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Volumn 46, Issue , 2010, Pages 207-225

Retinal inflammation: Uveitis/uveoretinitis

Author keywords

Autoimmune disease; EAU; Experimental autoimmune uveitis; T lymphocytes; Tolerance; Uveitis; Uveoretinitis

Indexed keywords

ALKYLATING AGENT; ANTIMETABOLITE; CORTICOSTEROID DERIVATIVE; CYCLOSPORIN; DACLIZUMAB; RAPAMYCIN; TACROLIMUS;

EID: 74549159664     PISSN: 08932336     EISSN: 19406045     Source Type: Book Series    
DOI: 10.1007/978-1-60761-541-5_11     Document Type: Review
Times cited : (11)

References (61)
  • 1
    • 1442275270 scopus 로고    scopus 로고
    • Incidence and prevalence of uveitis in Northern California
    • the Northern California Epidemiology of Uveitis Study. discussion
    • Gritz DC, Wong IG (2004) Incidence and prevalence of uveitis in Northern California; the Northern California Epidemiology of Uveitis Study. Ophthalmology 111(3):491-500 discussion
    • (2004) Ophthalmology , vol.111 , Issue.3 , pp. 491-500
    • Gritz, D.C.1    Wong, I.G.2
  • 3
    • 0035997379 scopus 로고    scopus 로고
    • Genetic control of susceptibility in clinical and experimental uveitis
    • Pennesi G, Caspi RR (2002) Genetic control of susceptibility in clinical and experimental uveitis. Int Rev Immunol 21(2-3):67-88
    • (2002) Int Rev Immunol , vol.21 , Issue.2-3 , pp. 67-88
    • Pennesi, G.1    Caspi, R.R.2
  • 4
    • 33645872110 scopus 로고    scopus 로고
    • Animal models of autoimmune and immune-mediated uveitis
    • Caspi RR (2006) Animal models of autoimmune and immune-mediated uveitis. Drug Discov Today Dis Models 3:3-10 (http:// dxdoiorg/101016/jddmec200605006)
    • (2006) Drug Discov Today Dis Models , vol.3 , pp. 3-10
    • Caspi, R.R.1
  • 5
    • 1842558530 scopus 로고    scopus 로고
    • New insights into the pathogenesis and therapy of Behcet's disease
    • Arayssi T, Hamdan A (2004) New insights into the pathogenesis and therapy of Behcet's disease. Curr Opin Pharmacol 4(2):183-188
    • (2004) Curr Opin Pharmacol , vol.4 , Issue.2 , pp. 183-188
    • Arayssi, T.1    Hamdan, A.2
  • 8
  • 9
    • 59849104241 scopus 로고    scopus 로고
    • Molecular pathology of age-related macular degeneration
    • Ding X, Patel M, Chan CC (2009) Molecular pathology of age-related macular degeneration. Prog Retin Eye Res 28(1):1-18
    • (2009) Prog Retin Eye Res , vol.28 , Issue.1 , pp. 1-18
    • Ding, X.1    Patel, M.2    Chan, C.C.3
  • 10
    • 16644374531 scopus 로고    scopus 로고
    • Rodent models of experimental autoimmune uveitis
    • Agarwal RK, Caspi RR (2004) Rodent models of experimental autoimmune uveitis. Methods Mol Med 102:395-419
    • (2004) Methods Mol Med , vol.102 , pp. 395-419
    • Agarwal, R.K.1    Caspi, R.R.2
  • 11
    • 0031666065 scopus 로고    scopus 로고
    • Immunotolerance against a foreign antigen transgenically expressed in the lens
    • Lai JC, Fukushima A, Wawrousek EF et al (1998) Immunotolerance against a foreign antigen transgenically expressed in the lens. Invest Ophthalmol Vis Sci 39(11): 2049-2057
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , Issue.11 , pp. 2049-2057
    • Lai, J.C.1    Fukushima, A.2    Wawrousek, E.F.3
  • 12
    • 0033565592 scopus 로고    scopus 로고
