Mechanisms of action of the carcinogenic heterocyclic amine PhIP

Toxicology Letters

Volumn 168, Issue 3, 2007, Pages 269-277

  Gooderham, N J ^a   Creton, S ^a   Lauber, S N ^a   Zhu, H ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Heterocyclic amines; Oestrogens; Signal transduction

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; BETA ACTIN; CARCINOGEN; CYCLIN DEPENDENT KINASE INHIBITOR 1; ESTROGEN RECEPTOR; HETEROCYCLIC AMINE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; PROTEIN P53;

ARTICLE; CANCER GROWTH; CARCINOGENESIS; CARCINOGENICITY; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; COOKING; DNA DAMAGE; ENZYME ACTIVATION; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MEAT; METABOLISM; MUTATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; WESTERN BLOTTING;

CARCINOGENS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOCHROME P-450 CYP1A2; ESTRADIOL; ESTROGEN ANTAGONISTS; HUMANS; IMIDAZOLES; MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, ESTROGEN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33846220744     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2006.10.022     Document Type: Article

References (32)

1. Alessi D.R., Saito Y., Campbell D.G., Cohen P., Sithanandam G., Rapp U., Ashworth A., Marshall C.J., and Cowley S. Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J. 1 (1994) 1610-1619
2. Bonkhoff H., Fixemer T., Hunsicker I., and Remberger K. Progesterone receptor expression in human prostate cancer: correlation with tumor progression. Prostate 48 (2001) 285-291
3. Crews C.M., Alessandrini A., and Erikson R.L. Erks: their fifteen minutes has arrived. Cell Growth Differ. 3 (1992) 135-142
4. DeBruin L.S., Martos P.A., and Josephy P.D. Detection of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in the milk of healthy women. Chem. Res. Toxicol. 14 (2001) 1523-1528
5. Di Leo A., Messa C., Cavallini A., and Linsalata M. Estrogens and colorectal cancer. Curr. Drug Targets Immune Endocr. Metabol. Disord. 1 (2001) 1-12
6. Doll R., and Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst. 66 (1981) 1191-1308
7. English M.A., Stewart P.M., and Hewison M. Estrogen metabolism and malignancy: analysis of the expression and function of 17α-hydroxysteroid dehydrogenases in colonic cancer. Mol. Cell. Endocrinol. 171 (2001) 56-60
8. Gioeli D., Mandell J.W., Petroni G.R., Frierson Jr. H.F., and Weber M.J. Activation of mitogen-activated protein kinase associated with prostate cancer progression. Cancer Res. 59 (1999) 279-284
9. Gooderham N.J., Zhu H., Lauber S., Boyce A., and Creton S. Molecular and genetic toxicology of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mutat. Res. 506-507 (2002) 91-99
10. Hoshino R., Chatani Y., Yamori T., Tsuruo T., Oka H., Yoshida O., Shimada Y., Ari-i S., Wada H., Fujimoto J., and Kohno M. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene 18 (1999) 813-822
11. Ito N., Hasegawa R., Sano M., Tamano S., Esumi H., Takayama S., and Sugimura T. A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis 12 (1991) 1503-1506
12. Kastan M.B., Onyekwere O., Sidransky D., Vogelstein B., and Craig R.W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51 (1991) 6304-6311
13. Lauber S., Ali S., and Gooderham N.J. The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity. Carcinogenesis 25 (2004) 2509-2517
14. Layton D.W., Bogen K.T., Knize M.G., Hatch F.T., Johnson V.M., and Felton J.S. Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research. Carcinogenesis 16 (1995) 39-52
15. Lynch A.M., Knize M.G., Boobis A.R., Gooderham N.J., Davies D.S., and Murray S. Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef. Cancer Res. 52 (1992) 6216-6223
16. Maemura M., Iino Y., Koibuchi Y., Yokoe T., and Morishita Y. Mitogen-activated protein kinase cascade in breast cancer. Oncology 57 (1999) 37-44
17. Migliaccio A., Di Domenico M., Castoria G., de Falco A., Bontempo P., Nola E., and Auricchio F. Tyrosine kinase/p21ras/MAPK-kinase pathway activation by estradiol-receptor complex in MCF7 cells. EMBO J. 15 (1996) 1292-1300
18. Noble R.L. The development of prostatic adenoma in Nb cells following prolonged sex hormone administration. Cancer Res. 37 (1997) 1929-1933
19. Reddy K.B., Nabha S.M., and Atanaskova N. Role of MAP kinase in tumor progression and invasion. Cancer Metastasis Rev. 22 (2003) 395-403
20. Shirai T., Sano M., Tamano S., Takahashi S., Hirose M., Futukuchi M., Hasegawa R., Imaida K., Matsumoto K., Wakabayashi K., and Sugimura T. The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods. Cancer Res. 52 (1997) 195-198
21. Snyderwine E.G., Thorgeirsson U.P., Venugopal M., and Roberts-Thomson S.J. Mammary gland carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Sprague-Dawley rats on high- and low-fat diets. Nutr. Cancer 31 (1998) 160-167
22. Spink B.C., Cole R.W., Katz B.H., Gierthy J.F., Bradley L.M., and Spink D.C. Inhibition of MCF-7 breast cancer cell proliferation by MCF-10A breast epithelial cells in coculture. Cell Biol. Int. 30 (2006) 227-238
23. Stone R. Environmental estrogens stir debate. Science 265 (1994) 308-310
24. Su B., and Karin M. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8 (1996) 402-411
25. Sugimura T. Overview of carcinogenic heterocyclic amines. Mutat. Res. 376 (1997) 211-219
26. Sun Y.-W., Guengerich F.P., Sharma A.K., Boyiri T., Amin S., and El-Bayoumy K. Humans cytochromes CYP1A1 and 1B1 catalyse ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines. Chem. Res. Toxicol. 17 (2004) 1077-1085
27. Suzukawa K., Weber T.J., and Colburn N.H. AP-1, NF-kappa-B, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model. Environ. Health Perspect. 110 (2002) 865-870
28. Takayama K., Yamashita K., Wakabayashi K., Sugimura T., and Nagao M. DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats. Jpn. J. Cancer Res. 80 (1989) 1145-1148
29. Wang B., and Miller F.R. Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells. Int. J. Oncol. 16 (2000) 1035-1042
30. WCRF (World Cancer Research Fund/American Institute for Cancer Research). Food Nutrition and the Prevention of Cancer: A Global Perspective (1997), American Institute for Cancer Research, Washington, DC pp. 1-670
31. Zhu J., Chang P., Bondy M.L., Sahin A.A., Singletary S.E., Takahashi S., Shirai T., and Li D. Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer. Cancer Epidemiol. Biomarkers Prev. 12 (2003) 830-837
32. Zhu H., Boobis A.R., and Gooderham N.J. The food carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine activates S-phase checkpoint and apoptosis and induces gene mutation on human lymphoblastoid TK6 cells. Cancer Res. 60 (2000) 1283-1289