONOPHOSPHATE; ACTIN; BETA1 INTEGRIN; CYCLIC AMP DERIVATIVE; CYTOCHALASIN D; GUANINE NUCLEOTIDE EXCHANGE FACTOR; RAC1 PROTEIN; RAP1 PROTEIN; UNCLASSIFIED DRUG; VIRUS VECTOR;

ACTIN POLYMERIZATION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOSKELETON; DOWNSTREAM PROCESSING; ENZYME ACTIVATION; ERYTHROID PRECURSOR CELL; EX VIVO GENE TRANSFER; HUMAN; HUMAN CELL; INTERNALIZATION; NONHUMAN; PARVOVIRUS; PROTEIN FUNCTION; STEM CELL; VIRAL GENE THERAPY;

ANIMALS; ANTIGENS, CD29; CELL LINE; CYCLIC AMP; CYTOCHALASIN D; ERYTHROID PRECURSOR CELLS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MICE; PARVOVIRUS B19, HUMAN; RAP1 GTP-BINDING PROTEINS; THIONUCLEOTIDES;

PARVOVIRUS;

EID: 74549164815     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2009.123     Document Type: Article

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