    • Retinal expression of a neo-self antigen, betagalactosidase, is not tolerogenic and creates a target for autoimmune uveoretinitis
    • Gregerson DS, Torseth JW, McPherson SW, Roberts JP, Shinohara T, Zack DJ (1999) Retinal expression of a neo-self antigen, betagalactosidase, is not tolerogenic and creates a target for autoimmune uveoretinitis. J Immunol 163(2):1073-1080
    • (1999) J Immunol , vol.163 , Issue.2 , pp. 1073-1080
    • Gregerson, D.S.1    Torseth, J.W.2    McPherson, S.W.3    Roberts, J.P.4    Shinohara, T.5    Zack, D.J.6
  • 13
    • 1542637061 scopus 로고    scopus 로고
    • Central immunotolerance in transgenic mice expressing a foreign antigen under control of the rhodopsin promoter
    • Ham DI, Kim SJ, Chen J et al (2004) Central immunotolerance in transgenic mice expressing a foreign antigen under control of the rhodopsin promoter. Invest Ophthalmol Vis Sci 45(3):857-862
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , Issue.3 , pp. 857-862
    • Ham, D.I.1    Kim, S.J.2    Chen, J.3
  • 14
    • 33947650779 scopus 로고    scopus 로고
    • Limited peripheral T cell anergy predisposes to retinal autoimmunity
    • Lambe T, Leung JC, Ferry H et al (2007) Limited peripheral T cell anergy predisposes to retinal autoimmunity. J Immunol 178(7):4276-4283
    • (2007) J Immunol , vol.178 , Issue.7 , pp. 4276-4283
    • Lambe, T.1    Leung, J.C.2    Ferry, H.3
  • 15
    • 33744933703 scopus 로고    scopus 로고
    • Regulatory T cells control uveoretinitis induced by pathogenic Th1 cells reacting to a specific retinal neoantigen
    • Terrada C, Fisson S, De Kozak Y et al (2006) Regulatory T cells control uveoretinitis induced by pathogenic Th1 cells reacting to a specific retinal neoantigen. J Immunol 176(12):7171-7179
    • (2006) J Immunol , vol.176 , Issue.12 , pp. 7171-7179
    • Terrada, C.1    Fisson, S.2    De Kozak, Y.3
  • 16
    • 0025027630 scopus 로고
    • Experimental autoimmune uveoretinitis in mice. Induction by a single eliciting event and dependence on quantitative parameters of immunization
    • Caspi RR, Chan CC, Leake WC, Higuchi M, Wiggert B, Chader GJ (1990) Experimental autoimmune uveoretinitis in mice. Induction by a single eliciting event and dependence on quantitative parameters of immunization. J Autoimmun 3(3):237-246
    • (1990) J Autoimmun , vol.3 , Issue.3 , pp. 237-246
    • Caspi, R.R.1    Chan, C.C.2    Leake, W.C.3    Higuchi, M.4    Wiggert, B.5    Chader, G.J.6
  • 17
    • 52049094091 scopus 로고    scopus 로고
    • A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images
    • Xu H, Koch P, Chen M, Lau A, Reid DM, Forrester JV (2008) A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images. Exp Eye Res 87(4):319-326
    • (2008) Exp Eye Res , vol.87 , Issue.4 , pp. 319-326
    • Xu, H.1    Koch, P.2    Chen, M.3    Lau, A.4    Reid, D.M.5    Forrester, J.V.6
  • 18
    • 58149261815 scopus 로고    scopus 로고
    • The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation
    • Copland DA, Wertheim MS, Armitage WJ, Nicholson LB, Raveney BJ, Dick AD (2008) The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation. Invest Ophthalmol Vis Sci 49(12):5458-5465
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , Issue.12 , pp. 5458-5465
