Systemic expression of rat soluble retinal antigen induces resistance to experimental autoimmune uveoretinitis

Journal of Immunology

Volumn 163, Issue 8, 1999, Pages 4269-4276

  McPherson, Scott W ^a   Roberts, Josh P ^a   Gregerson, Dale S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINA ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CHIMERA; DISEASE COURSE; DISEASE RESISTANCE; DISEASE SEVERITY; GENE TRANSFER; GENETIC TRANSDUCTION; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RETROVIRUS; UVEORETINITIS;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; ARRESTIN; AUTOANTIGENS; AUTOIMMUNE DISEASES; BONE MARROW CELLS; CATTLE; CELL LINE; FIBROBLASTS; IMMUNITY, NATURAL; MICE; MOLECULAR SEQUENCE DATA; RADIATION CHIMERA; RATS; RATS, INBRED BUF; RATS, INBRED LEW; RETINITIS; RETROVIRIDAE; SOLUBILITY; TRANSCRIPTION, GENETIC; TRANSDUCTION, GENETIC; UVEITIS;

EID: 0032829512     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Hargrave, P. A., and J. H. McDowell. 1992. Rhodopsin and phototransduction: a model system for G protein-linked receptors. FASEB J. 6:2323.
2. Krupnick, J. G., V. V. Gurevich, T. Schepers, H. E. Hamm, and J. L. Benovic. 1994. Arrestin-rhodopsin interaction: multi-site binding delineated by peptide inhibition. J. Biol. Chem. 269:3226.
3. Gurevich, V. V., C. Y. Chen, C. M. Kim, and J. L. Benovic. 1994. Visual arrestin binding to rhodopsin. Intramolecular interaction between the basic N terminus and acidic C terminus of arrestin may regulate binding selectivity. J. Biol. Chem. 269:8721.
4. Gurevich, V. V., and J. L. Benovic. 1993. Visual arrestin interaction with rhodopsin: sequential multisite binding ensures strict selectivity toward light-activated phosphorylaled rhodopsin. J. Biol. Chem. 268:11628.
5. Lohse, M. J., J. L. Benovic, J. Codina, M. G. Caron, and R. J. Lefkowitz. 1990. β-Arrestin: a protein that regulates β-adrenergic receptor function. Science 248: 1547.
6. Attramadal, H., J. L. Arriza, C. Aoki, T. M. Dawson, J. Codina, M. M. Kwatra, S. H. Snyder, M. G. Caron, and R. J. Lefkowitz. 1992. β-Amestin2, a novel member of the arrestin/β-arrestin gene family. J. Biol. Chem. 267:17882.
7. Sterne-Marr, R., V. V. Gurevich, P. Goldsmith, R. C. Bodine, C. Sanders, L. A. Donoso, and J. L. Benovic. 1993. Polypeptide variants of β-arrestin and arrestin3. J. Biol. Chem. 268:15640.
8. Craft, C. M., and D. H. Whitmore. 1995. The arrestin superfamily: cone arrestins are a fourth family. FEBS Lett. 362:247.
9. Gurevich, V. V., S. B. Dion, J. J. Onorato, J. Ptasienski, C. M. Kim, R. Sterne-Marr, M. M. Hosey, and J. L. Benovic. 1995. Arrestin interactions with G protein-coupled receptors: direct binding studies of wild type and mutant arrestins with rhodopsin, β2-adrenergic, and m2 muscarinic cholinergic receptors. J. Biol. Chem. 270:720.
10. Gery, I., M. Mochizuki, and R. B. Nussenblatt. 1986. Retinal specific antigens and the immunopathogenic processes they provoke. In Progress in Retinal Research, Vol. 5. N. Osborne, and G. Chader, eds. Pergamon Press, New York, p. 75.
11. Donoso, L. A., C. F. Merryman, T. Shinohara, B. Dietzschold, G. Wistow, C. Craft, W. Morley, and R. T. Henry. 1986. S-antigen: identification of the MAbA9-C6 monoclonal antibody binding site and the uveitopathogenic sites [published erratum appears in 1987, Curr. Eye Res. 6:408]. Curr. Eye Res. 5:995.
