Local administration of DFO-loaded lipid particles improves recovery after end-to-end reconstruction of rat median nerve

Restorative Neurology and Neuroscience

Volumn 27, Issue 6, 2009, Pages 651-662

  Sinis, Nektarios ^a   Di Scipio, Frederica ^b   Schönle, Phillip ^a   Werdin, Frank ^a   Kraus, Armin ^a   Koopmanns, Guido ^c   Masanneck, Carmen ^c   Hermanns, Susanne ^c   Danker, Timm ^d   Guenther, Elke ^d   Haerle, Max ^e   Schaller, Hans Eberhard ^a   Geuna, Stefano ^b   Mueller, Hans Werner ^f  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF TURIN   (Italy)

^c Neuraxo Biopharmaceuticals   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e Klinik für Hand und Plastische Chirurgie   (Germany)

^f HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Iron chelator; Median nerve; Nerve regeneration; Primary nerve suture

Indexed keywords

DEFEROXAMINE; PERINEURIN; PERINEURINN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CONVALESCENCE; END TO END ANASTOMOSIS; EXTERNAL JUGULAR VEIN; FEMALE; FUNCTIONAL ASSESSMENT; GRIP STRENGTH; HAND MUSCLE; MEDIAN NERVE; MICROSURGERY; MOTOR PERFORMANCE; MUSCLE INNERVATION; MUSCLE MASS; NERVE ANASTOMOSIS; NERVE CONDUCTION; NERVE FIBER; NERVE FIBER REGENERATION; NERVE SUTURE; NERVE TRANSECTION; NEUROFILAMENT; NEURORRHAPHY; NONHUMAN; POSTOPERATIVE CARE; PRIORITY JOURNAL; RAT;

ANALYSIS OF VARIANCE; ANIMALS; BODY WEIGHT; DEFEROXAMINE; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; FEMALE; LIPIDS; MEDIAN NEUROPATHY; MUSCLE, SKELETAL; NEUROFILAMENT PROTEINS; ORGAN SIZE; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; SIDEROPHORES; TIME FACTORS;

EID: 74249123358     PISSN: 09226028     EISSN: None     Source Type: Journal    
DOI: 10.3233/RNN-2009-0517     Document Type: Article

References (55)