    • Copland, D.A.1    Wertheim, M.S.2    Armitage, W.J.3    Nicholson, L.B.4    Raveney, B.J.5    Dick, A.D.6
  • 19
    • 0032776148 scopus 로고    scopus 로고
    • HLA class II transgenic mice as models of human diseases
    • Taneja V, David CS (1999) HLA class II transgenic mice as models of human diseases. Immunol Rev 169:67-79
    • (1999) Immunol Rev , vol.169 , pp. 67-79
    • Taneja, V.1    David, C.S.2
  • 20
    • 0037399446 scopus 로고    scopus 로고
    • A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice
    • Pennesi G, Mattapallil MJ, Sun SH et al (2003) A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice. J Clin Invest 111(8):1171-1180
    • (2003) J Clin Invest , vol.111 , Issue.8 , pp. 1171-1180
    • Pennesi, G.1    Mattapallil, M.J.2    Sun, S.H.3
  • 21
    • 0027134625 scopus 로고
    • Human S-antigen: Presence of multiple immunogenic and immunopathogenic sites in the Lewis rat
    • DOI 10.1006/jaut.1993.1048
    • de Smet MD, Bitar G, Roberge FG, Gery I, Nussenblatt RB (1993) Human S-antigen: presence of multiple immunogenic and immunopathogenic sites in the Lewis rat. J Autoimmun 6(5):587-599 (Pubitemid 23334529)
    • (1993) Journal of Autoimmunity , vol.6 , Issue.5 , pp. 587-599
    • De Smet, M.D.1    Bitar, G.2    Roberge, F.G.3    Gery, I.4    Nussenblatt, R.B.5
  • 22
    • 0032858055 scopus 로고    scopus 로고
    • Uveitis induced by lymphocytes sensitized against a transgenically expressed lens protein
    • Lai JC, Lobanoff MC, Fukushima A et al (1999) Uveitis induced by lymphocytes sensitized against a transgenically expressed lens protein. Invest Ophthalmol Vis Sci 40(11):2735-2739
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , Issue.11 , pp. 2735-2739
    • Lai, J.C.1    Lobanoff, M.C.2    Fukushima, A.3
  • 23
    • 34247586615 scopus 로고    scopus 로고
    • Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: Initial encounter with autoantigen defines disease phenotype
    • Tang J, Zhu W, Silver PB, Su SB, Chan CC, Caspi RR (2007) Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype. J Immunol 178(9):5578-5587
    • (2007) J Immunol , vol.178 , Issue.9 , pp. 5578-5587
    • Tang, J.1    Zhu, W.2    Silver, P.B.3    Su, S.B.4    Chan, C.C.5    Caspi, R.R.6
  • 24
    • 0035957005 scopus 로고    scopus 로고
    • Spontaneous retinopathy in HLA-A29 transgenic mice
    • Szpak Y, Vieville JC, Tabary T et al (2001) Spontaneous retinopathy in HLA-A29 transgenic mice. Proc Natl Acad Sci U S A 98(5):2572-2576
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.5 , pp. 2572-2576
    • Szpak, Y.1    Vieville, J.C.2    Tabary, T.3
  • 25
    • 42449127138 scopus 로고    scopus 로고
    • Pathological aspects of spontaneous uveitis and retinopathy in HLA-A29 transgenic mice and in animal models of retinal autoimmunity: Relevance to human pathologies
    • de Kozak Y, Camelo S, Pla M (2008) Pathological aspects of spontaneous uveitis and retinopathy in HLA-A29 transgenic mice and in animal models of retinal autoimmunity: relevance to human pathologies. Ophthalmic Res 40(3-4):175-180
    • (2008) Ophthalmic Res , vol.40 , Issue.3-4 , pp. 175-180
    • De Kozak, Y.1    Camelo, S.2    Pla, M.3
  • 26
