New insights into the pathogenesis and therapy of Behçet's disease

Current Opinion in Pharmacology

Volumn 4, Issue 2, 2004, Pages 183-188

  Arayssi, Thurayya ^a   Hamdan, Ayad ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ALPHA INTERFERON; ALPHA2A INTERFERON; ANTINUCLEAR ANTIBODY; AZAPROPAZONE; AZATHIOPRINE; BENZATHINE PENICILLIN; COLCHICINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTOKINE; DNA ANTIBODY; ETANERCEPT; HLA B51 ANTIGEN; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; SODIUM CHLORIDE; THALIDOMIDE; THYROID ANTIBODY;

ANTIBODY PRODUCTION; ARTHRITIS; BEHCET DISEASE; CLINICAL FEATURE; DISEASE ASSOCIATION; DNA POLYMORPHISM; ETHNIC GROUP; EYE DISEASE; FLU LIKE SYNDROME; GENETIC SUSCEPTIBILITY; GENITAL ULCER; HAIR LOSS; HUMAN; INFLAMMATORY DISEASE; LEUKOPENIA; MOUTH ULCER; PATHOGENESIS; PRIORITY JOURNAL; RETINOPATHY; REVIEW; TH1 CELL;

BEHCET SYNDROME; HLA-B ANTIGENS; HUMANS; INTERFERONS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 1842558530     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2003.10.009     Document Type: Review

References (56)