1. Angelov, D.N., Guntinas-Lichius, O., Wewetzer, K., Neiss, W.F. & Streppel, M. (2005). Axonal Branching and Recovery of Coordinated Muscle Activity after Transection of the Facial Nerve in Adult Rats. Adv Anat Embryol Cell Biol, 180, 1-130.
2. Barakat-Walter, I., Kraftsik, R., Schenker, M. & Kuntzer, T. (2007). Thyroid hormone in biodegradable nerve guides stimulates sciatic nerve regeneration: a potential therapeutic approach for human peripheral nerve injuries. J Neurotrauma, 24, 567-577.
3. Bertelli, J.A. & Mira, J.C. (1995). The grasping test: a simple behavioral method for objective quantitative assessment of peripheral nerve regeneration in the rat. J Neurosci Methods, 58, 151-155.
4. Boddaert, N, Le Quan Sang, K.H., Rotig, A., Leroy-Willig, A., Gallet, S., Brunelle, F., Sidi, D., Thalabard, J.C., Munnich, A. & Cabantchik, Z.I. (2007). Selective iron chelation in Friedreich ataxia: biological and clinical implications. Blood, 110, 401-408.
5. Chalfoun, C.T., Wirth, G.A. & Evans, G.R. (2006). Tissue engineered nerve constructs: where do we stand? J Cell Mol Med, 10, 309-317.
6. Chen, L.E., Seaber, A.V., Glisson, R.R., Davies, H., Murrell, G.A., Anthony, D.C. & Urbaniak, J.R.(1992). The functional recovery of peripheral nerves following defined acute crush injuries. J Orthop Res, 10, 657-664.
7. Ciardelli, G. & Chiono, V. (2006). Materials for peripheral nerve regeneration. Macromol Biosci, 6, 13-26.
8. Dam-Hieu, P., Lacroix, C., Said, G., Devanz, P., Liu, S. & Tadie, M. (2005). Reduction of postoperative perineural adhesions by Hyaloglide gel: an experimental study in the rat sciatic nerve. Neurosurgery, 56, 425-433.
9. Devanur, L.D., Evans, R.W., Evans, P.J. & Hider, R.C. (2008). Chelator-facilitated removal of iron fromtransferrin: relevance to combined chelation therapy. Biochem J, 409, 439-447.
10. Di Patti, M.C., Persichini, T., Mazzone, V., Polticelli, F., Colasanti, M. & Musci, G. (2004). Interleukin-1 beta upregulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis. Neurosci Lett, 363, 182-186.
11. Dvali, L. & Mackinnon, S. (2007). The role of microsurgery in nerve repair and nerve grafting. Hand Clin, 23, 73-81.
12. Evans, G.R. (2001) Peripheral nerve injury: a review and approach to tissue engineered constructs. Anat Rec, 263 (3), 96-404.
13. Gaeta, A. & Hider, R.C. (2005). The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy. Br J Pharmacol, 146, 1041-1059.
14. Geuna, S., Gigo-Benato, D. & De Castro Rodrigues, A. (2004). On sampling and sampling errors in histomorphometry of peripheral nerve fibers. Microsurgery, 24, 72-76.
15. Geuna, S., Papalia, I. & Tos, P. (2006). End-to-side (terminolateral) nerve regeneration: a challenge for neuroscientists coming from an intriguing nerve repair concept. Brain Res Rev, 52, 381-388.
16. Geuna, S., Tos, P., Guglielmone, R., Battiston B. & Giacobini-Robecchi, M.G. (2001). Methodological issue in size estimation of myelinated nerve fibers in peripheral nerves. Anat Embryol, 203, 418-427.
17. Geuna, S.,Tos, P., Battiston, B., Guglielmone, R. (2000). Verification of the Two-Dimensional Disector, a Method for the Unbiased Estimation of Density and Number of Myelinated Nerve Fibers in Peripheral Nerves. Ann Anat, 182, 23-34.
18. Gigo-Benato, D., Geuna, S.&Rochkind, S. (2005). Phototherapy for enhancing peripheral nerve repair: a review of the literature. Muscle Nerve, 31, 694-701.
19. Gordon, T., Sulaiman, O. & Boyd, J.G. (2003). Experimental strategies to promote functional recovery after peripheral nerve injuries. J Peripher Nerv Syst, 8, 236-250.
20. Hall, S. (2005). The response to injury in the peripheral nervous system. J Bone Joint Surg [Br.], 87, 1309-1319.
21. Hermanns, S., Reiprich, P.&M̈uller, H.W. (2001). A reliable method to reduce collagen scar formation in the lesioned rat spinal cord. J Neurosci Methods, 110, 141-146.
22. Ḧoke, A. & Mi, R. (2007). In search of novel treatments for peripheral neuropathies and nerve regeneration. Discov Med, 7, 109-112.
23. Ḧoke, A. (2006). Mechanisms of Disease: what factors limit the success of peripheral nerve regeneration in humans? Nat Clin Pract Neurol, 2, 448-454.
24. Hontanilla, B., Aub́a, C. & Gorŕia, O. (2007). Nerve regeneration through nerve autografts after local administration of brain-derived neurotrophic factor with osmotic pumps. Neurosurgery, 61, 1268-1274.
25. Kerrebijn, J.D.F. & Freeman, J.L. (1998). Facial nerve reconstruction: outcome and features. J Otolaryngol, 27, 183-186.
26. Kim, Y., De Miguel, F., Usiene, I., Kwon, D., Yoshimura, N., Huard, J. & Chancellor, M.B. (2006). Injection of skeletal musclederived cells into the penis improves erectile function. Int J Impot Res, 18, 329-334.
27. Klapka, N., Hermanns, S., Straten, G., Masanneck, C., Duis, S., Hamers, F.P., M̈uller, D., Zuschratter, W. & M̈uller, H.W. (2005). Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery. Eur J Neurosci, 22, 3047-3058.
28. Kretschmer, T., Antoniadis, G., Braun, V., Rath, S.A. & Richter, H.P. (2001). Evaluation of iatrogenic lesions in 722 surgically treated cases of peripheral nerve trauma. J Neurosurg, 94, 905-912.