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • Anderson MS, Venanzi ES, Klein L et al (2002) Projection of an immunological self shadow within the thymus by the aire protein. Science 298(5597):1395-1401
    • (2002) Science , vol.298 , Issue.5597 , pp. 1395-1401
    • Anderson, M.S.1    Venanzi, E.S.2    Klein, L.3
  • 27
    • 33751513054 scopus 로고    scopus 로고
    • Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
    • DeVoss J, Hou Y, Johannes K et al (2006) Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med 203(12):2727-2735
    • (2006) J Exp Med , vol.203 , Issue.12 , pp. 2727-2735
    • Devoss, J.1    Hou, Y.2    Johannes, K.3
  • 28
    • 0026049256 scopus 로고
    • Spontaneous development of autoimmune uveoretinitis in nude mice following reconstitution with embryonic rat thymus
    • Ichikawa T, Taguchi O, Takahashi T et al (1991) Spontaneous development of autoimmune uveoretinitis in nude mice following reconstitution with embryonic rat thymus. Clin Exp Immunol 86(1):112-117
    • (1991) Clin Exp Immunol , vol.86 , Issue.1 , pp. 112-117
    • Ichikawa, T.1    Taguchi, O.2    Takahashi, T.3
  • 29
    • 0037446749 scopus 로고    scopus 로고
    • T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: The soluble form is more effective than the membrane-bound form
    • Zhang M, Vacchio MS, Vistica BP et al (2003) T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form. J Immunol 170(8):3954-3962
    • (2003) J Immunol , vol.170 , Issue.8 , pp. 3954-3962
    • Zhang, M.1    Vacchio, M.S.2    Vistica, B.P.3
  • 30
    • 60549102353 scopus 로고    scopus 로고
    • Lymphopenia-induced proliferation is a potent activator for CD4+ T cell-mediated autoimmune disease in the retina
    • McPherson SW, Heuss ND, Gregerson DS (2009) Lymphopenia-induced proliferation is a potent activator for CD4+ T cell-mediated autoimmune disease in the retina. J Immunol 182(2):969-979
    • (2009) J Immunol , vol.182 , Issue.2 , pp. 969-979
    • McPherson, S.W.1    Heuss, N.D.2    Gregerson, D.S.3
  • 31
    • 10744232942 scopus 로고    scopus 로고
    • An immunologically privileged retinal antigen elicits tolerance: Major role for central selection mechanisms
    • Avichezer D, Grajewski RS, Chan CC et al (2003) An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms. J Exp Med 198(11): 1665-1676
    • (2003) J Exp Med , vol.198 , Issue.11 , pp. 1665-1676
    • Avichezer, D.1    Grajewski, R.S.2    Chan, C.C.3
  • 32
    • 33645863161 scopus 로고    scopus 로고
    • Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBPinduced retinal autoimmunity
    • Grajewski RS, Silver PB, Agarwal RK et al (2006) Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBPinduced retinal autoimmunity. J Exp Med 203(4):851-856
    • (2006) J Exp Med , vol.203 , Issue.4 , pp. 851-856
    • Grajewski, R.S.1    Silver, P.B.2    Agarwal, R.K.3
  • 33
    • 23844439642 scopus 로고    scopus 로고
    • Thymic expression of peripheral tissue antigens in humans: A remarkable variability among individuals
    • Takase H, Yu CR, Mahdi RM et al (2005) Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals. Int Immunol 17(8): 1131-1140
    • (2005) Int Immunol , vol.17 , Issue.8 , pp. 1131-1140
    • Takase, H.1    Yu, C.R.2    Mahdi, R.M.3
  • 34
    • 33748745741 scopus 로고    scopus 로고
    • Ocular autoimmunity: The price of privilege?
