Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people

Journal of Bone and Mineral Research

Volumn 20, Issue 6, 2005, Pages 921-929

  Dhonukshe Rutten, Rosalie A M ^a   Pluijm, Saskia M F ^b   De Groot, Lisette C P G M ^a   Lips, Paul ^b   Smit, Johannes H ^b,c   Van Staveren, Wija A ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Bone turnover markers; Bone ultrasound; Fractures; Homocysteine; Vitamin B12

Indexed keywords

CREATININE; CYANOCOBALAMIN; DEOXYPYRIDINOLINE; HOMOCYSTEINE; OSTEOCALCIN; CREATINE;

AGED; ARTICLE; BLOOD SAMPLING; BONE TURNOVER; CALCANEUS; CONTROLLED STUDY; DAIRY PRODUCT; ECHOGRAPHY; FEMALE; FOLLOW UP; FRACTURE; HUMAN; HYPERHOMOCYSTEINEMIA; IMMUNOASSAY; IMMUNORADIOMETRIC ASSAY; INCIDENCE; MAJOR CLINICAL STUDY; MALE; OSTEOPOROSIS; PROSPECTIVE STUDY; URINARY EXCRETION; BLOOD; BODY WEIGHT; BONE; CLINICAL TRIAL; COHORT ANALYSIS; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PROPORTIONAL HAZARDS MODEL; REGRESSION ANALYSIS; RISK; RISK FACTOR; TIME;

AGED; AGED, 80 AND OVER; BODY WEIGHT; BONE AND BONES; COHORT STUDIES; CREATINE; FEMALE; FRACTURES, BONE; HOMOCYSTEINE; HUMANS; IMMUNOASSAY; IMMUNORADIOMETRIC ASSAY; MALE; MIDDLE AGED; OSTEOCALCIN; OSTEOPOROSIS; PROPORTIONAL HAZARDS MODELS; REGRESSION ANALYSIS; RISK; RISK FACTORS; TIME FACTORS; VITAMIN B 12;

EID: 19044364357     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.050202     Document Type: Article

References (53)