29. Liu, D., Liu, J., Sun, D. & Wen, J. (2004). The time course of hydroxyl radical formation following spinal cord injury: the possible role of the iron-catalyzed Haber - Weiss reaction. J Neurotrauma, 21, 805-816.
30. Lundborg, G. (2000). A 25-year perspective of peripheral nerve surgery: evolving neuroscientific concepts and clinical significance. J Hand Surg [Am.], 25, 391-414.
31. Lundborg, G. (2002). Enhancing posttraumatic nerve regeneration. J Peripher Nerv Syst, 7, 139-140.
32. Midha, R. (2006). Emerging techniques for nerve repair: nerve transfers and nerve guidance tubes. Clin Neurosurg, 53, 185-190.
33. Millesi, H. (2006). Factors affecting the outcome of peripheral nerve surgery. Microsurgery, 26, 295-302.
34. Molina-Holgado, F., Hider, R.C., Gaeta, A., Williams, R. & Francis, P. (2007). Metals ions and neurodegeneration. Biometals, 20, 639-654.
35. O'Brien-Ladner, A.R., Nelson, S.R., Murphy, W.J., Blumer, B.M. & Wesselius, L.J. (2000). Iron is a regulatory component of human IL-1beta production. Support for regional variability in the lung. Am J Respir Cell Mol Biol, 23, 112-119.
36. Pakkenberg, B. & Gundersen, H.J. (1997). Neocortical neuron number in humans: effect of sex and age. J Comp Neurol, 384, 312-320.
37. Papalia, I., Tos, P., Scevola, A., Raimondo, S. & Geuna, S. (2006). The ulnar test: a method for the quantitative functional assessment of posttraumatic ulnar nerve recovery in the rat. J Neurosci Methods, 154, 198-203.
38. Papalia, I., Tos, P., Stagno d'Alcontres, F., Battiston, B. & Geuna, S. (2003) On the use of the grasping test in the rat median nerve model: a re-appraisal of its efficacy for quantitative assessment of motor function recovery. J Neurosci Methods, 127, 43-47.
39. Pfister, L.A., Papalöizos, M., Merkle, H.P. & Gander, B. (1997). Nerve conduits and growth factor delivery in peripheral nerve repair. J Peripher Nerv Syst, 12, 65-82.
40. Piquilloud, G., Christen, T., Pfister, L.A., Gander, B. & Papalöizos, M.Y. (2007). Variations in glial cell line-derived neurotrophic factor release from biodegradable nerve conduits modify the rate of functional motor recovery after rat primary nerve repairs. Eur J Neurosci, 26, 1109-1117.
41. Roganovi, Z., Misovi, S., Kronja, G. & Savi, M. (2007). Peripheral nerve lesions associated with missile-induced pseudoaneurysms. J Neurosurg, 107, 765-775.
42. Ruijs, A.C., Jaquet, J.B., Kalmijn, S., Giele, H. & Hovius, S.E. (2005). Median and ulnar nerve injuries: a meta-analysis of predictors of motor and sensory recovery after modern microsurgical nerve repair. Plast Reconstr Surg, 116, 484-494.
43. Samii, M., Carvalho, G.A., Nikkhah, G.&Penkert, G. (1997). Surgical reconstruction of the musculocutaneous nerve in traumatic brachial plexus injuries. J Neurosurg, 87, 881-886. (Pubitemid 27508594)
44. Schaller, H.-E., Lassner, F., Becker, M., Walter, G.F. & Berger, A. (1991). Regeneration of autologous and allogenic nerve grafts in a rat genetic model: a preliminary report. J Reconstr Microsurg, 7, 9-12.
45. Schlosshauer, B., Dreesmann, L., Schaller, H.-E.,&Sinis, N. (2007). Synthetic nerve guide implants in humans: a comprehensive survey. Neurosurgery, 59, 740-747.
46. Schmitz, C. (1998). Variation of fractionator estimates and its prediction. Anat Embryol, 198, 371-397.
47. Shieh, S.J., Lee, J.W. & Chiu, H.Y. (2007). Long-term functional results of primary reconstruction of severe forearm injuries. J Plast Reconstr Aesthet Surg, 60, 339-348.
48. Sinis, N., Guntinas-Lichius, O., Irintchev, A., Skouras, E., Kuerten, S., Pavlov, S.P., Schaller, H.-E., Dunlop, S.A. & Angelov, D.N. (2008). Manual stimulation of forearm muscles does not improve recovery of motor function after injury to a mixed peripheral nerve. Exp Brain Res, 3, 469-483.
49. Sinis, N., Schaller, H.-E., Becker, S.T., Lanaras, T., Schulte-Eversum, C.,M̈uller, H.W., Vonthein, R.,R̈osner, H &Haerle, M. (2006). Cross-chest median nerve transfer: a new model for the evaluation of nerve regeneration across a 40 mm gap in the rat. J Neurosci Methods, 156, 166-172.
50. Sinis, N., Haerle, M., Becker, S., Schulte-Eversum, C., Vonthein, R. & Schaller, H.-E. (2007). Neuroma formation in a rat median nerve model - influence of distal stump and muscular coating. Plast Reconstr Surg, 3, 960-966.
51. Snyder, A.K., Fox, I.K., Nichols, C.M., Rickman, S.R., Hunter, D.A., Tung T.H.&Mackinnon, S.E. (2006).Neuroregenerative effects of preinjury FK-506 administration. Plast Reconstr Surg, 2, 360-367.
52. Stichel, C.C., Hermanns, S., Luhmann, H., Lausberg, J.F., Niermann, H., D'Urso, D., Servos, G., Hartwig, H.G. & M̈uller, H.W. (1999). Inhibition of collagen IV deposition promotes regeneration of injured CNS axons. Eur J Neurosci, 11, 632-646.
53. Stoll, G. & M̈uller, H.W. (1999). Nerve injury, axonal degeneration and neural regeneration: basic insights. Brain Pathol, 9, 313-325.
54. Terzis, J.K. & Kostas, I. (2007) Vein grafts used as nerve conduits for obstetrical brachial plexus palsy reconstruction. Plast Reconstr Surg, 120, 1930-1941.
55. Zaman, K., Ryu, H., Hall, D., O'Donovan, K., Lin, K.I., Miller, M.P., Marquis J.C., Barban, J.M., Semenza, G.L. & Ratan, R.R. (1999). Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21 (waf1/cip1), and erythropoietin. J Neurosci, 22, 9821-9830.