Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)

Food and Chemical Toxicology

Volumn 48, Issue SUPPL. 1, 2010, Pages

  Carthew, Philip ^a   DiNovi, Michael ^b   Woodrow Setzer, R ^c  

^a UNILEVER RESEARCH   (United Kingdom)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

2 Amino 1 methyl 6 phenylimidazo 4,5 b pyridine; Margin of exposure; MoE; PhIP

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; CREATININE; SUGAR;

ARTICLE; BREAST CANCER; BREAST TUMOR; CARCINOGENESIS; CARCINOGENICITY; CLINICAL PROTOCOL; COLON CANCER; COLON TUMOR; DOSE RESPONSE; FISH; FOOD CONTAMINATION; FOOD INTAKE; FRYING; GENOTOXICITY; GLYCATION; HUMAN; MARGIN OF EXPOSURE; MATHEMATICAL ANALYSIS; MEAT; NONHUMAN; PROSTATE CANCER; PROSTATE TUMOR; QUALITY CONTROL; RODENT; TOXICITY TESTING; TUMOR CLASSIFICATION;

ANIMALS; BREAST NEOPLASMS; CARCINOGENS; COLONIC NEOPLASMS; COOKERY; DATA INTERPRETATION, STATISTICAL; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOOD CONTAMINATION; HUMANS; IMIDAZOLES; MALE; MICE; MODELS, STATISTICAL; MUTAGENS; NEOPLASMS; PROSTATIC NEOPLASMS; RATS;

RODENTIA;

EID: 74549135361     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.10.035     Document Type: Article

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