12. Gregerson, D. S., C. F. Merryman, W. F. Obritsch, and L. A. Donoso. 1990. Identification of a potent new pathogenic site in human retinal S-antigen which induces experimental autoimmune uveoretinitis in Lewis rats. Cell. Immunol. 128:209.
13. Merryman, C. F., L. A. Donoso, X. M. Zhang, E. Heber-Katz, and D. S. Gregerson. 1991. Characterization of a new, potent, immunopathogenic epitope in S- antigen that elicits T cells expressing Vβ8 and Vα2-like genes. J. Immunol. 146:75.
14. Gregerson, D. S., W. F. Obritsch, S. P. Fling, and J. D. Cameron. 1986. S-antigen-specific rat T cell lines recognize peptide fragments of S-antigen and mediate experimental autoimmune uveoretinitis and pinealitis. J. Immunol. 136: 2875.
15. Caspi, R. R., F. G. Roberge, C. G. McAllister, M. el-Saied, T. Kuwabara, I. Gery, E. Hanna, and R. B. Nussenblatt. 1986. T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat. J. Immunol. 136:928.
16. Fling, S. P., L. A. Donoso, and D. S. Gregerson. 1991. In vitro unresponsiveness to autologous sequences of the immunopathogenic autoantigen, S-antigen. J. Immunol. 147:483.
17. Fling, S. P., D. P. Gold, and D. S. Gregerson. 1992. Multiple, autoreactive TCR Vβ genes utilized in response to a small pathogenic peptide of an autoantigen in EAU. Cell. Immunol. 142:275.
18. Gregerson, D. S., S. P. Fling, L. A. Donoso, and D. P. Gold. 1992. Unresponsiveness to self-peptides of S-antigen in EAU: an overview of recent results. Curr. Eye Res. 11:67.
19. Gregerson, D. S. 1998. Immune privilege in the retina. Ocular Immunol. Inflam. 6:257.
20. Faure, J.-P. 1980. Autoimmunity and the retina. Curr. Top. Eye Res. 2:215.
21. Streilein, J. W. 1993. Immune privilege as the result of local tissue barriers and immunosuppressive microenvironments. Curr. Opin. Immunol. 5:428.
22. Wilbanks, G. A., M. Mammolenti, and J. W. Streilein. 1992. Studies on the induction of anterior chamber-associated immune deviation (ACAID). III. Induction of ACAID depends upon intraocular transforming growth factor-β. Eur. J. Immunol. 22:165.
23. Kosiewicz, M. M., S. Okamoto, S. Miki, B. R. Ksander, T. Shimizu, and J. W. Streilein. 1994. Imposing deviant immunity on the presensitized state. J. Immunol. 153:2962.
24. Griffith, T. S., T. Brunner, S. M. Fletcher, D. R. Green, and T. A. Ferguson. 1995. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270: 1189.
25. Kawashima, H., S. A. Prasad, and D. S. Gregerson. 1994. Corneal endothelial cells inhibit T cell proliferation by blocking IL-2 production. J. Immunol. 153: 1982.
26. Egwuagu, C. E., P. Charukamnoetkanok, and I. Gery. 1997. Thymic expression of autoantigens correlates with resistance to autoimmune disease. J. Immunol. 159:3109.
27. Egan, R. M., C. Yorkey, R. Black, W. K. Loh, J. L. Stevens, and J. G. Woodward. 1996. Peptide-specific T cell clonal expansion in vivo following immunization in the eye, an immune-privileged site. J. Immunol. 157:2262.
28. Forrester, J. V., P. G. McMenamin, I. Holthouse, L. Lumsden, and J. Liversidge. 1994. Localization and characterization of major histocompatibility complex class II-positive cells in the posterior segment of the eye: implications for induction of autoimmune uveoretinitis. Invest. Ophthalmol. Vis. Sci. 35:64.