    • Caspi RR (2006) Ocular autoimmunity: the price of privilege? Immunol Rev 213:23-35
    • (2006) Immunol Rev , vol.213 , pp. 23-35
    • Caspi, R.R.1
  • 35
    • 0032829512 scopus 로고    scopus 로고
    • Systemic expression of rat soluble retinal antigen induces resistance to experimental autoimmune uveoretinitis
    • McPherson SW, Roberts JP, Gregerson DS (1999) Systemic expression of rat soluble retinal antigen induces resistance to experimental autoimmune uveoretinitis. J Immunol 163(8):4269-4276
    • (1999) J Immunol , vol.163 , Issue.8 , pp. 4269-4276
    • McPherson, S.W.1    Roberts, J.P.2    Gregerson, D.S.3
  • 36
    • 0033987174 scopus 로고    scopus 로고
    • Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis
    • Xu H, Wawrousek EF, Redmond TM et al (2000) Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis. Eur J Immunol 30(1):272-278
    • (2000) Eur J Immunol , vol.30 , Issue.1 , pp. 272-278
    • Xu, H.1    Wawrousek, E.F.2    Redmond, T.M.3
  • 37
    • 42449131836 scopus 로고    scopus 로고
    • Evidence for extrathymic generation of regulatory T cells specific for a retinal antigen
    • Gregerson DS, Heuss ND, Lehmann U, McPherson SW (2008) Evidence for extrathymic generation of regulatory T cells specific for a retinal antigen. Ophthalmic Res 40(3-4):154-159
    • (2008) Ophthalmic Res , vol.40 , Issue.3-4 , pp. 154-159
    • Gregerson, D.S.1    Heuss, N.D.2    Lehmann, U.3    McPherson, S.W.4
  • 38
    • 34250005444 scopus 로고    scopus 로고
    • TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
    • Amadi-Obi A, Yu CR, Liu X et al (2007) TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med 13(6):711-718
    • (2007) Nat Med , vol.13 , Issue.6 , pp. 711-718
    • Amadi-Obi, A.1    Yu, C.R.2    Liu, X.3
  • 39
    • 34247552894 scopus 로고    scopus 로고
    • IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease
    • Chi W, Yang P, Li B et al (2007) IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease. J Allergy Clin Immunol 119(5):1218-1224
    • (2007) J Allergy Clin Immunol , vol.119 , Issue.5 , pp. 1218-1224
    • Chi, W.1    Yang, P.2    Li, B.3
  • 40
    • 48249149556 scopus 로고    scopus 로고
    • Upregulated IL-23 and IL-17 in behcet patients with active uveitis
    • Chi W, Zhu X, Yang P et al (2008) Upregulated IL-23 and IL-17 in behcet patients with active uveitis. Invest Ophthalmol Vis Sci 49(7):3058-3064
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , Issue.7 , pp. 3058-3064
    • Chi, W.1    Zhu, X.2    Yang, P.3
  • 41
    • 42249084849 scopus 로고    scopus 로고
    • Either a Th17 or a Th1 effector response can drive autoimmunity: Conditions of disease induction affect dominant effector category
    • Luger D, Silver PB, Tang J et al (2008) Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med 205(4):799-810
    • (2008) J Exp Med , vol.205 , Issue.4 , pp. 799-810
    • Luger, D.1    Silver, P.B.2    Tang, J.3
  • 42
    • 49049113716 scopus 로고    scopus 로고
    • Decreased frequency and diminished function of CD4+CD25high regulatory T cells are associated with active uveitis in patients with Vogt-Koyanagi-Harada syndrome
    • Chen L, Yang P, Zhou H et al (2008) Decreased frequency and diminished function of CD4+CD25high regulatory T cells are associated with active uveitis in patients with Vogt-Koyanagi-Harada syndrome. Invest Ophthalmol Vis Sci 49(8):3475-3482
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , Issue.8 , pp. 3475-3482
    • Chen, L.1    Yang, P.2    Zhou, H.3
  • 43
    • 53149143166 scopus 로고    scopus 로고