1. International Study Group for Behcet's Disease: Criteria for diagnosis of Behcet's disease. Lancet 1990, 335:1078-1080.
2. Sakane T. Takeno M. Suzuki N. Inaba G. Behcet's disease N. Engl. J. Med. 341 1999 1284-1291
3. Zierhut M. Mizuki N. Ohno S. Inoko H. Gul A. Onoe K. Isogai E. Immunology and functional genomics of Behcet's disease Cell Mol. Life Sci. 60 2003 1903-1922
4. Direskeneli H. Behcet's disease: infectious aetiology, new autoantigens, and HLA-B51 Ann. Rheum Dis. 60 2001 996-1002
5. Ohno S. Ohguchi M. Hirose S. Matsuda H. Wakisaka A. Aizawa M. Close association of HLA-Bw51 with Behcet's disease Arch. Ophthalmol. 100 1982 1455-1458
6. Ahmad T. Wallace G.R. James T. Neville M. Bunce M. Mulcahy-Hawes K. Armuzzi A. Crawshaw J. Fortune F. Walton R. et al. Mapping the HLA association in Behcet's disease: a role for tumor necrosis factor polymorphisms? Arthritis Rheum 48 2003 807-813
7. Sano K. Yabuki K. Imagawa Y. Shiina T.Mizuki N. Ohno S. Kulski J.K. Inoko H. The absence of disease-specific polymorphisms within the HLA-B51 gene that is the susceptible locus for Behcet's disease Tissue Antigens 58 2001 77-82
8. Goldstein D.B. Islands of linkage disequilibrium Nat. Genet. 29 2001 109-111
9. Mizuki N. Ota M. Yabuki K. Katsuyama Y. Ando H. Palimeris G.D. Kaklamani E. Accorinti M. Pivetti-Pezzi P. Ohno S. et al. Localization of the pathogenic gene of Behcet's disease by microsatellite analysis of three different populations Invest. Ophthalmol. Vis. Sci. 41 2000 3702-3708
10. Cohen R. Metzger S. Nahir M. Chajek-Shaul T. Association of the MIC-A gene and HLA-B51 with Behcet's disease in Arabs and non-Ashkenazi Jews in Israel Ann Rheum Dis. 61 2002 157-160
11. Salvarani C. Boiardi L. Mantovani V. Olivieri I. Ciancio G. Cantini F. Salvi F. Malatesta R. Molinotti C. Govoni M. et al. Association of MICA alleles and HLA-B51 in Italian patients with Behcet's disease J. Rheumatol. 28 2001 1867-1870
12. Mizuki N. Yabuki K. Ota M. Verity D. Katsuyama Y. Ando H. Onari K. Goto K. Imagawa Y. Mandanat W. et al. Microsatellite mapping of a susceptible locus within the HLA region for Behcet's disease using Jordanian patients Hum. Immunol. 62 2001 186-190
13. Choukri F. Chakib A. Himmich H. Hue S. Caillat-Zucman S. HLA-B*51 and B*15 alleles confer predisposition to Behcet's disease in Moroccan patients Hum. Immunol. 62 2001 180-185
14. Gonzalez-Escribano M.F. Rodriguez M.R. Walter K. Sanchez-Roman J. Garcia-Lozano J.R. Nunez-Roldan A. Association of HLA-B51 subtypes and Behcet's disease in Spain Tissue Antigens 52 1998 78-80
15. Mizuki N. Yabuki K. Ota M. Katsuyama Y. Ando H. Nomura E. Funakoshi K. Davatchi F. Chams H. Nikbin B. et al. Analysis of microsatellite polymorphism around the HLA-B locus in Iranian patients with Behcet's disease Tissue Antigens 60 2002 396-399
16. Park S.H. Park K.S. Seo Y.I. Min D.J. Kim W.U. Kim T.G. Cho C.S. Mok J.W. Kim H.Y. Association of MICA polymorphism with HLA-B51 and disease severity in Korean patients with Behcet's disease J. Korean Med. Sci. 17 2002 366-370
17. Kotter I. Gunaydin I. Stubiger N. Yazici H. Fresko I. Zouboulis C.C. Adler Y. Steiert I. Kurz B. Wernet D. et al. Comparative analysis of the association of HLA-B*51 suballeles with Behcet's disease in patients of German and Turkish origin Tissue Antigens 58 2001 166-170
18. Kimura T. Goto K. Yabuki K. Mizuki N. Tamiya G. Sato M. Kimura M. Inoko H. Ohno S. Microsatellite polymorphism within the MICB gene among Japanese patients with Behcet's disease Hum. Immunol. 59 1998 500-502
19. Lee E.B. Kim J.Y. Lee Y.J. Park M.H. Song Y.W. TNF and TNF receptor polymorphisms in Korean Behcet's disease patients Hum. Immunol. 64 2003 614-620
20. Gul A. Hajeer A.H. Worthington J. Ollier W.E. Silman A.J. Linkage mapping of a novel susceptibility locus for Behcet's disease to chromosome 6p22-23 Arthritis Rheum 44 2001 2693-2696
