Comprehensive microarray analysis of bone morphogenetic protein 2-induced osteoblast differentiation resulting in the identification of novel markers for bone development

Journal of Bone and Mineral Research

Volumn 17, Issue 12, 2002, Pages 2106-2118

  Vaes, Bart L T ^a   Dechering, Koen J ^b   Feijen, Alie ^c   Hendriks, José M A ^a   Lefévre, Christophe ^b   Mummery, Christine L ^c   Olijve, Wiebe ^a,b   Van Zoelen, Everardus J J ^a   Steegenga, Wilma T ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b NV ORGANON   (Netherlands)

^c HUBRECHT INSTITUTE   (Netherlands)

Author keywords

Bone; Bone morphogenetic protein; C2C12 cells; Embryogenesis; Microarray

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CELL MARKER; OSTEOCALCIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; WNT INHIBITORY FACTOR 1; WNT PROTEIN; BIOLOGICAL MARKER; BMP2 PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA MICROARRAY; EMBRYO; EMBRYO DEVELOPMENT; EXPRESSED SEQUENCE TAG; EXTRACELLULAR MATRIX; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENETIC MARKER; GENETIC SCREENING; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; OSTEOBLAST; PROTEIN INDUCTION; SEQUENCE ANALYSIS; UNINDEXED SEQUENCE; ANIMAL; CELL STRAIN 3T3; CLUSTER ANALYSIS; CYTOLOGY; GENE EXPRESSION PROFILING; GENETICS; NORTHERN BLOTTING; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

3T3 CELLS; ANIMALS; BIOLOGICAL MARKERS; BLOTTING, NORTHERN; BONE DEVELOPMENT; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CLUSTER ANALYSIS; EXPRESSED SEQUENCE TAGS; GENE EXPRESSION PROFILING; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOBLASTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036896867     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2002.17.12.2106     Document Type: Article

References (43)

