The role of low endothelial shear stress in the conversion of atherosclerotic lesions from stable to unstable plaque

Current Opinion in Cardiology

Volumn 24, Issue 6, 2009, Pages 580-590

  Koskinas, Konstantinos C ^a   Chatzizisisa, Yiannis S ^a,b   Baker, Aaron B ^b   Edelman, Elazer R ^a,b   Stone, Peter H ^a   Feldman, Charles L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Coronary atherosclerosis; Extracellular matrix degrading enzymes; Inflammation; Remodeling; Shear stress; Unstable plaque

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; PROTEINASE; PROTEOHEPARAN SULFATE; SIMVASTATIN; VALSARTAN;

ACUTE CORONARY SYNDROME; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTERY WALL; ATHEROMA; ATHEROSCLEROTIC PLAQUE; BALLOON CATHETER; CELL MIGRATION; CLINICAL ASSESSMENT; CLINICAL FEATURE; CLINICAL TRIAL; CORONARY ARTERY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; CORONARY ARTERY THROMBOSIS; DISEASE COURSE; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG ELUTING STENT; ELASTIC FIBER; ENDOTHELIAL SHEAR STRESS; EXTRACELLULAR MATRIX; FIBROATHEROMATA; HEART CATHETERIZATION; HIGH RISK PATIENT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIPID STORAGE; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REVIEW; RISK FACTOR; RISK REDUCTION; SHEAR STRESS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; THROMBOGENICITY; VASCULITIS;

CORONARY ARTERY DISEASE; ENDOTHELIUM, VASCULAR; HUMANS;

EID: 74249117301     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/HCO.0b013e328331630b     Document Type: Review

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