Polymorphisms within the CTLA4 gene are associated with infant atopic dermatitis

British Journal of Dermatology

Volumn 154, Issue 3, 2006, Pages 467-471

  Jones, G ^a   Wu, S ^a   Jang, N ^a   Fulcher, D ^a   Hogan, P ^b   Stewart, G ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

Author keywords

Atopic dermatitis; CTLA4; Genetic association study; Polymorphism

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DNA;

3' UNTRANSLATED REGION; ARTICLE; ASTHMA; ATOPIC DERMATITIS; AUSTRALIA; AUTOIMMUNE DISEASE; COHORT ANALYSIS; CONFIDENCE INTERVAL; DERMATOLOGY; DISEASE ASSOCIATION; EXON; FAMILY; GENE FUNCTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC CODE; GENETIC POLYMORPHISM; GENETIC RISK; HAPLOTYPE; HUMAN; INFANT; MEDICAL SPECIALIST; ONSET AGE; PARENT; PEDIATRICS; PRIORITY JOURNAL; REGULATORY MECHANISM; RNA TRANSLATION; T LYMPHOCYTE;

ADOLESCENT; AGE OF ONSET; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CHILD; CHILD, PRESCHOOL; DERMATITIS, ATOPIC; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; IMMUNOGLOBULIN E; INFANT; LINKAGE DISEQUILIBRIUM; POLYMORPHISM, GENETIC; SEVERITY OF ILLNESS INDEX;

EID: 33644890177     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2005.07080.x     Document Type: Article

References (42)

