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Volumn 7, Issue 1 PART 1, 2010, Pages 79-88

How does chronic sildenafil prevent vascular oxidative stress in insulin-resistant rats?

Author keywords

Endothelium; Insulin resistance; Nitric oxide; Oxidative stress; Pde5 inhibitors; Superoxide

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN; NITRIC OXIDE; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SILDENAFIL; SUPEROXIDE;

EID: 74049127873     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2009.01551.x     Document Type: Article
Times cited : (11)

References (31)
  • 1
    • 33645978121 scopus 로고    scopus 로고
    • Metabolic syndrome-a new world-wide definition. A consensus statement from the International Diabetes Federation
    • Alberti KG, Zimmet P, Shaw J. Metabolic syndrome-a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabet Med 2006, 23:469-80.
    • (2006) Diabet Med , vol.23 , pp. 469-480
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 4
    • 42949165933 scopus 로고    scopus 로고
    • Daily treatment with sildenafil reverses endothelial dysfunction and oxidative stress in an animal model of insulin resistance
    • Behr-Roussel D, Oudot A, Caisey S, Coz OL, Gorny D, Bernabe J, Wayman C, Alexandre L, Giuliano FA. Daily treatment with sildenafil reverses endothelial dysfunction and oxidative stress in an animal model of insulin resistance. Eur Urol 2008, 53:1272-80.
    • (2008) Eur Urol , vol.53 , pp. 1272-1280
    • Behr-Roussel, D.1    Oudot, A.2    Caisey, S.3    Coz, O.L.4    Gorny, D.5    Bernabe, J.6    Wayman, C.7    Alexandre, L.8    Giuliano, F.A.9
  • 6
    • 21644482050 scopus 로고    scopus 로고
    • Erection capability is potentiated by long-term sildenafil treatment: Role of blood flow-induced endothelial nitric-oxide synthase phosphorylation
    • Musicki B, Champion HC, Becker RE, Liu T, Kramer MF, Burnett AL. Erection capability is potentiated by long-term sildenafil treatment: Role of blood flow-induced endothelial nitric-oxide synthase phosphorylation. Mol Pharmacol 2005, 68:226-32.
    • (2005) Mol Pharmacol , vol.68 , pp. 226-232
    • Musicki, B.1    Champion, H.C.2    Becker, R.E.3    Liu, T.4    Kramer, M.F.5    Burnett, A.L.6
  • 7
    • 67649675049 scopus 로고    scopus 로고
    • Nitrite or sildenafil, but not BAY 41-2272, blunt acute pulmonary embolism-induced increases in circulating matrix metalloproteinase-9 and oxidative stress
    • Dias-Junior CA, Cau SB, Oliveira AM, Castro MM, Montenegro MF, Gerlach RF, Tanus-Santos JE. Nitrite or sildenafil, but not BAY 41-2272, blunt acute pulmonary embolism-induced increases in circulating matrix metalloproteinase-9 and oxidative stress. Thromb Res 2009, 124:349-55.
    • (2009) Thromb Res , vol.124 , pp. 349-355
    • Dias-Junior, C.A.1    Cau, S.B.2    Oliveira, A.M.3    Castro, M.M.4    Montenegro, M.F.5    Gerlach, R.F.6    Tanus-Santos, J.E.7
  • 8
    • 34447498964 scopus 로고    scopus 로고
    • FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through antioxidative mechanisms
    • Lagoda G, Jin L, Lehrfeld TJ, Liu T, Burnett AL. FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through antioxidative mechanisms. J Sex Med 2007, 4:908-16.
    • (2007) J Sex Med , vol.4 , pp. 908-916
    • Lagoda, G.1    Jin, L.2    Lehrfeld, T.J.3    Liu, T.4    Burnett, A.L.5
  • 9
    • 23244448247 scopus 로고    scopus 로고
    • Sildenafil inhibits the formation of superoxide and the expression of gp47 NAD[P]H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells
    • Koupparis AJ, Jeremy JY, Muzaffar S, Persad R, Shukla N. Sildenafil inhibits the formation of superoxide and the expression of gp47 NAD[P]H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells. BJU Int 2005, 96:423-7.
    • (2005) BJU Int , vol.96 , pp. 423-427
    • Koupparis, A.J.1    Jeremy, J.Y.2    Muzaffar, S.3    Persad, R.4    Shukla, N.5
  • 10
    • 0030775322 scopus 로고    scopus 로고