21. Gul A. Uyar F.A. Inanc M. Ocal L. Barrett J.H. Aral O. Konice M. Saruhan-Direskeneli G. A weak association of HLA-B*2702 with Behcet's disease Genes Immun. 3 2002 368-372
22. Vandenbroeck K. Goris A. Cytokine gene polymorphisms in multifactorial diseases: gateways to novel targets for immunotherapy? Trends Pharmacol. Sci. 24 2003 284-289
23. Douglas J.A. Boehnke M. Gillanders E. Trent J.M. Gruber S.B. Experimentally-derived haplotypes substantially increase the efficiency of linkage disequilibrium studies Nat. Genet. 28 2001 361-364
24. Yabuki K. Mizuki N. Ota M. Katsuyama Y. Palimeris G. Stavropoulos C. Koumantaki Y. Spyropoulou M. Giziaki E. Kaklamani V. et al. Association of MICA gene and HLA-B*5101 with Behcet's disease in Greece Invest. Ophthalmol. Vis. Sci. 40 1999 1921-1926
25. Gonzalez-Escribano M.F. Rodriguez M.R. Aguilar F. Alvarez A. Sanchez-Roman J. Nunez-Roldan A. Lack of association of MICA transmembrane region polymorphism and Behcet's disease in Spain Tissue Antigens 54 1999 278-281
26. Witkin S.S. Gerber S. Ledger W.J. Influence of interleukin-1 receptor antagonist gene polymorphism on disease Clin. Infect Dis. 34 2002 204-209
27. Muhl H. Pfeilschifter J. Anti-inflammatory properties of pro-inflammatory interferon-gamma Int. Immunopharmacol. 3 2003 1247-1255
28. Karasneh J. Hajeer A.H. Barrett J. Ollier W.E. Thornhill M. Gul A. Association of specific interleukin 1 gene cluster polymorphisms with increased susceptibility for Behcet's disease Rheumatology (Oxford) 42 2003 860-864
29. Verity D.H. Vaughan R.W. Kondeatis E. Madanat W. Zureikat H. Fayyad F. Marr J.E. Kanawati C.A. Wallace G.R. Stanford M.R. Intercellular adhesion molecule-1 gene polymorphisms in Behcet's disease Eur. J. Immunogenet. 27 2000 73-76
30. Boiardi L. Salvarani C. Casali B. Olivieri I. Ciancio G. Cantini F. Salvi F. Malatesta R. Govoni M. Trotta F. et al. Intercellular adhesion molecule-1 gene polymorphisms in Behcet's Disease J. Rheumatol. 28 2001 1283-1287
31. Salvarani C. Boiardi L. Casali B. Olivieri I. Ciancio G. Cantini F. Salvi F. Malatesta R. Govoni M. Trotta F. et al. Endothelial nitric oxide synthase gene polymorphisms in Behcet's disease J. Rheumatol. 29 2002 535-540
32. Renauld J.C. Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators Nat. Rev. Immunol. 3 2003 667-676
33. Alpsoy E. Durusoy C. Yilmaz E. Ozgurel Y. Ermis O. Yazar S. Basaran E. Interferon alfa-2a in the treatment of Behcet disease: a randomized placebo-controlled and double-blind study Arch Dermatol. 138 2002 467-471
34. Kotter I. Zierhut M. Eckstein A.K. Vonthein R. Ness T. Gunaydin I. Grimbacher B. Blaschke S. Meyer-Riemann W. Peter H.H. et al. Human recombinant interferon alfa-2a for the treatment of Behcet's disease with sight threatening posterior or panuveitis Br. J. Ophthalmol. 87 2003 423-431
35. Budak-Alpdogan T, Demircay, Alpdogan O, Direskeneli H, Ergun T, Ozturk A, Gunay A, Yavuz S, Uskent N, Akoglu T: Skin hyperreactivity of Behcet's patients (pathergy reaction) is also positive in interferon alpha-treated chronic myeloid leukaemia patients, indicating similarly altered neutrophil functions in both disorders. Br J Rheumatol 1998, 37:1148-1151.
36. Kawano T. Shigehira M. Uto H. Nakama T. Kato J. Hayashi K. Maruyama T. Kuribayashi T. Chuman T. Futami T. et al. Retinal complications during interferon therapy for chronic hepatitis C Am. J. Gastroenterol. 91 1996 309-313
37. Santos Lacomba M. Marcos Martin C. Gallardo Galera J.M. Gomez Vidal M.A. Collantes Estevez E. Ramirez Chamond R. Omar M. Aqueous humor and serum tumor necrosis factor-alpha in clinical uveitis Ophthalmic Res. 33 2001 251-255
38. Sfikakis P.P. Theodossiadis P.G. Katsiari C.G. Kaklamanis P. Markomichelakis N.N. Effect of infliximab on sight-threatening panuveitis in Behcet's disease Lancet 358 2001 295-296