1. Lian JB, Stein GS, Stein JL, van Wijnen AJ 1998 Transcriptional control of osteoblast differentiation. Biochem Soc Trans 26:14-21.
2. Thiede MA, Yoon K, Golub EE, Noda M, Rodan GA 1988 Structure and expression of rat osteosarcoma (ROS 17/2.8) alkaline phosphatase: Product of a single copy gene. Proc Natl Acad Sci USA 85:319-323.
3. Jung C, Ou YC, Yeung F, Frierson HF Jr, Kao C 2001 Osteocalcin is incompletely spliced in non-osseous tissues. Gene 271:143-150.
4. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G 1997 Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 89:747-754.
5. Ducy P, Schinke T, Karsenty G 2000 The osteoblast: A sophisticated fibroblast under central surveillance. Science 289: 1501-1504.
6. Yoshida Y, Tanaka S, Umemori H, Minowa O, Usui M, Ikematsu N, Hosoda E, Imamura T, Kuno J, Yamashita T, Miyazono K, Noda M, Noda T, Yamamoto T 2000 Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell 103:1085-1097.
7. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T 1997 Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764.
8. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B 2002 The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108:17-29.
9. Schena M, Shalon D, Davis RW, Brown PO 1995 Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270:467-470.
10. Wodicka L, Dong H, Mittmann M, Ho MH, Lockhart DJ 1997 Genome-wide expression monitoring in Saccharomyces cerevisiae. Nat Biotechnol 15:1359-1367.
11. Lian J, Stewart C, Puchacz E, Mackowiak S, Shalhoub V, Collart D, Zambetti G, Stein G 1989 Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression. Proc Natl Acad Sci USA 86:1143-1147.
12. Chen D, Ji X, Harris MA, Feng JQ, Karsenty G, Celeste AJ, Rosen V, Mundy GR, Harris SE 1998 Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J Cell Biol 142: 295-305.
13. Feijen A, Goumans MJ, van den Eijnden-van Raaij AJ 1994 Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins. Development 120: 3621-3637.
14. Katagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, Rosen V, Wozney JM, Fujisawa-Sehara A, Suda T 1994 Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol 127:1755-1766.
15. Lee MH, Javed A, Kim HJ, Shin HI, Gutierrez S, Choi JY, Rosen V, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Ryoo HM 1999 Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation. J Cell Biochem 73:114-125.
16. Eisen MB, Spellman PT, Brown PO, Botstein D 1998 Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95:14863-14868.
17. Shiffman D, Mikita T, Tai JT, Wade DP, Porter JG, Seilhamer JJ, Somogyi R, Liang S, Lawn RM 2000 Large scale gene expression analysis of cholesterol-loaded macrophages. J Biol Chem 275:37324-37332.
18. Kaufman MA 1992 The Atlas of Mouse Development. Academic Press, London.
19. Jernvall J, Aberg T, Kettunen P, Keranen S, Thesleff I 1998 The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot. Development 125:161-169.
20. Lyons KM, Pelton RW, Hogan BL 1990 Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development 109:833-844.
21. Ji X, Chen D, Xu C, Harris SE, Mundy GR, Yoneda T 2000 Patterns of gene expression associated with BMP-2-induced osteoblast and adipocyte differentiation of mesenchymal progenitor cell 3T3-F442A. J Bone Miner Metab 18:132-139.
22. Suga K, Saitoh M, Fukushima S, Takahashi K, Nara H, Yasuda S, Miyata K 2001 Interleukin-11 induces osteoblast differentiation and acts synergistically with bone morphogenetic protein-2 in c3h10t1/2 cells. J Interferon Cytokine Res 21: 695-707.
23. Bachner D, Ahrens M, Schroder D, Hoffmann A, Lauber J, Betat N, Steinert P, Flohe L, Gross G 1998 Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T1/2). Dev Dyn 213:398-411.
24. Fournier T, Medjoubi NN, Porquet D 2000 Alpha-l-acid glycoprotein. Biochim Biophys Acta 1482:157-171.
25. Mbuyi JM, Dequeker J, Bloemmen F, Stevens E 1982 Plasma proteins in human cortical bone: Enrichment of alpha 2 HS-glycoprotein, alpha 1 acid-glycoprotein, and IgE. Calcif Tissue Int 34:229-231.
26. Ishibashi H, Harumiya S, Koshihara Y 1999 Involvement of type VI collagen in interleukin-4-induced mineralization by human osteoblast-like cells in vitro. Biochim Biophys Acta 1472:153-164.
27. Shin CS, Lecanda F, Sheikh S, Weitzmann L, Cheng SL, Civitelli R 2000 Relative abundance of different cadherins defines differentiation of mesenchymal precursors into osteogenic, myogenic, or adipogenic pathways. J Cell Biochem 78:566-577.
28. Malpe R, Baylink DJ, Linkhart TA, Wergedal JE, Mohan S 1997 Insulin-like growth factor (IGF)-I, -II, IGF binding proteins (IGFBP)-3, -4, and -5 levels in the conditioned media of normal human bone cells are skeletal site-dependent. J Bone Miner Res 12:423-430.
29. Mackie EJ, Ramsey S 1996 Modulation of osteoblast behaviour by tenascin. J Cell Sci 109:1597-1604.
30. Jung HS, Oropeza V, Thesleff I 1999 Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae. Mech Dev 81:179-182.
31. Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J 1999 A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature 398:431-436.
32. Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GC, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Juppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard MJ, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML 2001 LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107:513-523.
33. Bafico A, Liu G, Yaniv A, Gazit A, Aaronson SA 2001 Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol 3:683-686.
34. Boskey AL, Spevak L, Doty SB, Rosenberg L 1997 Effects of bone CS-proteoglycans, DS-decorin, and DS-biglycan on hydroxyapatite formation in a gelatin gel. Calcif Tissue Int 61: 298-305.
35. Iozzo RV 1999 The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins. J Biol Chem 274:18843-18846.
36. Banerjee C, Javed A, Choi JY, Green J, Rosen V, van Wijnen AJ, Stein JL, Lian JB, Stein GS 2001 Differential regulation of the two principal Runx2/Cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype. Endocrinology 142:4026-4039.
37. Beck GR Jr, Zerler B, Moran E 2001 Gene array analysis of osteoblast differentiation. Cell Growth Differ 12:61-83.
38. Doi M, Nagano A, Nakamura Y 2002 Genome-wide screening by cDNA microarray of genes associated with matrix mineralization by human mesenchymal stem cells in vitro. Biochem Biophys Res Commun 290:381-390.
39. Locklin RM, Riggs BL, Hicok KC, Horton HF, Byrne MC, Khosla S 2001 Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology. J Bone Miner Res 16:2192-2204.
40. Seth A, Lee BK, Qi S, Vary CP 2000 Coordinate expression of novel genes during osteoblast differentiation. J Bone Miner Res 15:1683-1696.
41. Raouf A, Seth A 2002 Discovery of osteoblast-associated genes using cDNA microarrays. Bone 30:463-471.
42. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G 1997 Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386:78-81.
43. Gopalakrishnan R, Ouyang H, Somerman MJ, McCauley LK, Franceschi RT 2001 Matrix gamma-carboxyglutamic acid protein is a key regulator of PTH-mediated inhibition of mineralization in MC3T3-E1 osteoblast-like cells. Endocrinology 142:4379-4388.