29. Gregerson, D. S., J. W. Torseth, S. W. McPherson, J. P. Roberts, T. Shinohara, and D. J. Zack. 1999. Retinal expression of a neo-self antigen, β-galactosidase, is not tolerogenic, and creates a target for autoimmune uveoretinitis. J. Immunol. 163:1073.
30. Miller, A. D., and G. J. Rosman. 1989. Improved retroviral vectors for gene transfer and expression. BioTechniques 7:980.
31. Sambrook, J. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
32. Markowitz, D., S. Goff, and A. Bank. 1988. A safe packaging line for gene transfer: separating viral genes on two different plasmids. J. Virol. 62:1120.
33. Shastri, N., G. Gammon, A. Miller, and E. Sercarz. 1986. Ia molecule-associated selectivity in T cell recognition of a 23-amino-acid peptide of lysozyme. J. Exp. Med. 164:382.
34. Bohjanen, P. R. 1991. An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3′ untranslated region of lymphokine mRNA. Mol. Cell. Biol. 11:3288.
35. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophageT4. Nature 227:680.
36. Knospe, V., L. A. Donoso, J. P. Banga, S. Yue, E. Kasp, and D. S. Gregerson. 1988. Epitope mapping of bovine retinal S-antigen with monoclonal antibodies. Curr. Eye Res. 7:1137.
37. Donoso, L. A., D. S. Gregerson, L. Smith, S. Robertson, V. Knospe, T. Vrabec, and C. M. Kalsow. 1990. S-antigen: preparation and characterization of sitespecific monoclonal antibodies. Curr. Eye Res. 9:343.
38. Gregerson, D. S., V. Knospe, and L. A. Donoso. 1989. Selection of antibody epitopes in an immunopathogenic neural autoantigen. J. Neuroimmunol. 24:191.
39. Kang, J., E. Ido, J. Pawling, U. Beutner, B. T. Huber, and N. Hozumi. 1994. Expression of Mtv-7 sag gene in vivo using a retroviral vector results in selective inactivation of superantigen reactive T cells. J. Immunol. 152:1039.
40. Kang, J., J. Wither, and N. Hozumi. 1990. Long-term expression of a T-cell receptor β-chain in mice reconstituted with retrovirus-infected hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 87:9803.
41. Fletcher, F. A., K. A. Moore, M. Ashkenazi, P. De Vries, P. A. Overbeek, D. E. Williams, and J. W. Belmont. 1991. Leukemia inhibitory factor improves survival of retroviral vector-infected hematopoietic stem cells in vitro, allowing efficient long-term expression of vector-encoded human adenosine deaminase in vivo. J. Exp. Med. 174:837.
42. Gregerson, D. S., W. F. Obritsch, and L. A. Donoso. 1993. Oral tolerance in experimental autoimmune uveoretinitis: distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols. J. Immunol. 151:5751.
43. Ramsdell, F., and B. J. Fowlkes. 1990. Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance. Science 248:1342.
44. Ally, B. A., T. S. Hawley, K. J. McKall-Faienza, T. M. Kundig, S. U. Oehen, H. Pircher, R. G. Hawley, and P. S. Ohashi. 1995. Prevention of autoimmune disease by retroviral-mediated gene therapy. J. Immunol. 155:5404.
45. York, I., and. K. L. Rock. 1996. Presentation of antigens of MHC class I molecules. Annu. Rev. Immunol. 14:369.
46. Vinitsky, A., L. C. Anton, H. L. Snyder, M. Orlowsky, J. R. Bennick, and J. W. Yewdell. 1997. The generation of MHC class I-associated peptides is only partially inhibited by proteosome inhibitors. J. Immunol. 159:554.
47. Wick, M. J., and J. D. Pfeifer. 1996. Major histocompatibility complex class I presentation of ovalbumin peptide 257-264 from exogenous sources: protein context influences the degree of TAP-independent presentation. Eur. J. Immunol. 26:2790.