    • Ocular regulatory T cells distinguish monophasic from recurrent autoimmune uveitis
    • Ke Y, Jiang G, Sun D, Kaplan HJ, Shao H (2008) Ocular regulatory T cells distinguish monophasic from recurrent autoimmune uveitis. Invest Ophthalmol Vis Sci 49(9):3999-4007
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , Issue.9 , pp. 3999-4007
    • Ke, Y.1    Jiang, G.2    Sun, D.3    Kaplan, H.J.4    Shao, H.5
  • 44
    • 33846821852 scopus 로고    scopus 로고
    • Suppressor role of rat CD8+CD45RClow T cells in experimental autoimmune uveitis (EAU)
    • Han G, Shao H, Peng Y et al (2007) Suppressor role of rat CD8+CD45RClow T cells in experimental autoimmune uveitis (EAU). J Neuroimmunol 183(1-2):81-88
    • (2007) J Neuroimmunol , vol.183 , Issue.1-2 , pp. 81-88
    • Han, G.1    Shao, H.2    Peng, Y.3
  • 45
    • 0026547871 scopus 로고
    • Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model. Concomitant regulation by MHC and non-MHC genes
    • Caspi RR, Grubbs BG, Chan CC, Chader GJ, Wiggert B (1992) Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model. Concomitant regulation by MHC and non-MHC genes. J Immunol 148(8):2384-2389
    • (1992) J Immunol , vol.148 , Issue.8 , pp. 2384-2389
    • Caspi, R.R.1    Grubbs, B.G.2    Chan, C.C.3    Chader, G.J.4    Wiggert, B.5
  • 46
    • 0030587090 scopus 로고    scopus 로고
    • Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response
    • Caspi RR, Silver PB, Chan CC et al (1996) Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response. J Immunol 157(6):2668-2675
    • (1996) J Immunol , vol.157 , Issue.6 , pp. 2668-2675
    • Caspi, R.R.1    Silver, P.B.2    Chan, C.C.3
  • 47
    • 0032799515 scopus 로고    scopus 로고
    • Autoimmunity to a pathogenic retinal antigen begins as a balanced cytokine response that polarizes towards type 1 in a disease-susceptible and towards type 2 in a disease-resistant genotype
    • Sun B, Sun SH, Chan CC, Wiggert B, Caspi RR (1999) Autoimmunity to a pathogenic retinal antigen begins as a balanced cytokine response that polarizes towards type 1 in a disease-susceptible and towards type 2 in a disease-resistant genotype. Int Immunol 11(8):1307-1312
    • (1999) Int Immunol , vol.11 , Issue.8 , pp. 1307-1312
    • Sun, B.1    Sun, S.H.2    Chan, C.C.3    Wiggert, B.4    Caspi, R.R.5
  • 49
    • 13044311376 scopus 로고    scopus 로고
    • Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: A phase I/II clinical trial
    • Nussenblatt RB, Fortin E, Schiffman R et al (1999) Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: a phase I/II clinical trial. Proc Natl Acad Sci U S A 96(13): 7462-7466
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.13 , pp. 7462-7466
    • Nussenblatt, R.B.1    Fortin, E.2    Schiffman, R.3
  • 50
    • 0035997394 scopus 로고    scopus 로고
    • Bench to bedside: New approaches to the immunotherapy of uveitic disease
    • Nussenblatt RB (2002) Bench to bedside: new approaches to the immunotherapy of uveitic disease. Int Rev Immunol 21(2-3):273-289
    • (2002) Int Rev Immunol , vol.21 , Issue.2-3 , pp. 273-289
    • Nussenblatt, R.B.1
  • 51
    • 50549090768 scopus 로고    scopus 로고
    • High-dose humanized anti-IL-2 receptor alpha antibody (daclizumab) for the treatment of active, non-infectious uveitis
    • Yeh S, Wroblewski K, Buggage R et al (2008) High-dose humanized anti-IL-2 receptor alpha antibody (daclizumab) for the treatment of active, non-infectious uveitis. J Autoimmun 31(2):91-97
    • (2008) J Autoimmun , vol.31 , Issue.2 , pp. 91-97
    • Yeh, S.1    Wroblewski, K.2    Buggage, R.3
  • 52