    • Oxidative stress and cardiovascular disease
    • Griendling KK, Alexander RW. Oxidative stress and cardiovascular disease. Circulation 1997, 96:3264-5.
    • (1997) Circulation , vol.96 , pp. 3264-3265
    • Griendling, K.K.1    Alexander, R.W.2
  • 11
    • 17744377431 scopus 로고    scopus 로고
    • The sources of oxidative stress in the vessel wall
    • Wolin MS, Ahmad M, Gupte SA. The sources of oxidative stress in the vessel wall. Kidney Int 2005, 67:1659-61.
    • (2005) Kidney Int , vol.67 , pp. 1659-1661
    • Wolin, M.S.1    Ahmad, M.2    Gupte, S.A.3
  • 12
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-54.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 13
    • 0033512422 scopus 로고    scopus 로고
    • Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2-imbalance in insulin-resistant rat aorta
    • Shinozaki K, Kashiwagi A, Nishio Y, Okamura T, Yoshida Y, Masada M, Toda N, Kikkawa R. Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2-imbalance in insulin-resistant rat aorta. Diabetes 1999, 48:2437-45.
    • (1999) Diabetes , vol.48 , pp. 2437-2445
    • Shinozaki, K.1    Kashiwagi, A.2    Nishio, Y.3    Okamura, T.4    Yoshida, Y.5    Masada, M.6    Toda, N.7    Kikkawa, R.8
  • 14
    • 0037216768 scopus 로고    scopus 로고
    • Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
    • Fleming I, Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 2003, 284:R1-12.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.284
    • Fleming, I.1    Busse, R.2
  • 15
    • 58149181332 scopus 로고    scopus 로고
    • Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in a mouse model of secondhand smoke induced erectile dysfunction
    • Bivalacqua TJ, Sussan TE, Gebska MA, Strong TD, Berkowitz DE, Biswal S, Burnett AL, Champion HC. Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in a mouse model of secondhand smoke induced erectile dysfunction. J Urol 2009, 181:899-906.
    • (2009) J Urol , vol.181 , pp. 899-906
    • Bivalacqua, T.J.1    Sussan, T.E.2    Gebska, M.A.3    Strong, T.D.4    Berkowitz, D.E.5    Biswal, S.6    Burnett, A.L.7    Champion, H.C.8
  • 16
    • 19744369830 scopus 로고    scopus 로고
    • Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats
    • Miatello R, Vazquez M, Renna N, Cruzado M, Zumino AP, Risler N. Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats. Am J Hypertens 2005, 18:864-70.
    • (2005) Am J Hypertens , vol.18 , pp. 864-870
    • Miatello, R.1    Vazquez, M.2    Renna, N.3    Cruzado, M.4    Zumino, A.P.5    Risler, N.6
  • 18
    • 0034730795 scopus 로고    scopus 로고
    • Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats
    • Shinozaki K, Nishio Y, Okamura T, Yoshida Y, Maegawa H, Kojima H, Masada M, Toda N, Kikkawa R, Kashiwagi A. Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats. Circ Res 2000, 87:566-73.
    • (2000) Circ Res , vol.87 , pp. 566-573
    • Shinozaki, K.1    Nishio, Y.2    Okamura, T.3    Yoshida, Y.4    Maegawa, H.5    Kojima, H.6    Masada, M.7    Toda, N.8    Kikkawa, R.9    Kashiwagi, A.10
  • 19
    • 13844296360 scopus 로고    scopus 로고
    • Involvement of oxidative stress and NADPH oxidase activation in the development of cardiovascular complications in a model of insulin resistance, the fructose-fed rat
    • Delbosc S, Paizanis E, Magous R, Araiz C, Dimo T, Cristol JP, Cros G, Azay J. Involvement of oxidative stress and NADPH oxidase activation in the development of cardiovascular complications in a model of insulin resistance, the fructose-fed rat. Atherosclerosis 2005, 179:43-9.
    • (2005) Atherosclerosis , vol.179 , pp. 43-49
    • Delbosc, S.1    Paizanis, E.2    Magous, R.3    Araiz, C.4    Dimo, T.5    Cristol, J.P.6    Cros, G.7    Azay, J.8
  • 20
    • 34047094881 scopus 로고    scopus 로고
    • Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice
    • Ayala JE, Bracy DP, Julien BM, Rottman JN, Fueger PT, Wasserman DH. Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Diabetes 2007, 56:1025-33.