48. Harding, C. V. 1996. Class I MHC presentation of exogenous antigens. J. Clin. Immunol. 16:90.
49. Mitchell, D. A., S. K. Nair, and E. Gilboa. 1998. Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells. Eur. J. Immunol. 28:1923.
50. Aichinger, G., L. Karlsson, M. R. Jackson, M. Vestberg, J. H. Vaughan, L. Teyton, R. I. Lecler, and P. A. Peterson. 1997. Major histocompatibility complex class II-dependent unfolding, transport, and degradation of endogenous proteins. J. Biol. Chem. 14:29127.
51. Oukka, M., E. Colucci-Guyon, P. L. Tran, M. Cohen-Tannoudji, C. Babinet, V. Lotteau, and K. Kosmatopoulos. 1996. CD4 T cell tolerance to nuclear proteins induced by medullary thymic epithelium. Immunity 4:545.
52. Broekhuyse, R. M., and E. D. Kuhlmann. 1989. Assay of S-antigen immunoreactivity in mammalian retinas in relation to age, ocular dimension and retinal degeneration. Jpn. J. Ophthal. 33:243.
53. Palmer, T. D., O. J. Rosman, W. R. A. Osborne, and A. D. Miller. 1991. Genetically modified skin fibroblast persist after transplantation but gradually inactivate introduced genes. Proc. Natl. Acad. Sci. USA 88:1330.
54. Agus, D. B., C. D. Surh, and J. Sprent. 1991. Reentry of T cells to the adult thymus is restricted to activated T cells. J. Exp. Med. 173:1039.
55. Zambidis, E. T., R. K. Barth, and D. W. Scott. 1997. Both resting and activated B lymphocytes expressing engineered peptide-Ig molecules serve as highly efficient tolerogenic vehicles in immunocompetent adult recipients. J. Immunol. 158: 2174.
56. Zambidis, E. T., A. Kurup, and D. W. Scott. 1997. Genetically transferred central and peripheral immune tolerance via retroviral-mediated expression of immunogenic epitopes in hematopoietic progenitors or peripheral B lymphocytes. Mol. Med 3:212.
57. Ramsdell, F., and B. J. Fowlkes. 1992. Maintenance of in vivo tolerance by persistence of antigen. Science 257:1130.
58. Posselt, A., C. Barker, A. Friedman, and A. Naji. 1992. Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth. Science 216:1321.
59. Charlton, B., C. Taylor-Edwards, R. Tisch, and C. G. Fathman. 1994. Prevention of diabetes and insulitis by neonatal intrathymic islet administration in NOD mice. J. Autoimmun. 7:549.
60. Khoury, S. J., M. H. Sayegh, W. W. Hancock, L. Gallon, C, B. Carpenter, and H. L. Weiner. 1993. Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide. J. Exp. Med. 178:559.
61. Jolicoeur, C., D. Hanahan, and K. M. Smith. 1994. T cell tolerance toward a transgenic β-cell antigen and transcription of endogenous pancreatic genes in thymus. Proc. Natl. Acad. Sci. USA 91:6707.
62. Fritz, R. B., and M. Zhao. 1996. Thymic expression of myelin basic protein (MBP). J. Immunol. 157:5249.
63. Mathisen, P. M., S. Pease, J. Garvey, L. Hood, and C. Readhead. 1993. Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo. Proc. Natl. Acad. Sci. USA 90:10125.
64. Farr, A. G., and A. Rudensky. 1998. Medullary thymic epithelium: a mosaic of epithelial "self." J. Exp. Med. 188:1.
65. McPherson, S. W., and D. S. Gregerson. 1994. Nucleotide sequences homologous to retinal S-antigen in the rat thymus lack a known EAU inducing epitope. In Sixth International Symposium on the Immunology and Immunopathology of the Eye. R. B. Nussenblatt, S. M. Whitcup, R. R. Caspi, and I. Gery, eds. Elsevier Sciences, Bethesda, p. 67.