1. Boonen S, Autier P, Barette M, Vanderschueren D, Lips P, Haentjens P 2004 Functional outcome and quality of life following hip fracture in elderly women: A prospective controlled study. Osteoporos Int 15:87-94.
2. Burger H, Van Daele PL, Grashuis K, Hofman A, Grobbee DE, Schutte HE, Birkenhager JC, Pols HA 1997 Vertebral deformities and functional impairment in men and women. J Bone Miner Res 12:152-157.
3. de Laet CE, van Hout BA, Burger H, Weel AE, Hofman A, Pols HA 1999 Incremental cost of medical care after hip fracture and first vertebral fracture: The Rotterdam study. Osteoporos Int 10:66-72.
4. Johnell O, Kanis JA, Oden A, Sernbo I, Redlund-Johnell I, Petterson C, De Laet C, Jonsson B 2004 Mortality after osteoporotic fractures. Osteoporos Int 15:38-42.
5. Minisola S, Grossi C 2002 Quality of life issues in patients with osteoporotic fractures. Aging (Milano) 14:60-63.
6. Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ 1992 Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 327:1637-1642.
7. New SA 2001 Exercise, bone and nutrition. Proc Nutr Soc 60:265-274.
8. Prestwood KM, Pannullo AM, Kenny AM, Pilbeam CC, Raisz LG 1996 The effect of a short course of calcium and vitamin D on bone turnover in older women. Osteoporos Int 6:314-319.
9. Mudd SH, Skovby F, Levy HL, Pettigrew KD, Wilcken B, Pyeritz RE, Andria G, Boers GH, Bromberg IL, Cerone R 1985 The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet 37:1-31.
10. Van Asselt DZ, de Groot LC, Van Staveren WA, Blom HJ, Wevers RA, Biemond I, Hoefnagels WH 1998 Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects. Am J Clin Nutr 68:328-334.
11. Carmel R, Green R, Jacobsen DW, Rasmussen K, Florea M, Azen C 1999 Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: Ethnic and sex differences in cobalamin and metabolite abnormalities. Am J Clin Nutr 70:904-910.
12. Johnson MA, Hawthorne NA, Brackett WR, Fischer JG, Gunter EW, Allen RH, Stabler SP 2003 Hyperhomocysteinemia and vitamin B-12 deficiency in elderly using Title IIIc nutrition services. Am J Clin Nutr 77:211-220.
13. Lubec B, Fang-Kircher S, Lubec T, Blom HJ, Boers GH 1996 Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria. Biochim Biophys Acta 1315:159-162.
14. McKusick VA 1966 Heritable Disorders of Connective Tissue, 3rd ed. C.V. Mosby, St. Louis, MO, USA.
15. van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, Van Der Klift M, de Jonge R, Lindemans J, de Groot LC, Hofman A, Witteman JC, van Leeuwen JP, Breteler MM, Lips P, Pols HA, Uitterlinden AG 2004 Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 350:2033-2041.
16. McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP 2004 Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 350:2042-2049.
17. Njeh CF, Fuerst T, Diessel E, Genant HK 2001 Is quantitative ultrasound dependent on bone structure? A reflection. Osteoporos Int 12:1-15.
18. Pluijm SM, Graafmans WC, Bouter LM, Lips P 1999 Ultrasound measurements for the prediction of osteoporotic fractures in elderly people. Osteoporos Int 9:550-556.
19. Deeg DJH, Knipscheer CPM, van Tilburg W (eds.) 1993 Autonomy and Well-Being in the Aging Population: Concepts and Design of the Longitudinal Aging Study Amsterdam. Netherlands Institute of Gerontology, Bunnik, The Netherlands.
20. Smit JH, de Vries MZ, Poppelaars JL 1994 Data-collection and fieldwork procedures. In: Deeg DJH, Westendorp-de Seriere M (eds.) Autonomy and Well-Being in the Aging Population II: Report from the Longitudinal Aging Study Amsterdam 1992-1996. VU University Press, Amsterdam, The Netherlands, pp. 9-20.
21. Graafmans WC, van Lingen A, Ooms ME, Bezemer PD, Lips P 1996 Ultrasound measurements in the calcaneus: Precision and its relation with bone mineral density of the heel, hip and lumbar spine. Bone 19:97-100.
22. Smit JH, de Vries MZ 1994 Procedures and results of the field work. In: Deeg DJH, Westendorp-de Seriere M (eds.) Autonomy and Well-Being in the Aging Population I: Report from the Longitudinal Aging Study Amsterdam 1992-1993. VU University Press, Amsterdam, The Netherlands, pp. 7-13.
23. Tromp AM, Smit JH, Deeg DJ, Bouter LM, Lips P 1998 Predictors for falls and fractures in the Longitudinal Aging Study Amsterdam. J Bone Miner Res 13:1932-1939.
24. Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB 1994 A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 49:M85-M94.
25. Tombaugh TN, McIntyre NJ 1992 The mini-mental state examination: A comprehensive review. J Am Geriatr Soc 40:922-935.
26. Welch GN, Loscalzo J 1998 Homocysteine and atherothrombosis. N Engl J Med 338:1042-1050.
27. Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH 1993 Total homocysteine in plasma or serum: Methods and clinical applications. Clin Chem 39:1764-1779.