    • (2007) Diabetes , vol.56 , pp. 1025-1033
    • Ayala, J.E.1    Bracy, D.P.2    Julien, B.M.3    Rottman, J.N.4    Fueger, P.T.5    Wasserman, D.H.6
  • 21
    • 59649114150 scopus 로고    scopus 로고
    • Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats
    • Zhao CX, Xu X, Cui Y, Wang P, Wei X, Yang S, Edin ML, Zeldin DC, Wang DW. Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats. J Pharmacol Exp Ther 2009, 328:610-20.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 610-620
    • Zhao, C.X.1    Xu, X.2    Cui, Y.3    Wang, P.4    Wei, X.5    Yang, S.6    Edin, M.L.7    Zeldin, D.C.8    Wang, D.W.9
  • 22
    • 12344288164 scopus 로고    scopus 로고
    • Chronic treatment with tadalafil improves endothelial function in men with increased cardiovascular risk
    • Rosano GM, Aversa A, Vitale C, Fabbri A, Fini M, Spera G. Chronic treatment with tadalafil improves endothelial function in men with increased cardiovascular risk. Eur Urol 2005, 47:214-20.
    • (2005) Eur Urol , vol.47 , pp. 214-220
    • Rosano, G.M.1    Aversa, A.2    Vitale, C.3    Fabbri, A.4    Fini, M.5    Spera, G.6
  • 23
    • 69949108553 scopus 로고    scopus 로고
    • The endothelial-erectile dysfunction connection: An essential update
    • Costa C, Virag R. The endothelial-erectile dysfunction connection: An essential update. J Sex Med 2009, 6:2390-404.
    • (2009) J Sex Med , vol.6 , pp. 2390-2404
    • Costa, C.1    Virag, R.2
  • 26
    • 16844382827 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling
    • Das A, Xi L, Kukreja RC. Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling. J Biol Chem 2005, 280:12944-55.
    • (2005) J Biol Chem , vol.280 , pp. 12944-12955
    • Das, A.1    Xi, L.2    Kukreja, R.C.3
  • 27
    • 34548297591 scopus 로고    scopus 로고
    • Daily administration of phosphodiesterase type 5 inhibitors for urological and nonurological indications
    • Bella AJ, Deyoung LX, Al Numi M, Brock GB. Daily administration of phosphodiesterase type 5 inhibitors for urological and nonurological indications. Eur Urol 2007, 52:990-1005.
    • (2007) Eur Urol , vol.52 , pp. 990-1005
    • Bella, A.J.1    Deyoung, L.X.2    Al Numi, M.3    Brock, G.B.4
  • 28
    • 33751407982 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibitors: The day after
    • Hatzimouratidis K, Hatzichristou D. Phosphodiesterase type 5 inhibitors: The day after. Eur Urol 2007, 51:75-88.
    • (2007) Eur Urol , vol.51 , pp. 75-88
    • Hatzimouratidis, K.1    Hatzichristou, D.2
  • 29
    • 33750633515 scopus 로고    scopus 로고
    • Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: Present and future
    • Uckert S, Hedlund P, Andersson KE, Truss MC, Jonas U, Stief CG. Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: Present and future. Eur Urol 2006, 50:1194-207.
    • (2006) Eur Urol , vol.50 , pp. 1194-1207
    • Uckert, S.1    Hedlund, P.2    Andersson, K.E.3    Truss, M.C.4    Jonas, U.5    Stief, C.G.6
  • 30
    • 56049103760 scopus 로고    scopus 로고
    • Oral phosphodiesterase type 5 inhibitors: Nonerectogenic beneficial uses
    • Mostafa T. Oral phosphodiesterase type 5 inhibitors: Nonerectogenic beneficial uses. J Sex Med 2008, 5:2502-18.
    • (2008) J Sex Med , vol.5 , pp. 2502-2518
    • Mostafa, T.1
  • 31
    • 67649887476 scopus 로고    scopus 로고
    • 2009 Update on phosphodiesterase type 5 inhibitor therapy part 1: Recent studies on routine dosing for penile rehabilitation, lower urinary tract symptoms, and other indications (CME)
    • Shindel AW. 2009 Update on phosphodiesterase type 5 inhibitor therapy part 1: Recent studies on routine dosing for penile rehabilitation, lower urinary tract symptoms, and other indications (CME). J Sex Med 2009, 6:1794-808.
    • (2009) J Sex Med , vol.6 , pp. 1794-1808
    • Shindel, A.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.