39. Arayssi T. Hamra R. Awwad S. Kazma I. Homaidan F. Uthman I. Bashour Z. Treatment of refractory vitritis in Behçet disease with infliximab Arthritis Rheum Abstr. 46 2002 S181
40. Robertson L.P. Hickling P. Treatment of recalcitrant orogenital ulceration of Behcet's syndrome with infliximab Rheumatology (Oxford) 40 2001 473-474
41. Kram M.T. May L.D. Goodman S. Molinas S. Behcet's ileocolitis: successful treatment with tumor necrosis factor-alpha antibody (infliximab) therapy: report of a case Dis. Colon. Rectum 46 2003 118-121
42. Licata G. Pinto A. Tuttolomondo A. Banco A. Ciccia F. Ferrante A. Triolo G. Anti-tumour necrosis factor alpha monoclonal antibody therapy for recalcitrant cerebral vasculitis in a patient with Behcet's syndrome Ann. Rheum. Dis. 62 2003 280-281
43. Melikoglu M. Fresko I. Mat C. Ozyazgan Y. Gogus F. Yurdakul S. Hamuryudan V. Yazici H. Etanercept is beneficial in controlling the mucocutaneous lesions of Behcet's syndrome (BS) at short term but does not suppress the pathergy reaction and the cutaneous response to intradermally injected monosodium urate (MSU) crystals: a double blind placebo controlled trial Arthritis Rheum Abstr. 46 2002 S206
44. Melikoglu M. Ozyazgan Y. Fresko I. Mat C. Yurdakul S. Hamuryudan V. Yazici H. The response of treatment resistant uveitis in Behçet's syndrome (BS) to a TNF-a blocker, etanercept: an open study Arthritis Rheum Abstr. 46 2002 S181
45. Hamuryudan V. Mat C. Saip S. Ozyazgan Y. Siva A. Yurdakul S. Zwingenberger K. Yazici H. Thalidomide in the treatment of the mucocutaneous lesions of the Behcet syndrome. A randomized, double-blind, placebo-controlled trial Ann. Intern. Med. 128 1998 443-450
46. Yurdakul S. Mat C. Tuzun Y. Ozyazgan Y. Hamuryudan V. Uysal O. Senocak M. Yazici H. A double-blind trial of colchicine in Behcet's syndrome Arthritis Rheum 44 2001 2686-2692
47. Aktulga E. Altac M. Muftuoglu A. Ozyazgan Y. Pazarli H. Tuzun Y. Yalcin B. Yazici H. Yurdakul S. A double blind study of colchicine in Behcet's disease Haematologica 65 1980 399-402
48. Davies U.M. Palmer R.G. Denman A.M. Treatment with acyclovir does not affect orogenital ulcers in Behcet's syndrome: a randomized double-blind trial Br. J. Rheumatol. 27 1988 300-302
49. Benamour S. Bennis R. Messoudi M. Zaoui A. Amor B. [Desensitization by autologous saliva and Behcet's disease] Rev. Med. Interne 12 1991 339-342
50. Hamuryudan V. Yurdakul S. Rosenkaimer F. Yazici H. Inefficacy of topical alpha interferon in the treatment of oral ulcers of Behcet's syndrome: a randomized, double blind trial Br. J. Rheumatol. 30 1991 395-396
51. Moral F. Hamuryudan V. Yurdakul S. Yazici H. Inefficacy of azapropazone in the acute arthritis of Behcet's syndrome: a randomized, double blind, placebo controlled study Clin. Exp. Rheumatol. 13 1995 493-495
52. Calguneri M. Ertenli I. Kiraz S. Erman M. Celik I. Effect of prophylactic benzathine penicillin on mucocutaneous symptoms of Behcet's disease Dermatology 192 1996 125-128
53. BenEzra D. Cohen E. Chajek T. Friedman G. Pizanti S. de Courten C. Harris W. Evaluation of conventional therapy versus cyclosporine A in Behcet's syndrome Transplant Proc. 20 1988 136-143
54. Masuda K. Nakajima A. Urayama A. Nakae K. Kogure M. Inaba G. Double-masked trial of cyclosporin versus colchicine and long-term open study of cyclosporin in Behcet's disease Lancet 1 1989 1093-1096
55. Yazici H. Pazarli H. Barnes C.G. Tuzun Y. Ozyazgan Y. Silman A. Serdaroglu S. Oguz V. Yurdakul S. Lovatt G.E. et al. A controlled trial of azathioprine in Behcet's syndrome N. Engl. J. Med. 322 1990 281-285
56. Ozyazgan Y. Yurdakul S. Yazici H. Tuzun B. Iscimen A. Tuzun Y. Aktunc T. Pazarli H. Hamuryudan V. Muftuoglu A. Low dose cyclosporin A versus pulsed cyclophosphamide in Behcet's syndrome: a single masked trial Br. J. Ophthalmol. 76 1992 241-243