28. Mudd SH, Levy HL, Skovby F 1995 Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds.) The Metabolic and Molecular Bases of Inherited Disease. McGraw-Hill, New York, NY, USA, pp. 1279-1327.
29. Hans D, Dargent-Molina P, Schott AM, Sebert JL, Cormier C, Kotzki PO, Delmas PD, Fouilles JM, Breart G, Meunier PJ 1996 Ultrasonographic heel measurements to predict hip fracture in elderly women: The EPIDOS prospective study. Lancet 348:511-514.
30. Khaw KT, Reeve J, Luben R, Bingham S, Welch A, Wareham N, Oakes S, Day N 2004 Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population study. Lancet 363:197-202.
31. Garnero P, Delmas PD 1998 Biochemical markers of bone turnover. Applications for osteoporosis. Endocrinol Metab Clin North Am 27:303-323.
32. Ebeling PR, Akesson K 2001 Role of biochemical markers in the management of osteoporosis. Best Pract Res Clin Rheumatol 15:385-400.
33. Rogers A, Hannon RA, Eastell R 2000 Biochemical markers as predictors of rates of bone loss after menopause. J Bone Miner Res 15:1398-1404.
34. Dhonukshe-Rutten RAM, Lips M, De Jong N, Chin A, Paw MMJ, Hiddink GJ, Van Dusseldorp M, de-Groot LCPG, Van Staveren WA 2003 Vitamin B-12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men. J Nutr 133:801-807.
35. Stone KL, Bauer DC, Sellmeyer D, Cummings SR 2004 Low serum vitamin B-12 levels are associated with increased hip bone loss in older women: A prospective study. J Clin Endocrinol Metab 89:1217-1221.
36. Kim GS, Kim CH, Park JY, Lee KU, Park CS 1996 Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cells. Metabolism 45:1443-1446.
37. Carmel R, Lau KH, Baylink DJ, Saxena S, Singer FR 1988 Cobalamin and osteoblast-specific proteins. N Engl J Med 319:70-75.
38. Klee GG 2000 Cobalamin and folate evaluation: Measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate. Clin Chem 46:1277-1283.
39. Lindenbaum J, Healton EB, Savage DG, Brust JC, Garrett TJ, Podell ER, Marcell PD, Stabler SP, Allen RH 1988 Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 318:1720-1728.
40. Brattstrom L, Wilcken DE, Ohrvik J, Brudin L 1998 Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: The result of a meta-analysis. Circulation 98:2520-2526.
41. Abrahamsen B, Madsen JS, Tofteng CL, Stilgren L, Bladbjerg EM, Kristensen SR, Brixen K, Mosekilde L 2003 A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: Longitudinal data from the Danish osteoporosis prevention study. J Bone Miner Res 18:723-729.
42. Bathum L, Von Bornemann H, Christiansen L, Madsen JS, Skytthe A, Christensen K 2004 Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: Results from a population-based Danish twin study. Osteoporos Int 15:659-664.
43. Jorgensen HL, Madsen JS, Madsen B, Saleh MM, Abrahamsen B, Fenger M, Lauritzen JB 2002 Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case control study in Danish postmenopausal women. Calcif Tissue Int 71:386-392.
44. Miyao M, Morita H, Hosoi T, Kurihara H, Inoue S, Hoshino S, Shiraki M, Yazaki Y, Ouchi Y 2000 Association of methylene-tetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women. Calcif Tissue Int 66:190-194.
45. McLean RR, Karasik D, Selhub J, Tucker KL, Ordovas JM, Russo GT, Cupples LA, Jacques PF, Kiel DP 2004 Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status. J Bone Miner Res 19:410-418.
46. Walsh BW, Paul S, Wild RA, Dean RA, Tracy RP, Cox DA, Anderson PW 2000 The effects of hormone replacement therapy and raloxifene on C-reactive protein and homocysteine in healthy postmenopausal women: A randomized, controlled trial. J Clin Endocrinol Metab 85:214-218.
47. Christodoulakos G, Lambrinoudaki I, Panoulis C, Rizos D, Coutoukos J, Creatsas G 2003 Effect of raloxifene, estrogen, and hormone replacement therapy on serum homocysteine levels in postmenopausal women. Fertil Steril 79:455-456.
48. van Baal WM, Smolders RG, van der Mooren MJ, Teerlink T, Kenemans P 1999 Hormone replacement therapy and plasma homocysteine levels. Obstet Gynecol 94:485-491.
49. Madsen JS, Kristensen SR, Klitgaard NA, Bladbjerg EM, Abrahamsen B, Stilgren L, Jespersen J 2002 Effect of long-term hormone replacement therapy on plasma homocysteine in postmenopausal women: A randomized controlled study. Am J Obstet Gynecol 187:33-39.
50. Figlin E, Chetrit A, Shahar A, Shpilberg O, Zivelin A, Rosenberg N, Brok-Simoni F, Gadoth N, Sela BA, Seligsohn U 2003 High prevalences of vitamin B12 and folic acid deficiency in elderly subjects in Israel. Br J Haematol 123:696-701.
51. Baik HW, Russell RM 1999 Vitamin B12 deficiency in the elderly. Annu Rev Nutr 19:357-377.
52. Lindenbaum J, Savage DG, Stabler SP, Allen RH 1990 Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am J Hematol 34:99-107.
53. Brattstrom L 1996 Vitamins as homocysteine-lowering agents. J Nutr 126(9 Suppl):12765-12805.