    • 0033927572 scopus 로고    scopus 로고
    • Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis
    • Agarwal RK, Kang Y, Zambidis E, Scott DW, Chan CC, Caspi RR (2000) Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis. J Clin Invest 106(2):245-252
    • (2000) J Clin Invest , vol.106 , Issue.2 , pp. 245-252
    • Agarwal, R.K.1    Kang, Y.2    Zambidis, E.3    Scott, D.W.4    Chan, C.C.5    Caspi, R.R.6
  • 53
    • 38449123397 scopus 로고    scopus 로고
    • Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells
    • Silver PB, Agarwal RK, Su SB et al (2007) Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells. J Immunol 179(8):5146-5158
    • (2007) J Immunol , vol.179 , Issue.8 , pp. 5146-5158
    • Silver, P.B.1    Agarwal, R.K.2    Su, S.B.3
  • 54
    • 56749180605 scopus 로고    scopus 로고
    • Immunotherapy of autoimmunity and cancer: The penalty for success
    • Caspi RR (2008) Immunotherapy of autoimmunity and cancer: the penalty for success. Nat Rev Immunol 8(12):970-976
    • (2008) Nat Rev Immunol , vol.8 , Issue.12 , pp. 970-976
    • Caspi, R.R.1
  • 55
    • 24944449409 scopus 로고    scopus 로고
    • Tetracycline-inducible viral interleukin-10 intraocular gene transfer, using adeno-associated virus in experimental autoimmune uveoretinitis
    • Smith JR, Verwaerde C, Rolling F et al (2005) Tetracycline-inducible viral interleukin-10 intraocular gene transfer, using adeno-associated virus in experimental autoimmune uveoretinitis. Hum Gene Ther 16(9):1037-1046
    • (2005) Hum Gene Ther , vol.16 , Issue.9 , pp. 1037-1046
    • Smith, J.R.1    Verwaerde, C.2    Rolling, F.3
  • 57
    • 32944473388 scopus 로고    scopus 로고
    • Antigen/ MHC class II/Ig dimers for study of uveitogenic T cells: IRBP p161-180 presented by both IA and IE molecules
    • Karabekian Z, Lytton SD, Silver PB, Sergeev YV, Schneck JP, Caspi RR (2005) Antigen/ MHC class II/Ig dimers for study of uveitogenic T cells: IRBP p161-180 presented by both IA and IE molecules. Invest Ophthalmol Vis Sci 46(10):3769-3776
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , Issue.10 , pp. 3769-3776
    • Karabekian, Z.1    Lytton, S.D.2    Silver, P.B.3    Sergeev, Y.V.4    Schneck, J.P.5    Caspi, R.R.6
  • 59
    • 44649104711 scopus 로고    scopus 로고
    • Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice
    • Cortes LM, Mattapallil MJ, Silver PB et al (2008) Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice. Invest Ophthalmol Vis Sci 49(5):1946-1956
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , Issue.5 , pp. 1946-1956
    • Cortes, L.M.1    Mattapallil, M.J.2    Silver, P.B.3
  • 60
    • 0028937786 scopus 로고
    • Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype
    • Silver PB, Rizzo LV, Chan CC, Donoso LA, Wiggert B, Caspi RR (1995) Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype. Invest Ophthalmol Vis Sci 36(5):946-954
    • (1995) Invest Ophthalmol Vis Sci , vol.36 , Issue.5 , pp. 946-954
    • Silver, P.B.1    Rizzo, L.V.2    Chan, C.C.3    Donoso, L.A.4    Wiggert, B.5    Caspi, R.R.6
  • 61
    • 6844226208 scopus 로고    scopus 로고
    • Identification of a peptide inducing experimental autoimmune uveoretinitis (EAU) in H-2Ak-carrying mice
    • Namba K, Ogasawara K, Kitaichi N et al (1998) Identification of a peptide inducing experimental autoimmune uveoretinitis (EAU) in H-2Ak-carrying mice. Clin Exp Immunol 111(2):442-449
    • (1998) Clin Exp Immunol , vol.111 , Issue.2 , pp. 442-449
    • Namba, K.1    Ogasawara, K.2    Kitaichi, N.3


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