1. Pajno GB Peroni DG Barberio G et al. Predictive features for persistence of atopic dermatitis in children Pediatr Allergy Immunol 2003 14 292 5
2. Spergel JM Paller AS Atopic dermatitis and the atopic march J Allergy Clin Immunol 2003 112 S118 27
3. Illi S von Mutius E Lau S et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma J Allergy Clin Immunol 2004 113 925 31
4. van Eerdewegh P Little RD Dupuis J et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness Nature 2002 418 426 30
5. Laitinen T Polvi A Rydman P et al. Characterization of a common susceptibility locus for asthma-related traits Science 2004 304 300 4
6. Allen M Heinzmann A Noguchi E et al. Positional cloning of a novel gene influencing asthma from chromosome 2q14 Nat Genet 2003 35 258 63
7. Zhang Y Leaves NI Anderson GG et al. Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma Nat Genet 2003 34 181 6
8. Jang N Stewart G Jones G Polymorphisms within the PHF11 gene at chromosome 13q14 are associated with childhood atopic dermatitis Genes Immun 2005 6 262 4
9. Xu J Postma DS Howard TD et al. Major genes regulating total serum immunoglobulin E levels in families with asthma Am J Hum Genet 2000 67 1163 73
10. Howard TD Postma DS Hawkins GA et al. Fine mapping of an IgE-controlling gene on chromosome 2q: analysis of CTLA4 and CD28 J Allergy Clin Immunol 2002 110 743 51
11. Khattri R Auger JA Griffin MD et al. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses J Immunol 1999 162 5784 91
12. Jirapongsananuruk O Hofer MF Trumble AE et al. Enhanced expression of B7.2 (CD86) in patients with atopic dermatitis: a potential role in the modulation of IgE synthesis J Immunol 1998 160 4622 7
13. Morikawa H Nagashima S The role of costimulatory molecules (B7-1 and B7-2) on allergen-stimulated B cells in cedar pollinosis subjects Clin Exp Allergy 2000 30 383 92
14. Hidi R Riches V Al-Ali M et al. Role of B7-CD28/CTLA-4 costimulation and NF-kappa B in allergen-induced T cell chemotaxis by IL-16 and RANTES J Immunol 2000 164 412 18
15. Kouki T Sawai Y Gardine CA et al. CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease J Immunol 2000 165 6606 11
16. Ueda H Howson JM Esposito L et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease Nature 2003 423 506 11
17. Munthe-Kaas MC Carlsen KH Helms PJ et al. CTLA-4 polymorphisms in allergy and asthma and the TH1/TH2 paradigm J Allergy Clin Immunol 2004 114 280 7
18. Williams HC Burney PG Hay RJ et al. The U.K. Working Party's diagnostic criteria for atopic dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis Br J Dermatol 1994 131 383 96
19. Williams HC Burney PG Strachan D Hay RJ The U.K. Working Party's diagnostic criteria for atopic dermatitis. II. Observer variation of clinical diagnosis and signs of atopic dermatitis Br J Dermatol 1994 131 397 405
20. Williams HC Burney PG Pembroke AC Hay RJ The U.K. Working Party's diagnostic criteria for atopic dermatitis. III. Independent hospital validation Br J Dermatol 1994 131 406 16
21. Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis.q1 Dermatology 1993 186 23 31
22. Kunz B Oranje AP Labreze L et al. Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis Dermatology 1997 195 10 19
23. Miller SA Dykes DD Polesky HF A simple salting out procedure for extracting DNA from human nucleated cells Nucleic Acids Res 1988 16 1215
24. Ye S Dhillon S Ke X et al. An efficient procedure for genotyping single nucleotide polymorphisms Nucleic Acids Res 2001 29 E88 8
25. Lindblad-Toh K Winchester E Daly MJ et al. Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse Nat Genet 2000 24 381 6
26. Spielman RS McGinnis RE Ewens WJ Transmission test for linkage disequilibrium. the insulin gene region and insulin-dependent diabetes mellitus (IDDM) Am J Hum Genet 1993 52 506 16
27. Wuthrich B Schmid-Grendelmeier P The atopic eczema/dermatitis syndrome. Epidemiology, natural course, and immunology of the IgE-associated ('extrinsic') and the nonallergic ('intrinsic') AEDS J Invest Allergol Clin Immunol 2003 13 1 5
28. Schmid-Grendelmeier P Simon D Simon HU et al. Epidemiology, clinical features, and immunology of the 'intrinsic' (non-IgE-mediated) type of atopic dermatitis (constitutional dermatitis) Allergy 2001 56 841 9
29. Chan EY McKenzie SA Normative data for total serum immunoglobulin E measurements in children of three ethnicities Clin Exp Allergy 2003 33 752 6
30. Perkin MR Strachan DP Williams HC et al. Natural history of atopic dermatitis and its relationship to serum total immunoglobulin E in a population-based birth cohort study Pediatr Allergy Immunol 2004 15 221 9
31. Flohr C Johansson SG Wahlgren CF et al. How atopic is atopic dermatitis? J Allergy Clin Immunol 2004 114 150 8
32. Yang KD Liu CA Chang JC et al. Polymorphism of the immune-braking gene CTLA-4 (+49) involved in gender discrepancy of serum total IgE levels and allergic diseases Clin Exp Allergy 2004 34 32 7
33. Tivol EA Borriello F Schweitzer AN et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 Immunity 1995 3 541 7
34. Pioli C Gatta L Ubaldi V et al. Inhibition of IgG1 and IgE production by stimulation of the B cell CTLA-4 receptor J Immunol 2000 165 5530 6
35. Liu X Nickel R Beyer K et al. An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90) J Allergy Clin Immunol 2000 106 167 70
36. Rafatpanah H Bennett E Pravica V et al. Association between novel GM-CSF gene polymorphisms and the frequency and severity of atopic dermatitis J Allergy Clin Immunol 2003 112 593 8
37. Nickel RG Casolaro V Wahn U et al. Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES J Immunol 2000 164 1612 16
38. Cardwell CR Shields MD Carson DJ et al. A meta-analysis of the association between childhood type 1 diabetes and atopic disease Diabetes Care 2003 26 2568 74
39. Sheikh A Smeeth L Hubbard R There is no evidence of an inverse relationship between TH2-mediated atopy and TH1-mediated autoimmune disorders: lack of support for the hygiene hypothesis J Allergy Clin Immunol 2003 111 131 5
40. Ihara K Ahmed S Nakao F et al. Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with type 1 diabetes in the Japanese population Immunogenetics 2001 53 447 54
41. Donner H Braun J Seidl C et al. Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease J Clin Endocrinol Metab 1997 82 4130 2
42. Ligers A Teleshova N Masterman T et al. CTLA-4 gene expression is influenced by promoter and exon 1 polymorphisms Genes Immun 2001 2 145 52