Structural characterization and pharmacology of a potent (Cys101-Cys119, Cys110-Cys117) bicyclic agouti-related protein (AGRP) melanocortin receptor antagonist

Journal of Medicinal Chemistry

Volumn 47, Issue 23, 2004, Pages 5662-5673

  Wilczynski, Andrzej ^a   Wang, Xiang S ^b   Bauzo, Rayna M ^a   Xiang, Zhimin ^a   Shaw, Amanda M ^a   Millard, William J ^a   Richards, Nigel G ^b   Edison, Arthur S ^a   Haskell Luevano, Carrie ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b Department of Medicinal Chemistry ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; AMINO ACID; BICYCLO COMPOUND; CYSTINE; DISULFIDE; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; PEPTIDE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG STRUCTURE; GLUCOSE HOMEOSTASIS; LIGAND BINDING; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PROTEIN STRUCTURE; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CELL LINE; CYCLIC AMP; CYSTINE KNOT MOTIFS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; PROTEINS; RADIOLIGAND ASSAY; RECEPTORS, MELANOCORTIN;

EID: 7444238720     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049620r     Document Type: Article

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