Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: Consequences for smooth muscle cell migration

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 22, Issue 3, 2002, Pages 405-411

  Palumbo, Roberta ^a   Gaetano, Carlo ^a   Antonini, Annalisa ^a   Pompilio, Giulio ^a   Bracco, Enrico ^a   Rönnstrand, Lars ^a   Heldin, Carl Henrik ^a   Capogrossi, Maurizio C ^a  

^a LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

Author keywords

Endothelial cells; Platelet derived growth factor receptors; Platelet derived growth factors; Shear stress; Smooth muscle cells

Indexed keywords

ISOPROTEIN; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR AA; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BB; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ARTERY INTIMA PROLIFERATION; ARTICLE; CATTLE; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SHEAR STRESS; SMOOTH MUSCLE FIBER;

ANIMALS; CATTLE; CHEMOTAXIS; CULTURE MEDIA, CONDITIONED; ENDOTHELIUM, VASCULAR; MUSCLE, SMOOTH, VASCULAR; MUTATION; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; STRESS, MECHANICAL; TRANSFECTION;

EID: 0036123021     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/hq0302.104528     Document Type: Article

References (45)

1. The pathogenesis of atherosclerosis: An update
2. Flow regulation of 72-kD collagenase IV (MMP-2) after experimental arterial injury
3. Structural changes and recovery of function after arterial injury
4. Increased blood flow inhibits neointimal hyperplasia in endothelialized vascular grafts
5. Time course of flow-induced smooth muscle cell proliferation and intimal thickening in endothelialized baboon vascular grafts
6. Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury
7. PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
8. PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor
9. Mechanism of action and in vivo role of platelet-derived growth factor
10. Effect of platelet-derived growth factor receptor-alpha and -beta blockade on flow-induced neointimal formation in endothelialized baboon vascular grafts
11. Regulation of chemotaxis by the platelet-derived growth factor receptor-beta
12. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF
13. Regulatory effects of platelet-derived growth factor AA homodimer on migration of vascular smooth muscle cells
14. The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP
15. Shear stress modulates the proliferation rate, protein synthesis, and mitogenic activity of arterial smooth muscle cells
16. Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro
17. Migration of cultured vascular smooth muscle cells through a basement membrane barrier requires type IV collagenase activity and is inhibited by cellular differentiation
18. Nicotine regulates basic fibroblastic growth factor and transforming growth factor betal production in endothelial cells
19. Shear stress downregulation of platelet-derived growth factor receptor-β and matrix metalloprotease-2 is associated with inhibition of smooth muscle cell invasion and migration
20. Transformation of mammalian cells with genes from procaryotes and eucaryotes
21. Simultaneous induction of stimulatory and inhibitory signal PDGF
22. The chemotactic and mitogenic effects of platelet-derived growth factor-BB on rat aorta smooth muscle cells are inhibited by basic fibroblast growth factor
23. Membrane ruffling and chemotaxis transduced by the PDGF β-receptor require the binding site for phosphatidylinositol 3′ kinase
24. Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis
25. Signal transduction via platelet-derived growth factor receptors
26. Different functions of the platelet-derived growth factor-alpha and -beta receptors for the migration and proliferation of cultured baboon smooth muscle cells
27. Platelet-derived growth factor (PDGF) alpha receptor activation modulates the calcium mobilizing activity of the PDGF beta receptor in Balb/c3T3 fibroblasts
28. 2-terminal kinase-1 and antagonizes PDGF receptor-β induced phenotypic transformation
29. Adaptive regulation of wall shear stress to flow change in the canine carotid artery
30. Pulsatile flow and atherosclerosis in the human carotid bifurcation: Positive correlation between plaque location and low and oscillating shear stress
31. Carotid artery intima-media thickness measured by ultrasonography in normal clinical practice correlates well with atherosclerosis risk factors
32. In the femoral artery bifurcation, differences in mean wall shear stress within subjects are associated with different intima-media thicknesses
33. Low wall shear stress contributes to atheroscterosis of the carotid artery in hypertensive patients
34. Increased blood flow inhibits neointimal hyperplasia in endothelialized vascular grafts
35. Shear stress regulates smooth muscle proliferation and neointimal thickening in porous polytetrafluoroethylene grafts
36. Effect of platelet-derived growth factor receptor-alpha and -beta blockade on flow-induced neointimal formation in endothelialized baboon vascular grafts
37. PDGFβ receptor blockade inhibits intimal hyperplasia in the baboon
38. Endothelial cells inhibit flow-induced smooth muscle cell migration: Role of plasminogen activator inhibitor-1
39. Primate smooth muscle cell migration from aortic explants is mediated by endogenous platelet-derived growth factor and basic fibroblast growth factor acting through matrix metalloproteinases 2 and 9
40. Shear stress increases endothelial platelet-derived growth factor mRNA levels
41. Fluid shear stress increases the release of platelet-derived growth factor BB (PDGFBB) by aortic endothelial cells
42. Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium
43. Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element
44. Fluid shear stress stimulates platelet-derived growth factor expression in endothelial cells
45. Platelet-derived growth factor ligand and receptor expression in response to altered blood flow in vivo